MGI:Bcl10

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Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0001772	immunological synapse	MGI:MGI:3032475 PMID:14724296^[1]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0001843	neural tube closure	MGI:MGI:1930354 PMID:11163238^[2]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0002020	protease binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:O95999	F	From MGI
	GO:0002906	negative regulation of mature B cell apoptotic process	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:O95999	P	From MGI
	GO:0003713	transcription coactivator activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:O95999	F	From MGI
	GO:0005515	protein binding	MGI:MGI:3052574 PMID:15213237^[3]	IPI: Inferred from Physical Interaction	UniProtKB:Q8BST6	F	From MGI
	GO:0005515	protein binding	MGI:MGI:3656456 PMID:16495340^[4]	IPI: Inferred from Physical Interaction	UniProtKB:Q2TBA3	F	From MGI
	GO:0005622	intracellular	MGI:MGI:1930354 PMID:11163238^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2158304	C	From MGI
	GO:0005622	intracellular	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR001315	C	From MGI
	GO:0005634	nucleus	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:O95999	C	From MGI
	GO:0005737	cytoplasm	MGI:MGI:1334917 PMID:10187815^[5]	ISA: Inferred from Sequence Alignment	EMBL:AF127386	C	From MGI
	GO:0005737	cytoplasm	MGI:MGI:3039643 PMID:12867038^[6]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005737	cytoplasm	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:O95999	C	From MGI
	GO:0005764	lysosome	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:O95999	C	From MGI
	GO:0005829	cytosol	MGI:MGI:3694380 PMID:16831874^[7]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005829	cytosol	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_112618	C	From MGI
	GO:0005829	cytosol	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:O95999	C	From MGI
	GO:0006915	apoptotic process	MGI:MGI:1355482 PMID:10753917^[8]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0006915	apoptotic process	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_112618	P	From MGI
	GO:0006915	apoptotic process	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:O95999	P	From MGI
	GO:0006917	induction of apoptosis	MGI:MGI:1327773 PMID:9989495^[9]	ISA: Inferred from Sequence Alignment	EMBL:AJ006288	P	From MGI
	GO:0006917	induction of apoptosis	MGI:MGI:1339119 PMID:10364242^[10]	ISA: Inferred from Sequence Alignment	EMBL:AF134395	P	From MGI
	GO:0006917	induction of apoptosis	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_112618	P	From MGI
	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	MGI:MGI:1334917 PMID:10187815^[5]	ISA: Inferred from Sequence Alignment	EMBL:AF127386	P	From MGI
	GO:0006968	cellular defense response	MGI:MGI:1930354 PMID:11163238^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2158304	P	From MGI
	GO:0007249	I-kappaB kinase/NF-kappaB cascade	MGI:MGI:1334919 PMID:10187770^[11]	ISO: Inferred from Sequence Orthology	EMBL:AF057700	P	From MGI
	GO:0007249	I-kappaB kinase/NF-kappaB cascade	MGI:MGI:1930354 PMID:11163238^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2158304	P	From MGI
	GO:0008022	protein C-terminus binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:O95999	F	From MGI
	GO:0008134	transcription factor binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:O95999	F	From MGI
	GO:0008219	cell death	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:O95999	P	From MGI
	GO:0008656	cysteine-type endopeptidase activator activity involved in apoptotic process	MGI:MGI:1334917 PMID:10187815^[5]	ISA: Inferred from Sequence Alignment	EMBL:AF127386	F	From MGI
	GO:0009620	response to fungus	MGI:MGI:3654747 PMID:16862125^[12]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2158304	P	From MGI
	GO:0016020	membrane	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0472	C	From MGI
	GO:0016064	immunoglobulin mediated immune response	MGI:MGI:1930354 PMID:11163238^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2158304	P	From MGI
	GO:0019899	enzyme binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:O95999	F	From MGI
	GO:0019900	kinase binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:O95999	F	From MGI
	GO:0019901	protein kinase binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:O95999	F	From MGI
	GO:0031398	positive regulation of protein ubiquitination	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:O95999	P	From MGI
	GO:0031625	ubiquitin protein ligase binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:O95999	F	From MGI
	GO:0042221	response to chemical stimulus	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:O95999	P	From MGI
	GO:0042327	positive regulation of phosphorylation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:O95999	P	From MGI
	GO:0042803	protein homodimerization activity	MGI:MGI:1339119 PMID:10364242^[10]	ISA: Inferred from Sequence Alignment	EMBL:AF134395	F	From MGI
	GO:0042981	regulation of apoptotic process	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR001315	P	From MGI
	GO:0043130	ubiquitin binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:O95999	F	From MGI
	GO:0043234	protein complex	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_112618	C	From MGI
	GO:0043234	protein complex	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:O95999	C	From MGI
	GO:0043422	protein kinase B binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:O95999	F	From MGI
	GO:0043621	protein self-association	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:O95999	F	From MGI
