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MGI:App
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | App ( synonyms: Abeta, Adap, appican, betaAPP, Cvap, protease nexin II ) | |
| Protein Name(s) | amyloid beta (A4) precursor protein, | |
| External Links | ||
| MGI | MGI:88059 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000085 |
G2 phase of mitotic cell cycle |
MGI:MGI:3525784 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2154535 |
P |
From MGI |
||
| GO:0001967 |
suckling behavior |
MGI:MGI:1196191 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:88047 |
P |
From MGI |
||
| GO:0003677 |
DNA binding |
MGI:MGI:3589585 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0004867 |
serine-type endopeptidase inhibitor activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005102 |
receptor binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:1343748 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:2179624 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3688020 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3688062 |
IPI: Inferred from Physical Interaction |
UniProtKB:P97318 |
F |
From MGI |
||
| GO:0005515 |
protein binding |
MGI:MGI:3689807 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3698695 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3762243 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3829123 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3835738 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:4399021 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:4881369 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:5139915 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:5315676 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005622 |
intracellular |
MGI:MGI:2154812 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2136847 |
C |
From MGI |
||
| GO:0005622 |
intracellular |
MGI:MGI:4835593 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:97180 |
C |
From MGI |
||
| GO:0005624 |
membrane fraction |
MGI:MGI:1202047 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005624 |
membrane fraction |
MGI:MGI:1861579 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005624 |
membrane fraction |
MGI:MGI:3589713 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:1861579 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005794 |
Golgi apparatus |
MGI:MGI:3608016 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005794 |
Golgi apparatus |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005794 |
Golgi apparatus |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005886 |
plasma membrane |
MGI:MGI:3622834 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005886 |
plasma membrane |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005905 |
coated pit |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0168 |
C |
From MGI |
||
| GO:0006378 |
mRNA polyadenylation |
MGI:MGI:3610697 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0006417 |
regulation of translation |
MGI:MGI:3610697 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0006468 |
protein phosphorylation |
MGI:MGI:3604036 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2652346 |
P |
From MGI |
||
| GO:0006878 |
cellular copper ion homeostasis |
MGI:MGI:1346371 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2136847 |
P |
From MGI |
||
| GO:0006878 |
cellular copper ion homeostasis |
MGI:MGI:3056718 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:88047 |
P |
From MGI |
||
| GO:0006897 |
endocytosis |
MGI:MGI:3604036 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2652346 |
P |
From MGI |
||
| GO:0006915 |
apoptotic process |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0053 |
P |
From MGI |
||
| GO:0006917 |
induction of apoptosis |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0006979 |
response to oxidative stress |
MGI:MGI:3617683 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1202717 |
P |
From MGI |
||
| GO:0007155 |
cell adhesion |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0130 |
P |
From MGI |
||
| GO:0007176 |
regulation of epidermal growth factor-activated receptor activity |
MGI:MGI:3714214 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:88047 |
P |
From MGI |
||
| GO:0007219 |
