MGI:Apoa1

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Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0001540	beta-amyloid binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P02647	F	From MGI
	GO:0001932	regulation of protein phosphorylation	MGI:MGI:2675932 PMID:12869555^[1]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0001935	endothelial cell proliferation	MGI:MGI:3698572 PMID:16339487^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857127	P	From MGI
	GO:0002740	negative regulation of cytokine secretion involved in immune response	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P02647	P	From MGI
	GO:0005319	lipid transporter activity	MGI:MGI:2176648 PMID:11744719^[3]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0005319	lipid transporter activity	MGI:MGI:50633 PMID:1496008^[4]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857127	F	From MGI
	GO:0005515	protein binding	MGI:MGI:3611144 PMID:16204232^[5]	IPI: Inferred from Physical Interaction	UniProtKB:P41233	F	From MGI
	GO:0005543	phospholipid binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P02647	F	From MGI
	GO:0005548	phospholipid transporter activity	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P04639	F	From MGI
	GO:0005576	extracellular region	MGI:MGI:3575626 PMID:15793583^[6]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005615	extracellular space	MGI:MGI:1096057 PMID:9300780^[7]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005615	extracellular space	MGI:MGI:1096304 PMID:9275209^[8]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005615	extracellular space	MGI:MGI:1196678 PMID:9507992^[9]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005615	extracellular space	MGI:MGI:1339278 PMID:10357841^[10]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005615	extracellular space	MGI:MGI:2154458	ISO: Inferred from Sequence Orthology	UniProtKB:P02647	C	From MGI
	GO:0005615	extracellular space	MGI:MGI:2176648 PMID:11744719^[3]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005615	extracellular space	MGI:MGI:2668299 PMID:12859204^[11]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005615	extracellular space	MGI:MGI:3709144 PMID:14595002^[12]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005615	extracellular space	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P04639	C	From MGI
	GO:0005615	extracellular space	MGI:MGI:49599 PMID:1596514^[13]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005615	extracellular space	MGI:MGI:55488 PMID:6403543^[14]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005615	extracellular space	MGI:MGI:70238 PMID:7798939^[15]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005615	extracellular space	MGI:MGI:70854 PMID:7751823^[16]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005615	extracellular space	MGI:MGI:892202 PMID:9186920^[17]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005634	nucleus	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P04639	C	From MGI
	GO:0006644	phospholipid metabolic process	MGI:MGI:3688492 PMID:9795222^[18]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857127	P	From MGI
	GO:0006656	phosphatidylcholine biosynthetic process	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P02647	P	From MGI
	GO:0006695	cholesterol biosynthetic process	MGI:MGI:2180727 PMID:8647961^[19]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2180783	P	From MGI
	GO:0007186	G-protein coupled receptor signaling pathway	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P02647	P	From MGI
	GO:0008035	high-density lipoprotein particle binding	MGI:MGI:2176648 PMID:11744719^[3]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0008035	high-density lipoprotein particle binding	MGI:MGI:3709144 PMID:14595002^[12]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0008203	cholesterol metabolic process	MGI:MGI:1099137 PMID:9327769^[20]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857127	P	From MGI
	GO:0008203	cholesterol metabolic process	MGI:MGI:1339278 PMID:10357841^[10]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857127	P	From MGI
	GO:0008203	cholesterol metabolic process	MGI:MGI:3487338 PMID:15466405^[21]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857127	P	From MGI
	GO:0008203	cholesterol metabolic process	MGI:MGI:3588626 PMID:15995171^[22]	IGI: Inferred from Genetic Interaction	MGI:MGI:104663	P	From MGI
	GO:0008203	cholesterol metabolic process	MGI:MGI:3588626 PMID:15995171^[22]	IGI: Inferred from Genetic Interaction	MGI:MGI:104993	P	From MGI
