MGI:Apob

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Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0001701	in utero embryonic development	MGI:MGI:1201298 PMID:9502790^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2157775	P	From MGI
	GO:0001701	in utero embryonic development	MGI:MGI:71076 PMID:7878058^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857625	P	From MGI
	GO:0005543	phospholipid binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P04114	F	From MGI
	GO:0005615	extracellular space	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q62970	C	From MGI
	GO:0005783	endoplasmic reticulum	MGI:MGI:2386141 PMID:12072432^[3]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005792	microsome	MGI:MGI:2386141 PMID:12072432^[3]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005792	microsome	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q62970	C	From MGI
	GO:0006629	lipid metabolic process	MGI:MGI:1928445 PMID:11120757^[4]	IGI: Inferred from Genetic Interaction	MGI:MGI:88057 MGI:MGI:96765	P	From MGI
	GO:0006629	lipid metabolic process	MGI:MGI:2386141 PMID:12072432^[3]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0006629	lipid metabolic process	MGI:MGI:3612778 PMID:15790761^[5]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2183298	P	From MGI
	GO:0006629	lipid metabolic process	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q62970	P	From MGI
	GO:0006629	lipid metabolic process	MGI:MGI:64433 PMID:8460149^[6]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857141	P	From MGI
	GO:0006642	triglyceride mobilization	MGI:MGI:1913181 PMID:10893242^[7]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2183298	P	From MGI
	GO:0007283	spermatogenesis	MGI:MGI:83280 PMID:8855280^[8]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2157090	P	From MGI
	GO:0007399	nervous system development	MGI:MGI:1201298 PMID:9502790^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2157775	P	From MGI
	GO:0007399	nervous system development	MGI:MGI:71076 PMID:7878058^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857625	P	From MGI
	GO:0007399	nervous system development	MGI:MGI:83856 PMID:8921909^[9]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3665449	P	From MGI
	GO:0008201	heparin binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P04114	F	From MGI
	GO:0008203	cholesterol metabolic process	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P04114	P	From MGI
	GO:0008289	lipid binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q62970	F	From MGI
	GO:0009566	fertilization	MGI:MGI:83280 PMID:8855280^[8]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2157090	P	From MGI
	GO:0009743	response to carbohydrate stimulus	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q62970	P	From MGI
	GO:0009791	post-embryonic development	MGI:MGI:1316893 PMID:9852051^[10]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2157108	P	From MGI
	GO:0010744	positive regulation of macrophage derived foam cell differentiation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P04114	P	From MGI
	GO:0010884	positive regulation of lipid storage	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P04114	P	From MGI
	GO:0010886	positive regulation of cholesterol storage	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P04114	P	From MGI
	GO:0012506	vesicle membrane	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q62970	C	From MGI
	GO:0016042	lipid catabolic process	MGI:MGI:3652707 PMID:16455790^[11]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2183298	P	From MGI
	GO:0017127	cholesterol transporter activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P04114	F	From MGI
	GO:0019433	triglyceride catabolic process	MGI:MGI:3652707 PMID:16455790^[11]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2183298	P	From MGI
	GO:0019433	triglyceride catabolic process	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q62970	P	From MGI
	GO:0019899	enzyme binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P04114	F	From MGI
	GO:0030301	cholesterol transport	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P04114	P	From MGI
	GO:0030301	cholesterol transport	MGI:MGI:77225 PMID:7593600^[12]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2157090	P	From MGI
