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MGI:Bcl2
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Bcl2 ( synonyms: Bcl-2 ) | |
| Protein Name(s) | B cell leukemia/lymphoma 2, | |
| External Links | ||
| MGI | MGI:88138 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000082 |
G1/S transition of mitotic cell cycle |
MGI:MGI:2679141 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0000082 |
G1/S transition of mitotic cell cycle |
MGI:MGI:3032471 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0000082 |
G1/S transition of mitotic cell cycle |
MGI:MGI:3032471 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0000209 |
protein polyubiquitination |
MGI:MGI:3694309 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0000902 |
cell morphogenesis |
MGI:MGI:1307011 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857430 |
P |
From MGI |
||
| GO:0001101 |
response to acid |
MGI:MGI:77140 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0001503 |
ossification |
MGI:MGI:1307011 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857430 |
P |
From MGI |
||
| GO:0001541 |
ovarian follicle development |
MGI:MGI:75799 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857134 |
P |
From MGI |
||
| GO:0001656 |
metanephros development |
MGI:MGI:70413 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857134 |
P |
From MGI |
||
| GO:0001656 |
metanephros development |
MGI:MGI:81253 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2156165 |
P |
From MGI |
||
| GO:0001657 |
ureteric bud development |
MGI:MGI:81253 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2156165 |
P |
From MGI |
||
| GO:0001658 |
branching involved in ureteric bud morphogenesis |
MGI:MGI:3036971 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0001658 |
branching involved in ureteric bud morphogenesis |
MGI:MGI:3768986 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:97486 |
P |
From MGI |
||
| GO:0001662 |
behavioral fear response |
MGI:MGI:3692132 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857430 |
P |
From MGI |
||
| GO:0001776 |
leukocyte homeostasis |
MGI:MGI:85476 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2156165 |
P |
From MGI |
||
| GO:0001782 |
B cell homeostasis |
MGI:MGI:2156164 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2156165 |
P |
From MGI |
||
| GO:0001782 |
B cell homeostasis |
MGI:MGI:2385423 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857134 |
P |
From MGI |
||
| GO:0001822 |
kidney development |
MGI:MGI:1331308 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857134 |
P |
From MGI |
||
| GO:0001822 |
kidney development |
MGI:MGI:2154874 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1197519 |
P |
From MGI |
||
| GO:0001822 |
kidney development |
MGI:MGI:2154874 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2156165 |
P |
From MGI |
||
| GO:0001822 |
kidney development |
MGI:MGI:3760608 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2156165 |
P |
From MGI |
||
| GO:0001822 |
kidney development |
MGI:MGI:3767491 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2156165 |
P |
From MGI |
||
| GO:0001822 |
kidney development |
MGI:MGI:3768986 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:97486 |
P |
From MGI |
||
| GO:0001822 |
kidney development |
MGI:MGI:70264 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2156165 |
P |
From MGI |
||
| GO:0001822 |
kidney development |
MGI:MGI:70413 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857134 |
P |
From MGI |
||
| GO:0001822 |
kidney development |
MGI:MGI:81960 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857134 |
P |
From MGI |
||
| GO:0001822 |
kidney development |
MGI:MGI:894988 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:99702 |
P |
From MGI |
||
| GO:0001952 |
regulation of cell-matrix adhesion |
MGI:MGI:3526739 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857134 |
P |
From MGI |
||
| GO:0002020 |
protease binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0002260 |
lymphocyte homeostasis |
MGI:MGI:2154874 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1197519 |
P |
From MGI |
||
| GO:0002260 |
lymphocyte homeostasis |
MGI:MGI:2154874 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2156165 |
P |
From MGI |
||
| GO:0002260 |
lymphocyte homeostasis |
MGI:MGI:2156164 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2156165 |
P |
From MGI |
||
| GO:0002260 |
lymphocyte homeostasis |
MGI:MGI:3767491 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1197519 |
P |
From MGI |
||
| GO:0002320 |
lymphoid progenitor cell differentiation |
MGI:MGI:85476 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2156165 |
P |
From MGI |
||
| GO:0002326 |
B cell lineage commitment |
MGI:MGI:78866 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2156165 |
P |
From MGI |
||
| GO:0002360 |
T cell lineage commitment |
MGI:MGI:78866 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2156165 |
P |
From MGI |
||
| GO:0002520 |
immune system development |
MGI:MGI:62849 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2156165 |
P |
From MGI |
||
| GO:0002520 |
immune system development |
MGI:MGI:70264 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2158305 |
P |
From MGI |
||
| GO:0003014 |
renal system process |
MGI:MGI:81960 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857134 |
P |
From MGI |
||
| GO:0005515 |
protein binding |
MGI:MGI:3527292 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3694309 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005622 |
intracellular |
MGI:MGI:1928555 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005622 |
intracellular |
MGI:MGI:85084 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005622 |
intracellular |
MGI:MGI:894974 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005624 |
membrane fraction |
