MGI:Atp7b

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Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0000166	nucleotide binding	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0547	F	From MGI
	GO:0000166	nucleotide binding	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR008250	F	From MGI
	GO:0003824	catalytic activity	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR005834	F	From MGI
	GO:0004008	copper-exporting ATPase activity	MGI:MGI:3576400 PMID:15634671^[1]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0005375	copper ion transmembrane transporter activity	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q64535	F	From MGI
	GO:0005507	copper ion binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q64535	F	From MGI
	GO:0005507	copper ion binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P35670	F	From MGI
	GO:0005524	ATP binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P35670	F	From MGI
	GO:0005622	intracellular	MGI:MGI:3618018 PMID:16436657^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2158253	C	From MGI
	GO:0005624	membrane fraction	MGI:MGI:1345026 PMID:10441329^[3]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005770	late endosome	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P35670	C	From MGI
	GO:0005794	Golgi apparatus	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0333	C	From MGI
	GO:0005802	trans-Golgi network	MGI:MGI:1929057 PMID:11085952^[4]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005802	trans-Golgi network	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q64535	C	From MGI
	GO:0005886	plasma membrane	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q64535	C	From MGI
	GO:0005923	tight junction	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q64535	C	From MGI
	GO:0006200	ATP catabolic process	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR006416 InterPro:IPR001757	P	From MGI
	GO:0006754	ATP biosynthetic process	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR006416	P	From MGI
	GO:0006810	transport	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0813	P	From MGI
	GO:0006811	ion transport	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0406	P	From MGI
	GO:0006812	cation transport	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR001757	P	From MGI
	GO:0006825	copper ion transport	MGI:MGI:1929057 PMID:11085952^[4]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856220	P	From MGI
	GO:0006825	copper ion transport	MGI:MGI:3576400 PMID:15634671^[1]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0006825	copper ion transport	MGI:MGI:3688655 PMID:11237756^[5]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0006825	copper ion transport	MGI:MGI:3688655 PMID:11237756^[5]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856220	P	From MGI
	GO:0006825	copper ion transport	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P35670	P	From MGI
	GO:0006878	cellular copper ion homeostasis	MGI:MGI:1100407 PMID:9392450^[6]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856220	P	From MGI
	GO:0006878	cellular copper ion homeostasis	MGI:MGI:1196719 PMID:9484715^[7]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856220	P	From MGI
	GO:0006878	cellular copper ion homeostasis	MGI:MGI:1345026 PMID:10441329^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2158253	P	From MGI
	GO:0006878	cellular copper ion homeostasis	MGI:MGI:1929057 PMID:11085952^[4]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856220	P	From MGI
	GO:0006878	cellular copper ion homeostasis	MGI:MGI:49578 PMID:1588441^[8]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856220	P	From MGI
	GO:0006878	cellular copper ion homeostasis	MGI:MGI:55573 PMID:6863890^[9]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856220	P	From MGI
	GO:0006878	cellular copper ion homeostasis	MGI:MGI:64054 PMID:8257436^[10]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856220	P	From MGI
	GO:0006878	cellular copper ion homeostasis	MGI:MGI:66663 PMID:8040371^[11]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856220	P	From MGI
	GO:0006878	cellular copper ion homeostasis	MGI:MGI:87446 PMID:2845190^[12]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856220	P	From MGI
	GO:0006882	cellular zinc ion homeostasis	MGI:MGI:1100407 PMID:9392450^[6]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856220	P	From MGI
	GO:0006882	cellular zinc ion homeostasis	MGI:MGI:1196719 PMID:9484715^[7]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856220	P	From MGI
	GO:0006882	cellular zinc ion homeostasis	MGI:MGI:64054 PMID:8257436^[10]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856220	P	From MGI
	GO:0006882	cellular zinc ion homeostasis	MGI:MGI:66663 PMID:8040371^[11]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856220	P	From MGI
