Ambox notice.png

GONUTS is under stress! The website is currently experiencing long-wait times and frequent time-outs due to the record number of students, groups, and annotations related to CACAO this semester. We are currently working on increasing performance -- please accept our apologies for the technical difficulties.

You can help reduce stress on the server by:

  1. not reloading pages frequently - this just adds
  2. opening links in new windows (so you can read the old page)

MGI:Apc

From GONUTS
Jump to: navigation, search

Contents

Species (Taxon ID) Mus musculus (house mouse) (taxon:10090)
Gene Name(s) Apc ( synonyms: CC1, Min )
Protein Name(s) adenomatosis polyposis coli,
External Links
MGI MGI:88039

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000281

cytokinesis after mitosis

MGI:MGI:2154458

ISO: Inferred from Sequence Orthology

UniProtKB:P25054

P

From MGI

GO:0000281

cytokinesis after mitosis

MGI:MGI:3759948
PMID:17570218[1]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857951

P

From MGI

GO:0000281

cytokinesis after mitosis

MGI:MGI:3789811
PMID:17893240[2]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1856318

P

From MGI

GO:0000776

kinetochore

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P25054

C

From MGI

GO:0001822

kidney development

MGI:MGI:3526227
PMID:15550389[3]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857966

P

From MGI

GO:0001942

hair follicle development

MGI:MGI:3688426
PMID:17002498[4]

IMP: Inferred from Mutant Phenotype

MGI:MGI:3688435

P

From MGI

GO:0005515

protein binding

MGI:MGI:3053243
PMID:15327768[5]

IPI: Inferred from Physical Interaction

UniProtKB:Q02248

F

From MGI

GO:0005634

nucleus

MGI:MGI:1337926
PMID:10346819[6]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005634

nucleus

MGI:MGI:2154458

ISO: Inferred from Sequence Orthology

UniProtKB:P25054

C

From MGI

GO:0005634

nucleus

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P70478

C

From MGI

GO:0005737

cytoplasm

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P70478

C

From MGI

GO:0005737

cytoplasm

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P25054

C

From MGI

GO:0005737

cytoplasm

MGI:MGI:81094
PMID:8670282[7]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005813

centrosome

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P25054

C

From MGI

GO:0005874

microtubule

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P70478

C

From MGI

GO:0005881

cytoplasmic microtubule

MGI:MGI:3656452
PMID:16525027[8]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005881

cytoplasmic microtubule

MGI:MGI:3689461
PMID:16621792[9]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005886

plasma membrane

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P25054

C

From MGI

GO:0005923

tight junction

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P25054

C

From MGI

GO:0006461

protein complex assembly

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P25054

P

From MGI

GO:0006974

response to DNA damage stimulus

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P25054

P

From MGI

GO:0007026

negative regulation of microtubule depolymerization

MGI:MGI:2154458

ISO: Inferred from Sequence Orthology

UniProtKB:P25054

P

From MGI

GO:0007026

negative regulation of microtubule depolymerization

MGI:MGI:3656452
PMID:16525027[8]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0007050

cell cycle arrest

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P25054

P

From MGI

GO:0007091

mitotic metaphase/anaphase transition

MGI:MGI:3574170
PMID:15767571[10]

IGI: Inferred from Genetic Interaction

MGI:MGI:1333889

P

From MGI

GO:0007091

mitotic metaphase/anaphase transition

MGI:MGI:3574170
PMID:15767571[10]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1856318

P

From MGI

GO:0007091

mitotic metaphase/anaphase transition

MGI:MGI:3588595
PMID:16025118[11]

IMP: Inferred from Mutant Phenotype

MGI:MGI:3589207

P

From MGI

GO:0007094

mitotic cell cycle spindle assembly checkpoint

MGI:MGI:2154458

ISO: Inferred from Sequence Orthology

UniProtKB:P25054

P

From MGI

GO:0007163

establishment or maintenance of cell polarity

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P70478

P

From MGI

GO:0007389

pattern specification process

MGI:MGI:3629263
PMID:16740478[12]