MGI:MGI:67308 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:3702851 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:67308 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:67686 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:69023 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:71477 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:3702851 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:67308 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:74951 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:77140 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005739 |
mitochondrion |
MGI:MGI:2445910 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005739 |
mitochondrion |
MGI:MGI:2682130 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005739 |
mitochondrion |
MGI:MGI:3852644 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005739 |
mitochondrion |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005739 |
mitochondrion |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005739 |
mitochondrion |
MGI:MGI:67686 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005739 |
mitochondrion |
MGI:MGI:69023 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005739 |
mitochondrion |
MGI:MGI:71477 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005741 |
mitochondrial outer membrane |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005783 |
endoplasmic reticulum |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005783 |
endoplasmic reticulum |
MGI:MGI:67308 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005789 |
endoplasmic reticulum membrane |
MGI:MGI:3527292 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005792 |
microsome |
MGI:MGI:67686 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005792 |
microsome |
MGI:MGI:69023 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005829 |
cytosol |
MGI:MGI:2385392 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005829 |
cytosol |
MGI:MGI:2683362 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005829 |
cytosol |
MGI:MGI:67308 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0006470 |
protein dephosphorylation |
MGI:MGI:3694309 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0006582 |
melanin metabolic process |
MGI:MGI:2154874 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2156165 |
P |
From MGI |
||
| GO:0006808 |
regulation of nitrogen utilization |
MGI:MGI:894988 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:99702 |
P |
From MGI |
||
| GO:0006874 |
cellular calcium ion homeostasis |
MGI:MGI:69023 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0006915 |
apoptotic process |
MGI:MGI:67275 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0006916 |
anti-apoptosis |
MGI:MGI:1098920 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2156165 |
P |
From MGI |
||
| GO:0006916 |
anti-apoptosis |
MGI:MGI:1203837 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0006916 |
anti-apoptosis |
MGI:MGI:1330635 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857430 |
P |
From MGI |
||
| GO:0006916 |
anti-apoptosis |
MGI:MGI:1336407 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857430 |
P |
From MGI |
||
| GO:0006916 |
anti-apoptosis |
MGI:MGI:1350782 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2156165 |
P |
From MGI |
||
| GO:0006916 |
anti-apoptosis |
MGI:MGI:2179928 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1309517 |
P |
From MGI |
||
| GO:0006916 |
anti-apoptosis |
MGI:MGI:2679141 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0006916 |
anti-apoptosis |
MGI:MGI:2683362 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0006916 |
anti-apoptosis |
MGI:MGI:3032471 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0006916 |
anti-apoptosis |
MGI:MGI:3032471 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0006916 |
anti-apoptosis |
MGI:MGI:3655321 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857134 |
P |
From MGI |
||
| GO:0006916 |
anti-apoptosis |
MGI:MGI:3700106 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0006916 |
anti-apoptosis |
MGI:MGI:3722566 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2156165 |
P |
From MGI |
||
| GO:0006916 |
anti-apoptosis |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0006916 |
anti-apoptosis |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0006916 |
anti-apoptosis |
MGI:MGI:49478 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0006916 |
anti-apoptosis |
MGI:MGI:64930 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0006916 |
anti-apoptosis |
MGI:MGI:68112 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0006916 |
anti-apoptosis |
MGI:MGI:68114 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0006916 |
anti-apoptosis |
MGI:MGI:68149 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0006916 |
anti-apoptosis |
MGI:MGI:70413 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857134 |
P |
From MGI |
||
| GO:0006916 |
anti-apoptosis |
MGI:MGI:71191 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0006916 |
anti-apoptosis |
MGI:MGI:80727 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0006916 |
anti-apoptosis |
MGI:MGI:81253 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2156165 |
P |
From MGI |
||
| GO:0006916 |
anti-apoptosis |
MGI:MGI:81960 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857134 |
P |
From MGI |
||
| GO:0006916 |
anti-apoptosis |
MGI:MGI:82221 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0006916 |
anti-apoptosis |
MGI:MGI:82221 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:108047 |
P |
From MGI |
||
| GO:0006916 |
anti-apoptosis |
MGI:MGI:894621 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2158305 |
P |
From MGI |
||
| GO:0006974 |
response to DNA damage stimulus |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0006979 |
response to oxidative stress |
MGI:MGI:2679141 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0007015 |
actin filament organization |
MGI:MGI:1331308 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857134 |
P |
From MGI |
||
| GO:0007409 |
axonogenesis |
MGI:MGI:85682 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0007569 |
cell aging |
MGI:MGI:62849 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2156165 |
P |
From MGI |
||
| GO:0008134 |
transcription factor binding |
MGI:MGI:3721729 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0008219 |
cell death |