Notch signaling pathway |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0914 |
P |
From MGI |
||
| GO:0007409 |
axonogenesis |
MGI:MGI:3606204 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2136847 |
P |
From MGI |
||
| GO:0007617 |
mating behavior |
MGI:MGI:1196191 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:88047 |
P |
From MGI |
||
| GO:0007626 |
locomotory behavior |
MGI:MGI:1196191 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:88047 |
P |
From MGI |
||
| GO:0008088 |
axon cargo transport |
MGI:MGI:2154812 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2136847 |
P |
From MGI |
||
| GO:0008088 |
axon cargo transport |
MGI:MGI:4835593 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:97180 |
P |
From MGI |
||
| GO:0008201 |
heparin binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0358 |
F |
From MGI |
||
| GO:0008201 |
heparin binding |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0008203 |
cholesterol metabolic process |
MGI:MGI:3762423 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:88047 |
P |
From MGI |
||
| GO:0008203 |
cholesterol metabolic process |
MGI:MGI:3762423 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2136847 |
P |
From MGI |
||
| GO:0008344 |
adult locomotory behavior |
MGI:MGI:1289627 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2154522 |
P |
From MGI |
||
| GO:0008344 |
adult locomotory behavior |
MGI:MGI:1333449 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2136847 |
P |
From MGI |
||
| GO:0008344 |
adult locomotory behavior |
MGI:MGI:69837 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2154522 |
P |
From MGI |
||
| GO:0008344 |
adult locomotory behavior |
MGI:MGI:73228 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2136847 |
P |
From MGI |
||
| GO:0008542 |
visual learning |
MGI:MGI:1344078 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2136847 |
P |
From MGI |
||
| GO:0009986 |
cell surface |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0010466 |
negative regulation of peptidase activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0646 |
P |
From MGI |
||
| GO:0010468 |
regulation of gene expression |
MGI:MGI:3604278 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0010951 |
negative regulation of endopeptidase activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0010952 |
positive regulation of peptidase activity |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0016020 |
membrane |
MGI:MGI:2179624 |
TAS: Traceable Author Statement |
C |
From MGI |
|||
| GO:0016020 |
membrane |
MGI:MGI:2674181 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0016021 |
integral to membrane |
MGI:MGI:2674181 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0016199 |
axon midline choice point recognition |
MGI:MGI:69837 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2154522 |
P |
From MGI |
||
| GO:0016322 |
neuron remodeling |
MGI:MGI:1334893 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2136847 |
P |
From MGI |
||
| GO:0016358 |
dendrite development |
MGI:MGI:1333449 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2136847 |
P |
From MGI |
||
| GO:0016358 |
dendrite development |
MGI:MGI:3577153 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:88047 |
P |
From MGI |
||
| GO:0016358 |
dendrite development |
MGI:MGI:3606204 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2136847 |
P |
From MGI |
||
| GO:0016504 |
peptidase activator activity |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0019717 |
synaptosome |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0030198 |
extracellular matrix organization |
MGI:MGI:3056838 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:2154545 |
P |
From MGI |
||
| GO:0030414 |
peptidase inhibitor activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0646 |
F |
From MGI |
||
| GO:0030424 |
axon |
MGI:MGI:2154812 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0030424 |
axon |
MGI:MGI:3579206 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0030900 |
forebrain development |
MGI:MGI:1336515 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2154522 |
P |
From MGI |
||
| GO:0030900 |
forebrain development |
MGI:MGI:69837 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2154522 |
P |
From MGI |
||
| GO:0031175 |
neuron projection development |
