Have any questions? Please email us at ecoliwiki@gmail.com

MGI:Axin1

From GONUTS
Jump to: navigation, search
Species (Taxon ID) Mus musculus (house mouse) (taxon:10090)
Gene Name(s) Axin1
Protein Name(s) axin 1,
External Links
MGI MGI:1096327

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000209

protein polyubiquitination

MGI:MGI:3628833
PMID:16601693[1]

IDA: Inferred from Direct Assay

P

From MGI

GO:0001701

in utero embryonic development

MGI:MGI:3840033
PMID:19204372[2]

IGI: Inferred from Genetic Interaction

MGI:MGI:88276

P

From MGI

GO:0001701

in utero embryonic development

MGI:MGI:3840033
PMID:19204372[2]

IMP: Inferred from Mutant Phenotype

MGI:MGI:3840236
MGI:MGI:3840238

P

From MGI

GO:0001743

optic placode formation

MGI:MGI:4459044

PANTHER:PTN000090599

P

From MGI

GO:0001932

regulation of protein phosphorylation

MGI:MGI:3028427
PMID:14734535[3]

IGI: Inferred from Genetic Interaction

MGI:MGI:94941

P

From MGI

GO:0001934

positive regulation of protein phosphorylation

MGI:MGI:1337175
PMID:10330403[4]

IDA: Inferred from Direct Assay

P

From MGI

GO:0001934

positive regulation of protein phosphorylation

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:O15169

P

From MGI

GO:0002039

p53 binding

MGI:MGI:3521522
PMID:15526030[5]

ISO: Inferred from Sequence Orthology

UniProtKB:O15169

F

From MGI

GO:0004871

signal transducer activity

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:O15169

F

From MGI

GO:0005096

GTPase activator activity

MGI:MGI:4459044

PANTHER:PTN000090250

F

From MGI

GO:0005515

protein binding

MGI:MGI:1333284
PMID:9920888[6]

IPI: Inferred from Physical Interaction

UniProtKB:P63330

F

From MGI

GO:0005515

protein binding

MGI:MGI:1930830
PMID:11113207[7]

IPI: Inferred from Physical Interaction

UniProtKB:P51141

F

From MGI

GO:0005515

protein binding

MGI:MGI:2664441
PMID:12805222[8]

IPI: Inferred from Physical Interaction

UniProtKB:P98078
UniProtKB:Q61062

F

From MGI

GO:0005515

protein binding

MGI:MGI:2675921
PMID:12878610[9]

IPI: Inferred from Physical Interaction

UniProtKB:P53349
UniProtKB:O08648

F

From MGI

GO:0005515

protein binding

MGI:MGI:3053243
PMID:15327768[10]

IPI: Inferred from Physical Interaction

UniProtKB:Q02248

F

From MGI

GO:0005515

protein binding

MGI:MGI:3573812
PMID:15579909[11]

IPI: Inferred from Physical Interaction

UniProtKB:Q80Y83
UniProtKB:Q60838

F

From MGI

GO:0005515

protein binding

MGI:MGI:3700435
PMID:10688669[12]

IPI: Inferred from Physical Interaction

UniProtKB:Q9PTP2

F

From MGI

GO:0005515

protein binding

MGI:MGI:3799599
PMID:17681137[13]

IPI: Inferred from Physical Interaction

UniProtKB:P51141

F

From MGI

GO:0005515

protein binding

MGI:MGI:3799599
PMID:17681137[13]

IPI: Inferred from Physical Interaction

UniProtKB:Q8C4Q6
UniProtKB:F8VQ72
UniProtKB:O08648

F

From MGI

GO:0005515

protein binding

MGI:MGI:3817405
PMID:18632848[14]

IPI: Inferred from Physical Interaction

UniProtKB:Q9WV60
UniProtKB:Q91VN0

F

From MGI

GO:0005515

protein binding

MGI:MGI:3835914
PMID:19075000[15]