	GO:0007595	lactation	MGI:MGI:49578 PMID:1588441^[8]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856220	P	From MGI
	GO:0007595	lactation	MGI:MGI:55573 PMID:6863890^[9]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856220	P	From MGI
	GO:0007595	lactation	MGI:MGI:71982	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856221	P	From MGI
	GO:0008152	metabolic process	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR005834	P	From MGI
	GO:0008270	zinc ion binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q64535	F	From MGI
	GO:0015662	ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR006416 InterPro:IPR001757	F	From MGI
	GO:0015677	copper ion import	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P35670	P	From MGI
	GO:0015680	intracellular copper ion transport	MGI:MGI:3618018 PMID:16436657^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2158253	P	From MGI
	GO:0016020	membrane	MGI:MGI:3576400 PMID:15634671^[1]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0016021	integral to membrane	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0812	C	From MGI
	GO:0016021	integral to membrane	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR006416	C	From MGI
	GO:0016787	hydrolase activity	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0378	F	From MGI
	GO:0030001	metal ion transport	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR006416 InterPro:IPR017969 InterPro:IPR006121	P	From MGI
	GO:0034220	ion transmembrane transport	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR006416 InterPro:IPR001757	P	From MGI
	GO:0035434	copper ion transmembrane transport	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q64535	P	From MGI
	GO:0043682	copper-transporting ATPase activity	MGI:MGI:3688655 PMID:11237756^[5]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0043682	copper-transporting ATPase activity	MGI:MGI:3688655 PMID:11237756^[5]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856220	F	From MGI
	GO:0046034	ATP metabolic process	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR006403	P	From MGI
	GO:0046688	response to copper ion	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P35670	P	From MGI
	GO:0046872	metal ion binding	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0479	F	From MGI
	GO:0046872	metal ion binding	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR008250 InterPro:IPR017969 InterPro:IPR006121	F	From MGI
	GO:0051208	sequestering of calcium ion	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P35670	P	From MGI
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Barnes N et al. (2005) The copper-transporting ATPases, menkes and wilson disease proteins, have distinct roles in adult and developing cerebellum. J Biol Chem 280: 9640-5 PubMed GONUTS page
↑ ^2.0 ^2.1 Huster D et al. (2006) Consequences of copper accumulation in the livers of the Atp7b-/- (Wilson disease gene) knockout mice. Am J Pathol 168: 423-34 PubMed GONUTS page
↑ ^3.0 ^3.1 Buiakova OI et al. (1999) Null mutation of the murine ATP7B (Wilson disease) gene results in intracellular copper accumulation and late-onset hepatic nodular transformation. Hum Mol Genet 8: 1665-71 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Michalczyk AA et al. (2000) Defective localization of the Wilson disease protein (ATP7B) in the mammary gland of the toxic milk mouse and the effects of copper supplementation. Biochem J 352 Pt 2: 565-71 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Voskoboinik I et al. (2001) Functional studies on the Wilson copper P-type ATPase and toxic milk mouse mutant. Biochem Biophys Res Commun 281: 966-70 PubMed GONUTS page
↑ ^6.0 ^6.1 Ono S et al. (1997) Regional brain distribution of metallothionein, zinc and copper in toxic milk mutant and transgenic mice. Toxicology 124: 1-10 PubMed GONUTS page
↑ ^7.0 ^7.1 Deng DX et al. (1998) Metallothionein and apoptosis in the toxic milk mutant mouse. Lab Invest 78: 175-83 PubMed GONUTS page
↑ ^8.0 ^8.1 Mercer JF et al. (1992) Hepatic metallothionein gene expression in toxic milk mice. J Nutr 122: 1254-9 PubMed GONUTS page
↑ ^9.0 ^9.1 Rauch H (1983) Toxic milk, a new mutation affecting cooper metabolism in the mouse. J Hered 74: 141-4 PubMed GONUTS page
↑ ^10.0 ^10.1 Koropatnick J & Cherian MG (1993) A mutant mouse (tx) with increased hepatic metallothionein stability and accumulation. Biochem J 296 ( Pt 2): 443-9 PubMed GONUTS page
↑ ^11.0 ^11.1 Howell JM & Mercer JF (1994) The pathology and trace element status of the toxic milk mutant mouse. J Comp Pathol 110: 37-47 PubMed GONUTS page
↑ Biempica L et al. (1988) Morphologic and chemical studies on a murine mutation (toxic milk mice) resulting in hepatic copper toxicosis. Lab Invest 59: 500-8 PubMed GONUTS page