MGI:MGI:68291 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0031410 |
cytoplasmic vesicle |
MGI:MGI:2154812 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0031410 |
cytoplasmic vesicle |
MGI:MGI:3579206 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0031594 |
neuromuscular junction |
MGI:MGI:1861579 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0033130 |
acetylcholine receptor binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0035235 |
ionotropic glutamate receptor signaling pathway |
MGI:MGI:3604036 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2652346 |
P |
From MGI |
||
| GO:0035253 |
ciliary rootlet |
MGI:MGI:3608016 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0040014 |
regulation of multicellular organism growth |
MGI:MGI:1289627 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2154522 |
P |
From MGI |
||
| GO:0042802 |
identical protein binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0043005 |
neuron projection |
MGI:MGI:3612205 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0043231 |
intracellular membrane-bounded organelle |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0043393 |
regulation of protein binding |
MGI:MGI:3762423 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:88047 |
P |
From MGI |
||
| GO:0043393 |
regulation of protein binding |
MGI:MGI:3762423 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2136847 |
P |
From MGI |
||
| GO:0045177 |
apical part of cell |
MGI:MGI:3525784 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0045665 |
negative regulation of neuron differentiation |
MGI:MGI:3835738 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045665 |
negative regulation of neuron differentiation |
MGI:MGI:3835738 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:104518 |
P |
From MGI |
||
| GO:0045931 |
positive regulation of mitotic cell cycle |
MGI:MGI:3525784 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2154535 |
P |
From MGI |
||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:3589585 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:3589585 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:107765 |
P |
From MGI |
||
| GO:0046872 |
metal ion binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0479 |
F |
From MGI |
||
| GO:0046914 |
transition metal ion binding |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0048471 |
perinuclear region of cytoplasm |
MGI:MGI:66935 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0048669 |
collateral sprouting in absence of injury |
MGI:MGI:3577153 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:88047 |
P |
From MGI |
||
| GO:0050803 |
regulation of synapse structure and activity |
MGI:MGI:1334893 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2136847 |
P |
From MGI |
||
| GO:0050885 |
neuromuscular process controlling balance |
MGI:MGI:1196191 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:88047 |
P |
From MGI |
||
| GO:0051124 |
synaptic growth at neuromuscular junction |
MGI:MGI:3577153 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:88047 |
P |
From MGI |
||
| GO:0051233 |
spindle midzone |
MGI:MGI:3525784 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0051402 |
neuron apoptotic process |
MGI:MGI:3617683 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1202717 |
P |
From MGI |
||
| GO:0051402 |
neuron apoptotic process |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0051425 |
PTB domain binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0051563 |
smooth endoplasmic reticulum calcium ion homeostasis |
MGI:MGI:2449878 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1202717 |
P |
From MGI |
||
| GO:0070851 |
growth factor receptor binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
|
NOT |
GO:0008088 |
axon cargo transport |
MGI:MGI:3579206 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2136847 |
P |
From MGI |
|
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 López-Sánchez N et al. (2005) Lengthening of G2/mitosis in cortical precursors from mice lacking beta-amyloid precursor protein. Neuroscience 130: 51-60 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 von Koch CS et al. (1997) Generation of APLP2 KO mice and early postnatal lethality in APLP2/APP double KO mice. Neurobiol Aging 18: 661-9 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Pardossi-Piquard R et al. (2005) Presenilin-dependent transcriptional control of the Abeta-degrading enzyme neprilysin by intracellular domains of betaAPP and APLP. Neuron 46: 541-54 PubMed GONUTS page