	GO:0045121	membrane raft	MGI:MGI:3039643 PMID:12867038^[6]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0045416	positive regulation of interleukin-8 biosynthetic process	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:O95999	P	From MGI
	GO:0045576	mast cell activation	MGI:MGI:3694284 PMID:16432253^[13]	NAS: Non-traceable Author Statement		P	From MGI
	GO:0045893	positive regulation of transcription, DNA-dependent	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:O95999	P	From MGI
	GO:0046982	protein heterodimerization activity	MGI:MGI:1339119 PMID:10364242^[10]	ISA: Inferred from Sequence Alignment	EMBL:AF134395	F	From MGI
	GO:0048471	perinuclear region of cytoplasm	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:O95999	C	From MGI
	GO:0050852	T cell receptor signaling pathway	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:O95999	P	From MGI
	GO:0050856	regulation of T cell receptor signaling pathway	MGI:MGI:3629264 PMID:14614861^[14]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2158304	P	From MGI
	GO:0050870	positive regulation of T cell activation	MGI:MGI:3629264 PMID:14614861^[14]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2158304	P	From MGI
	GO:0051059	NF-kappaB binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:O95999	F	From MGI
	GO:0051092	positive regulation of NF-kappaB transcription factor activity	MGI:MGI:1327773 PMID:9989495^[9]	ISA: Inferred from Sequence Alignment	EMBL:AJ006288	P	From MGI
	GO:0051092	positive regulation of NF-kappaB transcription factor activity	MGI:MGI:1339119 PMID:10364242^[10]	ISA: Inferred from Sequence Alignment	EMBL:AF134395	P	From MGI
	GO:0051092	positive regulation of NF-kappaB transcription factor activity	MGI:MGI:3629264 PMID:14614861^[14]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2158304	P	From MGI
	GO:0051092	positive regulation of NF-kappaB transcription factor activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:O95999	P	From MGI
	GO:0051259	protein oligomerization	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:O95999	P	From MGI
	GO:0051260	protein homooligomerization	MGI:MGI:3694380 PMID:16831874^[7]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0051291	protein heterooligomerization	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_112618	P	From MGI
NOT	GO:0006915	apoptotic process	MGI:MGI:1930354 PMID:11163238^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2158304	P	From MGI
NOT	GO:0007257	activation of JUN kinase activity	MGI:MGI:1334920 PMID:10187771^[15]	ISA: Inferred from Sequence Alignment	EMBL:AF100338	P	From MGI
NOT	GO:0051092	positive regulation of NF-kappaB transcription factor activity	MGI:MGI:1334920 PMID:10187771^[15]	ISA: Inferred from Sequence Alignment	EMBL:AF100338	P	From MGI
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Schaefer BC et al. (2004) Complex and dynamic redistribution of NF-kappaB signaling intermediates in response to T cell receptor stimulation. Proc Natl Acad Sci U S A 101: 1004-9 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Ruland J et al. (2001) Bcl10 is a positive regulator of antigen receptor-induced activation of NF-kappaB and neural tube closure. Cell 104: 33-42 PubMed GONUTS page
↑ Liu Y et al. (2004) BCL10 mediates lipopolysaccharide/toll-like receptor-4 signaling through interaction with Pellino2. J Biol Chem 279: 37436-44 PubMed GONUTS page
↑ Rossman JS et al. (2006) POLKADOTS are foci of functional interactions in T-Cell receptor-mediated signaling to NF-kappaB. Mol Biol Cell 17: 2166-76 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Yan M et al. (1999) mE10, a novel caspase recruitment domain-containing proapoptotic molecule. J Biol Chem 274: 10287-92 PubMed GONUTS page
↑ ^6.0 ^6.1 Egawa T et al. (2003) Requirement for CARMA1 in antigen receptor-induced NF-kappa B activation and lymphocyte proliferation. Curr Biol 13: 1252-8 PubMed GONUTS page
↑ ^7.0 ^7.1 Dong W et al. (2006) The IRAK-1-BCL10-MALT1-TRAF6-TAK1 cascade mediates signaling to NF-kappaB from Toll-like receptor 4. J Biol Chem 281: 26029-40 PubMed GONUTS page
↑ Yoneda T et al. (2000) Regulatory mechanisms of TRAF2-mediated signal transduction by Bcl10, a MALT lymphoma-associated protein. J Biol Chem 275: 11114-20 PubMed GONUTS page
↑ ^9.0 ^9.1 Willis TG et al. (1999) Bcl10 is involved in t(1;14)(p22;q32) of MALT B cell lymphoma and mutated in multiple tumor types. Cell 96: 35-45 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 Srinivasula SM et al. (1999) CLAP, a novel caspase recruitment domain-containing protein in the tumor necrosis factor receptor pathway, regulates NF-kappaB activation and apoptosis. J Biol Chem 274: 17946-54 PubMed GONUTS page
↑ Koseki T et al. (1999) CIPER, a novel NF kappaB-activating protein containing a caspase recruitment domain with homology to Herpesvirus-2 protein E10. J Biol Chem 274: 9955-61 PubMed GONUTS page
↑ Gross O et al. (2006) Card9 controls a non-TLR signalling pathway for innate anti-fungal immunity. Nature 442: 651-6 PubMed GONUTS page
↑ Klemm S et al. (2006) The Bcl10-Malt1 complex segregates Fc epsilon RI-mediated nuclear factor kappa B activation and cytokine production from mast cell degranulation. J Exp Med 203: 337-47 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 Ruland J et al. (2003) Differential requirement for Malt1 in T and B cell antigen receptor signaling. Immunity 19: 749-58 PubMed GONUTS page
↑ ^15.0 ^15.1 Thome M et al. (1999) Equine herpesvirus-2 E10 gene product, but not its cellular homologue, activates NF-kappaB transcription factor and c-Jun N-terminal kinase. J Biol Chem 274: 9962-8 PubMed GONUTS page