IPI: Inferred from Physical Interaction

UniProtKB:Q91VN0

F

From MGI

GO:0005515

protein binding

MGI:MGI:3844787
PMID:19141611[16]

IPI: Inferred from Physical Interaction

UniProtKB:Q9D0L1

F

From MGI

GO:0005515

protein binding

MGI:MGI:4943616
PMID:20368287[17]

IPI: Inferred from Physical Interaction

UniProtKB:P49841

F

From MGI

GO:0005515

protein binding

MGI:MGI:5298339
PMID:19759537[18]

IPI: Inferred from Physical Interaction

UniProtKB:O95271

F

From MGI

GO:0005515

protein binding

MGI:MGI:5306548
PMID:21242974[19]

IPI: Inferred from Physical Interaction

UniProtKB:P49841
UniProtKB:Q9JIF0
UniProtKB:Q9JIF0-1
UniProtKB:Q9JIF0-3

F

From MGI

GO:0005515

protein binding

MGI:MGI:5315336
PMID:21057547[20]

IPI: Inferred from Physical Interaction

UniProtKB:Q60953-2

F

From MGI

GO:0005515

protein binding

MGI:MGI:5437379
PMID:22682247[21]

IPI: Inferred from Physical Interaction

UniProtKB:P49841

F

From MGI

GO:0005622

intracellular

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR001158

C

From MGI

GO:0005634

nucleus

MGI:MGI:2154458

ISO: Inferred from Sequence Orthology

UniProtKB:O15169

C

From MGI

GO:0005737

cytoplasm

MGI:MGI:1930830
PMID:11113207[7]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005737

cytoplasm

MGI:MGI:2154458

ISO: Inferred from Sequence Orthology

UniProtKB:O15169

C

From MGI

GO:0005737

cytoplasm

MGI:MGI:3628833
PMID:16601693[1]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005881

cytoplasmic microtubule

MGI:MGI:3028427
PMID:14734535[3]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005886

plasma membrane

MGI:MGI:3640889
PMID:16815997[22]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005886

plasma membrane

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:O70239

C

From MGI

GO:0005886

plasma membrane

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:O15169

C

From MGI

GO:0005938

cell cortex

MGI:MGI:1337175
PMID:10330403[4]

IDA: Inferred from Direct Assay

C

From MGI

GO:0006913

nucleocytoplasmic transport

MGI:MGI:3036437
PMID:14981260[23]

IDA: Inferred from Direct Assay

P

From MGI

GO:0006915

apoptotic process

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0053

P

From MGI

GO:0007257

activation of JUN kinase activity

MGI:MGI:4459044

PANTHER:PTN000090599

P

From MGI

GO:0007275

multicellular organismal development

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0217

P

From MGI

GO:0007275

multicellular organismal development

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR001158

P

From MGI

GO:0007368

determination of left/right symmetry

MGI:MGI:4459044

PANTHER:PTN000090599

P

From MGI

GO:0007605

sensory perception of sound

MGI:MGI:48780
PMID:17247179[24]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1856035

P

From MGI

GO:0007605

sensory perception of sound

MGI:MGI:48782

IMP: Inferred from Mutant Phenotype

MGI:MGI:1856035

P

From MGI

GO:0007628

adult walking behavior

MGI:MGI:48782

IMP: Inferred from Mutant Phenotype

MGI:MGI:1856035

P

From MGI

GO:0008013

beta-catenin binding

MGI:MGI:1336856
PMID:10318824[25]

IPI: Inferred from Physical Interaction

UniProtKB:Q02248

F

From MGI

GO:0008013

beta-catenin binding

MGI:MGI:1337175
PMID:10330403[4]

IPI: Inferred from Physical Interaction

UniProtKB:P35222

F

From MGI

GO:0008013

beta-catenin binding

MGI:MGI:3817405
PMID:18632848[14]

IPI: Inferred from Physical Interaction

UniProtKB:Q02248

F

From MGI

GO:0008013

beta-catenin binding

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:O70239

F

From MGI

GO:0008013

beta-catenin binding

MGI:MGI:4462715
PMID:10581160[26]