- ↑ Homayouni R et al. (1999) Disabled-1 binds to the cytoplasmic domain of amyloid precursor-like protein 1. J Neurosci 19: 7507-15 PubMed GONUTS page
- ↑ 5.0 5.1 Tarr PE et al. (2002) Tyrosine phosphorylation of the beta-amyloid precursor protein cytoplasmic tail promotes interaction with Shc. J Biol Chem 277: 16798-804 PubMed GONUTS page
- ↑ Scheinfeld MH et al. (2002) Jun NH2-terminal kinase (JNK) interacting protein 1 (JIP1) binds the cytoplasmic domain of the Alzheimer's beta-amyloid precursor protein (APP). J Biol Chem 277: 3767-75 PubMed GONUTS page
- ↑ Matsuda S et al. (2001) c-Jun N-terminal kinase (JNK)-interacting protein-1b/islet-brain-1 scaffolds Alzheimer's amyloid precursor protein with JNK. J Neurosci 21: 6597-607 PubMed GONUTS page
- ↑ Hashimoto Y et al. (2005) Transforming growth factor beta2 is a neuronal death-inducing ligand for amyloid-beta precursor protein. Mol Cell Biol 25: 9304-17 PubMed GONUTS page
- ↑ Minopoli G et al. (2007) Essential roles for Fe65, Alzheimer amyloid precursor-binding protein, in the cellular response to DNA damage. J Biol Chem 282: 831-5 PubMed GONUTS page
- ↑ Mameza MG et al. (2007) Characterization of the adaptor protein ARH expression in the brain and ARH molecular interactions. J Neurochem 103: 927-41 PubMed GONUTS page
- ↑ Bai Y et al. (2008) The in vivo brain interactome of the amyloid precursor protein. Mol Cell Proteomics 7: 15-34 PubMed GONUTS page
- ↑ 12.0 12.1 12.2 Ma QH et al. (2008) A TAG1-APP signalling pathway through Fe65 negatively modulates neurogenesis. Nat Cell Biol 10: 283-94 PubMed GONUTS page
- ↑ Soba P et al. (2005) Homo- and heterodimerization of APP family members promotes intercellular adhesion. EMBO J 24: 3624-34 PubMed GONUTS page
- ↑ Duce JA et al. (2010) Iron-export ferroxidase activity of β-amyloid precursor protein is inhibited by zinc in Alzheimer's disease. Cell 142: 857-67 PubMed GONUTS page
- ↑ Ranganathan S et al. (2011) LRAD3, a novel low-density lipoprotein receptor family member that modulates amyloid precursor protein trafficking. J Neurosci 31: 10836-46 PubMed GONUTS page
- ↑ Steuble M et al. (2010) Molecular characterization of a trafficking organelle: dissecting the axonal paths of calsyntenin-1 transport vesicles. Proteomics 10: 3775-88 PubMed GONUTS page
- ↑ 17.0 17.1 17.2 17.3 Kamal A et al. (2001) Kinesin-mediated axonal transport of a membrane compartment containing beta-secretase and presenilin-1 requires APP. Nature 414: 643-8 PubMed GONUTS page
- ↑ 18.0 18.1 Vossel KA et al. (2010) Tau reduction prevents Abeta-induced defects in axonal transport. Science 330: 198 PubMed GONUTS page
- ↑ Apert C et al. (1998) Profiles of amyloid precursor and presenilin 2-like proteins are correlated during development of the mouse hypothalamus. J Neuroendocrinol 10: 101-9 PubMed GONUTS page
- ↑ 20.0 20.1 20.2 Akaaboune M et al. (2000) Developmental regulation of amyloid precursor protein at the neuromuscular junction in mouse skeletal muscle. Mol Cell Neurosci 15: 355-67 PubMed GONUTS page
- ↑ Vetrivel KS et al. (2005) Spatial segregation of gamma-secretase and substrates in distinct membrane domains. J Biol Chem 280: 25892-900 PubMed GONUTS page
- ↑ 22.0 22.1 Yang J & Li T (2005) The ciliary rootlet interacts with kinesin light chains and may provide a scaffold for kinesin-1 vesicular cargos. Exp Cell Res 309: 379-89 PubMed GONUTS page
- ↑ Yang Y et al. (2004) Presenilin-1 and intracellular calcium stores regulate neuronal glutamate uptake. J Neurochem 88: 1361-72 PubMed GONUTS page
- ↑ 24.0 24.1 Cao Q et al. (2005) Amyloid precursor proteins anchor CPEB to membranes and promote polyadenylation-induced translation. Mol Cell Biol 25: 10930-9 PubMed GONUTS page
- ↑ 25.0 25.1 25.2 Snyder EM et al. (2005) Regulation of NMDA receptor trafficking by amyloid-beta. Nat Neurosci 8: 1051-8 PubMed GONUTS page
- ↑ White AR et al. (1999) Copper levels are increased in the cerebral cortex and liver of APP and APLP2 knockout mice. Brain Res 842: 439-44 PubMed GONUTS page
