MGI:Atm

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Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0000077	DNA damage checkpoint	MGI:MGI:2679752 PMID:12937170^[1]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0000166	nucleotide binding	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0547	F	From MGI
	GO:0001666	response to hypoxia	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_001100291	P	From MGI
	GO:0001756	somitogenesis	MGI:MGI:3624894 PMID:16687486^[2]	IGI: Inferred from Genetic Interaction	MGI:MGI:104779	P	From MGI
	GO:0002331	pre-B cell allelic exclusion	MGI:MGI:3848557 PMID:19448632^[3]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0003677	DNA binding	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0238	F	From MGI
	GO:0004672	protein kinase activity	MGI:MGI:3053255 PMID:15364958^[4]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0004672	protein kinase activity	MGI:MGI:3522367 PMID:15604234^[5]	TAS: Traceable Author Statement		F	From MGI
	GO:0004674	protein serine/threonine kinase activity	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_001100291	F	From MGI
	GO:0004674	protein serine/threonine kinase activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q13315	F	From MGI
	GO:0004677	DNA-dependent protein kinase activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q13315	F	From MGI
	GO:0005524	ATP binding	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0067	F	From MGI
	GO:0005622	intracellular	MGI:MGI:1926715 PMID:11040211^[6]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1933746	C	From MGI
	GO:0005622	intracellular	MGI:MGI:3652689 PMID:16777961^[7]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1933746	C	From MGI
	GO:0005622	intracellular	MGI:MGI:3714678 PMID:17476307^[8]	IGI: Inferred from Genetic Interaction	MGI:MGI:109337	C	From MGI
	GO:0005634	nucleus	MGI:MGI:3522367 PMID:15604234^[5]	TAS: Traceable Author Statement		C	From MGI
	GO:0005634	nucleus	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_001100291	C	From MGI
	GO:0005737	cytoplasm	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_001100291	C	From MGI
	GO:0005819	spindle	MGI:MGI:3056244 PMID:15509711^[9]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0006281	DNA repair	MGI:MGI:2156121 PMID:11679583^[10]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857132	P	From MGI
	GO:0006281	DNA repair	MGI:MGI:3053255 PMID:15364958^[4]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0006281	DNA repair	MGI:MGI:3511081 PMID:15542845^[11]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2155399	P	From MGI
	GO:0006468	protein phosphorylation	MGI:MGI:3053255 PMID:15364958^[4]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0006974	response to DNA damage stimulus	MGI:MGI:1926715 PMID:11040211^[6]	TAS: Traceable Author Statement		P	From MGI
	GO:0006974	response to DNA damage stimulus	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_001100291	P	From MGI
	GO:0006974	response to DNA damage stimulus	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q13315	P	From MGI
	GO:0006975	DNA damage induced protein phosphorylation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q13315	P	From MGI
	GO:0007049	cell cycle	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0131	P	From MGI
	GO:0007050	cell cycle arrest	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q13315	P	From MGI
	GO:0007094	mitotic cell cycle spindle assembly checkpoint	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q13315	P	From MGI
	GO:0007292	female gamete generation	MGI:MGI:3529751 PMID:15640358^[12]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857132	P	From MGI
	GO:0007420	brain development	MGI:MGI:3624894 PMID:16687486^[2]	IGI: Inferred from Genetic Interaction	MGI:MGI:104779	P	From MGI
	GO:0007507	heart development	MGI:MGI:3624894 PMID:16687486^[2]	IGI: Inferred from Genetic Interaction	MGI:MGI:104779	P	From MGI
	GO:0008630	DNA damage response, signal transduction resulting in induction of apoptosis	MGI:MGI:1926715 PMID:11040211^[6]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1933746	P	From MGI
	GO:0008630	DNA damage response, signal transduction resulting in induction of apoptosis	MGI:MGI:3652689 PMID:16777961^[7]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1933746	P	From MGI
	GO:0008630	DNA damage response, signal transduction resulting in induction of apoptosis	MGI:MGI:3714678 PMID:17476307^[8]	IGI: Inferred from Genetic Interaction	MGI:MGI:109337	P	From MGI
	GO:0010212	response to ionizing radiation	MGI:MGI:1352316 PMID:10639175^[13]	IGI: Inferred from Genetic Interaction	MGI:MGI:99702	P	From MGI
	GO:0010212	response to ionizing radiation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q13315	P	From MGI
	GO:0016301	kinase activity	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0418	F	From MGI
	GO:0016303	1-phosphatidylinositol-3-kinase activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q13315	F	From MGI
	GO:0016310	phosphorylation	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0418	P	From MGI
	GO:0016572	histone phosphorylation	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_001100291	P	From MGI
	GO:0016740	transferase activity	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0808	F	From MGI
	GO:0016772	transferase activity, transferring phosphorus-containing groups	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR011009	F	From MGI
	GO:0016773	phosphotransferase activity, alcohol group as acceptor	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR000403 InterPro:IPR018936	F	From MGI
	GO:0018105	peptidyl-serine phosphorylation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q13315	P	From MGI
	GO:0030889	negative regulation of B cell proliferation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q13315	P	From MGI
	GO:0031410	cytoplasmic vesicle	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0968	C	From MGI