IMP: Inferred from Mutant Phenotype

F

From MGI

GO:0008013

beta-catenin binding

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:O15169

F

From MGI

GO:0008022

protein C-terminus binding

MGI:MGI:1333284
PMID:9920888[6]

IPI: Inferred from Physical Interaction

UniProtKB:P63330

F

From MGI

GO:0008022

protein C-terminus binding

MGI:MGI:1336856
PMID:10318824[25]

IDA: Inferred from Direct Assay

F

From MGI

GO:0008219

cell death

MGI:MGI:4459044

PANTHER:PTN000090568

P

From MGI

GO:0009950

dorsal/ventral axis specification

MGI:MGI:1337175
PMID:10330403[4]

IDA: Inferred from Direct Assay

P

From MGI

GO:0009950

dorsal/ventral axis specification

MGI:MGI:3799599
PMID:17681137[13]

ISO: Inferred from Sequence Orthology

UniProtKB:P57094

P

From MGI

GO:0009953

dorsal/ventral pattern formation

MGI:MGI:3797993
PMID:18316368[27]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1856035

P

From MGI

GO:0009953

dorsal/ventral pattern formation

MGI:MGI:3799599
PMID:17681137[13]

ISO: Inferred from Sequence Orthology

UniProtKB:P57094

P

From MGI

GO:0010800

positive regulation of peptidyl-threonine phosphorylation

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:O15169

P

From MGI

GO:0014069

postsynaptic density

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:O70239

C

From MGI

GO:0014069

postsynaptic density

MGI:MGI:4459044

PANTHER:PTN000090568

C

From MGI

GO:0016020

membrane

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0472

C

From MGI

GO:0016023

cytoplasmic membrane-bounded vesicle

MGI:MGI:1930830
PMID:11113207[7]

IDA: Inferred from Direct Assay

C

From MGI

GO:0016055

Wnt receptor signaling pathway

MGI:MGI:1930830
PMID:11113207[7]

IDA: Inferred from Direct Assay

P

From MGI

GO:0016055

Wnt receptor signaling pathway

MGI:MGI:1930830
PMID:11113207[7]

IPI: Inferred from Physical Interaction

UniProtKB:P51141

P

From MGI

GO:0016055

Wnt receptor signaling pathway

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:O70239

P

From MGI

GO:0016328

lateral plasma membrane

MGI:MGI:2154458

ISO: Inferred from Sequence Orthology

UniProtKB:O15169

C

From MGI

GO:0019899

enzyme binding

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:O15169

F

From MGI

GO:0019901

protein kinase binding

MGI:MGI:1336856
PMID:10318824[25]

IPI: Inferred from Physical Interaction

UniProtKB:P49841

F

From MGI

GO:0019901

protein kinase binding

MGI:MGI:3521522
PMID:15526030[5]

ISO: Inferred from Sequence Orthology

UniProtKB:O15169

F

From MGI

GO:0019901

protein kinase binding

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:O70239

F

From MGI

GO:0019904

protein domain specific binding

MGI:MGI:3573812
PMID:15579909[11]

IPI: Inferred from Physical Interaction

UniProtKB:Q60838

F

From MGI

GO:0019904

protein domain specific binding

MGI:MGI:3799599
PMID:17681137[13]

IPI: Inferred from Physical Interaction

UniProtKB:Q8C4Q6

F

From MGI

GO:0019904

protein domain specific binding

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:O70239

F

From MGI

GO:0020027

hemoglobin metabolic process

MGI:MGI:48782

IMP: Inferred from Mutant Phenotype

MGI:MGI:1856035

P

From MGI

GO:0021797

forebrain anterior/posterior pattern specification

MGI:MGI:4459044

PANTHER:PTN000090599

P

From MGI

GO:0021881

Wnt receptor signaling pathway involved in forebrain neuron fate commitment

MGI:MGI:4459044

PANTHER:PTN000090599

P

From MGI

GO:0030163

protein catabolic process

MGI:MGI:2662628
PMID:12717450[28]

