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MGI:Bdnf
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Bdnf | |
| Protein Name(s) | brain derived neurotrophic factor, | |
| External Links | ||
| MGI | MGI:88145 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0001657 |
ureteric bud development |
MGI:MGI:3588889 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0005102 |
receptor binding |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0005169 |
neurotrophin TRKB receptor binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:2152295 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005576 |
extracellular region |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0964 |
C |
From MGI |
||
| GO:0005623 |
cell |
MGI:MGI:3654775 |
IPI: Inferred from Physical Interaction |
C |
From MGI |
|||
| GO:0006120 |
mitochondrial electron transport, NADH to ubiquinone |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0006916 |
anti-apoptosis |
MGI:MGI:2670470 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0007399 |
nervous system development |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0007406 |
negative regulation of neuroblast proliferation |
MGI:MGI:2664423 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0007411 |
axon guidance |
MGI:MGI:3629534 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1929986 |
P |
From MGI |
||
| GO:0007412 |
axon target recognition |
MGI:MGI:3511733 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1930038 |
P |
From MGI |
||
| GO:0007610 |
behavior |
MGI:MGI:3047468 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2176750 |
P |
From MGI |
||
| GO:0007611 |
learning or memory |
MGI:MGI:3047468 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2176750 |
P |
From MGI |
||
| GO:0007631 |
feeding behavior |
MGI:MGI:2665156 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2663046 |
P |
From MGI |
||
| GO:0008021 |
synaptic vesicle |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0008038 |
neuron recognition |
MGI:MGI:3578094 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0008083 |
growth factor activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0339 |
F |
From MGI |
||
| GO:0014047 |
glutamate secretion |
MGI:MGI:3654775 |
IPI: Inferred from Physical Interaction |
P |
From MGI |
|||
| GO:0016023 |
cytoplasmic membrane-bounded vesicle |
MGI:MGI:2686789 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0016023 |
cytoplasmic membrane-bounded vesicle |
MGI:MGI:3046393 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0016358 |
dendrite development |
MGI:MGI:2669042 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0019222 |
regulation of metabolic process |
MGI:MGI:2447006 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2663046 |
P |
From MGI |
||
| GO:0021675 |
nerve development |
MGI:MGI:74182 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857136 |
P |
From MGI |
||
| GO:0042490 |
mechanoreceptor differentiation |
MGI:MGI:3505841 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1857232 |
P |
From MGI |
||
| GO:0042493 |
response to drug |
MGI:MGI:3047468 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2176750 |
P |
From MGI |
||
| GO:0042596 |
fear response |
MGI:MGI:3047468 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2176750 |
P |
From MGI |
||
| GO:0043523 |
regulation of neuron apoptotic process |
MGI:MGI:3621592 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0043524 |
negative regulation of neuron apoptotic process |
MGI:MGI:3590457 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1930038 |
P |
From MGI |
||
| GO:0043524 |
negative regulation of neuron apoptotic process |
MGI:MGI:80051 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0045666 |
positive regulation of neuron differentiation |
MGI:MGI:2664423 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045843 |
negative regulation of striated muscle tissue development |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0046668 |
regulation of retinal cell programmed cell death |
MGI:MGI:2155023 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0048167 |
regulation of synaptic plasticity |
MGI:MGI:3654775 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0048167 |
regulation of synaptic plasticity |