	GO:0031572	G2/M transition DNA damage checkpoint	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q13315	P	From MGI
	GO:0032403	protein complex binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q13315	F	From MGI
	GO:0035174	histone serine kinase activity	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_001100291	F	From MGI
	GO:0035404	histone-serine phosphorylation	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_001100291	P	From MGI
	GO:0036092	phosphatidylinositol-3-phosphate biosynthetic process	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q13315	P	From MGI
	GO:0042159	lipoprotein catabolic process	MGI:MGI:3588634 PMID:15863839^[14]	IGI: Inferred from Genetic Interaction	MGI:MGI:88057	P	From MGI
	GO:0043065	positive regulation of apoptotic process	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q13315	P	From MGI
	GO:0043066	negative regulation of apoptotic process	MGI:MGI:3691999 PMID:11536012^[15]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1926875	P	From MGI
	GO:0043517	positive regulation of DNA damage response, signal transduction by p53 class mediator	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q13315	P	From MGI
	GO:0043525	positive regulation of neuron apoptotic process	MGI:MGI:1352316 PMID:10639175^[13]	IGI: Inferred from Genetic Interaction	MGI:MGI:99702	P	From MGI
	GO:0043525	positive regulation of neuron apoptotic process	MGI:MGI:3652689 PMID:16777961^[7]	IGI: Inferred from Genetic Interaction	MGI:MGI:1335098	P	From MGI
	GO:0046777	protein autophosphorylation	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_001100291	P	From MGI
	GO:0046777	protein autophosphorylation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q13315	P	From MGI
	GO:0046854	phosphatidylinositol phosphorylation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q13315	P	From MGI
	GO:0046983	protein dimerization activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q13315	F	From MGI
	GO:0047485	protein N-terminus binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q13315	F	From MGI
	GO:0051402	neuron apoptotic process	MGI:MGI:1932010 PMID:11248063^[16]	IGI: Inferred from Genetic Interaction	MGI:MGI:1335098	P	From MGI
	GO:0051726	regulation of cell cycle	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_001100291	P	From MGI
	GO:0071044	histone mRNA catabolic process	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q13315	P	From MGI
	GO:0071480	cellular response to gamma radiation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q13315	P	From MGI
	GO:0090399	replicative senescence	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q13315	P	From MGI
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Yuan L et al. (2003) DNA damage-induced G2/M checkpoint in SV40 large T antigen-immortalized embryonic fibroblast cells requires SHP-2 tyrosine phosphatase. J Biol Chem 278: 42812-20 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Gladdy RA et al. (2006) p53-Independent apoptosis disrupts early organogenesis in embryos lacking both ataxia-telangiectasia mutated and Prkdc. Mol Cancer Res 4: 311-8 PubMed GONUTS page
↑ Hewitt SL et al. (2009) RAG-1 and ATM coordinate monoallelic recombination and nuclear positioning of immunoglobulin loci. Nat Immunol 10: 655-64 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Sengupta S et al. (2004) Functional interaction between BLM helicase and 53BP1 in a Chk1-mediated pathway during S-phase arrest. J Cell Biol 166: 801-13 PubMed GONUTS page
↑ ^5.0 ^5.1 Polci R et al. (2004) NIMA-related protein kinase 1 is involved early in the ionizing radiation-induced DNA damage response. Cancer Res 64: 8800-3 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Lee Y et al. (2000) Defective neurogenesis resulting from DNA ligase IV deficiency requires Atm. Genes Dev 14: 2576-80 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Orii KE et al. (2006) Selective utilization of nonhomologous end-joining and homologous recombination DNA repair pathways during nervous system development. Proc Natl Acad Sci U S A 103: 10017-22 PubMed GONUTS page
↑ ^8.0 ^8.1 Frappart PO et al. (2007) BRCA2 is required for neurogenesis and suppression of medulloblastoma. EMBO J 26: 2732-42 PubMed GONUTS page
↑ Liu J et al. (2004) Serine-threonine kinases and transcription factors active in signal transduction are detected at high levels of phosphorylation during mitosis in preimplantation embryos and trophoblast stem cells. Reproduction 128: 643-54 PubMed GONUTS page
↑ Stern N et al. (2002) Accumulation of DNA damage and reduced levels of nicotine adenine dinucleotide in the brains of Atm-deficient mice. J Biol Chem 277: 602-8 PubMed GONUTS page
↑ Shima N et al. (2004) The mouse genomic instability mutation chaos1 is an allele of Polq that exhibits genetic interaction with Atm. Mol Cell Biol 24: 10381-9 PubMed GONUTS page
↑ Di Giacomo M et al. (2005) Distinct DNA-damage-dependent and -independent responses drive the loss of oocytes in recombination-defective mouse mutants. Proc Natl Acad Sci U S A 102: 737-42 PubMed GONUTS page
↑ ^13.0 ^13.1 Chong MJ et al. (2000) Atm and Bax cooperate in ionizing radiation-induced apoptosis in the central nervous system. Proc Natl Acad Sci U S A 97: 889-94 PubMed GONUTS page
↑ Wu D et al. (2005) Heterozygous mutation of ataxia-telangiectasia mutated gene aggravates hypercholesterolemia in apoE-deficient mice. J Lipid Res 46: 1380-7 PubMed GONUTS page
↑ Morita Y et al. (2001) Caspase-2 deficiency prevents programmed germ cell death resulting from cytokine insufficiency but not meiotic defects caused by loss of ataxia telangiectasia-mutated (Atm) gene function. Cell Death Differ 8: 614-20 PubMed GONUTS page
↑ Sekiguchi J et al. (2001) Genetic interactions between ATM and the nonhomologous end-joining factors in genomic stability and development. Proc Natl Acad Sci U S A 98: 3243-8 PubMed GONUTS page