IMP: Inferred from Mutant Phenotype

MGI:MGI:3521822

P

From MGI

GO:0007409

axonogenesis

MGI:MGI:3047466
PMID:15207235[13]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0007409

axonogenesis

MGI:MGI:3806438
PMID:18716223[14]

IGI: Inferred from Genetic Interaction

MGI:MGI:98956

P

From MGI

GO:0007409

axonogenesis

MGI:MGI:3806438
PMID:18716223[14]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0008013

beta-catenin binding

MGI:MGI:1337926
PMID:10346819[6]

IDA: Inferred from Direct Assay

F

From MGI

GO:0008013

beta-catenin binding

MGI:MGI:2677113
PMID:12874278[15]

IPI: Inferred from Physical Interaction

UniProtKB:Q02248

F

From MGI

GO:0008013

beta-catenin binding

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P25054

F

From MGI

GO:0008017

microtubule binding

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P70478

F

From MGI

GO:0008017

microtubule binding

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P25054

F

From MGI

GO:0008285

negative regulation of cell proliferation

MGI:MGI:1096206
PMID:9288104[16]

IGI: Inferred from Genetic Interaction

MGI:MGI:104642

P

From MGI

GO:0008285

negative regulation of cell proliferation

MGI:MGI:1197404
PMID:9506519[17]

IGI: Inferred from Genetic Interaction

MGI:MGI:894293

P

From MGI

GO:0008285

negative regulation of cell proliferation

MGI:MGI:1197836
PMID:9515784[18]

IGI: Inferred from Genetic Interaction

MGI:MGI:104288

P

From MGI

GO:0008285

negative regulation of cell proliferation

MGI:MGI:1316850
PMID:9865728[19]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857951

P

From MGI

GO:0008285

negative regulation of cell proliferation

MGI:MGI:1327734
PMID:9927046[20]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857951

P

From MGI

GO:0008285

negative regulation of cell proliferation

MGI:MGI:1335981
PMID:10334197[21]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857951

P

From MGI

GO:0008285

negative regulation of cell proliferation

MGI:MGI:1346383
PMID:10506110[22]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1856318

P

From MGI

GO:0008285

negative regulation of cell proliferation

MGI:MGI:1351166
PMID:10626800[23]

IGI: Inferred from Genetic Interaction

MGI:MGI:894293

P

From MGI

GO:0008285

negative regulation of cell proliferation

MGI:MGI:1351747
PMID:10535960[24]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1856318

P

From MGI

GO:0008285

negative regulation of cell proliferation

MGI:MGI:1354560
PMID:10716720[25]

IGI: Inferred from Genetic Interaction

MGI:MGI:98834
MGI:MGI:104642

P

From MGI

GO:0008285

negative regulation of cell proliferation

MGI:MGI:1354571
PMID:10708962[26]

IGI: Inferred from Genetic Interaction

MGI:MGI:894293

P

From MGI

GO:0008285

negative regulation of cell proliferation

MGI:MGI:1855839
PMID:10783317[27]

IGI: Inferred from Genetic Interaction

MGI:MGI:97798

P

From MGI

GO:0008285

negative regulation of cell proliferation

MGI:MGI:1861347
PMID:10919675[28]

IGI: Inferred from Genetic Interaction

MGI:MGI:104642
MGI:MGI:94912

P

From MGI

GO:0008285

negative regulation of cell proliferation

MGI:MGI:1889178
PMID:10987272[29]

IGI: Inferred from Genetic Interaction

MGI:MGI:97797
MGI:MGI:97798

P

From MGI

GO:0008285

negative regulation of cell proliferation

MGI:MGI:1926681
PMID:10969066[30]

IGI: Inferred from Genetic Interaction

MGI:MGI:1195256

P

From MGI

GO:0008285

negative regulation of cell proliferation

MGI:MGI:1930688
PMID:11197776[31]