	GO:0008203	cholesterol metabolic process	MGI:MGI:3688492 PMID:9795222^[18]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857127	P	From MGI
	GO:0008203	cholesterol metabolic process	MGI:MGI:3696597 PMID:17071966^[23]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857127	P	From MGI
	GO:0008203	cholesterol metabolic process	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P02647	P	From MGI
	GO:0008203	cholesterol metabolic process	MGI:MGI:70854 PMID:7751823^[16]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857127	P	From MGI
	GO:0008211	glucocorticoid metabolic process	MGI:MGI:2180727 PMID:8647961^[19]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2180783	P	From MGI
	GO:0008289	lipid binding	MGI:MGI:68295 PMID:8049247^[24]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0010873	positive regulation of cholesterol esterification	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P02647	P	From MGI
	GO:0010903	negative regulation of very-low-density lipoprotein particle remodeling	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P02647	P	From MGI
	GO:0015485	cholesterol binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P02647	F	From MGI
	GO:0015914	phospholipid transport	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P04639	P	From MGI
	GO:0017127	cholesterol transporter activity	MGI:MGI:3056863 PMID:15269218^[25]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0017127	cholesterol transporter activity	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P04639	F	From MGI
	GO:0017127	cholesterol transporter activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P02647	F	From MGI
	GO:0018158	protein oxidation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P02647	P	From MGI
	GO:0018206	peptidyl-methionine modification	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P02647	P	From MGI
	GO:0019899	enzyme binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P02647	F	From MGI
	GO:0019915	lipid storage	MGI:MGI:2180727 PMID:8647961^[19]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2180783	P	From MGI
	GO:0030139	endocytic vesicle	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P02647	C	From MGI
	GO:0030300	regulation of intestinal cholesterol absorption	MGI:MGI:1339009 PMID:10073953^[26]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0030301	cholesterol transport	MGI:MGI:1096057 PMID:9300780^[7]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0030301	cholesterol transport	MGI:MGI:1196678 PMID:9507992^[9]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2180783	P	From MGI
	GO:0030301	cholesterol transport	MGI:MGI:1352038 PMID:10559507^[27]	ISO: Inferred from Sequence Orthology	UniProtKB:P02647	P	From MGI
	GO:0030301	cholesterol transport	MGI:MGI:3706653 PMID:9684752^[28]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857127	P	From MGI
	GO:0030301	cholesterol transport	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P04639	P	From MGI
	GO:0030325	adrenal gland development	MGI:MGI:2180727 PMID:8647961^[19]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2180783	P	From MGI
	GO:0031100	organ regeneration	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P04639	P	From MGI
	GO:0031410	cytoplasmic vesicle	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P02647	C	From MGI
	GO:0032488	Cdc42 protein signal transduction	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P02647	P	From MGI
	GO:0033344	cholesterol efflux	MGI:MGI:1096304 PMID:9275209^[8]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2180783	P	From MGI
	GO:0033344	cholesterol efflux	MGI:MGI:2176648 PMID:11744719^[3]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0033344	cholesterol efflux	MGI:MGI:2675932 PMID:12869555^[1]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0033344	cholesterol efflux	MGI:MGI:3056863 PMID:15269218^[25]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0033344	cholesterol efflux	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P02647	P	From MGI
	GO:0033344	cholesterol efflux	MGI:MGI:892202 PMID:9186920^[17]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0033700	phospholipid efflux	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P02647	P	From MGI
	GO:0034190	apolipoprotein receptor binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P02647	F	From MGI
	GO:0034191	apolipoprotein A-I receptor binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P02647	F	From MGI
	GO:0034361	very-low-density lipoprotein particle	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P02647	C	From MGI
