MGI:Bbc3

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Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0001836	release of cytochrome c from mitochondria	MGI:MGI:2178768 PMID:11463391^[1]	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q9BXH1	P	From MGI
	GO:0001836	release of cytochrome c from mitochondria	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q9BXH1	P	From MGI
	GO:0001844	protein insertion into mitochondrial membrane involved in induction of apoptosis	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q9BXH1	P	From MGI
	GO:0005515	protein binding	MGI:MGI:3603103 PMID:16151013^[2]	IPI: Inferred from Physical Interaction	UniProtKB:Q07817-1	F	From MGI
	GO:0005622	intracellular	MGI:MGI:3603103 PMID:16151013^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2681654	C	From MGI
	GO:0005622	intracellular	MGI:MGI:4944151 PMID:20818388^[3]	IGI: Inferred from Genetic Interaction	UniProtKB:P02340	C	From MGI
	GO:0005739	mitochondrion	MGI:MGI:2178768 PMID:11463391^[1]	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q9BXH1	C	From MGI
	GO:0005739	mitochondrion	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_776209	C	From MGI
	GO:0005739	mitochondrion	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q9BXH1	C	From MGI
	GO:0005740	mitochondrial envelope	MGI:MGI:2178768 PMID:11463391^[1]	ISO: Inferred from Sequence Orthology	EMBL:AF332558	C	From MGI
	GO:0006915	apoptotic process	MGI:MGI:2178768 PMID:11463391^[1]	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q9BXH1	P	From MGI
	GO:0006915	apoptotic process	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q9BXH1	P	From MGI
	GO:0006917	induction of apoptosis	MGI:MGI:2178768 PMID:11463391^[1]	ISO: Inferred from Sequence Orthology	EMBL:AF332558	P	From MGI
	GO:0006917	induction of apoptosis	MGI:MGI:2180967 PMID:11572983^[4]	ISO: Inferred from Sequence Orthology	EMBL:U82987	P	From MGI
	GO:0006917	induction of apoptosis	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_776209	P	From MGI
	GO:0006917	induction of apoptosis	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q9BXH1	P	From MGI
	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	MGI:MGI:2178768 PMID:11463391^[1]	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q9BXH1	P	From MGI
	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q9BXH1	P	From MGI
	GO:0008340	determination of adult lifespan	MGI:MGI:4944151 PMID:20818388^[3]	IGI: Inferred from Genetic Interaction	UniProtKB:P02340	P	From MGI
	GO:0016020	membrane	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q9BXH1	C	From MGI
	GO:0030308	negative regulation of cell growth	MGI:MGI:2178768 PMID:11463391^[1]	ISO: Inferred from Sequence Orthology	EMBL:AF332558	P	From MGI
	GO:0032464	positive regulation of protein homooligomerization	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q9BXH1	P	From MGI
	GO:0032471	reduction of endoplasmic reticulum calcium ion concentration	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q9BXH1	P	From MGI
	GO:0042771	DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis	MGI:MGI:3603103 PMID:16151013^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2681654	P	From MGI
	GO:0042771	DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis	MGI:MGI:4944151 PMID:20818388^[3]	IGI: Inferred from Genetic Interaction	UniProtKB:P02340	P	From MGI
	GO:0043065	positive regulation of apoptotic process	MGI:MGI:2679929 PMID:14500851^[5]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2681654	P	From MGI
	GO:0043065	positive regulation of apoptotic process	MGI:MGI:3654888 PMID:16832056^[6]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2681654	P	From MGI
	GO:0045926	negative regulation of growth	MGI:MGI:2178768 PMID:11463391^[1]	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q9BXH1	P	From MGI
	GO:0045926	negative regulation of growth	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q9BXH1	P	From MGI
	GO:0051209	release of sequestered calcium ion into cytosol	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q9BXH1	P	From MGI
	GO:0051400	BH domain binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_776209	F	From MGI
	GO:0070245	positive regulation of thymocyte apoptotic process	MGI:MGI:4944151 PMID:20818388^[3]	IGI: Inferred from Genetic Interaction	UniProtKB:P02340	P	From MGI
	GO:0071479	cellular response to ionizing radiation	MGI:MGI:3690827 PMID:16286009^[7]	IGI: Inferred from Genetic Interaction	MGI:MGI:98834 MGI:MGI:1096393	P	From MGI
	GO:0090200	positive regulation of release of cytochrome c from mitochondria	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q9BXH1	P	From MGI
	GO:2001244	positive regulation of intrinsic apoptotic signaling pathway	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q9BXH1	P	From MGI
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 Yu J et al. (2001) PUMA induces the rapid apoptosis of colorectal cancer cells. Mol Cell 7: 673-82 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Chipuk JE et al. (2005) PUMA couples the nuclear and cytoplasmic proapoptotic function of p53. Science 309: 1732-5 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Liu D et al. (2010) Puma is required for p53-induced depletion of adult stem cells. Nat Cell Biol 12: 993-8 PubMed GONUTS page
↑ Han J et al. (2001) Expression of bbc3, a pro-apoptotic BH3-only gene, is regulated by diverse cell death and survival signals. Proc Natl Acad Sci U S A 98: 11318-23 PubMed GONUTS page
↑ Villunger A et al. (2003) p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa. Science 302: 1036-8 PubMed GONUTS page
↑ Bauer A et al. (2006) The NF-kappaB regulator Bcl-3 and the BH3-only proteins Bim and Puma control the death of activated T cells. Proc Natl Acad Sci U S A 103: 10979-84 PubMed GONUTS page
↑ Wu WS et al. (2005) Slug antagonizes p53-mediated apoptosis of hematopoietic progenitors by repressing puma. Cell 123: 641-53 PubMed GONUTS page

[PMID:11463391-0] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 Yu J et al. (2001) PUMA induces the rapid apoptosis of colorectal cancer cells. Mol Cell 7: 673-82 PubMed GONUTS page

[PMID:16151013-1] 2.0 ^2.1 ^2.2 Chipuk JE et al. (2005) PUMA couples the nuclear and cytoplasmic proapoptotic function of p53. Science 309: 1732-5 PubMed GONUTS page

[PMID:20818388-2] 3.0 ^3.1 ^3.2 ^3.3 Liu D et al. (2010) Puma is required for p53-induced depletion of adult stem cells. Nat Cell Biol 12: 993-8 PubMed GONUTS page

[PMID:11572983-3] Han J et al. (2001) Expression of bbc3, a pro-apoptotic BH3-only gene, is regulated by diverse cell death and survival signals. Proc Natl Acad Sci U S A 98: 11318-23 PubMed GONUTS page

[PMID:14500851-4] Villunger A et al. (2003) p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa. Science 302: 1036-8 PubMed GONUTS page

[PMID:16832056-5] Bauer A et al. (2006) The NF-kappaB regulator Bcl-3 and the BH3-only proteins Bim and Puma control the death of activated T cells. Proc Natl Acad Sci U S A 103: 10979-84 PubMed GONUTS page

[PMID:16286009-6] Wu WS et al. (2005) Slug antagonizes p53-mediated apoptosis of hematopoietic progenitors by repressing puma. Cell 123: 641-53 PubMed GONUTS page

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Species (Taxon ID)	Mus musculus (house mouse) (taxon:10090)
Gene Name(s)	Bbc3 ( synonyms: PUMA )
Protein Name(s)	BCL2 binding component 3,
External Links
MGI	MGI:2181667

MGI:Bbc3

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