IGI: Inferred from Genetic Interaction

MGI:MGI:894293

P

From MGI

GO:0008285

negative regulation of cell proliferation

MGI:MGI:1932776
PMID:11274413[32]

IGI: Inferred from Genetic Interaction

MGI:MGI:104642

P

From MGI

GO:0008285

negative regulation of cell proliferation

MGI:MGI:1932795
PMID:11245490[33]

IGI: Inferred from Genetic Interaction

MGI:MGI:97798

P

From MGI

GO:0008285

negative regulation of cell proliferation

MGI:MGI:1933698
PMID:11309311[34]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1856318

P

From MGI

GO:0008285

negative regulation of cell proliferation

MGI:MGI:2135372
PMID:11381263[35]

IGI: Inferred from Genetic Interaction

MGI:MGI:109558

P

From MGI

GO:0008285

negative regulation of cell proliferation

MGI:MGI:2148459
PMID:11478486[36]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1856318

P

From MGI

GO:0008285

negative regulation of cell proliferation

MGI:MGI:2150286
PMID:11533709[37]

IGI: Inferred from Genetic Interaction

MGI:MGI:97794

P

From MGI

GO:0008285

negative regulation of cell proliferation

MGI:MGI:2150533
PMID:11559569[38]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0008285

negative regulation of cell proliferation

MGI:MGI:2151649
PMID:11606502[39]

IGI: Inferred from Genetic Interaction

MGI:MGI:97361

P

From MGI

GO:0008285

negative regulation of cell proliferation

MGI:MGI:2154629
PMID:11731407[40]

IGI: Inferred from Genetic Interaction

MGI:MGI:97361

P

From MGI

GO:0008285

negative regulation of cell proliferation

MGI:MGI:2157288
PMID:11809702[41]

IGI: Inferred from Genetic Interaction

MGI:MGI:97798
MGI:MGI:894293

P

From MGI

GO:0008285

negative regulation of cell proliferation

MGI:MGI:2157680
PMID:11385109[42]

IGI: Inferred from Genetic Interaction

MGI:MGI:95294

P

From MGI

GO:0008285

negative regulation of cell proliferation

MGI:MGI:2177999
PMID:11773073[43]

IGI: Inferred from Genetic Interaction

MGI:MGI:1914186

P

From MGI

GO:0008285

negative regulation of cell proliferation

MGI:MGI:2388776
PMID:12370429[44]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857951

P

From MGI

GO:0008285

negative regulation of cell proliferation

MGI:MGI:3044547
PMID:15198980[45]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857966

P

From MGI

GO:0008285

negative regulation of cell proliferation

MGI:MGI:3057261
PMID:15380519[46]

IGI: Inferred from Genetic Interaction

MGI:MGI:101884

P

From MGI

GO:0008285

negative regulation of cell proliferation

MGI:MGI:3513734
PMID:15563600[47]

IMP: Inferred from Mutant Phenotype

MGI:MGI:3521822

P

From MGI

GO:0008285

negative regulation of cell proliferation

MGI:MGI:3526227
PMID:15550389[3]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857966

P

From MGI

GO:0008285

negative regulation of cell proliferation

MGI:MGI:3530699
PMID:15684064[48]

IGI: Inferred from Genetic Interaction

MGI:MGI:1346834

P

From MGI

GO:0008285

negative regulation of cell proliferation

MGI:MGI:3582085
PMID:15958588[49]

IGI: Inferred from Genetic Interaction

MGI:MGI:98233

P

From MGI

GO:0008285

negative regulation of cell proliferation

MGI:MGI:3604168
PMID:16007074[50]

IGI: Inferred from Genetic Interaction

MGI:MGI:96646

P

From MGI

GO:0008285

negative regulation of cell proliferation

MGI:MGI:3618985
PMID:16478791[51]

