![]()
GONUTS is under stress! The website is currently experiencing long-wait times and frequent time-outs due to the record number of students, groups, and annotations related to CACAO this semester. We are currently working on increasing performance -- please accept our apologies for the technical difficulties.
You can help reduce stress on the server by:
- not reloading pages frequently - this just adds
- opening links in new windows (so you can read the old page)
MGI:Ar
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Ar | |
| Protein Name(s) | androgen receptor, | |
| External Links | ||
| MGI | MGI:88064 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000790 |
nuclear chromatin |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0001701 |
in utero embryonic development |
MGI:MGI:2661993 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856319 |
P |
From MGI |
||
| GO:0003677 |
DNA binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0238 |
F |
From MGI |
||
| GO:0003677 |
DNA binding |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0003682 |
chromatin binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0003700 |
sequence-specific DNA binding transcription factor activity |
MGI:MGI:2384368 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0003700 |
sequence-specific DNA binding transcription factor activity |
MGI:MGI:2684511 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0003700 |
sequence-specific DNA binding transcription factor activity |
MGI:MGI:3616918 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0003700 |
sequence-specific DNA binding transcription factor activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0003707 |
steroid hormone receptor activity |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0004872 |
receptor activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0675 |
F |
From MGI |
||
| GO:0004879 |
ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0004882 |
androgen receptor activity |
MGI:MGI:2384368 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0004882 |
androgen receptor activity |
MGI:MGI:3047515 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0004882 |
androgen receptor activity |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0004882 |
androgen receptor activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005102 |
receptor binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005102 |
receptor binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005496 |
steroid binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0754 |
F |
From MGI |
||
| GO:0005496 |
steroid binding |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0005497 |
androgen binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:2384368 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:2684511 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3588448 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3616918 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:4362014 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:2136569 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:2384368 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:2684511 |
IPI: Inferred from Physical Interaction |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:3529739 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:3618678 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:3708425 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:3714080 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:3822220 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:2384368 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:3708425 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0006351 |
transcription, DNA-dependent |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0006355 |
regulation of transcription, DNA-dependent |
MGI:MGI:2384368 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0006355 |
regulation of transcription, DNA-dependent |
MGI:MGI:2684511 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0006357 |
regulation of transcription from RNA polymerase II promoter |
MGI:MGI:3769837 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856319 |
P |
From MGI |
||
| GO:0008013 |
beta-catenin binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0008134 |
transcription factor binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0008270 |
zinc ion binding |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0008284 |
positive regulation of cell proliferation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0008289 |
lipid binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0446 |
F |
From MGI |
||
| GO:0008584 |
male gonad development |
MGI:MGI:2661993 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856319 |
P |
From MGI |
||
| GO:0008584 |
male gonad development |
MGI:MGI:3714080 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3716756 |
P |
From MGI |
||
| GO:0009987 |
cellular process |
MGI:MGI:2384368 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0010468 |
regulation of gene expression |
MGI:MGI:3769837 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856319 |
P |
From MGI |
||
| GO:0019102 |
male somatic sex determination |
