MGI:Bak1

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Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0001776	leukocyte homeostasis	MGI:MGI:1929371 PMID:11163212^[1]	IGI: Inferred from Genetic Interaction	MGI:MGI:99702	P	From MGI
	GO:0001776	leukocyte homeostasis	MGI:MGI:3581932 PMID:15967824^[2]	IGI: Inferred from Genetic Interaction	MGI:MGI:1197519	P	From MGI
	GO:0001782	B cell homeostasis	MGI:MGI:3581932 PMID:15967824^[2]	IGI: Inferred from Genetic Interaction	MGI:MGI:1197519	P	From MGI
	GO:0001782	B cell homeostasis	MGI:MGI:3588597 PMID:16055554^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2159364	P	From MGI
	GO:0001783	B cell apoptotic process	MGI:MGI:3588597 PMID:16055554^[3]	IGI: Inferred from Genetic Interaction	MGI:MGI:99702	P	From MGI
	GO:0001836	release of cytochrome c from mitochondria	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_446264	P	From MGI
	GO:0001836	release of cytochrome c from mitochondria	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q16611	P	From MGI
	GO:0001974	blood vessel remodeling	MGI:MGI:3692135 PMID:15955981^[4]	IGI: Inferred from Genetic Interaction	MGI:MGI:99702	P	From MGI
	GO:0002262	myeloid cell homeostasis	MGI:MGI:3581932 PMID:15967824^[2]	IGI: Inferred from Genetic Interaction	MGI:MGI:1197519	P	From MGI
	GO:0002352	B cell negative selection	MGI:MGI:3588597 PMID:16055554^[3]	IGI: Inferred from Genetic Interaction	MGI:MGI:99702	P	From MGI
	GO:0005622	intracellular	MGI:MGI:1928555 PMID:11146504^[5]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005624	membrane fraction	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_446264	C	From MGI
	GO:0005739	mitochondrion	MGI:MGI:2667259 PMID:12847083^[6]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005739	mitochondrion	MGI:MGI:3665364 PMID:17035996^[7]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005739	mitochondrion	MGI:MGI:3852644 PMID:18614015^[8]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005739	mitochondrion	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_446264	C	From MGI
	GO:0005739	mitochondrion	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q16611	C	From MGI
	GO:0005783	endoplasmic reticulum	MGI:MGI:2667259 PMID:12847083^[6]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005829	cytosol	MGI:MGI:2667259 PMID:12847083^[6]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005829	cytosol	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_446264	C	From MGI
	GO:0006915	apoptotic process	MGI:MGI:2665373 PMID:12819136^[9]	RCA: Inferred from Reviewed Computational Analysis		P	From MGI
	GO:0006915	apoptotic process	MGI:MGI:3581932 PMID:15967824^[2]	IGI: Inferred from Genetic Interaction	MGI:MGI:1197519	P	From MGI
	GO:0006915	apoptotic process	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_446264	P	From MGI
	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	MGI:MGI:2667259 PMID:12847083^[6]	IGI: Inferred from Genetic Interaction	MGI:MGI:99702	P	From MGI
	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	MGI:MGI:3575207 PMID:15776018^[10]	IGI: Inferred from Genetic Interaction	MGI:MGI:99702	P	From MGI
	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	MGI:MGI:3662939 PMID:16893972^[11]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2159364	P	From MGI
	GO:0008053	mitochondrial fusion	MGI:MGI:3662939 PMID:16893972^[11]	IGI: Inferred from Genetic Interaction	MGI:MGI:2159364 MGI:MGI:1857429	P	From MGI
	GO:0008053	mitochondrial fusion	MGI:MGI:3665364 PMID:17035996^[7]	IGI: Inferred from Genetic Interaction	MGI:MGI:2159364 MGI:MGI:1857429	P	From MGI
	GO:0008283	cell proliferation	MGI:MGI:892190 PMID:9176392^[12]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0008285	negative regulation of cell proliferation	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_446264	P	From MGI
	GO:0008624	induction of apoptosis by extracellular signals	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q16611	P	From MGI