MGI:MGI:3703330 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0048169 |
regulation of long-term neuronal synaptic plasticity |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0048170 |
positive regulation of long-term neuronal synaptic plasticity |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0048172 |
regulation of short-term neuronal synaptic plasticity |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0048839 |
inner ear development |
MGI:MGI:74182 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857136 |
P |
From MGI |
||
| GO:0060079 |
regulation of excitatory postsynaptic membrane potential |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Sajithlal G et al. (2005) Eya 1 acts as a critical regulator for specifying the metanephric mesenchyme. Dev Biol 284: 323-36 PubMed GONUTS page
- ↑ Coppola V et al. (2001) Dissection of NT3 functions in vivo by gene replacement strategy. Development 128: 4315-27 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Yano H et al. (2006) BDNF-mediated neurotransmission relies upon a myosin VI motor complex. Nat Neurosci 9: 1009-18 PubMed GONUTS page
- ↑ Schubert M et al. (2003) Insulin receptor substrate-2 deficiency impairs brain growth and promotes tau phosphorylation. J Neurosci 23: 7084-92 PubMed GONUTS page
- ↑ 5.0 5.1 Cheng A et al. (2003) Nitric oxide acts in a positive feedback loop with BDNF to regulate neural progenitor cell proliferation and differentiation in the mammalian brain. Dev Biol 258: 319-33 PubMed GONUTS page
- ↑ Tessarollo L et al. (2004) NT-3 replacement with brain-derived neurotrophic factor redirects vestibular nerve fibers to the cochlea. J Neurosci 24: 2575-84 PubMed GONUTS page
- ↑ Hellard D et al. (2004) Cranial sensory neuron development in the absence of brain-derived neurotrophic factor in BDNF/Bax double null mice. Dev Biol 275: 34-43 PubMed GONUTS page
- ↑ 8.0 8.1 8.2 8.3 Monteggia LM et al. (2004) Essential role of brain-derived neurotrophic factor in adult hippocampal function. Proc Natl Acad Sci U S A 101: 10827-32 PubMed GONUTS page
- ↑ Xu B et al. (2003) Brain-derived neurotrophic factor regulates energy balance downstream of melanocortin-4 receptor. Nat Neurosci 6: 736-42 PubMed GONUTS page
- ↑ Fritzsch B et al. (2005) Atoh1 null mice show directed afferent fiber growth to undifferentiated ear sensory epithelia followed by incomplete fiber retention. Dev Dyn 233: 570-83 PubMed GONUTS page
- ↑ Sadakata T et al. (2004) The secretory granule-associated protein CAPS2 regulates neurotrophin release and cell survival. J Neurosci 24: 43-52 PubMed GONUTS page
- ↑ Gauthier LR et al. (2004) Huntingtin controls neurotrophic support and survival of neurons by enhancing BDNF vesicular transport along microtubules. Cell 118: 127-38 PubMed GONUTS page
- ↑ Gorski JA et al. (2003) Brain-derived neurotrophic factor is required for the maintenance of cortical dendrites. J Neurosci 23: 6856-65 PubMed GONUTS page
- ↑ Biffo S et al. (1990) B-50/GAP43 Expression Correlates with Process Outgrowth in the Embryonic Mouse Nervous System. Eur J Neurosci 2: 487-499 PubMed GONUTS page
- ↑ 15.0 15.1 Ernfors P et al. (1995) Complementary roles of BDNF and NT-3 in vestibular and auditory development. Neuron 14: 1153-64 PubMed GONUTS page
- ↑ Sedý J et al. (2004) Pacinian corpuscle development involves multiple Trk signaling pathways. Dev Dyn 231: 551-63 PubMed GONUTS page
- ↑ Li HL et al. (2006) The novel neurotrophin-regulated neuronal development-associated protein, NDAP, mediates apoptosis. FEBS Lett 580: 1723-8 PubMed GONUTS page
- ↑ Guo H et al. (2005) Development of pontine noradrenergic A5 neurons requires brain-derived neurotrophic factor. Eur J Neurosci 21: 2019-23 PubMed GONUTS page
- ↑ Staecker H et al. (1996) NGF, BDNF and NT-3 play unique roles in the in vitro development and patterning of innervation of the mammalian inner ear. Brain Res Dev Brain Res 92: 49-60 PubMed GONUTS page
- ↑ Wahlin KJ et al. (2001) Neurotrophic signaling in normal and degenerating rodent retinas. Exp Eye Res 73: 693-701 PubMed GONUTS page
- ↑ Lynch G et al. (2007) Brain-derived neurotrophic factor restores synaptic plasticity in a knock-in mouse model of Huntington's disease. J Neurosci 27: 4424-34 PubMed GONUTS page
