MGI:Arrb2

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Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0001664	G-protein coupled receptor binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P32121	F	From MGI
	GO:0001932	regulation of protein phosphorylation	MGI:MGI:3616148 PMID:15218143^[1]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0001932	regulation of protein phosphorylation	MGI:MGI:3616148 PMID:15218143^[1]	IGI: Inferred from Genetic Interaction	MGI:MGI:2159617	P	From MGI
	GO:0001934	positive regulation of protein phosphorylation	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P29067	P	From MGI
	GO:0002031	G-protein coupled receptor internalization	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P32121	P	From MGI
	GO:0002032	desensitization of G-protein coupled receptor protein signaling pathway by arrestin	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P29067	P	From MGI
	GO:0002032	desensitization of G-protein coupled receptor protein signaling pathway by arrestin	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P32121	P	From MGI
	GO:0002092	positive regulation of receptor internalization	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P29067	P	From MGI
	GO:0005102	receptor binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P32121	F	From MGI
	GO:0005515	protein binding	MGI:MGI:4839696 PMID:20813258^[2]	IPI: Inferred from Physical Interaction	UniProtKB:Q7TMA4	F	From MGI
	GO:0005622	intracellular	MGI:MGI:1930835 PMID:11171997^[3]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005634	nucleus	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P32121	C	From MGI
	GO:0005737	cytoplasm	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P29067	C	From MGI
	GO:0005737	cytoplasm	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P32121	C	From MGI
	GO:0005886	plasma membrane	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P32121	C	From MGI
	GO:0005905	coated pit	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0168	C	From MGI
	GO:0006366	transcription from RNA polymerase II promoter	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P32121	P	From MGI
	GO:0006810	transport	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0813	P	From MGI
	GO:0006897	endocytosis	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P29067	P	From MGI
	GO:0007165	signal transduction	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR000698 InterPro:IPR014752 InterPro:IPR017864 InterPro:IPR014753	P	From MGI
	GO:0007179	transforming growth factor beta receptor signaling pathway	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P32121	P	From MGI
	GO:0007186	G-protein coupled receptor signaling pathway	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P29067	P	From MGI
	GO:0007628	adult walking behavior	MGI:MGI:3690676 PMID:16051150^[4]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0008277	regulation of G-protein coupled receptor protein signaling pathway	MGI:MGI:1351102 PMID:10617462^[5]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2157960	P	From MGI
	GO:0008277	regulation of G-protein coupled receptor protein signaling pathway	MGI:MGI:1927976 PMID:11130073^[6]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2157960	P	From MGI
	GO:0008277	regulation of G-protein coupled receptor protein signaling pathway	MGI:MGI:1930835 PMID:11171997^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2157960	P	From MGI
	GO:0008277	regulation of G-protein coupled receptor protein signaling pathway	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P29067	P	From MGI
	GO:0009968	negative regulation of signal transduction	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0734	P	From MGI
	GO:0014069	postsynaptic density	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P29067	C	From MGI
	GO:0015031	protein transport	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0653	P	From MGI
	GO:0016020	membrane	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0472	C	From MGI
	GO:0016323	basolateral plasma membrane	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P29067	C	From MGI
	GO:0016567	protein ubiquitination	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P32121	P	From MGI
	GO:0019904	protein domain specific binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P29067	F	From MGI
	GO:0031397	negative regulation of protein ubiquitination	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P29067	P	From MGI
	GO:0031397	negative regulation of protein ubiquitination	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P32121	P	From MGI
	GO:0031398	positive regulation of protein ubiquitination	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P32121	P	From MGI
	GO:0031410	cytoplasmic vesicle	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P32121	C	From MGI
	GO:0031623	receptor internalization	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P32121	P	From MGI
	GO:0031625	ubiquitin protein ligase binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P32121	F	From MGI
	GO:0031691	alpha-1A adrenergic receptor binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P29067	F	From MGI
	GO:0031692	alpha-1B adrenergic receptor binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P29067	F	From MGI
	GO:0031701	angiotensin receptor binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P32121	F	From MGI
	GO:0031702	type 1 angiotensin receptor binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P29067	F	From MGI
	GO:0031748	D1 dopamine receptor binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P29067	F	From MGI
	GO:0031762	follicle-stimulating hormone receptor binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P29067	F	From MGI
	GO:0031826	type 2A serotonin receptor binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P29067	F	From MGI
	GO:0032088	negative regulation of NF-kappaB transcription factor activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P32121	P	From MGI
	GO:0032226	positive regulation of synaptic transmission, dopaminergic	MGI:MGI:3690676 PMID:16051150^[4]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0032403	protein complex binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P29067	F	From MGI
	GO:0032691	negative regulation of interleukin-1 beta production	MGI:MGI:3662828 PMID:16378096^[7]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0032695	negative regulation of interleukin-12 production	MGI:MGI:3662828 PMID:16378096^[7]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0032715	negative regulation of interleukin-6 production	MGI:MGI:3662828 PMID:16378096^[7]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0032720	negative regulation of tumor necrosis factor production	MGI:MGI:3662828 PMID:16378096^[7]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0032947	protein complex scaffold	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P32121	F	From MGI
	GO:0034122	negative regulation of toll-like receptor signaling pathway	MGI:MGI:3662828 PMID:16378096^[7]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0034260	negative regulation of GTPase activity	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P29067	P	From MGI
	GO:0034392	negative regulation of smooth muscle cell apoptotic process	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P29067	P	From MGI
	GO:0042699	follicle-stimulating hormone signaling pathway	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P29067	P	From MGI
	GO:0043161	proteasomal ubiquitin-dependent protein catabolic process	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P32121	P	From MGI
	GO:0043197	dendritic spine	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P29067	C	From MGI
	GO:0043422	protein kinase B binding	MGI:MGI:3690676 PMID:16051150^[4]	IPI: Inferred from Physical Interaction	UniProtKB:P31750	F	From MGI
	GO:0045211	postsynaptic membrane	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P29067	C	From MGI
	GO:0045953	negative regulation of natural killer cell mediated cytotoxicity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P32121	P	From MGI
	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P29067	P	From MGI
	GO:0050965	detection of temperature stimulus involved in sensory perception of pain	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P29067	P	From MGI
	GO:0051019	mitogen-activated protein kinase binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P29067	F	From MGI
	GO:0051897	positive regulation of protein kinase B signaling cascade	MGI:MGI:3690676 PMID:16051150^[4]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0051897	positive regulation of protein kinase B signaling cascade	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P29067	P	From MGI
	GO:0051928	positive regulation of calcium ion transport	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P29067	P	From MGI
	GO:0060326	cell chemotaxis	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P32121	P	From MGI
	GO:0060765	regulation of androgen receptor signaling pathway	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P32121	P	From MGI
	GO:0070374	positive regulation of ERK1 and ERK2 cascade	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P29067	P	From MGI
	GO:0070374	positive regulation of ERK1 and ERK2 cascade	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P32121	P	From MGI
	GO:0071889	14-3-3 protein binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P29067	F	From MGI
NOT	GO:0031826	type 2A serotonin receptor binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P29067	F	From MGI
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Wang Q et al. (2004) Spinophilin blocks arrestin actions in vitro and in vivo at G protein-coupled receptors. Science 304: 1940-4 PubMed GONUTS page
↑ Oh DY et al. (2010) GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects. Cell 142: 687-98 PubMed GONUTS page
↑ ^3.0 ^3.1 Kohout TA et al. (2001) beta-Arrestin 1 and 2 differentially regulate heptahelical receptor signaling and trafficking. Proc Natl Acad Sci U S A 98: 1601-6 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 Beaulieu JM et al. (2005) An Akt/beta-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behavior. Cell 122: 261-73 PubMed GONUTS page
↑ Bohn LM et al. (1999) Enhanced morphine analgesia in mice lacking beta-arrestin 2. Science 286: 2495-8 PubMed GONUTS page
↑ Bohn LM et al. (2000) Mu-opioid receptor desensitization by beta-arrestin-2 determines morphine tolerance but not dependence. Nature 408: 720-3 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 Wang Y et al. (2006) Association of beta-arrestin and TRAF6 negatively regulates Toll-like receptor-interleukin 1 receptor signaling. Nat Immunol 7: 139-47 PubMed GONUTS page