[PMID:14724296-0] Schaefer BC et al. (2004) Complex and dynamic redistribution of NF-kappaB signaling intermediates in response to T cell receptor stimulation. Proc Natl Acad Sci U S A 101: 1004-9 PubMed GONUTS page

[PMID:11163238-1] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Ruland J et al. (2001) Bcl10 is a positive regulator of antigen receptor-induced activation of NF-kappaB and neural tube closure. Cell 104: 33-42 PubMed GONUTS page

[PMID:15213237-2] Liu Y et al. (2004) BCL10 mediates lipopolysaccharide/toll-like receptor-4 signaling through interaction with Pellino2. J Biol Chem 279: 37436-44 PubMed GONUTS page

[PMID:16495340-3] Rossman JS et al. (2006) POLKADOTS are foci of functional interactions in T-Cell receptor-mediated signaling to NF-kappaB. Mol Biol Cell 17: 2166-76 PubMed GONUTS page

[PMID:10187815-4] 5.0 ^5.1 ^5.2 Yan M et al. (1999) mE10, a novel caspase recruitment domain-containing proapoptotic molecule. J Biol Chem 274: 10287-92 PubMed GONUTS page

[PMID:12867038-5] 6.0 ^6.1 Egawa T et al. (2003) Requirement for CARMA1 in antigen receptor-induced NF-kappa B activation and lymphocyte proliferation. Curr Biol 13: 1252-8 PubMed GONUTS page

[PMID:16831874-6] 7.0 ^7.1 Dong W et al. (2006) The IRAK-1-BCL10-MALT1-TRAF6-TAK1 cascade mediates signaling to NF-kappaB from Toll-like receptor 4. J Biol Chem 281: 26029-40 PubMed GONUTS page

[PMID:10753917-7] Yoneda T et al. (2000) Regulatory mechanisms of TRAF2-mediated signal transduction by Bcl10, a MALT lymphoma-associated protein. J Biol Chem 275: 11114-20 PubMed GONUTS page

[PMID:9989495-8] 9.0 ^9.1 Willis TG et al. (1999) Bcl10 is involved in t(1;14)(p22;q32) of MALT B cell lymphoma and mutated in multiple tumor types. Cell 96: 35-45 PubMed GONUTS page

[PMID:10364242-9] 10.0 ^10.1 ^10.2 ^10.3 Srinivasula SM et al. (1999) CLAP, a novel caspase recruitment domain-containing protein in the tumor necrosis factor receptor pathway, regulates NF-kappaB activation and apoptosis. J Biol Chem 274: 17946-54 PubMed GONUTS page

[PMID:10187770-10] Koseki T et al. (1999) CIPER, a novel NF kappaB-activating protein containing a caspase recruitment domain with homology to Herpesvirus-2 protein E10. J Biol Chem 274: 9955-61 PubMed GONUTS page

[PMID:16862125-11] Gross O et al. (2006) Card9 controls a non-TLR signalling pathway for innate anti-fungal immunity. Nature 442: 651-6 PubMed GONUTS page

[PMID:16432253-12] Klemm S et al. (2006) The Bcl10-Malt1 complex segregates Fc epsilon RI-mediated nuclear factor kappa B activation and cytokine production from mast cell degranulation. J Exp Med 203: 337-47 PubMed GONUTS page

[PMID:14614861-13] 14.0 ^14.1 ^14.2 Ruland J et al. (2003) Differential requirement for Malt1 in T and B cell antigen receptor signaling. Immunity 19: 749-58 PubMed GONUTS page

[PMID:10187771-14] 15.0 ^15.1 Thome M et al. (1999) Equine herpesvirus-2 E10 gene product, but not its cellular homologue, activates NF-kappaB transcription factor and c-Jun N-terminal kinase. J Biol Chem 274: 9962-8 PubMed GONUTS page

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Species (Taxon ID)	Mus musculus (house mouse) (taxon:10090)
Gene Name(s)	Bcl10 ( synonyms: BCL-10, cE10, mE10 )
Protein Name(s)	B cell leukemia/lymphoma 10,
External Links
MGI	MGI:1337994

MGI:Bcl10

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