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MGI:Bcr
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Bcr | |
| Protein Name(s) | breakpoint cluster region, | |
| External Links | ||
| MGI | MGI:88141 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000166 |
nucleotide binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0547 |
F |
From MGI |
||
| GO:0004674 |
protein serine/threonine kinase activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0723 |
F |
From MGI |
||
| GO:0004674 |
protein serine/threonine kinase activity |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0005085 |
guanyl-nucleotide exchange factor activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0344 |
F |
From MGI |
||
| GO:0005085 |
guanyl-nucleotide exchange factor activity |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0005089 |
Rho guanyl-nucleotide exchange factor activity |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0005096 |
GTPase activator activity |
MGI:MGI:2152657 |
TAS: Traceable Author Statement |
F |
From MGI |
|||
| GO:0005096 |
GTPase activator activity |
MGI:MGI:3698699 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3698674 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005524 |
ATP binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0067 |
F |
From MGI |
||
| GO:0005543 |
phospholipid binding |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0005622 |
intracellular |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:XP_001079915 |
C |
From MGI |
||
| GO:0005829 |
cytosol |
MGI:MGI:3698699 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005886 |
plasma membrane |
MGI:MGI:3698699 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0006468 |
protein phosphorylation |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
P |
From MGI |
|||
| GO:0007165 |
signal transduction |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
P |
From MGI |
|||
| GO:0007420 |
brain development |
MGI:MGI:2152657 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:107771 |
P |
From MGI |
||
| GO:0016301 |
kinase activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0418 |
F |
From MGI |
||
| GO:0016310 |
phosphorylation |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0418 |
P |
From MGI |
||
| GO:0016740 |
transferase activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0808 |
F |
From MGI |
||
| GO:0019899 |
enzyme binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:XP_001079915 |
F |
From MGI |
||
| GO:0030036 |
actin cytoskeleton organization |
MGI:MGI:3698699 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:107771 |
P |
From MGI |
||
| GO:0030336 |
negative regulation of cell migration |
MGI:MGI:3698699 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:107771 |
P |
From MGI |
||
| GO:0030675 |
Rac GTPase activator activity |
MGI:MGI:4366690 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:107771 |
F |
From MGI |
||
| GO:0032496 |
response to lipopolysaccharide |
MGI:MGI:4366690 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2154396 |
P |
From MGI |
||
| GO:0032855 |
positive regulation of Rac GTPase activity |
MGI:MGI:4366690 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:107771 |
P |
From MGI |
||
| GO:0035023 |
regulation of Rho protein signal transduction |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
P |
From MGI |
|||
| GO:0035556 |
intracellular signal transduction |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
P |
From MGI |
|||
| GO:0042472 |
inner ear morphogenesis |
MGI:MGI:3622851 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:107771 |
P |
From MGI |
||
| GO:0043314 |
negative regulation of neutrophil degranulation |
MGI:MGI:4366690 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:107771 |
P |
From MGI |
||
| GO:0043547 |
positive regulation of GTPase activity |
MGI:MGI:2152657 |
TAS: Traceable Author Statement |
P |
From MGI |
|||
| GO:0043547 |
positive regulation of GTPase activity |
MGI:MGI:3698699 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0046777 |
protein autophosphorylation |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:XP_001079915 |
P |
From MGI |
||
| GO:0048008 |
platelet-derived growth factor receptor signaling pathway |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:XP_001079915 |
P |
From MGI |
||
| GO:0050728 |
negative regulation of inflammatory response |
MGI:MGI:4366690 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2154396 |
P |
From MGI |
||
| GO:0050766 |
positive regulation of phagocytosis |
MGI:MGI:3698699 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:107771 |
P |
From MGI |
||
| GO:0050790 |
regulation of catalytic activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0344 |
P |
From MGI |
||
| GO:0050790 |
regulation of catalytic activity |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
P |
From MGI |
|||
| GO:0050885 |
neuromuscular process controlling balance |
MGI:MGI:3622851 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:107771 |
P |
From MGI |
||
| GO:0051726 |
regulation of cell cycle |
MGI:MGI:2157287 |
IDA: Inferred from Direct Assay |
P |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Kaartinen V et al. (2001) Abnormal function of astroglia lacking Abr and Bcr RacGAPs. Development 128: 4217-27 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 Cho YJ et al. (2007) Abr and Bcr, two homologous Rac GTPase-activating proteins, control multiple cellular functions of murine macrophages. Mol Cell Biol 27: 899-911 PubMed GONUTS page
- ↑ Kostenko EV et al. (2006) Ccpg1, a novel scaffold protein that regulates the activity of the Rho guanine nucleotide exchange factor Dbs. Mol Cell Biol 26: 8964-75 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 4.4 Cunnick JM et al. (2009) Bcr and Abr cooperate in negatively regulating acute inflammatory responses. Mol Cell Biol 29: 5742-50 PubMed GONUTS page
- ↑ 5.0 5.1 Kaartinen V et al. (2002) Vestibular dysgenesis in mice lacking Abr and Bcr Cdc42/RacGAPs. Dev Dyn 223: 517-25 PubMed GONUTS page
- ↑ Jena N et al. (2002) Critical role for cyclin D2 in BCR/ABL-induced proliferation of hematopoietic cells. Cancer Res 62: 535-41 PubMed GONUTS page
