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MGI:Arhgef2
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Arhgef2 ( synonyms: GEF-H1, GEFH1, Lbcl1, Lfc, LFP40, P40 ) | |
| Protein Name(s) | rho/rac guanine nucleotide exchange factor (GEF) 2, | |
| External Links | ||
| MGI | MGI:103264 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000132 |
establishment of mitotic spindle orientation |
MGI:MGI:4457234 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0000902 |
cell morphogenesis |
MGI:MGI:3583726 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0000902 |
cell morphogenesis |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0005085 |
guanyl-nucleotide exchange factor activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0344 |
F |
From MGI |
||
| GO:0005089 |
Rho guanyl-nucleotide exchange factor activity |
MGI:MGI:3583726 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0005089 |
Rho guanyl-nucleotide exchange factor activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3583726 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:5009755 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005543 |
phospholipid binding |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0005622 |
intracellular |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
C |
From MGI |
|||
| GO:0005623 |
cell |
MGI:MGI:4457234 |
IMP: Inferred from Mutant Phenotype |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0963 |
C |
From MGI |
||
| GO:0005794 |
Golgi apparatus |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0333 |
C |
From MGI |
||
| GO:0005856 |
cytoskeleton |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0206 |
C |
From MGI |
||
| GO:0005874 |
microtubule |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005923 |
tight junction |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0796 |
C |
From MGI |
||
| GO:0007015 |
actin filament organization |
MGI:MGI:3583726 |
IPI: Inferred from Physical Interaction |
P |
From MGI |
|||
| GO:0007015 |
actin filament organization |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0007026 |
negative regulation of microtubule depolymerization |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0007049 |
cell cycle |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0131 |
P |
From MGI |
||
| GO:0007067 |
mitosis |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0498 |
P |
From MGI |
||
| GO:0008017 |
microtubule binding |
MGI:MGI:3583726 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0008017 |
microtubule binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0017048 |
Rho GTPase binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0030054 |
cell junction |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0965 |
C |
From MGI |
||
| GO:0030676 |
Rac guanyl-nucleotide exchange factor activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0032587 |
ruffle membrane |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0035023 |
regulation of Rho protein signal transduction |
MGI:MGI:3583726 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0035556 |
intracellular signal transduction |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
P |
From MGI |
|||
| GO:0043025 |
neuronal cell body |
MGI:MGI:3583726 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0043198 |
dendritic shaft |
MGI:MGI:3583726 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0046872 |
metal ion binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0479 |
F |
From MGI |
||
| GO:0048365 |
Rac GTPase binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0050768 |
negative regulation of neurogenesis |
MGI:MGI:4457234 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0050790 |
regulation of catalytic activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0051092 |
positive regulation of NF-kappaB transcription factor activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0051301 |
cell division |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0132 |
P |
From MGI |
| |
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Gauthier-Fisher A et al. (2009) Lfc and Tctex-1 regulate the genesis of neurons from cortical precursor cells. Nat Neurosci 12: 735-44 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 Ryan XP et al. (2005) The Rho-specific GEF Lfc interacts with neurabin and spinophilin to regulate dendritic spine morphology. Neuron 47: 85-100 PubMed GONUTS page
- ↑ Tonami K et al. (2011) Calpain-6, a microtubule-stabilizing protein, regulates Rac1 activity and cell motility through interaction with GEF-H1. J Cell Sci 124: 1214-23 PubMed GONUTS page