MGI:MGI:53651 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856319 |
P |
From MGI |
||
| GO:0019899 |
enzyme binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0019899 |
enzyme binding |
MGI:MGI:4943397 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0019904 |
protein domain specific binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0030424 |
axon |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0030425 |
dendrite |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0030521 |
androgen receptor signaling pathway |
MGI:MGI:3047515 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0030521 |
androgen receptor signaling pathway |
MGI:MGI:3529739 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0030521 |
androgen receptor signaling pathway |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0030521 |
androgen receptor signaling pathway |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0030522 |
intracellular receptor mediated signaling pathway |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0033148 |
positive regulation of intracellular estrogen receptor signaling pathway |
MGI:MGI:2683859 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2687199 |
P |
From MGI |
||
| GO:0042327 |
positive regulation of phosphorylation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0043066 |
negative regulation of apoptotic process |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0043401 |
steroid hormone mediated signaling pathway |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
P |
From MGI |
|||
| GO:0043401 |
steroid hormone mediated signaling pathway |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0043401 |
steroid hormone mediated signaling pathway |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0043410 |
positive regulation of MAPK cascade |
MGI:MGI:2683859 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2687199 |
P |
From MGI |
||
| GO:0043565 |
sequence-specific DNA binding |
MGI:MGI:65622 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0043568 |
positive regulation of insulin-like growth factor receptor signaling pathway |
MGI:MGI:2683859 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2687199 |
P |
From MGI |
||
| GO:0044212 |
transcription regulatory region DNA binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0045720 |
negative regulation of integrin biosynthetic process |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045726 |
positive regulation of integrin biosynthetic process |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045893 |
positive regulation of transcription, DNA-dependent |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:3616918 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:3616918 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:105098 |
P |
From MGI |
||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:3769837 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856319 |
P |
From MGI |
||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045945 |
positive regulation of transcription from RNA polymerase III promoter |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0046661 |
male sex differentiation |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0046872 |
metal ion binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0479 |
F |
From MGI |
||
| GO:0048608 |
reproductive structure development |
MGI:MGI:3714080 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3716756 |
P |
From MGI |
||
| GO:0048638 |
regulation of developmental growth |
MGI:MGI:3714080 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3716756 |
P |
From MGI |
||
| GO:0048645 |
organ formation |
MGI:MGI:3714080 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3716756 |
P |
From MGI |
||
| GO:0048808 |
male genitalia morphogenesis |
MGI:MGI:3845460 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2681507 |
P |
From MGI |
||
| GO:0050680 |
negative regulation of epithelial cell proliferation |
MGI:MGI:3718266 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2451025 |
P |
From MGI |
||
| GO:0050681 |
androgen receptor binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0050790 |
regulation of catalytic activity |
MGI:MGI:3770112 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3707001 |
P |
From MGI |
||
| GO:0051092 |
positive regulation of NF-kappaB transcription factor activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0060520 |
activation of prostate induction by androgen receptor signaling pathway |
MGI:MGI:3714080 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3716756 |
P |
From MGI |
||
| GO:0060571 |
morphogenesis of an epithelial fold |
MGI:MGI:3718266 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2451025 |
P |
From MGI |
||
| GO:0060599 |
lateral sprouting involved in mammary gland duct morphogenesis |
MGI:MGI:2683859 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2687199 |
P |
From MGI |
||
| GO:0060685 |
regulation of prostatic bud formation |
MGI:MGI:2673763 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1099809 |
P |
From MGI |
||
| GO:0060736 |
prostate gland growth |
MGI:MGI:3714080 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3716756 |
P |
From MGI |
||