MGI:MGI:2156164 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2156165 |
P |
From MGI |
||
| GO:0008219 |
cell death |
MGI:MGI:62849 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2156165 |
P |
From MGI |
||
| GO:0008219 |
cell death |
MGI:MGI:67546 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0008219 |
cell death |
MGI:MGI:84027 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0008283 |
cell proliferation |
MGI:MGI:1860799 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:99702 |
P |
From MGI |
||
| GO:0008285 |
negative regulation of cell proliferation |
MGI:MGI:80727 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0008584 |
male gonad development |
MGI:MGI:894988 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:99702 |
P |
From MGI |
||
| GO:0009605 |
response to external stimulus |
MGI:MGI:1351727 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857430 |
P |
From MGI |
||
| GO:0009636 |
response to toxin |
MGI:MGI:1350782 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2156165 |
P |
From MGI |
||
| GO:0009636 |
response to toxin |
MGI:MGI:3694309 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0009636 |
response to toxin |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0009791 |
post-embryonic development |
MGI:MGI:1352325 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0009791 |
post-embryonic development |
MGI:MGI:2154874 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1197519 |
P |
From MGI |
||
| GO:0009791 |
post-embryonic development |
MGI:MGI:2154874 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2156165 |
P |
From MGI |
||
| GO:0009791 |
post-embryonic development |
MGI:MGI:2156164 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2156165 |
P |
From MGI |
||
| GO:0009791 |
post-embryonic development |
MGI:MGI:70264 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2158305 |
P |
From MGI |
||
| GO:0009791 |
post-embryonic development |
MGI:MGI:81786 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857430 |
P |
From MGI |
||
| GO:0009791 |
post-embryonic development |
MGI:MGI:894988 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:99702 |
P |
From MGI |
||
| GO:0009887 |
organ morphogenesis |
MGI:MGI:2156164 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2156165 |
P |
From MGI |
||
| GO:0010039 |
response to iron ion |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0010224 |
response to UV-B |
MGI:MGI:1330635 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857430 |
P |
From MGI |
||
| GO:0010332 |
response to gamma radiation |
MGI:MGI:1858868 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2156165 |
P |
From MGI |
||
| GO:0010332 |
response to gamma radiation |
MGI:MGI:2156164 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2156165 |
P |
From MGI |
||
| GO:0010332 |
response to gamma radiation |
MGI:MGI:3722566 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2156165 |
P |
From MGI |
||
| GO:0010332 |
response to gamma radiation |
MGI:MGI:62849 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2156165 |
P |
From MGI |
||
| GO:0010468 |
regulation of gene expression |
MGI:MGI:2679141 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0010468 |
regulation of gene expression |
MGI:MGI:3526739 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857134 |
P |
From MGI |
||
| GO:0010523 |
negative regulation of calcium ion transport into cytosol |
MGI:MGI:3527292 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:99702 |
P |
From MGI |
||
| GO:0010559 |
regulation of glycoprotein biosynthetic process |
MGI:MGI:3526739 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857134 |
P |
From MGI |
||
| GO:0014031 |
mesenchymal cell development |
MGI:MGI:81253 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2156165 |
P |
From MGI |
||
| GO:0014042 |
positive regulation of neuron maturation |
MGI:MGI:1203785 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2156165 |
P |
From MGI |
||
| GO:0014911 |
positive regulation of smooth muscle cell migration |
MGI:MGI:3721729 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0015267 |
channel activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0016020 |
membrane |
MGI:MGI:71477 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0016049 |
cell growth |
MGI:MGI:68633 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0016337 |
cell-cell adhesion |
MGI:MGI:3526739 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857134 |
P |
From MGI |
||
| GO:0018105 |
peptidyl-serine phosphorylation |
MGI:MGI:3032471 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0018107 |
peptidyl-threonine phosphorylation |
MGI:MGI:3032471 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0019903 |
protein phosphatase binding |
MGI:MGI:3760740 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0021747 |
cochlear nucleus development |
MGI:MGI:1891561 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857134 |
P |
From MGI |
||
| GO:0022612 |
gland morphogenesis |
MGI:MGI:70264 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2158305 |
P |
From MGI |
||
| GO:0022898 |
regulation of transmembrane transporter activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0030097 |
hemopoiesis |
MGI:MGI:70264 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2158305 |
P |
From MGI |
||
| GO:0030183 |
B cell differentiation |
MGI:MGI:2156164 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2156165 |
P |
From MGI |
||
| GO:0030183 |
B cell differentiation |
MGI:MGI:85476 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2156165 |
P |
From MGI |
||
| GO:0030217 |
T cell differentiation |
MGI:MGI:2156164 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2156165 |
P |
From MGI |
||
| GO:0030279 |
negative regulation of ossification |
MGI:MGI:85084 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0030307 |
positive regulation of cell growth |
MGI:MGI:67546 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0030308 |
negative regulation of cell growth |
MGI:MGI:2679141 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0030318 |
melanocyte differentiation |