	GO:0008635	activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c	MGI:MGI:2178486 PMID:11836241^[13]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2159364	P	From MGI
	GO:0009620	response to fungus	MGI:MGI:3662939 PMID:16893972^[11]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2159364	P	From MGI
	GO:0010046	response to mycotoxin	MGI:MGI:3662939 PMID:16893972^[11]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2159364	P	From MGI
	GO:0010248	establishment or maintenance of transmembrane electrochemical gradient	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q16611	P	From MGI
	GO:0010332	response to gamma radiation	MGI:MGI:3722566 PMID:17068116^[14]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2159364	P	From MGI
	GO:0010524	positive regulation of calcium ion transport into cytosol	MGI:MGI:3527292 PMID:15613488^[15]	IGI: Inferred from Genetic Interaction	MGI:MGI:99702	P	From MGI
	GO:0010629	negative regulation of gene expression	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_446264	P	From MGI
	GO:0031072	heat shock protein binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_446264	F	From MGI
	GO:0031966	mitochondrial membrane	MGI:MGI:2178871 PMID:11980919^[16]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0032471	reduction of endoplasmic reticulum calcium ion concentration	MGI:MGI:3527292 PMID:15613488^[15]	IGI: Inferred from Genetic Interaction	MGI:MGI:99702 MGI:MGI:88138	P	From MGI
	GO:0033137	negative regulation of peptidyl-serine phosphorylation	MGI:MGI:3527292 PMID:15613488^[15]	IGI: Inferred from Genetic Interaction	MGI:MGI:99702	P	From MGI
	GO:0034644	cellular response to UV	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q16611	P	From MGI
	GO:0035108	limb morphogenesis	MGI:MGI:1929371 PMID:11163212^[1]	IGI: Inferred from Genetic Interaction	MGI:MGI:99702	P	From MGI
	GO:0042802	identical protein binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q16611	F	From MGI
	GO:0042803	protein homodimerization activity	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_446264	F	From MGI
	GO:0042981	regulation of apoptotic process	MGI:MGI:2665373 PMID:12819136^[9]	RCA: Inferred from Reviewed Computational Analysis		P	From MGI
	GO:0043065	positive regulation of apoptotic process	MGI:MGI:3575206 PMID:15680329^[17]	IGI: Inferred from Genetic Interaction	MGI:MGI:99702	P	From MGI
	GO:0043065	positive regulation of apoptotic process	MGI:MGI:3692135 PMID:15955981^[4]	IGI: Inferred from Genetic Interaction	MGI:MGI:99702	P	From MGI
	GO:0043065	positive regulation of apoptotic process	MGI:MGI:3722566 PMID:17068116^[14]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2159364	P	From MGI
	GO:0043065	positive regulation of apoptotic process	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q16611	P	From MGI
	GO:0043496	regulation of protein homodimerization activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q16611	P	From MGI
	GO:0043497	regulation of protein heterodimerization activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q16611	P	From MGI
	GO:0046902	regulation of mitochondrial membrane permeability	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q16611	P	From MGI
	GO:0046930	pore complex	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q16611	C	From MGI
	GO:0046982	protein heterodimerization activity	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_446264	F	From MGI
	GO:0046982	protein heterodimerization activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q16611	F	From MGI
	GO:0048597	post-embryonic camera-type eye morphogenesis	MGI:MGI:3692135 PMID:15955981^[4]	IGI: Inferred from Genetic Interaction	MGI:MGI:99702	P	From MGI
	GO:0048872	homeostasis of number of cells	MGI:MGI:1929371 PMID:11163212^[1]	IGI: Inferred from Genetic Interaction	MGI:MGI:99702	P	From MGI
	GO:0051087	chaperone binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_446264	F	From MGI
	GO:0051400	BH domain binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_446264	F	From MGI
	GO:0051726	regulation of cell cycle	MGI:MGI:3588597 PMID:16055554^[3]	IGI: Inferred from Genetic Interaction	MGI:MGI:99702	P	From MGI