IDA: Inferred from Direct Assay

P

From MGI

GO:0030178

negative regulation of Wnt receptor signaling pathway

MGI:MGI:2662628
PMID:12717450[28]

IDA: Inferred from Direct Assay

P

From MGI

GO:0030178

negative regulation of Wnt receptor signaling pathway

MGI:MGI:3799599
PMID:17681137[13]

IDA: Inferred from Direct Assay

P

From MGI

GO:0030178

negative regulation of Wnt receptor signaling pathway

MGI:MGI:4462715
PMID:10581160[26]

IDA: Inferred from Direct Assay

P

From MGI

GO:0030178

negative regulation of Wnt receptor signaling pathway

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:O15169

P

From MGI

GO:0030178

negative regulation of Wnt receptor signaling pathway

MGI:MGI:894149
PMID:9230313[29]

IDA: Inferred from Direct Assay

P

From MGI

GO:0030511

positive regulation of transforming growth factor beta receptor signaling pathway

MGI:MGI:3628833
PMID:16601693[1]

IDA: Inferred from Direct Assay

P

From MGI

GO:0030511

positive regulation of transforming growth factor beta receptor signaling pathway

MGI:MGI:3628833
PMID:16601693[1]

IGI: Inferred from Genetic Interaction

MGI:MGI:1934919

P

From MGI

GO:0030511

positive regulation of transforming growth factor beta receptor signaling pathway

MGI:MGI:3628833
PMID:16601693[1]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0030877

beta-catenin destruction complex

MGI:MGI:1336856
PMID:10318824[25]

IDA: Inferred from Direct Assay

C

From MGI

GO:0030877

beta-catenin destruction complex

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:O70239

C

From MGI

GO:0030877

beta-catenin destruction complex

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:O15169

C

From MGI

GO:0030910

olfactory placode formation

MGI:MGI:4459044

PANTHER:PTN000090599

P

From MGI

GO:0031122

cytoplasmic microtubule organization

MGI:MGI:3028427
PMID:14734535[3]

IGI: Inferred from Genetic Interaction

MGI:MGI:94941

P

From MGI

GO:0031398

positive regulation of protein ubiquitination

MGI:MGI:3628833
PMID:16601693[1]

IDA: Inferred from Direct Assay

P

From MGI

GO:0031398

positive regulation of protein ubiquitination

MGI:MGI:3628833
PMID:16601693[1]

IDA: Inferred from Direct Assay

P

From MGI

GO:0031398

positive regulation of protein ubiquitination

MGI:MGI:3628833
PMID:16601693[1]

IGI: Inferred from Genetic Interaction

MGI:MGI:1934919

P

From MGI

GO:0031398

positive regulation of protein ubiquitination

MGI:MGI:3628833
PMID:16601693[1]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0031398

positive regulation of protein ubiquitination

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:O15169

P

From MGI

GO:0031410

cytoplasmic vesicle

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:O70239

C

From MGI

GO:0031625

ubiquitin protein ligase binding

MGI:MGI:3628833
PMID:16601693[1]

IPI: Inferred from Physical Interaction

UniProtKB:Q99ML9

F

From MGI

GO:0031625

ubiquitin protein ligase binding

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:O15169

F

From MGI

GO:0032147

activation of protein kinase activity

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:O15169

P

From MGI

GO:0032436

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

MGI:MGI:3628833
PMID:16601693[1]

IDA: Inferred from Direct Assay

P

From MGI

GO:0032947

protein complex scaffold

MGI:MGI:3628833
PMID:16601693[1]

