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MGI:Ar

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Contents

Species (Taxon ID) Mus musculus (house mouse) (taxon:10090)
Gene Name(s) Ar
Protein Name(s) androgen receptor,
External Links
MGI MGI:88064

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000790

nuclear chromatin

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P10275

C

From MGI

GO:0001701

in utero embryonic development

MGI:MGI:2661993
PMID:10319319[1]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1856319

P

From MGI

GO:0003677

DNA binding

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0238

F

From MGI

GO:0003677

DNA binding

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR001103

F

From MGI

GO:0003682

chromatin binding

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P10275

F

From MGI

GO:0003700

sequence-specific DNA binding transcription factor activity

MGI:MGI:2384368
PMID:12145204[2]

IDA: Inferred from Direct Assay

F

From MGI

GO:0003700

sequence-specific DNA binding transcription factor activity

MGI:MGI:2684511
PMID:14576337[3]

IDA: Inferred from Direct Assay

F

From MGI

GO:0003700

sequence-specific DNA binding transcription factor activity

MGI:MGI:3616918
PMID:16254014[4]

IDA: Inferred from Direct Assay

F

From MGI

GO:0003700

sequence-specific DNA binding transcription factor activity

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P10275

F

From MGI

GO:0003707

steroid hormone receptor activity

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR008946
InterPro:IPR000536

F

From MGI

GO:0004872

receptor activity

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0675

F

From MGI

GO:0004879

ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P10275

F

From MGI

GO:0004882

androgen receptor activity

MGI:MGI:2384368
PMID:12145204[2]

IDA: Inferred from Direct Assay

F

From MGI

GO:0004882

androgen receptor activity

MGI:MGI:3047515
PMID:15199138[5]

IDA: Inferred from Direct Assay

F

From MGI

GO:0004882

androgen receptor activity

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P15207

F

From MGI

GO:0004882

androgen receptor activity

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P10275

F

From MGI

GO:0005102

receptor binding

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P15207

F

From MGI

GO:0005102

receptor binding

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P10275

F

From MGI

GO:0005496

steroid binding

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0754

F

From MGI

GO:0005496

steroid binding

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR001103

F

From MGI

GO:0005497

androgen binding

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P15207

F

From MGI

GO:0005515

protein binding

MGI:MGI:2384368
PMID:12145204[2]

IPI: Inferred from Physical Interaction

UniProtKB:P23804

F

From MGI

GO:0005515

protein binding

MGI:MGI:2684511
PMID:14576337[3]

IPI: Inferred from Physical Interaction

UniProtKB:Q9DAR1

F

From MGI

GO:0005515

protein binding

MGI:MGI:3588448
PMID:15919722[6]

IPI: Inferred from Physical Interaction

UniProtKB:O35437

F

From MGI

GO:0005515

protein binding

MGI:MGI:3616918
PMID:16254014[4]

IPI: Inferred from Physical Interaction

UniProtKB:O08759

F

From MGI

GO:0005515

protein binding

MGI:MGI:4362014
PMID:11997177[7]

IPI: Inferred from Physical Interaction

UniProtKB:P31361

F

From MGI

GO:0005634

nucleus

MGI:MGI:2136569
PMID:11356695[8]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005634

nucleus

MGI:MGI:2384368
PMID:12145204[2]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005634

nucleus

MGI:MGI:2684511
PMID:14576337[3]

IPI: Inferred from Physical Interaction

UniProtKB:Q9DAR1

C

From MGI

GO:0005634

nucleus

MGI:MGI:3529739
PMID:15660130[9]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005634

nucleus

MGI:MGI:3618678
PMID:11105903[10]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005634

nucleus

MGI:MGI:3708425
PMID:17142810[11]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005634

nucleus

MGI:MGI:3714080
PMID:17317769[12]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005634

nucleus

MGI:MGI:3822220
PMID:18827067[13]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005634

nucleus

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P15207

C

From MGI

GO:0005634

nucleus

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P10275

C

From MGI

GO:0005737

cytoplasm

MGI:MGI:2384368
PMID:12145204[2]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005737

cytoplasm

MGI:MGI:3708425
PMID:17142810[11]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005737

cytoplasm

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P10275

C

From MGI

GO:0006351

transcription, DNA-dependent

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P10275

P

From MGI

GO:0006355

regulation of transcription, DNA-dependent

MGI:MGI:2384368
PMID:12145204[2]