IGI: Inferred from Genetic Interaction

MGI:MGI:96224

P

From MGI

GO:0008285

negative regulation of cell proliferation

MGI:MGI:3707270
PMID:16638711[52]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857951

P

From MGI

GO:0008285

negative regulation of cell proliferation

MGI:MGI:3710040
PMID:17377531[53]

IGI: Inferred from Genetic Interaction

MGI:MGI:97250

P

From MGI

GO:0008285

negative regulation of cell proliferation

MGI:MGI:3715053
PMID:17371273[54]

IGI: Inferred from Genetic Interaction

MGI:MGI:98233

P

From MGI

GO:0008285

negative regulation of cell proliferation

MGI:MGI:3715559
PMID:17615359[55]

IGI: Inferred from Genetic Interaction

MGI:MGI:108005

P

From MGI

GO:0008285

negative regulation of cell proliferation

MGI:MGI:3719960
PMID:17671182[56]

IGI: Inferred from Genetic Interaction

MGI:MGI:1342287

P

From MGI

GO:0008285

negative regulation of cell proliferation

MGI:MGI:3720546
PMID:17596282[57]

IGI: Inferred from Genetic Interaction

MGI:MGI:97250

P

From MGI

GO:0008285

negative regulation of cell proliferation

MGI:MGI:3720546
PMID:17596282[57]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857966

P

From MGI

GO:0008285

negative regulation of cell proliferation

MGI:MGI:3722725
PMID:17875695[58]

IGI: Inferred from Genetic Interaction

MGI:MGI:103298

P

From MGI

GO:0008285

negative regulation of cell proliferation

MGI:MGI:3761904
PMID:17681179[59]

IGI: Inferred from Genetic Interaction

MGI:MGI:106923

P

From MGI

GO:0008285

negative regulation of cell proliferation

MGI:MGI:3762318
PMID:17893885[60]

IGI: Inferred from Genetic Interaction

MGI:MGI:97611

P

From MGI

GO:0008285

negative regulation of cell proliferation

MGI:MGI:3763775
PMID:17989230[61]

IGI: Inferred from Genetic Interaction

MGI:MGI:88274

P

From MGI

GO:0008285

negative regulation of cell proliferation

MGI:MGI:3771668
PMID:18056981[62]

IGI: Inferred from Genetic Interaction

MGI:MGI:96559

P

From MGI

GO:0008285

negative regulation of cell proliferation

MGI:MGI:3773114
PMID:17956267[63]

IGI: Inferred from Genetic Interaction

MGI:MGI:97595

P

From MGI

GO:0008285

negative regulation of cell proliferation

MGI:MGI:3778712
PMID:18258607[64]

IGI: Inferred from Genetic Interaction

MGI:MGI:97608

P

From MGI

GO:0008285

negative regulation of cell proliferation

MGI:MGI:3797426
PMID:18485889[65]

IGI: Inferred from Genetic Interaction

MGI:MGI:1927593

P

From MGI

GO:0008285

negative regulation of cell proliferation

MGI:MGI:3805661
PMID:18464259[66]

IGI: Inferred from Genetic Interaction

MGI:MGI:109392

P

From MGI

GO:0008285

negative regulation of cell proliferation

MGI:MGI:3806435
PMID:18719115[67]

IGI: Inferred from Genetic Interaction

MGI:MGI:95891

P

From MGI

GO:0008285

negative regulation of cell proliferation

MGI:MGI:3807093
PMID:18656477[68]

IGI: Inferred from Genetic Interaction

MGI:MGI:95294
MGI:MGI:99439

P

From MGI

GO:0008285

negative regulation of cell proliferation

MGI:MGI:3807093
PMID:18656477[68]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1856318

P

From MGI

GO:0008285

negative regulation of cell proliferation

MGI:MGI:3810244
PMID:17299058[69]

IGI: Inferred from Genetic Interaction

MGI:MGI:98373

P

From MGI

GO:0008285

negative regulation of cell proliferation

MGI:MGI:3813409
PMID:18644872[70]

