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MGI:Axl
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Axl ( synonyms: Ark, Tyro7, Ufo ) | |
| Protein Name(s) | AXL receptor tyrosine kinase, | |
| External Links | ||
| MGI | MGI:1347244 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000166 |
nucleotide binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0547 |
F |
From MGI |
||
| GO:0001764 |
neuron migration |
MGI:MGI:3817816 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:95660 |
P |
From MGI |
||
| GO:0001764 |
neuron migration |
MGI:MGI:4430466 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0001779 |
natural killer cell differentiation |
MGI:MGI:3662985 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:96965 |
P |
From MGI |
||
| GO:0001786 |
phosphatidylserine binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0001961 |
positive regulation of cytokine-mediated signaling pathway |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0001974 |
blood vessel remodeling |
MGI:MGI:3714893 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2387750 |
P |
From MGI |
||
| GO:0004672 |
protein kinase activity |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0004713 |
protein tyrosine kinase activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0829 |
F |
From MGI |
||
| GO:0004713 |
protein tyrosine kinase activity |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0004714 |
transmembrane receptor protein tyrosine kinase activity |
MGI:MGI:2152096 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0004872 |
receptor activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0675 |
F |
From MGI |
||
| GO:0005524 |
ATP binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0067 |
F |
From MGI |
||
| GO:0005524 |
ATP binding |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0005615 |
extracellular space |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005622 |
intracellular |
MGI:MGI:3528131 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:95660 |
C |
From MGI |
||
| GO:0005622 |
intracellular |
MGI:MGI:3714893 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2387750 |
C |
From MGI |
||
| GO:0005623 |
cell |
MGI:MGI:3528131 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2387750 |
C |
From MGI |
||
| GO:0005886 |
plasma membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-1003 |
C |
From MGI |
||
| GO:0006468 |
protein phosphorylation |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
InterPro:IPR000719 |
P |
From MGI |
||
| GO:0006909 |
phagocytosis |
MGI:MGI:4430045 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:96965 |
P |
From MGI |
||
| GO:0006909 |
phagocytosis |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0006916 |
anti-apoptosis |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0006954 |
inflammatory response |
MGI:MGI:3714893 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2387750 |
P |
From MGI |
||
| GO:0007167 |
enzyme linked receptor protein signaling pathway |
MGI:MGI:1099568 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:95660 |
P |
From MGI |
||
| GO:0007283 |
spermatogenesis |
MGI:MGI:1335700 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:96965 |
P |
From MGI |
||
| GO:0007283 |
spermatogenesis |
MGI:MGI:4430045 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:96965 |
P |
From MGI |
||
| GO:0009986 |
cell surface |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0016020 |
membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0472 |
C |
From MGI |
||
| GO:0016021 |
integral to membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0812 |
C |
From MGI |
||
| GO:0016301 |
kinase activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0418 |
F |
From MGI |
||
| GO:0016310 |
phosphorylation |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0418 |
P |
From MGI |
||
| GO:0016740 |
transferase activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0808 |
F |
From MGI |
||
| GO:0016772 |
transferase activity, transferring phosphorus-containing groups |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0021885 |
forebrain cell migration |
MGI:MGI:3817816 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:104294 |
P |
From MGI |
||
| GO:0030154 |
cell differentiation |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0030168 |
platelet activation |
MGI:MGI:3528131 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2387750 |
P |
From MGI |
||
| GO:0031668 |
cellular response to extracellular stimulus |
MGI:MGI:1335904 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0032036 |
myosin heavy chain binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0032689 |
negative regulation of interferon-gamma production |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0032720 |
negative regulation of tumor necrosis factor production |
MGI:MGI:3721468 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:107670 |
P |
From MGI |
||
| GO:0032825 |
positive regulation of natural killer cell differentiation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0032940 |
secretion by cell |
MGI:MGI:3528131 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2387750 |
P |
From MGI |
||
| GO:0034101 |
erythrocyte homeostasis |
MGI:MGI:3773112 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:95660 |
P |
From MGI |
||
| GO:0034101 |
erythrocyte homeostasis |
MGI:MGI:3773112 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2387750 |
P |
From MGI |
||
| GO:0034446 |
substrate adhesion-dependent cell spreading |
MGI:MGI:3528131 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2387750 |
P |
From MGI |
||