IMP: Inferred from Mutant Phenotype

F

From MGI

GO:0032947

protein complex scaffold

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:O15169

F

From MGI

GO:0033138

positive regulation of peptidyl-serine phosphorylation

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:O15169

P

From MGI

GO:0034101

erythrocyte homeostasis

MGI:MGI:48782

IMP: Inferred from Mutant Phenotype

MGI:MGI:1856035

P

From MGI

GO:0034244

negative regulation of transcription elongation from RNA polymerase II promoter

MGI:MGI:1336856
PMID:10318824[25]

IDA: Inferred from Direct Assay

P

From MGI

GO:0034244

negative regulation of transcription elongation from RNA polymerase II promoter

MGI:MGI:3840033
PMID:19204372[2]

IDA: Inferred from Direct Assay

P

From MGI

GO:0035412

regulation of catenin import into nucleus

MGI:MGI:3036437
PMID:14981260[23]

IDA: Inferred from Direct Assay

P

From MGI

GO:0036342

post-anal tail morphogenesis

MGI:MGI:2652932
PMID:12601169[30]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1856035

P

From MGI

GO:0036342

post-anal tail morphogenesis

MGI:MGI:48782

IMP: Inferred from Mutant Phenotype

MGI:MGI:1856035
MGI:MGI:1856036

P

From MGI

GO:0038032

termination of G-protein coupled receptor signaling pathway

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR000342
InterPro:IPR016137

P

From MGI

GO:0042802

identical protein binding

MGI:MGI:1333284
PMID:9920888[6]

IPI: Inferred from Physical Interaction

UniProtKB:O35625

F

From MGI

GO:0042802

identical protein binding

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:O70239

F

From MGI

GO:0042803

protein homodimerization activity

MGI:MGI:3573812
PMID:15579909[11]

IPI: Inferred from Physical Interaction

UniProtKB:O35625

F

From MGI

GO:0042803

protein homodimerization activity

MGI:MGI:3799599
PMID:17681137[13]

IPI: Inferred from Physical Interaction

UniProtKB:O35625

F

From MGI

GO:0042803

protein homodimerization activity

MGI:MGI:3817405
PMID:18632848[14]

IPI: Inferred from Physical Interaction

UniProtKB:O35625

F

From MGI

GO:0043234

protein complex

MGI:MGI:3628833
PMID:16601693[1]

IDA: Inferred from Direct Assay

C

From MGI

GO:0043507

positive regulation of JUN kinase activity

MGI:MGI:2675921
PMID:12878610[9]

IDA: Inferred from Direct Assay

P

From MGI

GO:0043507

positive regulation of JUN kinase activity

MGI:MGI:2675921
PMID:12878610[9]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0043507

positive regulation of JUN kinase activity

MGI:MGI:3573812
PMID:15579909[11]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0043507

positive regulation of JUN kinase activity

MGI:MGI:3799599
PMID:17681137[13]

ISO: Inferred from Sequence Orthology

UniProtKB:P57094

P

From MGI

GO:0043621

protein self-association

MGI:MGI:3573812
PMID:15579909[11]

IPI: Inferred from Physical Interaction

UniProtKB:O35625

F

From MGI

GO:0043623

cellular protein complex assembly

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:O15169

P

From MGI

GO:0044444

cytoplasmic part

MGI:MGI:1337175
PMID:10330403[4]

ISO: Inferred from Sequence Orthology

UniProtKB:Q9YGY0

C

From MGI

GO:0044444

cytoplasmic part

MGI:MGI:3799598
PMID:18606656[31]

IDA: Inferred from Direct Assay

C

From MGI

GO:0044459

plasma membrane part

MGI:MGI:1337175
PMID:10330403[4]

IDA: Inferred from Direct Assay

C

From MGI

GO:0045599

negative regulation of fat cell differentiation

MGI:MGI:3758508
PMID:10937998[32]

IDA: Inferred from Direct Assay

P

From MGI

GO:0045732

positive regulation of protein catabolic process

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:O15169

P

From MGI

GO:0045860

positive regulation of protein kinase activity

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:O70239

P

From MGI

GO:0045893

positive regulation of transcription, DNA-dependent

MGI:MGI:3628833
PMID:16601693[1]