MGI:MGI:2154874 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2156165 |
P |
From MGI |
||
| GO:0030318 |
melanocyte differentiation |
MGI:MGI:2180980 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:104554 |
P |
From MGI |
||
| GO:0030318 |
melanocyte differentiation |
MGI:MGI:2180980 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2158305 |
P |
From MGI |
||
| GO:0030318 |
melanocyte differentiation |
MGI:MGI:81816 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2158305 |
P |
From MGI |
||
| GO:0030336 |
negative regulation of cell migration |
MGI:MGI:3526739 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857134 |
P |
From MGI |
||
| GO:0030890 |
positive regulation of B cell proliferation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0031103 |
axon regeneration |
MGI:MGI:85682 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0031625 |
ubiquitin protein ligase binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0031647 |
regulation of protein stability |
MGI:MGI:3032471 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0031965 |
nuclear membrane |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0031965 |
nuclear membrane |
MGI:MGI:67308 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0031966 |
mitochondrial membrane |
MGI:MGI:2178871 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0032469 |
endoplasmic reticulum calcium ion homeostasis |
MGI:MGI:3527292 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1097161 |
P |
From MGI |
||
| GO:0032835 |
glomerulus development |
MGI:MGI:81253 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2156165 |
P |
From MGI |
||
| GO:0032848 |
negative regulation of cellular pH reduction |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0032880 |
regulation of protein localization |
MGI:MGI:1331308 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857134 |
P |
From MGI |
||
| GO:0033033 |
negative regulation of myeloid cell apoptotic process |
MGI:MGI:892837 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0033077 |
T cell differentiation in thymus |
MGI:MGI:2156164 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2156165 |
P |
From MGI |
||
| GO:0033077 |
T cell differentiation in thymus |
MGI:MGI:85476 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2156165 |
P |
From MGI |
||
| GO:0033138 |
positive regulation of peptidyl-serine phosphorylation |
MGI:MGI:3527292 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:99702 |
P |
From MGI |
||
| GO:0033689 |
negative regulation of osteoblast proliferation |
MGI:MGI:1307011 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857430 |
P |
From MGI |
||
| GO:0034097 |
response to cytokine stimulus |
MGI:MGI:2679141 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0034097 |
response to cytokine stimulus |
MGI:MGI:892164 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0035094 |
response to nicotine |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0035265 |
organ growth |
MGI:MGI:70264 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2158305 |
P |
From MGI |
||
| GO:0035265 |
organ growth |
MGI:MGI:81253 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2156165 |
P |
From MGI |
||
| GO:0040007 |
growth |
MGI:MGI:2156164 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2156165 |
P |
From MGI |
||
| GO:0040007 |
growth |
MGI:MGI:70264 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2158305 |
P |
From MGI |
||
| GO:0040018 |
positive regulation of multicellular organism growth |
MGI:MGI:2154874 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2156165 |
P |
From MGI |
||
| GO:0042100 |
B cell proliferation |
MGI:MGI:49478 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0042221 |
response to chemical stimulus |
MGI:MGI:77298 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0042493 |
response to drug |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0042493 |
response to drug |
MGI:MGI:84027 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0042493 |
response to drug |
MGI:MGI:87440 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0042542 |
response to hydrogen peroxide |
MGI:MGI:2679141 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0042802 |
identical protein binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0042803 |
protein homodimerization activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0042981 |
regulation of apoptotic process |
MGI:MGI:3767491 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1197519 |
P |
From MGI |
||
| GO:0043029 |
T cell homeostasis |
MGI:MGI:2156164 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2156165 |
P |
From MGI |
||
| GO:0043029 |
T cell homeostasis |
MGI:MGI:2385423 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857134 |
P |
From MGI |
||
| GO:0043029 |
T cell homeostasis |
MGI:MGI:3760056 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1197519 |
P |
From MGI |
||
| GO:0043066 |
negative regulation of apoptotic process |
MGI:MGI:2156164 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2156165 |
P |
From MGI |
||
| GO:0043066 |
negative regulation of apoptotic process |
MGI:MGI:2686748 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0043066 |
negative regulation of apoptotic process |
MGI:MGI:3575207 |
ISS: Inferred from Sequence or Structural Similarity |
P |
From MGI |
|||
| GO:0043066 |
negative regulation of apoptotic process |
MGI:MGI:3584078 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0043066 |
negative regulation of apoptotic process |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0043066 |
negative regulation of apoptotic process |
MGI:MGI:75819 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0043067 |
regulation of programmed cell death |
MGI:MGI:3768986 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:97486 |
P |
From MGI |
||
| GO:0043085 |
positive regulation of catalytic activity |
MGI:MGI:3721729 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0043209 |
myelin sheath |
MGI:MGI:67686 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0043375 |
CD8-positive, alpha-beta T cell lineage commitment |
MGI:MGI:2156164 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2156165 |