| GO:0060736 |
prostate gland growth |
MGI:MGI:3718266 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2451025 |
P |
From MGI |
||
| GO:0060740 |
prostate gland epithelium morphogenesis |
MGI:MGI:3718266 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2451025 |
P |
From MGI |
||
| GO:0060742 |
epithelial cell differentiation involved in prostate gland development |
MGI:MGI:3718266 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2451025 |
P |
From MGI |
||
| GO:0060748 |
tertiary branching involved in mammary gland duct morphogenesis |
MGI:MGI:2683859 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2687199 |
P |
From MGI |
||
| GO:0060749 |
mammary gland alveolus development |
MGI:MGI:2683859 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2687199 |
P |
From MGI |
||
| GO:0070974 |
POU domain binding |
MGI:MGI:4362014 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0090003 |
regulation of establishment of protein localization in plasma membrane |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Zimmermann S et al. (1999) Targeted disruption of the Insl3 gene causes bilateral cryptorchidism. Mol Endocrinol 13: 681-91 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 Lin HK et al. (2002) Phosphorylation-dependent ubiquitylation and degradation of androgen receptor by Akt require Mdm2 E3 ligase. EMBO J 21: 4037-48 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 Jeong BC et al. (2004) Androgen receptor corepressor-19 kDa (ARR19), a leucine-rich protein that represses the transcriptional activity of androgen receptor through recruitment of histone deacetylase. Mol Endocrinol 18: 13-25 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 Khan OY et al. (2006) Multifunction steroid receptor coactivator, E6-associated protein, is involved in development of the prostate gland. Mol Endocrinol 20: 544-59 PubMed GONUTS page
- ↑ 5.0 5.1 Sitz JH et al. (2004) Dyrk1A potentiates steroid hormone-induced transcription via the chromatin remodeling factor Arip4. Mol Cell Biol 24: 5821-34 PubMed GONUTS page
- ↑ Hong CY et al. (2005) Modulation of the expression and transactivation of androgen receptor by the basic helix-loop-helix transcription factor Pod-1 through recruitment of histone deacetylase 1. Mol Endocrinol 19: 2245-57 PubMed GONUTS page
- ↑ 7.0 7.1 González MI et al. (2002) Androgen receptor interactions with Oct-1 and Brn-1 are physically and functionally distinct. Mol Cell Endocrinol 190: 39-49 PubMed GONUTS page
- ↑ McPherson SJ et al. (2001) Elevated androgens and prolactin in aromatase-deficient mice cause enlargement, but not malignancy, of the prostate gland. Endocrinology 142: 2458-67 PubMed GONUTS page
- ↑ 9.0 9.1 Terada K et al. (2005) A type I DnaJ homolog, DjA1, regulates androgen receptor signaling and spermatogenesis. EMBO J 24: 611-22 PubMed GONUTS page
- ↑ Morales CR et al. (2000) Targeted disruption of the mouse prosaposin gene affects the development of the prostate gland and other male reproductive organs. J Androl 21: 765-75 PubMed GONUTS page
- ↑ 11.0 11.1 Yong W et al. (2007) Essential role for Co-chaperone Fkbp52 but not Fkbp51 in androgen receptor-mediated signaling and physiology. J Biol Chem 282: 5026-36 PubMed GONUTS page
- ↑ 12.0 12.1 12.2 12.3 12.4 12.5 12.6 Simanainen U et al. (2007) Disruption of prostate epithelial androgen receptor impedes prostate lobe-specific growth and function. Endocrinology 148: 2264-72 PubMed GONUTS page
- ↑ Svensson J et al. (2008) Liver-derived IGF1 enhances the androgenic response in prostate. J Endocrinol 199: 489-97 PubMed GONUTS page
- ↑ 14.0 14.1 14.2 O'Shaughnessy PJ et al. (2007) Altered expression of genes involved in regulation of vitamin A metabolism, solute transportation, and cytoskeletal function in the androgen-insensitive tfm mouse testis. Endocrinology 148: 2914-24 PubMed GONUTS page
- ↑ Lyon MF & Hawkes SG (1970) X-linked gene for testicular feminization in the mouse. Nature 227: 1217-9 PubMed GONUTS page
- ↑ Wissmann M et al. (2007) Cooperative demethylation by JMJD2C and LSD1 promotes androgen receptor-dependent gene expression. Nat Cell Biol 9: 347-53 PubMed GONUTS page
- ↑ 17.0 17.1 17.2 17.3 17.4 17.5 Yeh S et al. (2003) Abnormal mammary gland development and growth retardation in female mice and MCF7 breast cancer cells lacking androgen receptor. J Exp Med 198: 1899-908 PubMed GONUTS page
- ↑ Asadi FK et al. (1994) Androgen regulation of gene expression in primary epithelial cells of the mouse kidney. Endocrinology 134: 1179-87 PubMed GONUTS page
- ↑ Miyagawa S et al. (2009) Genetic interactions of the androgen and Wnt/beta-catenin pathways for the masculinization of external genitalia. Mol Endocrinol 23: 871-80 PubMed GONUTS page
- ↑ 20.0 20.1 20.2 20.3 20.4 Wu CT et al. (2007) Increased prostate cell proliferation and loss of cell differentiation in mice lacking prostate epithelial androgen receptor. Proc Natl Acad Sci U S A 104: 12679-84 PubMed GONUTS page
- ↑ Sano M et al. (2007) Ménage-à -trois 1 is critical for the transcriptional function of PPARgamma coactivator 1. Cell Metab 5: 129-42 PubMed GONUTS page
- ↑ Donjacour AA et al. (2003) FGF-10 plays an essential role in the growth of the fetal prostate. Dev Biol 261: 39-54 PubMed GONUTS page