	GO:0051881	regulation of mitochondrial membrane potential	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q16611	P	From MGI
	GO:0060068	vagina development	MGI:MGI:1929371 PMID:11163212^[1]	IGI: Inferred from Genetic Interaction	MGI:MGI:99702	P	From MGI
	GO:0070059	apoptosis in response to endoplasmic reticulum stress	MGI:MGI:2667259 PMID:12847083^[6]	IGI: Inferred from Genetic Interaction	MGI:MGI:99702	P	From MGI
	GO:0070059	apoptosis in response to endoplasmic reticulum stress	MGI:MGI:3575207 PMID:15776018^[10]	IGI: Inferred from Genetic Interaction	MGI:MGI:99702 UniProtKB:P10415	P	From MGI
	GO:0090200	positive regulation of release of cytochrome c from mitochondria	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_446264	P	From MGI
	GO:1900103	positive regulation of endoplasmic reticulum unfolded protein response	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q16611	P	From MGI
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Lindsten T et al. (2000) The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues. Mol Cell 6: 1389-99 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Hutcheson J et al. (2005) Combined loss of proapoptotic genes Bak or Bax with Bim synergizes to cause defects in hematopoiesis and in thymocyte apoptosis. J Exp Med 201: 1949-60 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Takeuchi O et al. (2005) Essential role of BAX,BAK in B cell homeostasis and prevention of autoimmune disease. Proc Natl Acad Sci U S A 102: 11272-7 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Hahn P et al. (2005) Persistent fetal ocular vasculature in mice deficient in bax and bak. Arch Ophthalmol 123: 797-802 PubMed GONUTS page
↑ Dominov JA et al. (2001) Pro- and anti-apoptotic members of the Bcl-2 family in skeletal muscle: a distinct role for Bcl-2 in later stages of myogenesis. Dev Dyn 220: 18-26 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 Zong WX et al. (2003) Bax and Bak can localize to the endoplasmic reticulum to initiate apoptosis. J Cell Biol 162: 59-69 PubMed GONUTS page
↑ ^7.0 ^7.1 Karbowski M et al. (2006) Role of Bax and Bak in mitochondrial morphogenesis. Nature 443: 658-62 PubMed GONUTS page
↑ Pagliarini DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell 134: 112-23 PubMed GONUTS page
↑ ^9.0 ^9.1 Reed JC et al. (2003) Comparative analysis of apoptosis and inflammation genes of mice and humans. Genome Res 13: 1376-88 PubMed GONUTS page
↑ ^10.0 ^10.1 Ruiz-Vela A et al. (2005) Proapoptotic BAX and BAK control multiple initiator caspases. EMBO Rep 6: 379-85 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 Pardo J et al. (2006) The mitochondrial protein Bak is pivotal for gliotoxin-induced apoptosis and a critical host factor of Aspergillus fumigatus virulence in mice. J Cell Biol 174: 509-19 PubMed GONUTS page
↑ Tzung SP et al. (1997) Expression of Bcl-2 family during liver regeneration and identification of Bcl-x as a delayed early response gene. Am J Pathol 150: 1985-95 PubMed GONUTS page
↑ Degenhardt K et al. (2002) Bax and Bak independently promote cytochrome C release from mitochondria. J Biol Chem 277: 14127-34 PubMed GONUTS page
↑ ^14.0 ^14.1 Przemeck SM et al. (2007) Radiation-induced gastric epithelial apoptosis occurs in the proliferative zone and is regulated by p53, bak, bax, and bcl-2. Am J Physiol Gastrointest Liver Physiol 292: G620-7 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 Oakes SA et al. (2005) Proapoptotic BAX and BAK regulate the type 1 inositol trisphosphate receptor and calcium leak from the endoplasmic reticulum. Proc Natl Acad Sci U S A 102: 105-10 PubMed GONUTS page
↑ Putcha GV et al. (2002) Intrinsic and extrinsic pathway signaling during neuronal apoptosis: lessons from the analysis of mutant mice. J Cell Biol 157: 441-53 PubMed GONUTS page
↑ Lum JJ et al. (2005) Growth factor regulation of autophagy and cell survival in the absence of apoptosis. Cell 120: 237-48 PubMed GONUTS page

