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MGI:Bcl11b
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Bcl11b ( synonyms: COUP-TF interacting protein 2, CTIP2, Rit1 ) | |
| Protein Name(s) | B cell leukemia/lymphoma 11B, | |
| External Links | ||
| MGI | MGI:1929913 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000978 |
RNA polymerase II core promoter proximal region sequence-specific DNA binding |
MGI:MGI:3808092 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0001077 |
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription |
MGI:MGI:3806183 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0001077 |
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription |
MGI:MGI:3838423 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0003334 |
keratinocyte development |
MGI:MGI:3839552 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3839576 |
P |
From MGI |
||
| GO:0003382 |
epithelial cell morphogenesis |
MGI:MGI:3838423 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3839578 |
P |
From MGI |
||
| GO:0003676 |
nucleic acid binding |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3806183 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3808092 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005622 |
intracellular |
MGI:MGI:3793380 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:2451207 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0006351 |
transcription, DNA-dependent |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0804 |
P |
From MGI |
||
| GO:0006355 |
regulation of transcription, DNA-dependent |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0805 |
P |
From MGI |
||
| GO:0007409 |
axonogenesis |
MGI:MGI:3578473 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2663971 |
P |
From MGI |
||
| GO:0008270 |
zinc ion binding |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0008285 |
negative regulation of cell proliferation |
MGI:MGI:2451207 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0009791 |
post-embryonic development |
MGI:MGI:2662810 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2663971 |
P |
From MGI |
||
| GO:0010837 |
regulation of keratinocyte proliferation |
MGI:MGI:3839552 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3839578 |
P |
From MGI |
||
| GO:0019216 |
regulation of lipid metabolic process |
MGI:MGI:3839552 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3839578 |
P |
From MGI |
||
| GO:0021773 |
striatal medium spiny neuron differentiation |
MGI:MGI:3773576 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2663971 |
P |
From MGI |
||
| GO:0021953 |
central nervous system neuron differentiation |
MGI:MGI:3790890 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1352456 |
P |
From MGI |
||
| GO:0031077 |
post-embryonic camera-type eye development |
MGI:MGI:2662810 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2663971 |
P |
From MGI |
||
| GO:0033077 |
T cell differentiation in thymus |
MGI:MGI:3774202 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2663971 |
P |
From MGI |
||
| GO:0033153 |
T cell receptor V(D)J recombination |
MGI:MGI:2662810 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2663971 |
P |
From MGI |
||
| GO:0042475 |
odontogenesis of dentin-containing tooth |
MGI:MGI:3838423 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3839578 |
P |
From MGI |
||
| GO:0043066 |
negative regulation of apoptotic process |
MGI:MGI:2662810 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2663971 |
P |
From MGI |
||
| GO:0043066 |
negative regulation of apoptotic process |
MGI:MGI:3774202 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2663971 |
P |
From MGI |
||
| GO:0043368 |
positive T cell selection |
MGI:MGI:3767367 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3767620 |
P |
From MGI |
||
| GO:0043565 |
sequence-specific DNA binding |
MGI:MGI:3808092 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0043588 |
skin development |
MGI:MGI:3839552 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3839576 |
P |
From MGI |
||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:2154458 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:2662810 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2663971 |
P |
From MGI |
||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:3806183 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:3808092 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:3808092 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:88327 |
P |
From MGI |
||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:3838423 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3839578 |
P |
From MGI |
||
| GO:0046632 |
alpha-beta T cell differentiation |
MGI:MGI:2662810 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2663971 |
P |
From MGI |
||
| GO:0046872 |
metal ion binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0479 |
F |
From MGI |
||
| GO:0048538 |
thymus development |
MGI:MGI:2662810 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2663971 |
P |
From MGI |
| |
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 Cismasiu VB et al. (2006) BCL11B participates in the activation of IL2 gene expression in CD4+ T lymphocytes. Blood 108: 2695-702 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Desplats PA et al. (2008) Functional roles for the striatal-enriched transcription factor, Bcl11b, in the control of striatal gene expression and transcriptional dysregulation in Huntington's disease. Neurobiol Dis 31: 298-308 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 Golonzhka O et al. (2009) Ctip2/Bcl11b controls ameloblast formation during mammalian odontogenesis. Proc Natl Acad Sci U S A 106: 4278-83 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 Golonzhka O et al. (2009) Dual role of COUP-TF-interacting protein 2 in epidermal homeostasis and permeability barrier formation. J Invest Dermatol 129: 1459-70 PubMed GONUTS page
- ↑ Britanova O et al. (2008) Satb2 is a postmitotic determinant for upper-layer neuron specification in the neocortex. Neuron 57: 378-92 PubMed GONUTS page
- ↑ 6.0 6.1 Wakabayashi Y et al. (2003) Homozygous deletions and point mutations of the Rit1/Bcl11b gene in gamma-ray induced mouse thymic lymphomas. Biochem Biophys Res Commun 301: 598-603 PubMed GONUTS page
- ↑ Arlotta P et al. (2005) Neuronal subtype-specific genes that control corticospinal motor neuron development in vivo. Neuron 45: 207-21 PubMed GONUTS page
- ↑ 8.0 8.1 8.2 8.3 8.4 8.5 8.6 Wakabayashi Y et al. (2003) Bcl11b is required for differentiation and survival of alphabeta T lymphocytes. Nat Immunol 4: 533-9 PubMed GONUTS page
- ↑ Arlotta P et al. (2008) Ctip2 controls the differentiation of medium spiny neurons and the establishment of the cellular architecture of the striatum. J Neurosci 28: 622-32 PubMed GONUTS page
- ↑ Lai T et al. (2008) SOX5 controls the sequential generation of distinct corticofugal neuron subtypes. Neuron 57: 232-47 PubMed GONUTS page
- ↑ 11.0 11.1 Inoue J et al. (2006) Expression of TCR alpha beta partly rescues developmental arrest and apoptosis of alpha beta T cells in Bcl11b-/- mice. J Immunol 176: 5871-9 PubMed GONUTS page
- ↑ Albu DI et al. (2007) BCL11B is required for positive selection and survival of double-positive thymocytes. J Exp Med 204: 3003-15 PubMed GONUTS page