	GO:0034364	high-density lipoprotein particle	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P02647	C	From MGI
	GO:0034366	spherical high-density lipoprotein particle	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P02647	C	From MGI
	GO:0034380	high-density lipoprotein particle assembly	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P02647	P	From MGI
	GO:0042158	lipoprotein biosynthetic process	MGI:MGI:3616112 PMID:16245952^[29]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857127	P	From MGI
	GO:0042158	lipoprotein biosynthetic process	MGI:MGI:3709144 PMID:14595002^[12]	IGI: Inferred from Genetic Interaction	MGI:MGI:88057	P	From MGI
	GO:0042632	cholesterol homeostasis	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P02647	P	From MGI
	GO:0042802	identical protein binding	MGI:MGI:2176648 PMID:11744719^[3]	IPI: Inferred from Physical Interaction	UniProtKB:Q00623	F	From MGI
	GO:0042802	identical protein binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P02647	F	From MGI
	GO:0042802	identical protein binding	MGI:MGI:68295 PMID:8049247^[24]	IPI: Inferred from Physical Interaction	UniProtKB:Q00623	F	From MGI
	GO:0043534	blood vessel endothelial cell migration	MGI:MGI:3698572 PMID:16339487^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857127	P	From MGI
	GO:0043691	reverse cholesterol transport	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P02647	P	From MGI
	GO:0050713	negative regulation of interleukin-1 beta secretion	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P02647	P	From MGI
	GO:0050821	protein stabilization	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P02647	P	From MGI
	GO:0051345	positive regulation of hydrolase activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P02647	P	From MGI
	GO:0051346	negative regulation of hydrolase activity	MGI:MGI:3588626 PMID:15995171^[22]	IGI: Inferred from Genetic Interaction	MGI:MGI:104993	P	From MGI
	GO:0051347	positive regulation of transferase activity	MGI:MGI:3616112 PMID:16245952^[29]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857127	P	From MGI
	GO:0055102	lipase inhibitor activity	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P04639	F	From MGI
	GO:0060192	negative regulation of lipase activity	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P04639	P	From MGI
	GO:0060228	phosphatidylcholine-sterol O-acyltransferase activator activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P02647	F	From MGI
	GO:0070508	cholesterol import	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P02647	P	From MGI
	GO:0070653	high-density lipoprotein particle receptor binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P02647	F	From MGI
	GO:0071813	lipoprotein particle binding	MGI:MGI:68295 PMID:8049247^[24]	IDA: Inferred from Direct Assay		F	From MGI
NOT	GO:0008104	protein localization	MGI:MGI:1097296 PMID:9325076^[30]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857127	P	From MGI
NOT	GO:0031103	axon regeneration	MGI:MGI:70238 PMID:7798939^[15]	IGI: Inferred from Genetic Interaction	MGI:MGI:88057	P	From MGI
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Martinez LO et al. (2003) Phosphorylation of a pest sequence in ABCA1 promotes calpain degradation and is reversed by ApoA-I. J Biol Chem 278: 37368-74 PubMed GONUTS page
↑ ^2.0 ^2.1 Seetharam D et al. (2006) High-density lipoprotein promotes endothelial cell migration and reendothelialization via scavenger receptor-B type I. Circ Res 98: 63-72 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 Reschly EJ et al. (2002) Apolipoprotein A-I alpha -helices 7 and 8 modulate high density lipoprotein subclass distribution. J Biol Chem 277: 9645-54 PubMed GONUTS page
↑ Williamson R et al. (1992) Marked reduction of high density lipoprotein cholesterol in mice genetically modified to lack apolipoprotein A-I. Proc Natl Acad Sci U S A 89: 7134-8 PubMed GONUTS page
↑ Maric J et al. (2005) Intracellular lipidation of newly synthesized apolipoprotein A-I in primary murine hepatocytes. J Biol Chem 280: 39942-9 PubMed GONUTS page
↑ Wolfrum C et al. (2005) Apolipoprotein M is required for prebeta-HDL formation and cholesterol efflux to HDL and protects against atherosclerosis. Nat Med 11: 418-22 PubMed GONUTS page
↑ ^7.0 ^7.1 Webb NR et al. (1997) Adenoviral vector-mediated overexpression of serum amyloid A in apoA-I-deficient mice. J Lipid Res 38: 1583-90 PubMed GONUTS page
↑ ^8.0 ^8.1 Stein O et al. (1997) Delayed loss of cholesterol from a localized lipoprotein depot in apolipoprotein A-I-deficient mice. Proc Natl Acad Sci U S A 94: 9820-4 PubMed GONUTS page