IDA: Inferred from Direct Assay

P

From MGI

GO:0006355

regulation of transcription, DNA-dependent

MGI:MGI:2684511
PMID:14576337[3]

IDA: Inferred from Direct Assay

P

From MGI

GO:0006357

regulation of transcription from RNA polymerase II promoter

MGI:MGI:3769837
PMID:17332066[14]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1856319

P

From MGI

GO:0008013

beta-catenin binding

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P10275

F

From MGI

GO:0008134

transcription factor binding

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P10275

F

From MGI

GO:0008270

zinc ion binding

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR001628
InterPro:IPR013088

F

From MGI

GO:0008284

positive regulation of cell proliferation

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P10275

P

From MGI

GO:0008289

lipid binding

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0446

F

From MGI

GO:0008584

male gonad development

MGI:MGI:2661993
PMID:10319319[1]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1856319

P

From MGI

GO:0008584

male gonad development

MGI:MGI:3714080
PMID:17317769[12]

IMP: Inferred from Mutant Phenotype

MGI:MGI:3716756

P

From MGI

GO:0009987

cellular process

MGI:MGI:2384368
PMID:12145204[2]

IDA: Inferred from Direct Assay

P

From MGI

GO:0010468

regulation of gene expression

MGI:MGI:3769837
PMID:17332066[14]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1856319

P

From MGI

GO:0019102

male somatic sex determination

MGI:MGI:53651
PMID:5452809[15]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1856319

P

From MGI

GO:0019899

enzyme binding

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P10275

F

From MGI

GO:0019899

enzyme binding

MGI:MGI:4943397
PMID:17277772[16]

IPI: Inferred from Physical Interaction

UniProtKB:Q8VCD7

F

From MGI

GO:0019904

protein domain specific binding

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P15207

F

From MGI

GO:0030424

axon

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P15207

C

From MGI

GO:0030425

dendrite

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P15207

C

From MGI

GO:0030521

androgen receptor signaling pathway

MGI:MGI:3047515
PMID:15199138[5]

IDA: Inferred from Direct Assay

P

From MGI

GO:0030521

androgen receptor signaling pathway

MGI:MGI:3529739
PMID:15660130[9]

IDA: Inferred from Direct Assay

P

From MGI

GO:0030521

androgen receptor signaling pathway

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P15207

P

From MGI

GO:0030521

androgen receptor signaling pathway

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P10275

P

From MGI

GO:0030522

intracellular receptor mediated signaling pathway

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P10275

P

From MGI

GO:0033148

positive regulation of intracellular estrogen receptor signaling pathway

MGI:MGI:2683859
PMID:14676301[17]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2687199

P

From MGI

GO:0042327

positive regulation of phosphorylation

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P10275

P

From MGI

GO:0043066

negative regulation of apoptotic process

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P10275

P

From MGI

GO:0043401

steroid hormone mediated signaling pathway

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR008946
InterPro:IPR000536

P

From MGI

GO:0043401

steroid hormone mediated signaling pathway

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P15207

P

From MGI

GO:0043401

steroid hormone mediated signaling pathway

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P10275

P

From MGI

GO:0043410

positive regulation of MAPK cascade

MGI:MGI:2683859
PMID:14676301[17]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2687199

P

From MGI

GO:0043565

sequence-specific DNA binding

MGI:MGI:65622
PMID:8119157[18]

IDA: Inferred from Direct Assay

F

From MGI

GO:0043568

positive regulation of insulin-like growth factor receptor signaling pathway

MGI:MGI:2683859
PMID:14676301[17]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2687199

P

From MGI

GO:0044212

transcription regulatory region DNA binding

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P10275

F

From MGI

GO:0045720

negative regulation of integrin biosynthetic process

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P10275

P

From MGI

GO:0045726

positive regulation of integrin biosynthetic process

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P10275

P

From MGI

GO:0045893

positive regulation of transcription, DNA-dependent

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P10275

P

From MGI

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

MGI:MGI:3616918
PMID:16254014[4]

IDA: Inferred from Direct Assay

P

From MGI

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

MGI:MGI:3616918
PMID:16254014[4]

IGI: Inferred from Genetic Interaction

MGI:MGI:105098

P

From MGI

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

MGI:MGI:3769837
PMID:17332066[14]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1856319