[PMID:15218143-0] 1.0 ^1.1 Wang Q et al. (2004) Spinophilin blocks arrestin actions in vitro and in vivo at G protein-coupled receptors. Science 304: 1940-4 PubMed GONUTS page

[PMID:20813258-1] Oh DY et al. (2010) GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects. Cell 142: 687-98 PubMed GONUTS page

[PMID:11171997-2] 3.0 ^3.1 Kohout TA et al. (2001) beta-Arrestin 1 and 2 differentially regulate heptahelical receptor signaling and trafficking. Proc Natl Acad Sci U S A 98: 1601-6 PubMed GONUTS page

[PMID:16051150-3] 4.0 ^4.1 ^4.2 ^4.3 Beaulieu JM et al. (2005) An Akt/beta-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behavior. Cell 122: 261-73 PubMed GONUTS page

[PMID:10617462-4] Bohn LM et al. (1999) Enhanced morphine analgesia in mice lacking beta-arrestin 2. Science 286: 2495-8 PubMed GONUTS page

[PMID:11130073-5] Bohn LM et al. (2000) Mu-opioid receptor desensitization by beta-arrestin-2 determines morphine tolerance but not dependence. Nature 408: 720-3 PubMed GONUTS page

[PMID:16378096-6] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 Wang Y et al. (2006) Association of beta-arrestin and TRAF6 negatively regulates Toll-like receptor-interleukin 1 receptor signaling. Nat Immunol 7: 139-47 PubMed GONUTS page

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Species (Taxon ID)	Mus musculus (house mouse) (taxon:10090)
Gene Name(s)	Arrb2 ( synonyms: beta arr2, beta-arrestin-2, beta-arrestin2 )
Protein Name(s)	arrestin, beta 2,
External Links
MGI	MGI:99474

MGI:Arrb2

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