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MGI:Atxn3
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Atxn3 ( synonyms: ataxin-3, Atx3, Mjd, MJD1, Sca3 ) | |
| Protein Name(s) | ataxin 3, | |
| External Links | ||
| MGI | MGI:1099442 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000226 |
microtubule cytoskeleton organization |
MGI:MGI:2154458 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0001012 |
RNA polymerase II regulatory region DNA binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3833820 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:3797202 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:4413539 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:4837069 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:3716223 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:3797202 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:4413539 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:4837069 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005759 |
mitochondrial matrix |
MGI:MGI:3797202 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0006351 |
transcription, DNA-dependent |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0804 |
P |
From MGI |
||
| GO:0006355 |
regulation of transcription, DNA-dependent |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0805 |
P |
From MGI |
||
| GO:0006508 |
proteolysis |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0645 |
P |
From MGI |
||
| GO:0006511 |
ubiquitin-dependent protein catabolic process |
MGI:MGI:3833207 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3833681 |
P |
From MGI |
||
| GO:0008233 |
peptidase activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0645 |
F |
From MGI |
||
| GO:0008234 |
cysteine-type peptidase activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0788 |
F |
From MGI |
||
| GO:0008242 |
omega peptidase activity |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0010810 |
regulation of cell-substrate adhesion |
MGI:MGI:2154458 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0010810 |
regulation of cell-substrate adhesion |
MGI:MGI:4837315 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0016575 |
histone deacetylation |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0016787 |
hydrolase activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0378 |
F |
From MGI |
||
| GO:0030036 |
actin cytoskeleton organization |
MGI:MGI:2154458 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0031966 |
mitochondrial membrane |
MGI:MGI:3797202 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0034605 |
cellular response to heat |
MGI:MGI:4413539 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0035640 |
exploration behavior |
MGI:MGI:3833207 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3833681 |
P |
From MGI |
||
| GO:0042405 |
nuclear inclusion body |
MGI:MGI:3716223 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0045104 |
intermediate filament cytoskeleton organization |
MGI:MGI:2154458 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
|
contributes_to |
GO:0004407 |
histone deacetylase activity |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
| |
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Boeddrich A et al. (2006) An arginine/lysine-rich motif is crucial for VCP/p97-mediated modulation of ataxin-3 fibrillogenesis. EMBO J 25: 1547-58 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 Pozzi C et al. (2008) Study of subcellular localization and proteolysis of ataxin-3. Neurobiol Dis 30: 190-200 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Reina CP et al. (2010) Proteotoxic stress increases nuclear localization of ataxin-3. Hum Mol Genet 19: 235-49 PubMed GONUTS page
- ↑ 4.0 4.1 Pastori V et al. (2010) CK2 and GSK3 phosphorylation on S29 controls wild-type ATXN3 nuclear uptake. Biochim Biophys Acta 1802: 583-92 PubMed GONUTS page
- ↑ 5.0 5.1 Bichelmeier U et al. (2007) Nuclear localization of ataxin-3 is required for the manifestation of symptoms in SCA3: in vivo evidence. J Neurosci 27: 7418-28 PubMed GONUTS page
- ↑ 6.0 6.1 Schmitt I et al. (2007) Inactivation of the mouse Atxn3 (ataxin-3) gene increases protein ubiquitination. Biochem Biophys Res Commun 362: 734-9 PubMed GONUTS page
- ↑ Rodrigues AJ et al. (2010) Absence of ataxin-3 leads to cytoskeletal disorganization and increased cell death. Biochim Biophys Acta 1803: 1154-63 PubMed GONUTS page