P

From MGI

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P10275

P

From MGI

GO:0045945

positive regulation of transcription from RNA polymerase III promoter

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P10275

P

From MGI

GO:0046661

male sex differentiation

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P15207

P

From MGI

GO:0046872

metal ion binding

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0479

F

From MGI

GO:0048608

reproductive structure development

MGI:MGI:3714080
PMID:17317769[12]

IMP: Inferred from Mutant Phenotype

MGI:MGI:3716756

P

From MGI

GO:0048638

regulation of developmental growth

MGI:MGI:3714080
PMID:17317769[12]

IMP: Inferred from Mutant Phenotype

MGI:MGI:3716756

P

From MGI

GO:0048645

organ formation

MGI:MGI:3714080
PMID:17317769[12]

IMP: Inferred from Mutant Phenotype

MGI:MGI:3716756

P

From MGI

GO:0048808

male genitalia morphogenesis

MGI:MGI:3845460
PMID:19282366[19]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2681507

P

From MGI

GO:0050680

negative regulation of epithelial cell proliferation

MGI:MGI:3718266
PMID:17652515[20]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2451025
MGI:MGI:2385927

P

From MGI

GO:0050681

androgen receptor binding

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P15207

F

From MGI

GO:0050790

regulation of catalytic activity

MGI:MGI:3770112
PMID:17276355[21]

IMP: Inferred from Mutant Phenotype

MGI:MGI:3707001

P

From MGI

GO:0051092

positive regulation of NF-kappaB transcription factor activity

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P10275

P

From MGI

GO:0060520

activation of prostate induction by androgen receptor signaling pathway

MGI:MGI:3714080
PMID:17317769[12]

IMP: Inferred from Mutant Phenotype

MGI:MGI:3716756

P

From MGI

GO:0060571

morphogenesis of an epithelial fold

MGI:MGI:3718266
PMID:17652515[20]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2451025
MGI:MGI:2385927

P

From MGI

GO:0060599

lateral sprouting involved in mammary gland duct morphogenesis

MGI:MGI:2683859
PMID:14676301[17]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2687199

P

From MGI

GO:0060685

regulation of prostatic bud formation

MGI:MGI:2673763
PMID:12941620[22]

IGI: Inferred from Genetic Interaction

MGI:MGI:1099809

P

From MGI

GO:0060736

prostate gland growth

MGI:MGI:3714080
PMID:17317769[12]

IMP: Inferred from Mutant Phenotype

MGI:MGI:3716756

P

From MGI

GO:0060736

prostate gland growth

MGI:MGI:3718266
PMID:17652515[20]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2451025
MGI:MGI:2385927

P

From MGI

GO:0060740

prostate gland epithelium morphogenesis

MGI:MGI:3718266
PMID:17652515[20]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2451025
MGI:MGI:2385927

P

From MGI

GO:0060742

epithelial cell differentiation involved in prostate gland development

MGI:MGI:3718266
PMID:17652515[20]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2451025
MGI:MGI:2385927

P

From MGI

GO:0060748

tertiary branching involved in mammary gland duct morphogenesis

MGI:MGI:2683859
PMID:14676301[17]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2687199

P

From MGI

GO:0060749

mammary gland alveolus development

MGI:MGI:2683859
PMID:14676301[17]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2687199

P

From MGI

GO:0070974

POU domain binding

MGI:MGI:4362014
PMID:11997177[7]