↑ ^9.0 ^9.1 Voyiaziakis E et al. (1998) ApoA-I deficiency causes both hypertriglyceridemia and increased atherosclerosis in human apoB transgenic mice. J Lipid Res 39: 313-21 PubMed GONUTS page
↑ ^10.0 ^10.1 Cabana VG et al. (1999) SAA-only HDL formed during the acute phase response in apoA-I+/+ and apoA-I-/- mice. J Lipid Res 40: 1090-103 PubMed GONUTS page
↑ Francone OL et al. (2003) Abnormal phospholipid composition impairs HDL biogenesis and maturation in mice lacking Abca1. Biochemistry 42: 8569-78 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 Cabana VG et al. (2004) Influence of apoA-I and apoE on the formation of serum amyloid A-containing lipoproteins in vivo and in vitro. J Lipid Res 45: 317-25 PubMed GONUTS page
↑ Srivastava RA et al. (1992) Dietary fatty acids and dietary cholesterol differ in their effect on the in vivo regulation of apolipoprotein A-I and A-II gene expression in inbred strains of mice. Biochim Biophys Acta 1125: 251-61 PubMed GONUTS page
↑ Lusis AJ et al. (1983) Genetic control of lipid transport in mice. II. Genes controlling structure of high density lipoproteins. J Biol Chem 258: 5071-8 PubMed GONUTS page
↑ ^15.0 ^15.1 Goodrum JF et al. (1995) Nerve regeneration and cholesterol reutilization occur in the absence of apolipoproteins E and A-I in mice. J Neurochem 64: 408-16 PubMed GONUTS page
↑ ^16.0 ^16.1 Parks JS et al. (1995) Effect of apolipoprotein A-I deficiency on lecithin:cholesterol acyltransferase activation in mouse plasma. J Lipid Res 36: 349-55 PubMed GONUTS page
↑ ^17.0 ^17.1 Plump AS et al. (1997) ApoA-I knockout mice: characterization of HDL metabolism in homozygotes and identification of a post-RNA mechanism of apoA-I up-regulation in heterozygotes. J Lipid Res 38: 1033-47 PubMed GONUTS page
↑ ^18.0 ^18.1 Hajri T et al. (1998) The acute phase response in apolipoprotein A-1 knockout mice: apolipoprotein serum amyloid A and lipid distribution in plasma high density lipoproteins. Biochim Biophys Acta 1394: 209-18 PubMed GONUTS page
↑ ^19.0 ^19.1 ^19.2 ^19.3 Plump AS et al. (1996) Apolipoprotein A-I is required for cholesteryl ester accumulation in steroidogenic cells and for normal adrenal steroid production. J Clin Invest 97: 2660-71 PubMed GONUTS page
↑ Hughes SD et al. (1997) HDL deficiency in genetically engineered mice requires elevated LDL to accelerate atherogenesis. Arterioscler Thromb Vasc Biol 17: 1725-9 PubMed GONUTS page
↑ Fagan AM et al. (2004) ApoAI deficiency results in marked reductions in plasma cholesterol but no alterations in amyloid-beta pathology in a mouse model of Alzheimer's disease-like cerebral amyloidosis. Am J Pathol 165: 1413-22 PubMed GONUTS page
↑ ^22.0 ^22.1 ^22.2 Gruen ML et al. (2005) Persistence of high density lipoprotein particles in obese mice lacking apolipoprotein A-I. J Lipid Res 46: 2007-14 PubMed GONUTS page
↑ Zabalawi M et al. (2007) Inflammation and skin cholesterol in LDLr-/-, apoA-I-/- mice: link between cholesterol homeostasis and self-tolerance? J Lipid Res 48: 52-65 PubMed GONUTS page
↑ ^24.0 ^24.1 ^24.2 Gong EL et al. (1994) Structural and functional properties of human and mouse apolipoprotein A-I. Biochim Biophys Acta 1213: 335-42 PubMed GONUTS page
↑ ^25.0 ^25.1 Hirsch-Reinshagen V et al. (2004) Deficiency of ABCA1 impairs apolipoprotein E metabolism in brain. J Biol Chem 279: 41197-207 PubMed GONUTS page
↑ Boisvert WA et al. (1999) ApoA1 reduces free cholesterol accumulation in atherosclerotic lesions of ApoE-deficient mice transplanted with ApoE-expressing macrophages. Arterioscler Thromb Vasc Biol 19: 525-30 PubMed GONUTS page
↑ Fournier N et al. (1999) Fractional efflux and net change in cellular cholesterol content mediated by sera from mice expressing both human apolipoprotein AI and human lecithin:cholesterol acyltransferase genes. Atherosclerosis 147: 227-35 PubMed GONUTS page
↑ Spady DK et al. (1998) Kinetic characteristics and regulation of HDL cholesteryl ester and apolipoprotein transport in the apoA-I-/- mouse. J Lipid Res 39: 1483-92 PubMed GONUTS page
↑ ^29.0 ^29.1 Chroni A et al. (2005) Point mutations in apolipoprotein A-I mimic the phenotype observed in patients with classical lecithin:cholesterol acyltransferase deficiency. Biochemistry 44: 14353-66 PubMed GONUTS page
↑ Elliott-Bryant R & Cathcart ES (1997) Apolipoprotein E and apolipoprotein A-1 knock-out mice readily develop amyloid A protein amyloidosis. Clin Immunol Immunopathol 85: 104-8 PubMed GONUTS page