[PMID:12937170-0] Yuan L et al. (2003) DNA damage-induced G2/M checkpoint in SV40 large T antigen-immortalized embryonic fibroblast cells requires SHP-2 tyrosine phosphatase. J Biol Chem 278: 42812-20 PubMed GONUTS page

[PMID:16687486-1] 2.0 ^2.1 ^2.2 Gladdy RA et al. (2006) p53-Independent apoptosis disrupts early organogenesis in embryos lacking both ataxia-telangiectasia mutated and Prkdc. Mol Cancer Res 4: 311-8 PubMed GONUTS page

[PMID:19448632-2] Hewitt SL et al. (2009) RAG-1 and ATM coordinate monoallelic recombination and nuclear positioning of immunoglobulin loci. Nat Immunol 10: 655-64 PubMed GONUTS page

[PMID:15364958-3] 4.0 ^4.1 ^4.2 Sengupta S et al. (2004) Functional interaction between BLM helicase and 53BP1 in a Chk1-mediated pathway during S-phase arrest. J Cell Biol 166: 801-13 PubMed GONUTS page

[PMID:15604234-4] 5.0 ^5.1 Polci R et al. (2004) NIMA-related protein kinase 1 is involved early in the ionizing radiation-induced DNA damage response. Cancer Res 64: 8800-3 PubMed GONUTS page

[PMID:11040211-5] 6.0 ^6.1 ^6.2 Lee Y et al. (2000) Defective neurogenesis resulting from DNA ligase IV deficiency requires Atm. Genes Dev 14: 2576-80 PubMed GONUTS page

[PMID:16777961-6] 7.0 ^7.1 ^7.2 Orii KE et al. (2006) Selective utilization of nonhomologous end-joining and homologous recombination DNA repair pathways during nervous system development. Proc Natl Acad Sci U S A 103: 10017-22 PubMed GONUTS page

[PMID:17476307-7] 8.0 ^8.1 Frappart PO et al. (2007) BRCA2 is required for neurogenesis and suppression of medulloblastoma. EMBO J 26: 2732-42 PubMed GONUTS page

[PMID:15509711-8] Liu J et al. (2004) Serine-threonine kinases and transcription factors active in signal transduction are detected at high levels of phosphorylation during mitosis in preimplantation embryos and trophoblast stem cells. Reproduction 128: 643-54 PubMed GONUTS page

[PMID:11679583-9] Stern N et al. (2002) Accumulation of DNA damage and reduced levels of nicotine adenine dinucleotide in the brains of Atm-deficient mice. J Biol Chem 277: 602-8 PubMed GONUTS page

[PMID:15542845-10] Shima N et al. (2004) The mouse genomic instability mutation chaos1 is an allele of Polq that exhibits genetic interaction with Atm. Mol Cell Biol 24: 10381-9 PubMed GONUTS page

[PMID:15640358-11] Di Giacomo M et al. (2005) Distinct DNA-damage-dependent and -independent responses drive the loss of oocytes in recombination-defective mouse mutants. Proc Natl Acad Sci U S A 102: 737-42 PubMed GONUTS page

[PMID:10639175-12] 13.0 ^13.1 Chong MJ et al. (2000) Atm and Bax cooperate in ionizing radiation-induced apoptosis in the central nervous system. Proc Natl Acad Sci U S A 97: 889-94 PubMed GONUTS page

[PMID:15863839-13] Wu D et al. (2005) Heterozygous mutation of ataxia-telangiectasia mutated gene aggravates hypercholesterolemia in apoE-deficient mice. J Lipid Res 46: 1380-7 PubMed GONUTS page

[PMID:11536012-14] Morita Y et al. (2001) Caspase-2 deficiency prevents programmed germ cell death resulting from cytokine insufficiency but not meiotic defects caused by loss of ataxia telangiectasia-mutated (Atm) gene function. Cell Death Differ 8: 614-20 PubMed GONUTS page

[PMID:11248063-15] Sekiguchi J et al. (2001) Genetic interactions between ATM and the nonhomologous end-joining factors in genomic stability and development. Proc Natl Acad Sci U S A 98: 3243-8 PubMed GONUTS page

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Species (Taxon ID)	Mus musculus (house mouse) (taxon:10090)
Gene Name(s)	Atm
Protein Name(s)	ataxia telangiectasia mutated homolog (human),
External Links
MGI	MGI:107202

MGI:Atm

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