| GO:0035457 |
cellular response to interferon-alpha |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0042698 |
ovulation cycle |
MGI:MGI:3817816 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:104294 |
P |
From MGI |
||
| GO:0043066 |
negative regulation of apoptotic process |
MGI:MGI:1099568 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:95660 |
P |
From MGI |
||
| GO:0043066 |
negative regulation of apoptotic process |
MGI:MGI:3714893 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2387750 |
P |
From MGI |
||
| GO:0043066 |
negative regulation of apoptotic process |
MGI:MGI:5315346 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0043277 |
apoptotic cell clearance |
MGI:MGI:3778590 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:96965 |
P |
From MGI |
||
| GO:0043277 |
apoptotic cell clearance |
MGI:MGI:3836130 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:104294 |
P |
From MGI |
||
| GO:0043277 |
apoptotic cell clearance |
MGI:MGI:3841855 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2387750 |
P |
From MGI |
||
| GO:0043491 |
protein kinase B signaling cascade |
MGI:MGI:3528131 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:95660 |
P |
From MGI |
||
| GO:0043491 |
protein kinase B signaling cascade |
MGI:MGI:3714893 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2387750 |
P |
From MGI |
||
| GO:0043524 |
negative regulation of neuron apoptotic process |
MGI:MGI:3817816 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:104294 |
P |
From MGI |
||
| GO:0043524 |
negative regulation of neuron apoptotic process |
MGI:MGI:3817816 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0043548 |
phosphatidylinositol 3-kinase binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0045087 |
innate immune response |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0399 |
P |
From MGI |
||
| GO:0046982 |
protein heterodimerization activity |
MGI:MGI:3817816 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0051250 |
negative regulation of lymphocyte activation |
MGI:MGI:2137182 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:96965 |
P |
From MGI |
||
| GO:0051897 |
positive regulation of protein kinase B signaling cascade |
MGI:MGI:5315346 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0060068 |
vagina development |
MGI:MGI:3820485 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:96965 |
P |
From MGI |
||
| GO:0070301 |
cellular response to hydrogen peroxide |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0071222 |
cellular response to lipopolysaccharide |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:2000669 |
negative regulation of dendritic cell apoptotic process |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Pierce A et al. (2008) Axl and Tyro3 modulate female reproduction by influencing gonadotropin-releasing hormone neuron survival and migration. Mol Endocrinol 22: 2481-95 PubMed GONUTS page
- ↑ Orso F et al. (2009) AP-2alpha regulates migration of GN-11 neurons via a specific genetic programme involving the Axl receptor tyrosine kinase. BMC Biol 7: 25 PubMed GONUTS page
- ↑ Caraux A et al. (2006) Natural killer cell differentiation driven by Tyro3 receptor tyrosine kinases. Nat Immunol 7: 747-54 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 4.4 Korshunov VA et al. (2006) Axl, a receptor tyrosine kinase, mediates flow-induced vascular remodeling. Circ Res 98: 1446-52 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 5.4 5.5 Angelillo-Scherrer A et al. (2005) Role of Gas6 receptors in platelet signaling during thrombus stabilization and implications for antithrombotic therapy. J Clin Invest 115: 237-46 PubMed GONUTS page
- ↑ 6.0 6.1 Chen Y et al. (2009) Functions of TAM RTKs in regulating spermatogenesis and male fertility in mice. Reproduction 138: 655-66 PubMed GONUTS page
- ↑ 7.0 7.1 Bellosta P et al. (1997) Signaling through the ARK tyrosine kinase receptor protects from apoptosis in the absence of growth stimulation. Oncogene 15: 2387-97 PubMed GONUTS page
- ↑ Lu Q et al. (1999) Tyro-3 family receptors are essential regulators of mammalian spermatogenesis. Nature 398: 723-8 PubMed GONUTS page
- ↑ Leimeister C et al. (1999) Screen for genes regulated during early kidney morphogenesis. Dev Genet 24: 273-83 PubMed GONUTS page
- ↑ Sharif MN et al. (2006) Twist mediates suppression of inflammation by type I IFNs and Axl. J Exp Med 203: 1891-901 PubMed GONUTS page
- ↑ 11.0 11.1 Angelillo-Scherrer A et al. (2008) Role of Gas6 in erythropoiesis and anemia in mice. J Clin Invest 118: 583-96 PubMed GONUTS page
- ↑ 12.0 12.1 Shankar SL et al. (2006) Gas6/Axl signaling activates the phosphatidylinositol 3-kinase/Akt1 survival pathway to protect oligodendrocytes from tumor necrosis factor alpha-induced apoptosis. J Neurosci 26: 5638-48 PubMed GONUTS page
- ↑ Xiong W et al. (2008) Gas6 and the Tyro 3 receptor tyrosine kinase subfamily regulate the phagocytic function of Sertoli cells. Reproduction 135: 77-87 PubMed GONUTS page
- ↑ Seitz HM et al. (2007) Macrophages and dendritic cells use different Axl/Mertk/Tyro3 receptors in clearance of apoptotic cells. J Immunol 178: 5635-42 PubMed GONUTS page
- ↑ Hoehn HJ et al. (2008) Axl-/- mice have delayed recovery and prolonged axonal damage following cuprizone toxicity. Brain Res 1240: 1-11 PubMed GONUTS page
- ↑ Lu Q & Lemke G (2001) Homeostatic regulation of the immune system by receptor tyrosine kinases of the Tyro 3 family. Science 293: 306-11 PubMed GONUTS page
- ↑ Wu H et al. (2008) High incidence of distal vaginal atresia in mice lacking Tyro3 RTK subfamily. Mol Reprod Dev 75: 1775-82 PubMed GONUTS page