P |
From MGI |
||
| GO:0043496 |
regulation of protein homodimerization activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0043497 |
regulation of protein heterodimerization activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0043524 |
negative regulation of neuron apoptotic process |
MGI:MGI:1860799 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857134 |
P |
From MGI |
||
| GO:0043524 |
negative regulation of neuron apoptotic process |
MGI:MGI:1891561 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857134 |
P |
From MGI |
||
| GO:0043524 |
negative regulation of neuron apoptotic process |
MGI:MGI:3655321 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857134 |
P |
From MGI |
||
| GO:0043524 |
negative regulation of neuron apoptotic process |
MGI:MGI:3702851 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0043524 |
negative regulation of neuron apoptotic process |
MGI:MGI:77306 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0043524 |
negative regulation of neuron apoptotic process |
MGI:MGI:79659 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0043583 |
ear development |
MGI:MGI:2154874 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1197519 |
P |
From MGI |
||
| GO:0043583 |
ear development |
MGI:MGI:2154874 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2156165 |
P |
From MGI |
||
| GO:0043583 |
ear development |
MGI:MGI:2156164 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2156165 |
P |
From MGI |
||
| GO:0045636 |
positive regulation of melanocyte differentiation |
MGI:MGI:3618415 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2158305 |
P |
From MGI |
||
| GO:0045930 |
negative regulation of mitotic cell cycle |
MGI:MGI:894988 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0046671 |
negative regulation of retinal cell programmed cell death |
MGI:MGI:1336407 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857430 |
P |
From MGI |
||
| GO:0046930 |
pore complex |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0046982 |
protein heterodimerization activity |
MGI:MGI:1095590 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0046982 |
protein heterodimerization activity |
MGI:MGI:1347718 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0046982 |
protein heterodimerization activity |
MGI:MGI:1931634 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0046982 |
protein heterodimerization activity |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0046982 |
protein heterodimerization activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0048041 |
focal adhesion assembly |
MGI:MGI:3526739 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857134 |
P |
From MGI |
||
| GO:0048066 |
developmental pigmentation |
MGI:MGI:2154874 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1197519 |
P |
From MGI |
||
| GO:0048066 |
developmental pigmentation |
MGI:MGI:2154874 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2156165 |
P |
From MGI |
||
| GO:0048066 |
developmental pigmentation |
MGI:MGI:2156164 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2156165 |
P |
From MGI |
||
| GO:0048070 |
regulation of developmental pigmentation |
MGI:MGI:3767491 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1197519 |
P |
From MGI |
||
| GO:0048087 |
positive regulation of developmental pigmentation |
MGI:MGI:1352325 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0048087 |
positive regulation of developmental pigmentation |
MGI:MGI:894988 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:88138 |
P |
From MGI |
||
| GO:0048536 |
spleen development |
MGI:MGI:3767491 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1197519 |
P |
From MGI |
||
| GO:0048536 |
spleen development |
MGI:MGI:3767491 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2156165 |
P |
From MGI |
||
| GO:0048538 |
thymus development |
MGI:MGI:3767491 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1197519 |
P |
From MGI |
||
| GO:0048538 |
thymus development |
MGI:MGI:3767491 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2156165 |
P |
From MGI |
||
| GO:0048538 |
thymus development |
MGI:MGI:894988 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857134 |
P |
From MGI |
||
| GO:0048545 |
response to steroid hormone stimulus |
MGI:MGI:2156164 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2156165 |
P |
From MGI |
||
| GO:0048546 |
digestive tract morphogenesis |
MGI:MGI:70264 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2158305 |
P |
From MGI |
||
| GO:0048589 |
developmental growth |
MGI:MGI:3767491 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2156165 |
P |
From MGI |
||
| GO:0048599 |
oocyte development |
MGI:MGI:75799 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857134 |
P |
From MGI |
||
| GO:0048743 |
positive regulation of skeletal muscle fiber development |
MGI:MGI:1928555 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857134 |
P |
From MGI |
||
| GO:0048753 |
pigment granule organization |
MGI:MGI:81816 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2158305 |
P |
From MGI |
||
| GO:0048873 |
homeostasis of number of cells within a tissue |
MGI:MGI:3618415 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2158305 |
P |
From MGI |
||
| GO:0048873 |
homeostasis of number of cells within a tissue |
MGI:MGI:894988 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857134 |
P |
From MGI |
||
| GO:0050790 |
regulation of catalytic activity |
MGI:MGI:3655321 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857134 |
P |
From MGI |
||
| GO:0050853 |
B cell receptor signaling pathway |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0051384 |
response to glucocorticoid stimulus |
MGI:MGI:62849 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2156165 |
P |
From MGI |
||
| GO:0051384 |
response to glucocorticoid stimulus |
MGI:MGI:64930 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0051400 |
BH domain binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0051402 |
neuron apoptotic process |
MGI:MGI:1860799 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:99702 |
