GONUTS is under stress! The website is currently experiencing long-wait times and frequent time-outs due to the record number of students, groups, and annotations related to CACAO this semester. We are currently working on increasing performance -- please accept our apologies for the technical difficulties.
You can help reduce stress on the server by:
- not reloading pages frequently - this just adds
- opening links in new windows (so you can read the old page)
MGI:Arnt
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Arnt ( synonyms: bHLHe2, D3Ertd557e, ESTM42, Hif1b ) | |
| Protein Name(s) | aryl hydrocarbon receptor nuclear translocator, | |
| External Links | ||
| MGI | MGI:88071 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000989 |
transcription factor binding transcription factor activity |
MGI:MGI:4459348 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0001666 |
response to hypoxia |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0001666 |
response to hypoxia |
MGI:MGI:82592 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0001892 |
embryonic placenta development |
MGI:MGI:3703383 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857680 |
P |
From MGI |
||
| GO:0003677 |
DNA binding |
MGI:MGI:85247 |
IGI: Inferred from Genetic Interaction |
F |
From MGI |
|||
| GO:0003677 |
DNA binding |
MGI:MGI:894004 |
IGI: Inferred from Genetic Interaction |
F |
From MGI |
|||
| GO:0003700 |
sequence-specific DNA binding transcription factor activity |
MGI:MGI:1926513 |
TAS: Traceable Author Statement |
F |
From MGI |
|||
| GO:0003713 |
transcription coactivator activity |
MGI:MGI:3056229 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0004871 |
signal transducer activity |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0004874 |
aryl hydrocarbon receptor activity |
MGI:MGI:1891529 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2176696 |
F |
From MGI |
||
| GO:0005515 |
protein binding |
MGI:MGI:82592 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:86070 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:1926513 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:1927954 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:1927954 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:3045517 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:4459348 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005667 |
transcription factor complex |
MGI:MGI:1926513 |
TAS: Traceable Author Statement |
C |
From MGI |
|||
| GO:0005667 |
transcription factor complex |
MGI:MGI:85247 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:1926513 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:1927954 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:1927954 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0006351 |
transcription, DNA-dependent |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0804 |
P |
From MGI |
||
| GO:0007165 |
signal transduction |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
P |
From MGI |
|||
| GO:0008134 |
transcription factor binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0009636 |
response to toxin |
MGI:MGI:1926513 |
TAS: Traceable Author Statement |
P |
From MGI |
|||
| GO:0010575 |
positive regulation vascular endothelial growth factor production |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0017162 |
aryl hydrocarbon receptor binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0030154 |
cell differentiation |
MGI:MGI:3703383 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857680 |
P |
From MGI |
||
| GO:0033235 |
positive regulation of protein sumoylation |
MGI:MGI:4359338 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0043619 |
regulation of transcription from RNA polymerase II promoter in response to oxidative stress |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045893 |
positive regulation of transcription, DNA-dependent |
MGI:MGI:2176655 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045893 |
positive regulation of transcription, DNA-dependent |
MGI:MGI:3056229 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045893 |
positive regulation of transcription, DNA-dependent |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:3577779 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:106918 |
P |
From MGI |
||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:85247 |
IGI: Inferred from Genetic Interaction |
P |
From MGI |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:894004 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:106918 |
P |
From MGI |
||
| GO:0046886 |
positive regulation of hormone biosynthetic process |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0046982 |
protein heterodimerization activity |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0046982 |
protein heterodimerization activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0046982 |
protein heterodimerization activity |
MGI:MGI:894004 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
|
contributes_to |
GO:0043565 |
sequence-specific DNA binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
| |
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Cheng K et al. (2010) Hypoxia-inducible factor-1alpha regulates beta cell function in mouse and human islets. J Clin Invest 120: 2171-83 PubMed GONUTS page
- ↑ 2.0 2.1 Li H et al. (1996) Induction of phosphoglycerate kinase 1 gene expression by hypoxia. Roles of Arnt and HIF1alpha. J Biol Chem 271: 21262-7 PubMed GONUTS page
- ↑ 3.0 3.1 Cowden Dahl KD et al. (2005) Hypoxia-inducible factors 1alpha and 2alpha regulate trophoblast differentiation. Mol Cell Biol 25: 10479-91 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 Tian H et al. (1997) Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells. Genes Dev 11: 72-82 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 Ema M et al. (1997) A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1alpha regulates the VEGF expression and is potentially involved in lung and vascular development. Proc Natl Acad Sci U S A 94: 4273-8 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 6.3 6.4 Sadek CM et al. (2000) Isolation and characterization of AINT: a novel ARNT interacting protein expressed during murine embryonic development. Mech Dev 97: 13-26 PubMed GONUTS page
- ↑ 7.0 7.1 Moser M et al. (2004) LE-PAS, a novel Arnt-dependent HLH-PAS protein, is expressed in limbic tissues and transactivates the CNS midline enhancer element. Brain Res Mol Brain Res 128: 141-9 PubMed GONUTS page
- ↑ Tomita S et al. (2000) Conditional disruption of the aryl hydrocarbon receptor nuclear translocator (Arnt) gene leads to loss of target gene induction by the aryl hydrocarbon receptor and hypoxia-inducible factor 1alpha. Mol Endocrinol 14: 1674-81 PubMed GONUTS page
- ↑ Probst MR et al. (1997) Two murine homologs of the Drosophila single-minded protein that interact with the mouse aryl hydrocarbon receptor nuclear translocator protein. J Biol Chem 272: 4451-7 PubMed GONUTS page
- ↑ 10.0 10.1 10.2 10.3 Sojka KM et al. (2000) Expression and subcellular localization of the aryl hydrocarbon receptor nuclear translocator (ARNT) protein in mouse and chicken over developmental time. Anat Rec 260: 327-34 PubMed GONUTS page
- ↑ Suliman HB et al. (2004) Superoxide dismutase-3 promotes full expression of the EPO response to hypoxia. Blood 104: 43-50 PubMed GONUTS page
- ↑ Oshima M et al. (2009) SUMO modification regulates the transcriptional repressor function of aryl hydrocarbon receptor repressor. J Biol Chem 284: 11017-26 PubMed GONUTS page
- ↑ Woods SL & Whitelaw ML (2002) Differential activities of murine single minded 1 (SIM1) and SIM2 on a hypoxic response element. Cross-talk between basic helix-loop-helix/per-Arnt-Sim homology transcription factors. J Biol Chem 277: 10236-43 PubMed GONUTS page
- ↑ Makita T et al. (2005) Retinoic acid, hypoxia, and GATA factors cooperatively control the onset of fetal liver erythropoietin expression and erythropoietic differentiation. Dev Biol 280: 59-72 PubMed GONUTS page