[PMID:11163212-0] 1.0 ^1.1 ^1.2 ^1.3 Lindsten T et al. (2000) The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues. Mol Cell 6: 1389-99 PubMed GONUTS page

[PMID:15967824-1] 2.0 ^2.1 ^2.2 ^2.3 Hutcheson J et al. (2005) Combined loss of proapoptotic genes Bak or Bax with Bim synergizes to cause defects in hematopoiesis and in thymocyte apoptosis. J Exp Med 201: 1949-60 PubMed GONUTS page

[PMID:16055554-2] 3.0 ^3.1 ^3.2 ^3.3 Takeuchi O et al. (2005) Essential role of BAX,BAK in B cell homeostasis and prevention of autoimmune disease. Proc Natl Acad Sci U S A 102: 11272-7 PubMed GONUTS page

[PMID:15955981-3] 4.0 ^4.1 ^4.2 Hahn P et al. (2005) Persistent fetal ocular vasculature in mice deficient in bax and bak. Arch Ophthalmol 123: 797-802 PubMed GONUTS page

[PMID:11146504-4] Dominov JA et al. (2001) Pro- and anti-apoptotic members of the Bcl-2 family in skeletal muscle: a distinct role for Bcl-2 in later stages of myogenesis. Dev Dyn 220: 18-26 PubMed GONUTS page

[PMID:12847083-5] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 Zong WX et al. (2003) Bax and Bak can localize to the endoplasmic reticulum to initiate apoptosis. J Cell Biol 162: 59-69 PubMed GONUTS page

[PMID:17035996-6] 7.0 ^7.1 Karbowski M et al. (2006) Role of Bax and Bak in mitochondrial morphogenesis. Nature 443: 658-62 PubMed GONUTS page

[PMID:18614015-7] Pagliarini DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell 134: 112-23 PubMed GONUTS page

[PMID:12819136-8] 9.0 ^9.1 Reed JC et al. (2003) Comparative analysis of apoptosis and inflammation genes of mice and humans. Genome Res 13: 1376-88 PubMed GONUTS page

[PMID:15776018-9] 10.0 ^10.1 Ruiz-Vela A et al. (2005) Proapoptotic BAX and BAK control multiple initiator caspases. EMBO Rep 6: 379-85 PubMed GONUTS page

[PMID:16893972-10] 11.0 ^11.1 ^11.2 ^11.3 Pardo J et al. (2006) The mitochondrial protein Bak is pivotal for gliotoxin-induced apoptosis and a critical host factor of Aspergillus fumigatus virulence in mice. J Cell Biol 174: 509-19 PubMed GONUTS page

[PMID:9176392-11] Tzung SP et al. (1997) Expression of Bcl-2 family during liver regeneration and identification of Bcl-x as a delayed early response gene. Am J Pathol 150: 1985-95 PubMed GONUTS page

[PMID:11836241-12] Degenhardt K et al. (2002) Bax and Bak independently promote cytochrome C release from mitochondria. J Biol Chem 277: 14127-34 PubMed GONUTS page

[PMID:17068116-13] 14.0 ^14.1 Przemeck SM et al. (2007) Radiation-induced gastric epithelial apoptosis occurs in the proliferative zone and is regulated by p53, bak, bax, and bcl-2. Am J Physiol Gastrointest Liver Physiol 292: G620-7 PubMed GONUTS page

[PMID:15613488-14] 15.0 ^15.1 ^15.2 Oakes SA et al. (2005) Proapoptotic BAX and BAK regulate the type 1 inositol trisphosphate receptor and calcium leak from the endoplasmic reticulum. Proc Natl Acad Sci U S A 102: 105-10 PubMed GONUTS page

[PMID:11980919-15] Putcha GV et al. (2002) Intrinsic and extrinsic pathway signaling during neuronal apoptosis: lessons from the analysis of mutant mice. J Cell Biol 157: 441-53 PubMed GONUTS page

[PMID:15680329-16] Lum JJ et al. (2005) Growth factor regulation of autophagy and cell survival in the absence of apoptosis. Cell 120: 237-48 PubMed GONUTS page

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Species (Taxon ID)	Mus musculus (house mouse) (taxon:10090)
Gene Name(s)	Bak1 ( synonyms: Bak, N-Bak )
Protein Name(s)	BCL2-antagonist/killer 1,
External Links
MGI	MGI:1097161

MGI:Bak1

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