IDA: Inferred from Direct Assay

P

From MGI

GO:0045893

positive regulation of transcription, DNA-dependent

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:O15169

P

From MGI

GO:0046330

positive regulation of JNK cascade

MGI:MGI:3797993
PMID:18316368[27]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1856035

P

From MGI

GO:0046330

positive regulation of JNK cascade

MGI:MGI:3799599
PMID:17681137[13]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0046332

SMAD binding

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:O15169

F

From MGI

GO:0048048

embryonic eye morphogenesis

MGI:MGI:4459044

PANTHER:PTN000090599

P

From MGI

GO:0048318

axial mesoderm development

MGI:MGI:894149
PMID:9230313[29]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857546

P

From MGI

GO:0048320

axial mesoderm formation

MGI:MGI:894149
PMID:9230313[29]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857546

P

From MGI

GO:0048471

perinuclear region of cytoplasm

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:O15169

C

From MGI

GO:0050877

neurological system process

MGI:MGI:48782

IMP: Inferred from Mutant Phenotype

MGI:MGI:1856035

P

From MGI

GO:0051248

negative regulation of protein metabolic process

MGI:MGI:1337175
PMID:10330403[4]

IDA: Inferred from Direct Assay

P

From MGI

GO:0051260

protein homooligomerization

MGI:MGI:1336856
PMID:10318824[25]

IDA: Inferred from Direct Assay

P

From MGI

GO:0051260

protein homooligomerization

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:O70239

P

From MGI

GO:0051443

positive regulation of ubiquitin-protein ligase activity

MGI:MGI:3628833
PMID:16601693[1]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0051443

positive regulation of ubiquitin-protein ligase activity

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:O15169

P

From MGI

GO:0055001

muscle cell development

MGI:MGI:4459044

PANTHER:PTN000090599

P

From MGI

GO:0060070

canonical Wnt receptor signaling pathway

MGI:MGI:3758508
PMID:10937998[32]

IDA: Inferred from Direct Assay

P

From MGI

GO:0060070

canonical Wnt receptor signaling pathway

MGI:MGI:3835914
PMID:19075000[15]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0060272

embryonic skeletal joint morphogenesis

MGI:MGI:48782

IMP: Inferred from Mutant Phenotype

MGI:MGI:1856035
MGI:MGI:1856036

P

From MGI

GO:0060823

canonical Wnt receptor signaling pathway involved in neural plate anterior/posterior pattern formation

MGI:MGI:4459044

PANTHER:PTN000090599

P

From MGI

GO:0070016

armadillo repeat domain binding

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:O70239

F

From MGI

GO:0070016

armadillo repeat domain binding

MGI:MGI:4459044

PANTHER:PTN000090568

F

From MGI

GO:0070411

I-SMAD binding

MGI:MGI:3628833
PMID:16601693[1]

IDA: Inferred from Direct Assay

F

From MGI

GO:0070411

I-SMAD binding

MGI:MGI:3628833
PMID:16601693[1]

IPI: Inferred from Physical Interaction

UniProtKB:O35253
UniprotKB:O35182

F

From MGI

GO:0070411

I-SMAD binding

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:O15169

F

From MGI

GO:0070412

R-SMAD binding

MGI:MGI:3628833
PMID:16601693[1]

IPI: Inferred from Physical Interaction

UniProtKB:Q8BUN5

F

From MGI

GO:0071407

cellular response to organic cyclic compound

MGI:MGI:4459044

PANTHER:PTN000090568

P

From MGI

GO:0071514

genetic imprinting

MGI:MGI:2652932
PMID:12601169[30]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1856035

P

From MGI

GO:0071944

cell periphery

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:O15169

C

From MGI

GO:0090090

negative regulation of canonical Wnt receptor signaling pathway

MGI:MGI:3573812
PMID:15579909[11]

IDA: Inferred from Direct Assay

P

From MGI

GO:0090090

negative regulation of canonical Wnt receptor signaling pathway

MGI:MGI:3840033
PMID:19204372[2]