[PMID:15634671-0] 1.0 ^1.1 ^1.2 Barnes N et al. (2005) The copper-transporting ATPases, menkes and wilson disease proteins, have distinct roles in adult and developing cerebellum. J Biol Chem 280: 9640-5 PubMed GONUTS page

[PMID:16436657-1] 2.0 ^2.1 Huster D et al. (2006) Consequences of copper accumulation in the livers of the Atp7b-/- (Wilson disease gene) knockout mice. Am J Pathol 168: 423-34 PubMed GONUTS page

[PMID:10441329-2] 3.0 ^3.1 Buiakova OI et al. (1999) Null mutation of the murine ATP7B (Wilson disease) gene results in intracellular copper accumulation and late-onset hepatic nodular transformation. Hum Mol Genet 8: 1665-71 PubMed GONUTS page

[PMID:11085952-3] 4.0 ^4.1 ^4.2 Michalczyk AA et al. (2000) Defective localization of the Wilson disease protein (ATP7B) in the mammary gland of the toxic milk mouse and the effects of copper supplementation. Biochem J 352 Pt 2: 565-71 PubMed GONUTS page

[PMID:11237756-4] 5.0 ^5.1 ^5.2 ^5.3 Voskoboinik I et al. (2001) Functional studies on the Wilson copper P-type ATPase and toxic milk mouse mutant. Biochem Biophys Res Commun 281: 966-70 PubMed GONUTS page

[PMID:9392450-5] 6.0 ^6.1 Ono S et al. (1997) Regional brain distribution of metallothionein, zinc and copper in toxic milk mutant and transgenic mice. Toxicology 124: 1-10 PubMed GONUTS page

[PMID:9484715-6] 7.0 ^7.1 Deng DX et al. (1998) Metallothionein and apoptosis in the toxic milk mutant mouse. Lab Invest 78: 175-83 PubMed GONUTS page

[PMID:1588441-7] 8.0 ^8.1 Mercer JF et al. (1992) Hepatic metallothionein gene expression in toxic milk mice. J Nutr 122: 1254-9 PubMed GONUTS page

[PMID:6863890-8] 9.0 ^9.1 Rauch H (1983) Toxic milk, a new mutation affecting cooper metabolism in the mouse. J Hered 74: 141-4 PubMed GONUTS page

[PMID:8257436-9] 10.0 ^10.1 Koropatnick J & Cherian MG (1993) A mutant mouse (tx) with increased hepatic metallothionein stability and accumulation. Biochem J 296 ( Pt 2): 443-9 PubMed GONUTS page

[PMID:8040371-10] 11.0 ^11.1 Howell JM & Mercer JF (1994) The pathology and trace element status of the toxic milk mutant mouse. J Comp Pathol 110: 37-47 PubMed GONUTS page

[PMID:2845190-11] Biempica L et al. (1988) Morphologic and chemical studies on a murine mutation (toxic milk mice) resulting in hepatic copper toxicosis. Lab Invest 59: 500-8 PubMed GONUTS page

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Species (Taxon ID)	Mus musculus (house mouse) (taxon:10090)
Gene Name(s)	Atp7b ( synonyms: Atp7a, Wilson protein, WND )
Protein Name(s)	ATPase, Cu++ transporting, beta polypeptide,
External Links
MGI	MGI:103297

MGI:Atp7b

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