	GO:0030317	sperm motility	MGI:MGI:83280 PMID:8855280^[8]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2157090	P	From MGI
	GO:0031983	vesicle lumen	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q62970	C	From MGI
	GO:0034359	mature chylomicron	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P04114	C	From MGI
	GO:0034361	very-low-density lipoprotein particle	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q62970	C	From MGI
	GO:0034361	very-low-density lipoprotein particle	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P04114	C	From MGI
	GO:0034362	low-density lipoprotein particle	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P04114	C	From MGI
	GO:0034363	intermediate-density lipoprotein particle	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P04114	C	From MGI
	GO:0034374	low-density lipoprotein particle remodeling	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P04114	P	From MGI
	GO:0034383	low-density lipoprotein particle clearance	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P04114	P	From MGI
	GO:0042157	lipoprotein metabolic process	MGI:MGI:1316893 PMID:9852051^[10]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2157108	P	From MGI
	GO:0042157	lipoprotein metabolic process	MGI:MGI:1354526 PMID:10713055^[13]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857303	P	From MGI
	GO:0042157	lipoprotein metabolic process	MGI:MGI:1928445 PMID:11120757^[4]	IGI: Inferred from Genetic Interaction	MGI:MGI:88057 MGI:MGI:96765	P	From MGI
	GO:0042157	lipoprotein metabolic process	MGI:MGI:3028770 PMID:13130124^[14]	IGI: Inferred from Genetic Interaction	MGI:MGI:88057	P	From MGI
	GO:0042157	lipoprotein metabolic process	MGI:MGI:3028770 PMID:13130124^[14]	IGI: Inferred from Genetic Interaction	MGI:MGI:96765	P	From MGI
	GO:0042157	lipoprotein metabolic process	MGI:MGI:3664699 PMID:10705993^[15]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3665449	P	From MGI
	GO:0042157	lipoprotein metabolic process	MGI:MGI:71076 PMID:7878058^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857625	P	From MGI
	GO:0042158	lipoprotein biosynthetic process	MGI:MGI:3028770 PMID:13130124^[14]	IGI: Inferred from Genetic Interaction	MGI:MGI:103298	P	From MGI
	GO:0042159	lipoprotein catabolic process	MGI:MGI:3588634 PMID:15863839^[16]	IGI: Inferred from Genetic Interaction	MGI:MGI:107202	P	From MGI
	GO:0042627	chylomicron	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P04114	C	From MGI
	GO:0042632	cholesterol homeostasis	MGI:MGI:1201298 PMID:9502790^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857304	P	From MGI
	GO:0042632	cholesterol homeostasis	MGI:MGI:1316893 PMID:9852051^[10]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2157108	P	From MGI
	GO:0042632	cholesterol homeostasis	MGI:MGI:1928445 PMID:11120757^[4]	IGI: Inferred from Genetic Interaction	MGI:MGI:88057 MGI:MGI:96765	P	From MGI
	GO:0042632	cholesterol homeostasis	MGI:MGI:3695082 PMID:16230502^[17]	IGI: Inferred from Genetic Interaction	MGI:MGI:88057	P	From MGI
	GO:0042632	cholesterol homeostasis	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P04114	P	From MGI
	GO:0042632	cholesterol homeostasis	MGI:MGI:71076 PMID:7878058^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857625	P	From MGI
	GO:0042632	cholesterol homeostasis	MGI:MGI:83856 PMID:8921909^[9]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3665449	P	From MGI
	GO:0042632	cholesterol homeostasis	MGI:MGI:893988 PMID:9202070^[18]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857304 MGI:MGI:1857303	P	From MGI
	GO:0042953	lipoprotein transport	MGI:MGI:3028770 PMID:13130124^[14]	IGI: Inferred from Genetic Interaction	MGI:MGI:103298	P	From MGI
	GO:0042953	lipoprotein transport	MGI:MGI:3028770 PMID:13130124^[14]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2183298	P	From MGI
	GO:0045540	regulation of cholesterol biosynthetic process	MGI:MGI:3652707 PMID:16455790^[11]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2183298	P	From MGI
	GO:0046982	protein heterodimerization activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P04114	F	From MGI
	GO:0048844	artery morphogenesis	MGI:MGI:3695082 PMID:16230502^[17]	IGI: Inferred from Genetic Interaction	MGI:MGI:88057	P	From MGI
