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MGI:Atp5a1

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Contents

Species (Taxon ID) Mus musculus (house mouse) (taxon:10090)
Gene Name(s) Atp5a1 ( synonyms: Atpm, D18Ertd206e, Mom2 )
Protein Name(s) ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1,
External Links
MGI MGI:88115

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000166

nucleotide binding

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0547

F

From MGI

GO:0000275

mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P15999

C

From MGI

GO:0001937

negative regulation of endothelial cell proliferation

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P25705

P

From MGI

GO:0005524

ATP binding

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P15999

F

From MGI

GO:0005524

ATP binding

MGI:MGI:52626
PMID:7916601[1]

IMP: Inferred from Mutant Phenotype

F

From MGI

GO:0005739

mitochondrion

MGI:MGI:2682130
PMID:14651853[2]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005739

mitochondrion

MGI:MGI:3852644
PMID:18614015[3]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005739

mitochondrion

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P15999

C

From MGI

GO:0005743

mitochondrial inner membrane

MGI:MGI:3590069
PMID:12865426[4]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005743

mitochondrial inner membrane

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P15999

C

From MGI

GO:0005743

mitochondrial inner membrane

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P25705

C

From MGI

GO:0005753

mitochondrial proton-transporting ATP synthase complex

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P15999

C

From MGI

GO:0005753

mitochondrial proton-transporting ATP synthase complex

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P25705

C

From MGI

GO:0005886

plasma membrane

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P25705

C

From MGI

GO:0006172

ADP biosynthetic process

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P15999

P

From MGI

GO:0006200

ATP catabolic process

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR005294
InterPro:IPR018118
InterPro:IPR004100

P

From MGI

GO:0006200

ATP catabolic process

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P15999

P

From MGI

GO:0006200

ATP catabolic process

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P25705

P

From MGI

GO:0006629

lipid metabolic process

MGI:MGI:3719337
PMID:17612527[5]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0006754

ATP biosynthetic process

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0066

P

From MGI

GO:0006810

transport

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0813

P

From MGI

GO:0006811

ion transport

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0406

P

From MGI

GO:0009790

embryo development

MGI:MGI:3713588
PMID:17387143[6]

IMP: Inferred from Mutant Phenotype

MGI:MGI:3530914

P

From MGI

GO:0015986

ATP synthesis coupled proton transport

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR005294

P

From MGI

GO:0015991

ATP hydrolysis coupled proton transport

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR000793

P

From MGI

GO:0016020

membrane

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0472

C

From MGI

GO:0016469

proton-transporting two-sector ATPase complex

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR018118
InterPro:IPR004100

C

From MGI

GO:0016820

hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR000793

F

From MGI

GO:0016887

ATPase activity

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P15999

F

From MGI

GO:0033178

proton-transporting two-sector ATPase complex, catalytic domain

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR000793

C

From MGI

GO:0042288

MHC class I protein binding

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P25705

F

From MGI

GO:0043499

eukaryotic cell surface binding

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P25705

F

From MGI

GO:0043531

ADP binding

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P15999

F

From MGI

GO:0045261

proton-transporting ATP synthase complex, catalytic core F(1)

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P15999

C

From MGI

GO:0046034

ATP metabolic process

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P15999

P

From MGI

GO:0046933

hydrogen ion transporting ATP synthase activity, rotational mechanism

MGI:MGI:3719337
PMID:17612527[5]

IMP: Inferred from Mutant Phenotype

F

From MGI

GO:0046961

proton-transporting ATPase activity, rotational mechanism

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR005294
InterPro:IPR018118
InterPro:IPR004100

F

From MGI


Notes

References

See Help:References for how to manage references in GONUTS.
  1. Yotov WV & St-Arnaud R (1993) Cloning and functional expression analysis of the alpha subunit of mouse ATP synthase. Biochem Biophys Res Commun 191: 142-8 PubMed GONUTS page
  2. Mootha VK et al. (2003) Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Cell 115: 629-40 PubMed GONUTS page
  3. Pagliarini DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell 134: 112-23 PubMed GONUTS page
  4. Da Cruz S et al. (2003) Proteomic analysis of the mouse liver mitochondrial inner membrane. J Biol Chem 278: 41566-71 PubMed GONUTS page
  5. 5.0 5.1 Arakaki N et al. (2007) Cell-surface H+-ATP synthase as a potential molecular target for anti-obesity drugs. FEBS Lett 581: 3405-9 PubMed GONUTS page
  6. Baran AA et al. (2007) The modifier of Min 2 (Mom2) locus: embryonic lethality of a mutation in the Atp5a1 gene suggests a novel mechanism of polyp suppression. Genome Res 17: 566-76 PubMed GONUTS page
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