IDA: Inferred from Direct Assay

F

From MGI

GO:0090003

regulation of establishment of protein localization in plasma membrane

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P10275

P

From MGI


Notes

References

See Help:References for how to manage references in GONUTS.
  1. ↑ 1.0 1.1 Zimmermann S et al. (1999) Targeted disruption of the Insl3 gene causes bilateral cryptorchidism. Mol Endocrinol 13: 681-91 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 Lin HK et al. (2002) Phosphorylation-dependent ubiquitylation and degradation of androgen receptor by Akt require Mdm2 E3 ligase. EMBO J 21: 4037-48 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 3.3 Jeong BC et al. (2004) Androgen receptor corepressor-19 kDa (ARR19), a leucine-rich protein that represses the transcriptional activity of androgen receptor through recruitment of histone deacetylase. Mol Endocrinol 18: 13-25 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 4.3 Khan OY et al. (2006) Multifunction steroid receptor coactivator, E6-associated protein, is involved in development of the prostate gland. Mol Endocrinol 20: 544-59 PubMed GONUTS page
  5. ↑ 5.0 5.1 Sitz JH et al. (2004) Dyrk1A potentiates steroid hormone-induced transcription via the chromatin remodeling factor Arip4. Mol Cell Biol 24: 5821-34 PubMed GONUTS page
  6. ↑ Hong CY et al. (2005) Modulation of the expression and transactivation of androgen receptor by the basic helix-loop-helix transcription factor Pod-1 through recruitment of histone deacetylase 1. Mol Endocrinol 19: 2245-57 PubMed GONUTS page
  7. ↑ 7.0 7.1 González MI et al. (2002) Androgen receptor interactions with Oct-1 and Brn-1 are physically and functionally distinct. Mol Cell Endocrinol 190: 39-49 PubMed GONUTS page
  8. ↑ McPherson SJ et al. (2001) Elevated androgens and prolactin in aromatase-deficient mice cause enlargement, but not malignancy, of the prostate gland. Endocrinology 142: 2458-67 PubMed GONUTS page
  9. ↑ 9.0 9.1 Terada K et al. (2005) A type I DnaJ homolog, DjA1, regulates androgen receptor signaling and spermatogenesis. EMBO J 24: 611-22 PubMed GONUTS page
  10. ↑ Morales CR et al. (2000) Targeted disruption of the mouse prosaposin gene affects the development of the prostate gland and other male reproductive organs. J Androl 21: 765-75 PubMed GONUTS page
  11. ↑ 11.0 11.1 Yong W et al. (2007) Essential role for Co-chaperone Fkbp52 but not Fkbp51 in androgen receptor-mediated signaling and physiology. J Biol Chem 282: 5026-36 PubMed GONUTS page
  12. ↑ 12.0 12.1 12.2 12.3 12.4 12.5 12.6 Simanainen U et al. (2007) Disruption of prostate epithelial androgen receptor impedes prostate lobe-specific growth and function. Endocrinology 148: 2264-72 PubMed GONUTS page
  13. ↑ Svensson J et al. (2008) Liver-derived IGF1 enhances the androgenic response in prostate. J Endocrinol 199: 489-97 PubMed GONUTS page
  14. ↑ 14.0 14.1 14.2 O'Shaughnessy PJ et al. (2007) Altered expression of genes involved in regulation of vitamin A metabolism, solute transportation, and cytoskeletal function in the androgen-insensitive tfm mouse testis. Endocrinology 148: 2914-24 PubMed GONUTS page
  15. ↑ Lyon MF & Hawkes SG (1970) X-linked gene for testicular feminization in the mouse. Nature 227: 1217-9 PubMed GONUTS page
  16. ↑ Wissmann M et al. (2007) Cooperative demethylation by JMJD2C and LSD1 promotes androgen receptor-dependent gene expression. Nat Cell Biol 9: 347-53 PubMed GONUTS page
  17. ↑ 17.0 17.1 17.2 17.3 17.4 17.5 Yeh S et al. (2003) Abnormal mammary gland development and growth retardation in female mice and MCF7 breast cancer cells lacking androgen receptor. J Exp Med 198: 1899-908 PubMed GONUTS page
  18. ↑ Asadi FK et al. (1994) Androgen regulation of gene expression in primary epithelial cells of the mouse kidney. Endocrinology 134: 1179-87 PubMed GONUTS page
  19. ↑ Miyagawa S et al. (2009) Genetic interactions of the androgen and Wnt/beta-catenin pathways for the masculinization of external genitalia. Mol Endocrinol 23: 871-80 PubMed GONUTS page
  20. ↑ 20.0 20.1 20.2 20.3 20.4 Wu CT et al. (2007) Increased prostate cell proliferation and loss of cell differentiation in mice lacking prostate epithelial androgen receptor. Proc Natl Acad Sci U S A 104: 12679-84 PubMed GONUTS page
  21. ↑ Sano M et al. (2007) Ménage-à-trois 1 is critical for the transcriptional function of PPARgamma coactivator 1. Cell Metab 5: 129-42 PubMed GONUTS page
  22. ↑ Donjacour AA et al. (2003) FGF-10 plays an essential role in the growth of the fetal prostate. Dev Biol 261: 39-54 PubMed GONUTS page
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