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MGI:Axin2
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Axin2 ( synonyms: Axil, Conductin ) | |
| Protein Name(s) | axin2, | |
| External Links | ||
| MGI | MGI:1270862 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0001756 |
somitogenesis |
MGI:MGI:3037351 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0001934 |
positive regulation of protein phosphorylation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0001957 |
intramembranous ossification |
MGI:MGI:3578608 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3579503 |
P |
From MGI |
||
| GO:0003413 |
chondrocyte differentiation involved in endochondral bone morphogenesis |
MGI:MGI:4818263 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3579503 |
P |
From MGI |
||
| GO:0004871 |
signal transducer activity |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0005096 |
GTPase activator activity |
MGI:MGI:4459044 |
PANTHER:PTHR10845 |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:1203346 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005622 |
intracellular |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:2154458 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005813 |
centrosome |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005813 |
centrosome |
MGI:MGI:4835108 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005881 |
cytoplasmic microtubule |
MGI:MGI:4459044 |
PANTHER:PTHR10845 |
C |
From MGI |
|||
| GO:0005886 |
plasma membrane |
MGI:MGI:4459044 |
PANTHER:PTHR10845 |
C |
From MGI |
|||
| GO:0005938 |
cell cortex |
MGI:MGI:4459044 |
PANTHER:PTHR10845 |
C |
From MGI |
|||
| GO:0006355 |
regulation of transcription, DNA-dependent |
MGI:MGI:4459044 |
PANTHER:PTHR10845 |
P |
From MGI |
|||
| GO:0007275 |
multicellular organismal development |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
P |
From MGI |
|||
| GO:0008013 |
beta-catenin binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0008013 |
beta-catenin binding |
MGI:MGI:4459044 |
PANTHER:PTHR10845 |
F |
From MGI |
|||
| GO:0008219 |
cell death |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0008219 |
cell death |
MGI:MGI:4459044 |
PANTHER:PTHR10845 |
P |
From MGI |
|||
| GO:0008283 |
cell proliferation |
MGI:MGI:4458942 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3579503 |
P |
From MGI |
||
| GO:0008285 |
negative regulation of cell proliferation |
MGI:MGI:3578608 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3579503 |
P |
From MGI |
||
| GO:0008285 |
negative regulation of cell proliferation |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0008285 |
negative regulation of cell proliferation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0009950 |
dorsal/ventral axis specification |
MGI:MGI:4459044 |
PANTHER:PTHR10845 |
P |
From MGI |
|||
| GO:0010718 |
positive regulation of epithelial to mesenchymal transition |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0010942 |
positive regulation of cell death |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0014069 |
postsynaptic density |
MGI:MGI:4459044 |
PANTHER:PTHR10845 |
C |
From MGI |
|||
| GO:0016023 |
cytoplasmic membrane-bounded vesicle |
MGI:MGI:4459044 |
PANTHER:PTHR10845 |
C |
From MGI |
|||
| GO:0016055 |
Wnt receptor signaling pathway |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0879 |
P |
From MGI |
||
| GO:0019899 |
enzyme binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0019901 |
protein kinase binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0019901 |
protein kinase binding |
MGI:MGI:4459044 |
PANTHER:PTHR10845 |
F |
From MGI |
|||
| GO:0030111 |
regulation of Wnt receptor signaling pathway |
MGI:MGI:1203346 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0030282 |
bone mineralization |
MGI:MGI:4818263 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3579503 |
P |
From MGI |
||
| GO:0031625 |
ubiquitin protein ligase binding |
MGI:MGI:3628833 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0031625 |
ubiquitin protein ligase binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0032423 |
regulation of mismatch repair |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0034613 |
cellular protein localization |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0034747 |
Axin-APC-beta-catenin-GSK3B complex |
MGI:MGI:4459044 |
PANTHER:PTHR10845 |
C |
From MGI |
|||
| GO:0035412 |
regulation of catenin import into nucleus |
MGI:MGI:4459044 |
PANTHER:PTHR10845 |
P |
From MGI |
|||
| GO:0035414 |
negative regulation of catenin import into nucleus |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0038032 |
termination of G-protein coupled receptor signaling pathway |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
P |
From MGI |
|||
| GO:0042476 |
odontogenesis |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0043234 |
protein complex |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0043547 |
positive regulation of GTPase activity |
MGI:MGI:4459044 |
PANTHER:PTHR10845 |
P |
From MGI |
|||
| GO:0043570 |
maintenance of DNA repeat elements |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045668 |
negative regulation of osteoblast differentiation |
MGI:MGI:3578608 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3579503 |
P |
From MGI |
||
| GO:0045860 |
positive regulation of protein kinase activity |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0048255 |
mRNA stabilization |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0061181 |
regulation of chondrocyte development |
MGI:MGI:4818263 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3579503 |
P |
From MGI |
||
| GO:0070016 |
armadillo repeat domain binding |
MGI:MGI:4459044 |
PANTHER:PTHR10845 |
F |
From MGI |
|||
| GO:0070411 |
I-SMAD binding |
MGI:MGI:3628833 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0070602 |
regulation of centromeric sister chromatid cohesion |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0070602 |
regulation of centromeric sister chromatid cohesion |
MGI:MGI:4835108 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0071407 |
cellular response to organic cyclic compound |
MGI:MGI:4459044 |
PANTHER:PTHR10845 |
P |
From MGI |
|||
| GO:0090090 |
negative regulation of canonical Wnt receptor signaling pathway |
MGI:MGI:4459044 |
PANTHER:PTHR10845 |
P |
From MGI |
|||
| GO:0090090 |
negative regulation of canonical Wnt receptor signaling pathway |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0090244 |
Wnt receptor signaling pathway involved in somitogenesis |
MGI:MGI:4459044 |
PANTHER:PTHR10845 |
P |
From MGI |
|||
| GO:2000054 |
negative regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Aulehla A et al. (2003) Wnt3a plays a major role in the segmentation clock controlling somitogenesis. Dev Cell 4: 395-406 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Yu HM et al. (2005) The role of Axin2 in calvarial morphogenesis and craniosynostosis. Development 132: 1995-2005 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Dao DY et al. (2010) Axin2 regulates chondrocyte maturation and axial skeletal development. J Orthop Res 28: 89-95 PubMed GONUTS page
- ↑ 4.0 4.1 Behrens J et al. (1998) Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK3beta. Science 280: 596-9 PubMed GONUTS page
- ↑ 5.0 5.1 Hadjihannas MV et al. (2010) Conductin/axin2 and Wnt signalling regulates centrosome cohesion. EMBO Rep 11: 317-24 PubMed GONUTS page
- ↑ Zeng YA & Nusse R (2010) Wnt proteins are self-renewal factors for mammary stem cells and promote their long-term expansion in culture. Cell Stem Cell 6: 568-77 PubMed GONUTS page
- ↑ 7.0 7.1 Liu W et al. (2006) Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia. EMBO J 25: 1646-58 PubMed GONUTS page
