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MGI:Atg7
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Atg7 ( synonyms: Apg7l ) | |
| Protein Name(s) | autophagy-related 7 (yeast), | |
| External Links | ||
| MGI | MGI:1921494 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000166 |
nucleotide binding |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0001889 |
liver development |
MGI:MGI:3587473 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3587769 |
P |
From MGI |
||
| GO:0003824 |
catalytic activity |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0004839 |
ubiquitin activating enzyme activity |
MGI:MGI:2177369 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:2177369 |
IPI: Inferred from Physical Interaction |
UniProtKB:Q9CQY1 |
F |
From MGI |
||
| GO:0005515 |
protein binding |
MGI:MGI:2447271 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0006497 |
protein lipidation |
MGI:MGI:2677578 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0006520 |
cellular amino acid metabolic process |
MGI:MGI:3587473 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3587769 |
P |
From MGI |
||
| GO:0006810 |
transport |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0813 |
P |
From MGI |
||
| GO:0006914 |
autophagy |
MGI:MGI:3587473 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3587769 |
P |
From MGI |
||
| GO:0006914 |
autophagy |
MGI:MGI:3587473 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3587769 |
P |
From MGI |
||
| GO:0006914 |
autophagy |
MGI:MGI:3653078 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3587771 |
P |
From MGI |
||
| GO:0006914 |
autophagy |
MGI:MGI:3711608 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0006914 |
autophagy |
MGI:MGI:3722981 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3587769 |
P |
From MGI |
||
| GO:0006914 |
autophagy |
MGI:MGI:4829568 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3587769 |
P |
From MGI |
||
| GO:0006996 |
organelle organization |
MGI:MGI:3587473 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3587769 |
P |
From MGI |
||
| GO:0007628 |
adult walking behavior |
MGI:MGI:3630371 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3587769 |
P |
From MGI |
||
| GO:0009791 |
post-embryonic development |
MGI:MGI:3587473 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3587769 |
P |
From MGI |
||
| GO:0009791 |
post-embryonic development |
MGI:MGI:3630371 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3587769 |
P |
From MGI |
||
| GO:0015031 |
protein transport |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0653 |
P |
From MGI |
||
| GO:0016044 |
cellular membrane organization |
MGI:MGI:3722981 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3587769 |
P |
From MGI |
||
| GO:0019778 |
APG12 activating enzyme activity |
MGI:MGI:4835103 |
IMP: Inferred from Mutant Phenotype |
F |
From MGI |
|||
| GO:0021680 |
cerebellar Purkinje cell layer development |
MGI:MGI:3630371 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3587769 |
P |
From MGI |
||
| GO:0021680 |
cerebellar Purkinje cell layer development |
MGI:MGI:4829568 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3587769 |
P |
From MGI |
||
| GO:0021860 |
pyramidal neuron development |
MGI:MGI:3630371 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3587769 |
P |
From MGI |
||
| GO:0021955 |
central nervous system neuron axonogenesis |
MGI:MGI:4829568 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3587769 |
P |
From MGI |
||
| GO:0021987 |
cerebral cortex development |
MGI:MGI:3630371 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3587769 |
P |
From MGI |
||
| GO:0030163 |
protein catabolic process |
MGI:MGI:3587473 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3587769 |
P |
From MGI |
||
| GO:0031175 |
neuron projection development |
MGI:MGI:3722981 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3587769 |
P |
From MGI |
||
| GO:0031396 |
regulation of protein ubiquitination |
MGI:MGI:3630371 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3587769 |
P |
From MGI |
||
| GO:0031401 |
positive regulation of protein modification process |
MGI:MGI:2447271 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0031401 |
positive regulation of protein modification process |
MGI:MGI:2677578 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0032446 |
protein modification by small protein conjugation |
MGI:MGI:3587473 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3587769 |
P |
From MGI |
||
| GO:0042594 |
response to starvation |
MGI:MGI:3587473 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3587769 |
P |
From MGI |
||
| GO:0042594 |
response to starvation |
MGI:MGI:3587473 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3587769 |
P |
From MGI |
||
| GO:0042803 |
protein homodimerization activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0043066 |
negative regulation of apoptotic process |
MGI:MGI:3630371 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3587769 |
P |
From MGI |
||
| GO:0043066 |
negative regulation of apoptotic process |
MGI:MGI:3711608 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0050877 |
neurological system process |
MGI:MGI:3630371 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3587769 |
P |
From MGI |
||
| GO:0055013 |
cardiac muscle cell development |
MGI:MGI:3711608 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 Komatsu M et al. (2005) Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice. J Cell Biol 169: 425-34 PubMed GONUTS page
- ↑ 2.0 2.1 Tanida I et al. (2002) Murine Apg12p has a substrate preference for murine Apg7p over three Apg8p homologs. Biochem Biophys Res Commun 292: 256-62 PubMed GONUTS page
- ↑ 3.0 3.1 Mizushima N et al. (2002) Mouse Apg10 as an Apg12-conjugating enzyme: analysis by the conjugation-mediated yeast two-hybrid method. FEBS Lett 532: 450-4 PubMed GONUTS page
- ↑ 4.0 4.1 Nemoto T et al. (2003) The mouse APG10 homologue, an E2-like enzyme for Apg12p conjugation, facilitates MAP-LC3 modification. J Biol Chem 278: 39517-26 PubMed GONUTS page
- ↑ Wang QJ et al. (2006) Induction of autophagy in axonal dystrophy and degeneration. J Neurosci 26: 8057-68 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 Nakai A et al. (2007) The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress. Nat Med 13: 619-24 PubMed GONUTS page
- ↑ 7.0 7.1 7.2 Komatsu M et al. (2007) Essential role for autophagy protein Atg7 in the maintenance of axonal homeostasis and the prevention of axonal degeneration. Proc Natl Acad Sci U S A 104: 14489-94 PubMed GONUTS page
- ↑ 8.0 8.1 8.2 Mariño G et al. (2010) Autophagy is essential for mouse sense of balance. J Clin Invest 120: 2331-44 PubMed GONUTS page
- ↑ 9.0 9.1 9.2 9.3 9.4 9.5 9.6 9.7 Komatsu M et al. (2006) Loss of autophagy in the central nervous system causes neurodegeneration in mice. Nature 441: 880-4 PubMed GONUTS page
- ↑ Radoshevich L et al. (2010) ATG12 conjugation to ATG3 regulates mitochondrial homeostasis and cell death. Cell 142: 590-600 PubMed GONUTS page