P |
From MGI |
||
| GO:0051402 |
neuron apoptotic process |
MGI:MGI:3702851 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857134 |
P |
From MGI |
||
| GO:0051434 |
BH3 domain binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0051607 |
defense response to virus |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0051721 |
protein phosphatase 2A binding |
MGI:MGI:3694309 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0051726 |
regulation of cell cycle |
MGI:MGI:1330635 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857430 |
P |
From MGI |
||
| GO:0051924 |
regulation of calcium ion transport |
MGI:MGI:67546 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0070059 |
apoptosis in response to endoplasmic reticulum stress |
MGI:MGI:3575207 |
ISS: Inferred from Sequence or Structural Similarity |
P |
From MGI |
|||
| GO:0071310 |
cellular response to organic substance |
MGI:MGI:2662654 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0072593 |
reactive oxygen species metabolic process |
MGI:MGI:1354607 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857134 |
P |
From MGI |
||
| GO:0072593 |
reactive oxygen species metabolic process |
MGI:MGI:2679141 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0072593 |
reactive oxygen species metabolic process |
MGI:MGI:3655321 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857134 |
P |
From MGI |
||
| GO:2001234 |
negative regulation of apoptotic signaling pathway |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
| ||
| edit table |
Notes
References
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- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 Deng X et al. (2003) Bcl2 retards G1/S cell cycle transition by regulating intracellular ROS. Blood 102: 3179-85 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 Deng X et al. (2004) Mono- and multisite phosphorylation enhances Bcl2's antiapoptotic function and inhibition of cell cycle entry functions. Proc Natl Acad Sci U S A 101: 153-8 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 3.4 Lin SS et al. (2006) PP2A regulates BCL-2 phosphorylation and proteasome-mediated degradation at the endoplasmic reticulum. J Biol Chem 281: 23003-12 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 Boot-Handford RP et al. (1998) The bcl-2 knockout mouse exhibits marked changes in osteoblast phenotype and collagen deposition in bone as well as a mild growth plate phenotype. Int J Exp Pathol 79: 329-35 PubMed GONUTS page
- ↑ 5.0 5.1 Gillardon F et al. (1995) Up-regulation of bax and down-regulation of bcl-2 is associated with kainate-induced apoptosis in mouse brain. Neurosci Lett 192: 85-8 PubMed GONUTS page
- ↑ 6.0 6.1 Ratts VS et al. (1995) Ablation of bcl-2 gene expression decreases the numbers of oocytes and primordial follicles established in the post-natal female mouse gonad. Endocrinology 136: 3665-8 PubMed GONUTS page
- ↑ 7.0 7.1 7.2 Sorenson CM et al. (1995) Fulminant metanephric apoptosis and abnormal kidney development in bcl-2-deficient mice. Am J Physiol 268: F73-81 PubMed GONUTS page
- ↑ 8.0 8.1 8.2 8.3 8.4 8.5 Nagata M et al. (1996) Apoptosis during an early stage of nephrogenesis induces renal hypoplasia in bcl-2-deficient mice. Am J Pathol 148: 1601-11 PubMed GONUTS page
- ↑ Sorenson CM (2004) Interaction of bcl-2 with Paxillin through its BH4 domain is important during ureteric bud branching. J Biol Chem 279: 11368-74 PubMed GONUTS page
- ↑ 10.0 10.1 10.2 Dziarmaga A et al. (2006) Suppression of ureteric bud apoptosis rescues nephron endowment and adult renal function in Pax2 mutant mice. J Am Soc Nephrol 17: 1568-75 PubMed GONUTS page
- ↑ Einat H et al. (2005) Increased anxiety-like behaviors and mitochondrial dysfunction in mice with targeted mutation of the Bcl-2 gene: further support for the involvement of mitochondrial function in anxiety disorders. Behav Brain Res 165: 172-80 PubMed GONUTS page
- ↑ 12.0 12.1 12.2 12.3 Matsuzaki Y et al. (1997) Role of bcl-2 in the development of lymphoid cells from the hematopoietic stem cell. Blood 89: 853-62 PubMed GONUTS page
- ↑ 13.00 13.01 13.02 13.03 13.04 13.05 13.06 13.07 13.08 13.09 13.10 13.11 13.12 13.13 13.14 13.15 Nakayama K et al. (1994) Targeted disruption of Bcl-2 alpha beta in mice: occurrence of gray hair, polycystic kidney disease, and lymphocytopenia. Proc Natl Acad Sci U S A 91: 3700-4 PubMed GONUTS page
- ↑ 14.0 14.1 Chao DT et al. (1995) Bcl-XL and Bcl-2 repress a common pathway of cell death. J Exp Med 182: 821-8 PubMed GONUTS page
- ↑ 15.0 15.1 15.2 Sorenson CM (1999) Nuclear localization of beta-catenin and loss of apical brush border actin in cystic tubules of bcl-2 -/- mice. Am J Physiol 276: F210-7 PubMed GONUTS page
- ↑ 16.00 16.01 16.02 16.03 16.04 16.05 16.06 16.07 16.08 16.09 16.10 16.11 16.12 Bouillet P et al. (2001) Degenerative disorders caused by Bcl-2 deficiency prevented by loss of its BH3-only antagonist Bim. Dev Cell 1: 645-53 PubMed GONUTS page
- ↑ Hughes P et al. (2006) Loss of PKD1 and loss of Bcl-2 elicit polycystic kidney disease through distinct mechanisms. Cell Death Differ 13: 1123-7 PubMed GONUTS page
- ↑ 18.0 18.1 18.2 18.3 18.4 18.5 18.6 18.7 18.8 Bouillet P et al. (2005) Polycystic kidney disease prevented by transgenic RNA interference. Cell Death Differ 12: 831-3 PubMed GONUTS page
- ↑ 19.0 19.1 19.2 19.3 19.4 19.5 19.6 19.7 Kamada S et al. (1995) bcl-2 deficiency in mice leads to pleiotropic abnormalities: accelerated lymphoid cell death in thymus and spleen, polycystic kidney, hair hypopigmentation, and distorted small intestine. Cancer Res 55: 354-9 PubMed GONUTS page
- ↑ 20.0 20.1 20.2 Sorenson CM et al. (1996) Abnormal postpartum renal development and cystogenesis in the bcl-2 (-/-) mouse. Am J Physiol 271: F184-93 PubMed GONUTS page
- ↑ 21.0 21.1 21.2 21.3 21.4 21.5 21.6 21.7 Knudson CM & Korsmeyer SJ (1997) Bcl-2 and Bax function independently to regulate cell death. Nat Genet 16: 358-63 PubMed GONUTS page
- ↑ 22.0 22.1 22.2 22.3 22.4 22.5 Ziehr J et al. (2004) Alterations in cell-adhesive and migratory properties of proximal tubule and collecting duct cells from bcl-2 -/- mice. Am J Physiol Renal Physiol 287: F1154-63 PubMed GONUTS page