IDA: Inferred from Direct Assay

P

From MGI

GO:0090244

Wnt receptor signaling pathway involved in somitogenesis

MGI:MGI:4459044

PANTHER:PTN000090568

P

From MGI

GO:2000060

positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process

MGI:MGI:3628833
PMID:16601693[1]

IDA: Inferred from Direct Assay

P

From MGI

GO:2000060

positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:O70239

P

From MGI


Notes

References

See Help:References for how to manage references in GONUTS.
  1. 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 1.12 1.13 1.14 1.15 1.16 1.17 1.18 Liu, W et al. (2006) Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia. EMBO J. 25 1646-58 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 Chia, IV et al. (2009) Both the RGS domain and the six C-terminal amino acids of mouse Axin are required for normal embryogenesis. Genetics 181 1359-68 PubMed GONUTS page
  3. 3.0 3.1 3.2 Ciani, L et al. (2004) A divergent canonical WNT-signaling pathway regulates microtubule dynamics: dishevelled signals locally to stabilize microtubules. J. Cell Biol. 164 243-53 PubMed GONUTS page
  4. 4.0 4.1 4.2 4.3 4.4 4.5 4.6 Fagotto, F et al. (1999) Domains of axin involved in protein-protein interactions, Wnt pathway inhibition, and intracellular localization. J. Cell Biol. 145 741-56 PubMed GONUTS page
  5. 5.0 5.1 Rui, Y et al. (2004) Axin stimulates p53 functions by activation of HIPK2 kinase through multimeric complex formation. EMBO J. 23 4583-94 PubMed GONUTS page
  6. 6.0 6.1 6.2 Hsu, W et al. (1999) Identification of a domain of Axin that binds to the serine/threonine protein phosphatase 2A and a self-binding domain. J. Biol. Chem. 274 3439-45 PubMed GONUTS page
  7. 7.0 7.1 7.2 7.3 7.4 Hino, S et al. (2001) Inhibition of the Wnt signaling pathway by Idax, a novel Dvl-binding protein. Mol. Cell. Biol. 21 330-42 PubMed GONUTS page
  8. Hocevar, BA et al. (2003) Regulation of the Wnt signaling pathway by disabled-2 (Dab2). EMBO J. 22 3084-94 PubMed GONUTS page
  9. 9.0 9.1 9.2 Luo, W et al. (2003) Axin utilizes distinct regions for competitive MEKK1 and MEKK4 binding and JNK activation. J. Biol. Chem. 278 37451-8 PubMed GONUTS page
  10. Ha, NC et al. (2004) Mechanism of phosphorylation-dependent binding of APC to beta-catenin and its role in beta-catenin degradation. Mol. Cell 15 511-21 PubMed GONUTS page
  11. 11.0 11.1 11.2 11.3 11.4 11.5 Luo, W et al. (2005) Axin contains three separable domains that confer intramolecular, homodimeric, and heterodimeric interactions involved in distinct functions. J. Biol. Chem. 280 5054-60 PubMed GONUTS page
  12. Itoh, K et al. (2000) Interaction of dishevelled and Xenopus axin-related protein is required for wnt signal transduction. Mol. Cell. Biol. 20 2228-38 PubMed GONUTS page
  13. 13.0 13.1 13.2 13.3 13.4 13.5 13.6 13.7 13.8 Rui, Y et al. (2007) A beta-catenin-independent dorsalization pathway activated by Axin/JNK signaling and antagonized by aida. Dev. Cell 13 268-82 PubMed GONUTS page
  14. 14.0 14.1 14.2 Kim, MJ et al. (2008) SUMOylation target sites at the C terminus protect Axin from ubiquitination and confer protein stability. FASEB J. 22 3785-94 PubMed GONUTS page