	GO:0050750	low-density lipoprotein particle receptor binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P04114	F	From MGI
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Kim E et al. (1998) Dual mechanisms for the low plasma levels of truncated apolipoprotein B proteins in familial hypobetalipoproteinemia. Analysis of a new mouse model with a nonsense mutation in the Apob gene. J Clin Invest 101: 1468-77 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Farese RV Jr et al. (1995) Knockout of the mouse apolipoprotein B gene results in embryonic lethality in homozygotes and protection against diet-induced hypercholesterolemia in heterozygotes. Proc Natl Acad Sci U S A 92: 1774-8 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Kulinski A et al. (2002) Microsomal triacylglycerol transfer protein is required for lumenal accretion of triacylglycerol not associated with ApoB, as well as for ApoB lipidation. J Biol Chem 277: 31516-25 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Véniant MM et al. (2000) Defining the atherogenicity of large and small lipoproteins containing apolipoprotein B100. J Clin Invest 106: 1501-10 PubMed GONUTS page
↑ Lin X et al. (2005) Reduced intestinal fat absorptive capacity but enhanced susceptibility to diet-induced fatty liver in mice heterozygous for ApoB38.9 truncation. Am J Physiol Gastrointest Liver Physiol 289: G146-52 PubMed GONUTS page
↑ Homanics GE et al. (1993) Targeted modification of the apolipoprotein B gene results in hypobetalipoproteinemia and developmental abnormalities in mice. Proc Natl Acad Sci U S A 90: 2389-93 PubMed GONUTS page
↑ Chen Z et al. (2000) A targeted apolipoprotein B-38.9-producing mutation causes fatty livers in mice due to the reduced ability of apolipoprotein B-38.9 to transport triglycerides. J Biol Chem 275: 32807-15 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Huang LS et al. (1996) A novel functional role for apolipoprotein B in male infertility in heterozygous apolipoprotein B knockout mice. Proc Natl Acad Sci U S A 93: 10903-7 PubMed GONUTS page
↑ ^9.0 ^9.1 Toth LR et al. (1996) Two distinct apolipoprotein B alleles in mice generated by a single 'in-out' targeting. Gene 178: 161-8 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 Kim E et al. (1998) A gene-targeted mouse model for familial hypobetalipoproteinemia. Low levels of apolipoprotein B mRNA in association with a nonsense mutation in exon 26 of the apolipoprotein B gene. J Biol Chem 273: 33977-84 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 Lin X et al. (2006) A targeted apoB38.9 mutation in mice is associated with reduced hepatic cholesterol synthesis and enhanced lipid peroxidation. Am J Physiol Gastrointest Liver Physiol 290: G1170-6 PubMed GONUTS page
↑ Huang LS et al. (1995) apo B gene knockout in mice results in embryonic lethality in homozygotes and neural tube defects, male infertility, and reduced HDL cholesterol ester and apo A-I transport rates in heterozygotes. J Clin Invest 96: 2152-61 PubMed GONUTS page
↑ Leung GK et al. (2000) A deficiency of microsomal triglyceride transfer protein reduces apolipoprotein B secretion. J Biol Chem 275: 7515-20 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 ^14.3 ^14.4 Chen Z et al. (2004) Hepatic secretion of apoB-100 is impaired in hypobetalipoproteinemic mice with an apoB-38.9-specifying allele. J Lipid Res 45: 155-63 PubMed GONUTS page
↑ Srivastava RA et al. (1999) Regulation of the apolipoprotein B in heterozygous hypobetalipoproteinemic knock-out mice expressing truncated apoB, B81. Low production and enhanced clearance of apoB cause low levels of apoB. Mol Cell Biochem 202: 37-46 PubMed GONUTS page
↑ Wu D et al. (2005) Heterozygous mutation of ataxia-telangiectasia mutated gene aggravates hypercholesterolemia in apoE-deficient mice. J Lipid Res 46: 1380-7 PubMed GONUTS page
↑ ^17.0 ^17.1 Tirziu D et al. (2005) Delayed arteriogenesis in hypercholesterolemic mice. Circulation 112: 2501-9 PubMed GONUTS page
↑ Véniant MM et al. (1997) Susceptibility to atherosclerosis in mice expressing exclusively apolipoprotein B48 or apolipoprotein B100. J Clin Invest 100: 180-8 PubMed GONUTS page