[PMID:12869555-0] 1.0 ^1.1 Martinez LO et al. (2003) Phosphorylation of a pest sequence in ABCA1 promotes calpain degradation and is reversed by ApoA-I. J Biol Chem 278: 37368-74 PubMed GONUTS page

[PMID:16339487-1] 2.0 ^2.1 Seetharam D et al. (2006) High-density lipoprotein promotes endothelial cell migration and reendothelialization via scavenger receptor-B type I. Circ Res 98: 63-72 PubMed GONUTS page

[PMID:11744719-2] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 Reschly EJ et al. (2002) Apolipoprotein A-I alpha -helices 7 and 8 modulate high density lipoprotein subclass distribution. J Biol Chem 277: 9645-54 PubMed GONUTS page

[PMID:1496008-3] Williamson R et al. (1992) Marked reduction of high density lipoprotein cholesterol in mice genetically modified to lack apolipoprotein A-I. Proc Natl Acad Sci U S A 89: 7134-8 PubMed GONUTS page

[PMID:16204232-4] Maric J et al. (2005) Intracellular lipidation of newly synthesized apolipoprotein A-I in primary murine hepatocytes. J Biol Chem 280: 39942-9 PubMed GONUTS page

[PMID:15793583-5] Wolfrum C et al. (2005) Apolipoprotein M is required for prebeta-HDL formation and cholesterol efflux to HDL and protects against atherosclerosis. Nat Med 11: 418-22 PubMed GONUTS page

[PMID:9300780-6] 7.0 ^7.1 Webb NR et al. (1997) Adenoviral vector-mediated overexpression of serum amyloid A in apoA-I-deficient mice. J Lipid Res 38: 1583-90 PubMed GONUTS page

[PMID:9275209-7] 8.0 ^8.1 Stein O et al. (1997) Delayed loss of cholesterol from a localized lipoprotein depot in apolipoprotein A-I-deficient mice. Proc Natl Acad Sci U S A 94: 9820-4 PubMed GONUTS page

[PMID:9507992-8] 9.0 ^9.1 Voyiaziakis E et al. (1998) ApoA-I deficiency causes both hypertriglyceridemia and increased atherosclerosis in human apoB transgenic mice. J Lipid Res 39: 313-21 PubMed GONUTS page

[PMID:10357841-9] 10.0 ^10.1 Cabana VG et al. (1999) SAA-only HDL formed during the acute phase response in apoA-I+/+ and apoA-I-/- mice. J Lipid Res 40: 1090-103 PubMed GONUTS page

[PMID:12859204-10] Francone OL et al. (2003) Abnormal phospholipid composition impairs HDL biogenesis and maturation in mice lacking Abca1. Biochemistry 42: 8569-78 PubMed GONUTS page

[PMID:14595002-11] 12.0 ^12.1 ^12.2 Cabana VG et al. (2004) Influence of apoA-I and apoE on the formation of serum amyloid A-containing lipoproteins in vivo and in vitro. J Lipid Res 45: 317-25 PubMed GONUTS page

[PMID:1596514-12] Srivastava RA et al. (1992) Dietary fatty acids and dietary cholesterol differ in their effect on the in vivo regulation of apolipoprotein A-I and A-II gene expression in inbred strains of mice. Biochim Biophys Acta 1125: 251-61 PubMed GONUTS page

[PMID:6403543-13] Lusis AJ et al. (1983) Genetic control of lipid transport in mice. II. Genes controlling structure of high density lipoproteins. J Biol Chem 258: 5071-8 PubMed GONUTS page

[PMID:7798939-14] 15.0 ^15.1 Goodrum JF et al. (1995) Nerve regeneration and cholesterol reutilization occur in the absence of apolipoproteins E and A-I in mice. J Neurochem 64: 408-16 PubMed GONUTS page

[PMID:7751823-15] 16.0 ^16.1 Parks JS et al. (1995) Effect of apolipoprotein A-I deficiency on lecithin:cholesterol acyltransferase activation in mouse plasma. J Lipid Res 36: 349-55 PubMed GONUTS page