- ↑ 23.0 23.1 Li T et al. (1996) Distinct patterns of Fas cell surface expression during development of T- or B-lymphocyte lineages in normal, scid, and mutant mice lacking or overexpressing p53, bcl-2, or rag-2 genes. Cell Growth Differ 7: 107-14 PubMed GONUTS page
- ↑ 24.0 24.1 24.2 24.3 24.4 Nakayama K et al. (1993) Disappearance of the lymphoid system in Bcl-2 homozygous mutant chimeric mice. Science 261: 1584-8 PubMed GONUTS page
- ↑ 25.0 25.1 25.2 25.3 25.4 Oakes SA et al. (2005) Proapoptotic BAX and BAK regulate the type 1 inositol trisphosphate receptor and calcium leak from the endoplasmic reticulum. Proc Natl Acad Sci U S A 102: 105-10 PubMed GONUTS page
- ↑ 26.0 26.1 Dominov JA et al. (2001) Pro- and anti-apoptotic members of the Bcl-2 family in skeletal muscle: a distinct role for Bcl-2 in later stages of myogenesis. Dev Dyn 220: 18-26 PubMed GONUTS page
- ↑ 27.0 27.1 Amling M et al. (1997) Bcl-2 lies downstream of parathyroid hormone-related peptide in a signaling pathway that regulates chondrocyte maturation during skeletal development. J Cell Biol 136: 205-13 PubMed GONUTS page
- ↑ von Freeden-Jeffry U et al. (1997) The earliest T lineage-committed cells depend on IL-7 for Bcl-2 expression and normal cell cycle progression. Immunity 7: 147-54 PubMed GONUTS page
- ↑ 29.0 29.1 29.2 29.3 29.4 29.5 Novack DV & Korsmeyer SJ (1994) Bcl-2 protein expression during murine development. Am J Pathol 145: 61-73 PubMed GONUTS page
- ↑ 30.0 30.1 30.2 30.3 Greenlund LJ et al. (1995) Role of BCL-2 in the survival and function of developing and mature sympathetic neurons. Neuron 15: 649-61 PubMed GONUTS page
- ↑ 31.0 31.1 31.2 31.3 Mizuguchi M et al. (1994) Expression of Bcl-2 protein in murine neural cells in culture. Brain Res 649: 197-202 PubMed GONUTS page
- ↑ 32.0 32.1 32.2 32.3 Magnelli L et al. (1994) Bcl-2 overexpression abolishes early calcium waving preceding apoptosis in NIH-3T3 murine fibroblasts. Biochem Biophys Res Commun 204: 84-90 PubMed GONUTS page
- ↑ 33.0 33.1 33.2 Yang T et al. (1995) The intracellular distribution and pattern of expression of Mcl-1 overlap with, but are not identical to, those of Bcl-2. J Cell Biol 128: 1173-84 PubMed GONUTS page
- ↑ Gillardon F et al. (1995) Differential regulation of bcl-2, bax, c-fos, junB, and krox-24 expression in the cerebellum of Purkinje cell degeneration mutant mice. J Neurosci Res 41: 708-15 PubMed GONUTS page
- ↑ Nakamura N et al. (2003) Sorting specificity of spermatogenic cell specific region of mouse hexokinase-s (mHk1-s). Mol Reprod Dev 64: 113-9 PubMed GONUTS page
- ↑ Mootha VK et al. (2003) Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Cell 115: 629-40 PubMed GONUTS page
- ↑ Pagliarini DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell 134: 112-23 PubMed GONUTS page
- ↑ Hu J et al. (2002) A novel transactivating factor that regulates interferon-gamma-dependent gene expression. J Biol Chem 277: 30253-63 PubMed GONUTS page
- ↑ 39.0 39.1 Kocher O et al. (2003) Targeted disruption of the PDZK1 gene in mice causes tissue-specific depletion of the high density lipoprotein receptor scavenger receptor class B type I and altered lipoprotein metabolism. J Biol Chem 278: 52820-5 PubMed GONUTS page
- ↑ Oltvai ZN et al. (1993) Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell 74: 609-19 PubMed GONUTS page
- ↑ Piñón LG et al. (1997) Bcl-2 is required for cranial sensory neuron survival at defined stages of embryonic development. Development 124: 4173-8 PubMed GONUTS page
- ↑ Jürgensmeier JM et al. (1998) Bax directly induces release of cytochrome c from isolated mitochondria. Proc Natl Acad Sci U S A 95: 4997-5002 PubMed GONUTS page
- ↑ 43.0 43.1 43.2 Gillardon F et al. (1999) Alterations in cell death and cell cycle progression in the UV-irradiated epidermis of bcl-2-deficient mice. Cell Death Differ 6: 55-60 PubMed GONUTS page
- ↑ 44.0 44.1 Cellerino A et al. (1999) Retinal ganglion cell loss after the period of naturally occurring cell death in bcl-2-/- mice. Neuroreport 10: 1091-5 PubMed GONUTS page
- ↑ 45.0 45.1 Pritchard DM et al. (1999) Damage-induced apoptosis in intestinal epithelia from bcl-2-null and bax-null mice: investigations of the mechanistic determinants of epithelial apoptosis in vivo. Oncogene 18: 7287-93 PubMed GONUTS page
- ↑ Fleischer A et al. (2002) Proapoptotic activity of ITM2B(s), a BH3-only protein induced upon IL-2-deprivation which interacts with Bcl-2. Oncogene 21: 3181-9 PubMed GONUTS page
- ↑ 47.0 47.1 47.2 47.3 Hochman A et al. (1998) Enhanced oxidative stress and altered antioxidants in brains of Bcl-2-deficient mice. J Neurochem 71: 741-8 PubMed GONUTS page
- ↑ Chen M et al. (2007) Regulation of the lifespan in dendritic cell subsets. Mol Immunol 44: 2558-65 PubMed GONUTS page
- ↑ 49.0 49.1 Przemeck SM et al. (2007) Radiation-induced gastric epithelial apoptosis occurs in the proliferative zone and is regulated by p53, bak, bax, and bcl-2. Am J Physiol Gastrointest Liver Physiol 292: G620-7 PubMed GONUTS page
- ↑ 50.0 50.1 Borzillo GV et al. (1992) Bcl-2 confers growth and survival advantage to interleukin 7-dependent early pre-B cells which become factor independent by a multistep process in culture. Oncogene 7: 869-76 PubMed GONUTS page
- ↑ 51.0 51.1 Merino R et al. (1994) Developmental regulation of the Bcl-2 protein and susceptibility to cell death in B lymphocytes. EMBO J 13: 683-91 PubMed GONUTS page
- ↑ Kondo S et al. (1994) bcl-2 gene enables rescue from in vitro myelosuppression (bone marrow cell death) induced by chemotherapy. Br J Cancer 70: 421-6 PubMed GONUTS page
- ↑ Takayama S et al. (1994) Evolutionary conservation of function among mammalian, avian, and viral homologs of the Bcl-2 oncoprotein. DNA Cell Biol 13: 679-92 PubMed GONUTS page
- ↑ Kondo S et al. (1994) bcl-2 gene prevents apoptosis of basic fibroblast growth factor-deprived murine aortic endothelial cells. Exp Cell Res 213: 428-32 PubMed GONUTS page
- ↑ Broome HE et al. (1995) Apoptosis and Bcl-2 expression in cultured murine splenic T cells. Immunology 84: 375-82 PubMed GONUTS page