- ↑ Bellingham SA et al. (2004) Gene knockout of amyloid precursor protein and amyloid precursor-like protein-2 increases cellular copper levels in primary mouse cortical neurons and embryonic fibroblasts. J Neurochem 91: 423-8 PubMed GONUTS page
- ↑ 28.0 28.1 Mohmmad Abdul H et al. (2006) Mutations in amyloid precursor protein and presenilin-1 genes increase the basal oxidative stress in murine neuronal cells and lead to increased sensitivity to oxidative stress mediated by amyloid beta-peptide (1-42), HO and kainic acid: implications for Alzheimer's disease. J Neurochem 96: 1322-35 PubMed GONUTS page
- ↑ Zhang YW et al. (2007) Presenilin/gamma-secretase-dependent processing of beta-amyloid precursor protein regulates EGF receptor expression. Proc Natl Acad Sci U S A 104: 10613-8 PubMed GONUTS page
- ↑ 30.0 30.1 Perez RG et al. (1997) The beta-amyloid precursor protein of Alzheimer's disease enhances neuron viability and modulates neuronal polarity. J Neurosci 17: 9407-14 PubMed GONUTS page
- ↑ 31.0 31.1 31.2 31.3 Liu Q et al. (2007) Amyloid precursor protein regulates brain apolipoprotein E and cholesterol metabolism through lipoprotein receptor LRP1. Neuron 56: 66-78 PubMed GONUTS page
- ↑ 32.0 32.1 Tremml P et al. (1998) Neurobehavioral development, adult openfield exploration and swimming navigation learning in mice with a modified beta-amyloid precursor protein gene. Behav Brain Res 95: 65-76 PubMed GONUTS page
- ↑ 33.0 33.1 Dawson GR et al. (1999) Age-related cognitive deficits, impaired long-term potentiation and reduction in synaptic marker density in mice lacking the beta-amyloid precursor protein. Neuroscience 90: 1-13 PubMed GONUTS page
- ↑ 34.0 34.1 34.2 Müller U et al. (1994) Behavioral and anatomical deficits in mice homozygous for a modified beta-amyloid precursor protein gene. Cell 79: 755-65 PubMed GONUTS page
- ↑ Zheng H et al. (1995) beta-Amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity. Cell 81: 525-31 PubMed GONUTS page
- ↑ Phinney AL et al. (1999) No hippocampal neuron or synaptic bouton loss in learning-impaired aged beta-amyloid precursor protein-null mice. Neuroscience 90: 1207-16 PubMed GONUTS page
- ↑ Fukami S et al. (2002) Abeta-degrading endopeptidase, neprilysin, in mouse brain: synaptic and axonal localization inversely correlating with Abeta pathology. Neurosci Res 43: 39-56 PubMed GONUTS page
- ↑ 38.0 38.1 Rouvinski A et al. (2003) Both raft- and non-raft proteins associate with CHAPS-insoluble complexes: some APP in large complexes. Biochem Biophys Res Commun 308: 750-8 PubMed GONUTS page
- ↑ 39.0 39.1 Seabrook GR et al. (1999) Mechanisms contributing to the deficits in hippocampal synaptic plasticity in mice lacking amyloid precursor protein. Neuropharmacology 38: 349-59 PubMed GONUTS page
- ↑ 40.0 40.1 40.2 Wang P et al. (2005) Defective neuromuscular synapses in mice lacking amyloid precursor protein (APP) and APP-Like protein 2. J Neurosci 25: 1219-25 PubMed GONUTS page
- ↑ Herms J et al. (2004) Cortical dysplasia resembling human type 2 lissencephaly in mice lacking all three APP family members. EMBO J 23: 4106-15 PubMed GONUTS page
- ↑ 42.0 42.1 42.2 Lazarov O et al. (2005) Axonal transport, amyloid precursor protein, kinesin-1, and the processing apparatus: revisited. J Neurosci 25: 2386-95 PubMed GONUTS page
- ↑ Magara F et al. (1999) Genetic background changes the pattern of forebrain commissure defects in transgenic mice underexpressing the beta-amyloid-precursor protein. Proc Natl Acad Sci U S A 96: 4656-61 PubMed GONUTS page
- ↑ Jin LW et al. (1994) Peptides containing the RERMS sequence of amyloid beta/A4 protein precursor bind cell surface and promote neurite extension. J Neurosci 14: 5461-70 PubMed GONUTS page
- ↑ Muresan Z & Muresan V (2005) Coordinated transport of phosphorylated amyloid-beta precursor protein and c-Jun NH2-terminal kinase-interacting protein-1. J Cell Biol 171: 615-25 PubMed GONUTS page
- ↑ Salbaum JM & Ruddle FH (1994) Embryonic expression pattern of amyloid protein precursor suggests a role in differentiation of specific subsets of neurons. J Exp Zool 269: 116-27 PubMed GONUTS page
- ↑ Herms J et al. (2003) Capacitive calcium entry is directly attenuated by mutant presenilin-1, independent of the expression of the amyloid precursor protein. J Biol Chem 278: 2484-9 PubMed GONUTS page