[PMID:9186920-16] 17.0 ^17.1 Plump AS et al. (1997) ApoA-I knockout mice: characterization of HDL metabolism in homozygotes and identification of a post-RNA mechanism of apoA-I up-regulation in heterozygotes. J Lipid Res 38: 1033-47 PubMed GONUTS page

[PMID:9795222-17] 18.0 ^18.1 Hajri T et al. (1998) The acute phase response in apolipoprotein A-1 knockout mice: apolipoprotein serum amyloid A and lipid distribution in plasma high density lipoproteins. Biochim Biophys Acta 1394: 209-18 PubMed GONUTS page

[PMID:8647961-18] 19.0 ^19.1 ^19.2 ^19.3 Plump AS et al. (1996) Apolipoprotein A-I is required for cholesteryl ester accumulation in steroidogenic cells and for normal adrenal steroid production. J Clin Invest 97: 2660-71 PubMed GONUTS page

[PMID:9327769-19] Hughes SD et al. (1997) HDL deficiency in genetically engineered mice requires elevated LDL to accelerate atherogenesis. Arterioscler Thromb Vasc Biol 17: 1725-9 PubMed GONUTS page

[PMID:15466405-20] Fagan AM et al. (2004) ApoAI deficiency results in marked reductions in plasma cholesterol but no alterations in amyloid-beta pathology in a mouse model of Alzheimer's disease-like cerebral amyloidosis. Am J Pathol 165: 1413-22 PubMed GONUTS page

[PMID:15995171-21] 22.0 ^22.1 ^22.2 Gruen ML et al. (2005) Persistence of high density lipoprotein particles in obese mice lacking apolipoprotein A-I. J Lipid Res 46: 2007-14 PubMed GONUTS page

[PMID:17071966-22] Zabalawi M et al. (2007) Inflammation and skin cholesterol in LDLr-/-, apoA-I-/- mice: link between cholesterol homeostasis and self-tolerance? J Lipid Res 48: 52-65 PubMed GONUTS page

[PMID:8049247-23] 24.0 ^24.1 ^24.2 Gong EL et al. (1994) Structural and functional properties of human and mouse apolipoprotein A-I. Biochim Biophys Acta 1213: 335-42 PubMed GONUTS page

[PMID:15269218-24] 25.0 ^25.1 Hirsch-Reinshagen V et al. (2004) Deficiency of ABCA1 impairs apolipoprotein E metabolism in brain. J Biol Chem 279: 41197-207 PubMed GONUTS page

[PMID:10073953-25] Boisvert WA et al. (1999) ApoA1 reduces free cholesterol accumulation in atherosclerotic lesions of ApoE-deficient mice transplanted with ApoE-expressing macrophages. Arterioscler Thromb Vasc Biol 19: 525-30 PubMed GONUTS page

[PMID:10559507-26] Fournier N et al. (1999) Fractional efflux and net change in cellular cholesterol content mediated by sera from mice expressing both human apolipoprotein AI and human lecithin:cholesterol acyltransferase genes. Atherosclerosis 147: 227-35 PubMed GONUTS page

[PMID:9684752-27] Spady DK et al. (1998) Kinetic characteristics and regulation of HDL cholesteryl ester and apolipoprotein transport in the apoA-I-/- mouse. J Lipid Res 39: 1483-92 PubMed GONUTS page

[PMID:16245952-28] 29.0 ^29.1 Chroni A et al. (2005) Point mutations in apolipoprotein A-I mimic the phenotype observed in patients with classical lecithin:cholesterol acyltransferase deficiency. Biochemistry 44: 14353-66 PubMed GONUTS page

[PMID:9325076-29] Elliott-Bryant R & Cathcart ES (1997) Apolipoprotein E and apolipoprotein A-1 knock-out mice readily develop amyloid A protein amyloidosis. Clin Immunol Immunopathol 85: 104-8 PubMed GONUTS page

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Species (Taxon ID)	Mus musculus (house mouse) (taxon:10090)
Gene Name(s)	Apoa1 ( synonyms: Alp-1, Apoa-1, Brp-14, Ltw-1, Lvtw-1, Sep-1, Sep-2, Sep2 )
Protein Name(s)	apolipoprotein A-I,
External Links
MGI	MGI:88049

MGI:Apoa1

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