- ↑ 56.0 56.1 Borner C (1996) Diminished cell proliferation associated with the death-protective activity of Bcl-2. J Biol Chem 271: 12695-8 PubMed GONUTS page
- ↑ 57.0 57.1 Takayama S et al. (1995) Cloning and functional analysis of BAG-1: a novel Bcl-2-binding protein with anti-cell death activity. Cell 80: 279-84 PubMed GONUTS page
- ↑ Tanabe H et al. (1997) Susceptibility of cerebellar granule neurons derived from Bcl-2-deficient and transgenic mice to cell death. Eur J Neurosci 9: 848-56 PubMed GONUTS page
- ↑ 59.0 59.1 Chen DF et al. (1997) Bcl-2 promotes regeneration of severed axons in mammalian CNS. Nature 385: 434-9 PubMed GONUTS page
- ↑ 60.0 60.1 60.2 Hou Y et al. (2007) c-Myc is essential for urokinase plasminogen activator expression on hypoxia-induced vascular smooth muscle cells. Cardiovasc Res 75: 186-94 PubMed GONUTS page
- ↑ 61.0 61.1 61.2 Lam M et al. (1994) Evidence that BCL-2 represses apoptosis by regulating endoplasmic reticulum-associated Ca2+ fluxes. Proc Natl Acad Sci U S A 91: 6569-73 PubMed GONUTS page
- ↑ 62.0 62.1 Lezoualc'h F et al. (1996) Bcl-2 prevents hippocampal cell death induced by the neuroleptic drug haloperidol. Brain Res 738: 176-9 PubMed GONUTS page
- ↑ 63.0 63.1 63.2 Middleton G et al. (2000) Differences in bcl-2- and bax-independent function in regulating apoptosis in sensory neuron populations. Eur J Neurosci 12: 819-27 PubMed GONUTS page
- ↑ Hata R et al. (1999) Targeted disruption of the bcl-2 gene in mice exacerbates focal ischemic brain injury. Metab Brain Dis 14: 117-24 PubMed GONUTS page
- ↑ 65.0 65.1 Müller-Röver S et al. (1999) Hair follicle apoptosis and Bcl-2. J Investig Dermatol Symp Proc 4: 272-7 PubMed GONUTS page
- ↑ Michaelidis TM et al. (1996) Inactivation of bcl-2 results in progressive degeneration of motoneurons, sympathetic and sensory neurons during early postnatal development. Neuron 17: 75-89 PubMed GONUTS page
- ↑ Hendry JH et al. (2000) Effects of deficiency in p53 or bcl-2 on the sensitivity of clonogenic cells in the small intestine to low dose-rate irradiation. Int J Radiat Biol 76: 559-65 PubMed GONUTS page
- ↑ Middleton G et al. (1998) Bcl-2 accelerates the maturation of early sensory neurons. J Neurosci 18: 3344-50 PubMed GONUTS page
- ↑ Cotter FE et al. (1994) Antisense oligonucleotides suppress B-cell lymphoma growth in a SCID-hu mouse model. Oncogene 9: 3049-55 PubMed GONUTS page
- ↑ Erin N et al. (2003) Calcium-dependent interaction of calcineurin with Bcl-2 in neuronal tissue. Neuroscience 117: 541-55 PubMed GONUTS page
- ↑ 71.0 71.1 Mostafapour SP et al. (2000) Patterns of cell death in mouse anteroventral cochlear nucleus neurons after unilateral cochlea removal. J Comp Neurol 426: 561-71 PubMed GONUTS page
- ↑ 72.0 72.1 McGill GG et al. (2002) Bcl2 regulation by the melanocyte master regulator Mitf modulates lineage survival and melanoma cell viability. Cell 109: 707-18 PubMed GONUTS page
- ↑ 73.0 73.1 Yamamura K et al. (1996) Accelerated disappearance of melanocytes in bcl-2-deficient mice. Cancer Res 56: 3546-50 PubMed GONUTS page
- ↑ Putcha GV et al. (2002) Intrinsic and extrinsic pathway signaling during neuronal apoptosis: lessons from the analysis of mutant mice. J Cell Biol 157: 441-53 PubMed GONUTS page
- ↑ Barge RM et al. (1997) Differential involvement of caspases in apoptosis of myeloid leukemic cells induced by chemotherapy versus growth factor withdrawal. FEBS Lett 409: 207-10 PubMed GONUTS page
- ↑ Li L et al. (1997) The apoptosis and proliferation of SAC-activated B cells by IL-10 are associated with changes in Bcl-2, Bcl-xL, and Mcl-1 expression. Cell Immunol 178: 33-41 PubMed GONUTS page
- ↑ Myers KM et al. (1995) Bcl-2 protects neural cells from cyanide/aglycemia-induced lipid oxidation, mitochondrial injury, and loss of viability. J Neurochem 65: 2432-40 PubMed GONUTS page
- ↑ Wlodarczyk BC et al. (1996) Valproic acid-induced changes in gene expression during neurulation in a mouse model. Teratology 54: 284-97 PubMed GONUTS page
- ↑ Wojciechowski S et al. (2007) Bim/Bcl-2 balance is critical for maintaining naive and memory T cell homeostasis. J Exp Med 204: 1665-75 PubMed GONUTS page
- ↑ Jung KC et al. (2004) TCR-independent and caspase-independent apoptosis of murine thymocytes by CD24 cross-linking. J Immunol 172: 795-802 PubMed GONUTS page
- ↑ 81.0 81.1 Ruiz-Vela A et al. (2005) Proapoptotic BAX and BAK control multiple initiator caspases. EMBO Rep 6: 379-85 PubMed GONUTS page
- ↑ Ishii H et al. (2005) Frag1, a homolog of alternative replication factor C subunits, links replication stress surveillance with apoptosis. Proc Natl Acad Sci U S A 102: 9655-60 PubMed GONUTS page
- ↑ Broome HE et al. (1995) Expression of Bcl-2, Bcl-x, and Bax after T cell activation and IL-2 withdrawal. J Immunol 155: 2311-7 PubMed GONUTS page
- ↑ Sagot Y et al. (1995) Bcl-2 overexpression prevents motoneuron cell body loss but not axonal degeneration in a mouse model of a neurodegenerative disease. J Neurosci 15: 7727-33 PubMed GONUTS page
- ↑ Middleton G et al. (1996) Bax promotes neuronal survival and antagonises the survival effects of neurotrophic factors. Development 122: 695-701 PubMed GONUTS page
- ↑ 86.0 86.1 Mak SS et al. (2006) Indispensable role of Bcl2 in the development of the melanocyte stem cell. Dev Biol 291: 144-53 PubMed GONUTS page
- ↑ Yang E et al. (1995) Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death. Cell 80: 285-91 PubMed GONUTS page
- ↑ Vukosavic S et al. (1999) Bax and Bcl-2 interaction in a transgenic mouse model of familial amyotrophic lateral sclerosis. J Neurochem 73: 2460-8 PubMed GONUTS page
- ↑ Vila M et al. (2001) Bax ablation prevents dopaminergic neurodegeneration in the 1-methyl- 4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease. Proc Natl Acad Sci U S A 98: 2837-42 PubMed GONUTS page
- ↑ Mu J et al. (2003) Apoptosis and related proteins in placenta of intrauterine fetal death in prostaglandin f receptor-deficient mice. Biol Reprod 68: 1968-74 PubMed GONUTS page
- ↑ Hochman A et al. (2000) Developmental changes in antioxidant enzymes and oxidative damage in kidneys, liver and brain of bcl-2 knockout mice. Cell Mol Biol (Noisy-le-grand) 46: 41-52 PubMed GONUTS page