[PMID:9502790-0] 1.0 ^1.1 ^1.2 Kim E et al. (1998) Dual mechanisms for the low plasma levels of truncated apolipoprotein B proteins in familial hypobetalipoproteinemia. Analysis of a new mouse model with a nonsense mutation in the Apob gene. J Clin Invest 101: 1468-77 PubMed GONUTS page

[PMID:7878058-1] 2.0 ^2.1 ^2.2 ^2.3 Farese RV Jr et al. (1995) Knockout of the mouse apolipoprotein B gene results in embryonic lethality in homozygotes and protection against diet-induced hypercholesterolemia in heterozygotes. Proc Natl Acad Sci U S A 92: 1774-8 PubMed GONUTS page

[PMID:12072432-2] 3.0 ^3.1 ^3.2 Kulinski A et al. (2002) Microsomal triacylglycerol transfer protein is required for lumenal accretion of triacylglycerol not associated with ApoB, as well as for ApoB lipidation. J Biol Chem 277: 31516-25 PubMed GONUTS page

[PMID:11120757-3] 4.0 ^4.1 ^4.2 Véniant MM et al. (2000) Defining the atherogenicity of large and small lipoproteins containing apolipoprotein B100. J Clin Invest 106: 1501-10 PubMed GONUTS page

[PMID:15790761-4] Lin X et al. (2005) Reduced intestinal fat absorptive capacity but enhanced susceptibility to diet-induced fatty liver in mice heterozygous for ApoB38.9 truncation. Am J Physiol Gastrointest Liver Physiol 289: G146-52 PubMed GONUTS page

[PMID:8460149-5] Homanics GE et al. (1993) Targeted modification of the apolipoprotein B gene results in hypobetalipoproteinemia and developmental abnormalities in mice. Proc Natl Acad Sci U S A 90: 2389-93 PubMed GONUTS page

[PMID:10893242-6] Chen Z et al. (2000) A targeted apolipoprotein B-38.9-producing mutation causes fatty livers in mice due to the reduced ability of apolipoprotein B-38.9 to transport triglycerides. J Biol Chem 275: 32807-15 PubMed GONUTS page

[PMID:8855280-7] 8.0 ^8.1 ^8.2 Huang LS et al. (1996) A novel functional role for apolipoprotein B in male infertility in heterozygous apolipoprotein B knockout mice. Proc Natl Acad Sci U S A 93: 10903-7 PubMed GONUTS page

[PMID:8921909-8] 9.0 ^9.1 Toth LR et al. (1996) Two distinct apolipoprotein B alleles in mice generated by a single 'in-out' targeting. Gene 178: 161-8 PubMed GONUTS page

[PMID:9852051-9] 10.0 ^10.1 ^10.2 Kim E et al. (1998) A gene-targeted mouse model for familial hypobetalipoproteinemia. Low levels of apolipoprotein B mRNA in association with a nonsense mutation in exon 26 of the apolipoprotein B gene. J Biol Chem 273: 33977-84 PubMed GONUTS page

[PMID:16455790-10] 11.0 ^11.1 ^11.2 Lin X et al. (2006) A targeted apoB38.9 mutation in mice is associated with reduced hepatic cholesterol synthesis and enhanced lipid peroxidation. Am J Physiol Gastrointest Liver Physiol 290: G1170-6 PubMed GONUTS page

[PMID:7593600-11] Huang LS et al. (1995) apo B gene knockout in mice results in embryonic lethality in homozygotes and neural tube defects, male infertility, and reduced HDL cholesterol ester and apo A-I transport rates in heterozygotes. J Clin Invest 96: 2152-61 PubMed GONUTS page

[PMID:10713055-12] Leung GK et al. (2000) A deficiency of microsomal triglyceride transfer protein reduces apolipoprotein B secretion. J Biol Chem 275: 7515-20 PubMed GONUTS page

[PMID:13130124-13] 14.0 ^14.1 ^14.2 ^14.3 ^14.4 Chen Z et al. (2004) Hepatic secretion of apoB-100 is impaired in hypobetalipoproteinemic mice with an apoB-38.9-specifying allele. J Lipid Res 45: 155-63 PubMed GONUTS page

[PMID:10705993-14] Srivastava RA et al. (1999) Regulation of the apolipoprotein B in heterozygous hypobetalipoproteinemic knock-out mice expressing truncated apoB, B81. Low production and enhanced clearance of apoB cause low levels of apoB. Mol Cell Biochem 202: 37-46 PubMed GONUTS page

[PMID:15863839-15] Wu D et al. (2005) Heterozygous mutation of ataxia-telangiectasia mutated gene aggravates hypercholesterolemia in apoE-deficient mice. J Lipid Res 46: 1380-7 PubMed GONUTS page

[PMID:16230502-16] 17.0 ^17.1 Tirziu D et al. (2005) Delayed arteriogenesis in hypercholesterolemic mice. Circulation 112: 2501-9 PubMed GONUTS page

[PMID:9202070-17] Véniant MM et al. (1997) Susceptibility to atherosclerosis in mice expressing exclusively apolipoprotein B48 or apolipoprotein B100. J Clin Invest 100: 180-8 PubMed GONUTS page

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Species (Taxon ID)	Mus musculus (house mouse) (taxon:10090)
Gene Name(s)	Apob ( synonyms: apob-100, apob-48 )
Protein Name(s)	apolipoprotein B,
External Links
MGI	MGI:88052

MGI:Apob

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