  15. 15.0 15.1 Haÿ, E et al. (2009) N-cadherin interacts with axin and LRP5 to negatively regulate Wnt/beta-catenin signaling, osteoblast function, and bone formation. Mol. Cell. Biol. 29 953-64 PubMed GONUTS page
  16. Chen, T et al. (2009) Identification of zinc-finger BED domain-containing 3 (Zbed3) as a novel Axin-interacting protein that activates Wnt/beta-catenin signaling. J. Biol. Chem. 284 6683-9 PubMed GONUTS page
  17. Pilot-Storck, F et al. (2010) Interactome mapping of the phosphatidylinositol 3-kinase-mammalian target of rapamycin pathway identifies deformed epidermal autoregulatory factor-1 as a new glycogen synthase kinase-3 interactor. Mol. Cell Proteomics 9 1578-93 PubMed GONUTS page
  18. Huang, SM et al. (2009) Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling. Nature 461 614-20 PubMed GONUTS page
  19. Cha, B et al. (2011) Methylation by protein arginine methyltransferase 1 increases stability of Axin, a negative regulator of Wnt signaling. Oncogene 30 2379-89 PubMed GONUTS page
  20. Li, Q et al. (2011) AXIN is an essential co-activator for the promyelocytic leukemia protein in p53 activation. Oncogene 30 1194-204 PubMed GONUTS page
  21. Li, VS et al. (2012) Wnt signaling through inhibition of β-catenin degradation in an intact Axin1 complex. Cell 149 1245-56 PubMed GONUTS page
  22. Chen, HJ et al. (2006) The role of microtubule actin cross-linking factor 1 (MACF1) in the Wnt signaling pathway. Genes Dev. 20 1933-45 PubMed GONUTS page
  23. 23.0 23.1 Cong, F & Varmus, H (2004) Nuclear-cytoplasmic shuttling of Axin regulates subcellular localization of beta-catenin. Proc. Natl. Acad. Sci. U.S.A. 101 2882-7 PubMed GONUTS page
  24. Dunn, LC & Caspari, E (1945) A Case of Neighboring Loci with Similar Effects. Genetics 30 543-68 PubMed GONUTS page
  25. 25.0 25.1 25.2 25.3 25.4 25.5 Sakanaka, C & Williams, LT (1999) Functional domains of axin. Importance of the C terminus as an oligomerization domain. J. Biol. Chem. 274 14090-3 PubMed GONUTS page
  26. 26.0 26.1 Jho, Eh et al. (1999) A GSK3beta phosphorylation site in axin modulates interaction with beta-catenin and Tcf-mediated gene expression. Biochem. Biophys. Res. Commun. 266 28-35 PubMed GONUTS page
  27. 27.0 27.1 Lu, Z et al. (2008) Protein encoded by the Axin(Fu) allele effectively down-regulates Wnt signaling but exerts a dominant negative effect on c-Jun N-terminal kinase signaling. J. Biol. Chem. 283 13132-9 PubMed GONUTS page
  28. 28.0 28.1 Reya, T et al. (2003) A role for Wnt signalling in self-renewal of haematopoietic stem cells. Nature 423 409-14 PubMed GONUTS page
  29. 29.0 29.1 29.2 Zeng, L et al. (1997) The mouse Fused locus encodes Axin, an inhibitor of the Wnt signaling pathway that regulates embryonic axis formation. Cell 90 181-92 PubMed GONUTS page
  30. 30.0 30.1 Rakyan, VK et al. (2003) Transgenerational inheritance of epigenetic states at the murine Axin(Fu) allele occurs after maternal and paternal transmission. Proc. Natl. Acad. Sci. U.S.A. 100 2538-43 PubMed GONUTS page
  31. Grujic, M et al. (2008) Delayed contraction of the CD8+ T cell response toward lymphocytic choriomeningitis virus infection in mice lacking serglycin. J. Immunol. 181 1043-51 PubMed GONUTS page
  32. 32.0 32.1 Ross, SE et al. (2000) Inhibition of adipogenesis by Wnt signaling. Science 289 950-3 PubMed GONUTS page
<protect>