IGI: Inferred from Genetic Interaction

MGI:MGI:1333813

P

From MGI

GO:0008285

negative regulation of cell proliferation

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P25054

P

From MGI

GO:0008285

negative regulation of cell proliferation

MGI:MGI:69758
PMID:7954428[71]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1856318

P

From MGI

GO:0008285

negative regulation of cell proliferation

MGI:MGI:84229
PMID:8945508[72]

IGI: Inferred from Genetic Interaction

MGI:MGI:97798

P

From MGI

GO:0008285

negative regulation of cell proliferation

MGI:MGI:84229
PMID:8945508[72]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857957

P

From MGI

GO:0008285

negative regulation of cell proliferation

MGI:MGI:84625
PMID:8978063[73]

IGI: Inferred from Genetic Interaction

MGI:MGI:104642

P

From MGI

GO:0008285

negative regulation of cell proliferation

MGI:MGI:84626
PMID:8978062[74]

IGI: Inferred from Genetic Interaction

MGI:MGI:104642

P

From MGI

GO:0008285

negative regulation of cell proliferation

MGI:MGI:87478
PMID:9135000[75]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1856318

P

From MGI

GO:0008285

negative regulation of cell proliferation

MGI:MGI:892642
PMID:9159163[76]

IGI: Inferred from Genetic Interaction

MGI:MGI:104642

P

From MGI

GO:0009798

axis specification

MGI:MGI:2449253
PMID:12645927[77]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2449944

P

From MGI

GO:0009952

anterior/posterior pattern specification

MGI:MGI:2449253
PMID:12645927[77]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2449944

P

From MGI

GO:0009953

dorsal/ventral pattern formation

MGI:MGI:2449253
PMID:12645927[77]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2449944

P

From MGI

GO:0009954

proximal/distal pattern formation

MGI:MGI:3655896
PMID:16887818[78]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1856318

P

From MGI

GO:0016055

Wnt receptor signaling pathway

MGI:MGI:1337926
PMID:10346819[6]

IDA: Inferred from Direct Assay

P

From MGI

GO:0016055

Wnt receptor signaling pathway

MGI:MGI:2449253
PMID:12645927[77]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2449944

P

From MGI

GO:0016328

lateral plasma membrane

MGI:MGI:2154458

ISO: Inferred from Sequence Orthology

UniProtKB:P25054

C

From MGI

GO:0016477

cell migration

MGI:MGI:3044547
PMID:15198980[45]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857966

P

From MGI

GO:0016477

cell migration

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P25054

P

From MGI

GO:0019827

stem cell maintenance

MGI:MGI:3806418
PMID:18725524[79]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857966

P

From MGI

GO:0019887

protein kinase regulator activity

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P25054

F

From MGI

GO:0019901

protein kinase binding

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P25054

F

From MGI

GO:0030027

lamellipodium

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P25054

C

From MGI

GO:0030178

negative regulation of Wnt receptor signaling pathway

MGI:MGI:2156303
PMID:11756652[80]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857966

P

From MGI

GO:0030178

negative regulation of Wnt receptor signaling pathway

MGI:MGI:3044547
PMID:15198980[45]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857966

P

From MGI

GO:0030178

negative regulation of Wnt receptor signaling pathway

MGI:MGI:3513734
PMID:15563600[47]

IMP: Inferred from Mutant Phenotype

MGI:MGI:3521822

P

From MGI

GO:0030178

negative regulation of Wnt receptor signaling pathway

MGI:MGI:3526227
PMID:15550389[3]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857966

P

From MGI

GO:0030178

negative regulation of Wnt receptor signaling pathway

MGI:MGI:3629263
PMID:16740478[12]

IMP: Inferred from Mutant Phenotype

MGI:MGI:3521822

P

From MGI

GO:0030178

negative regulation of Wnt receptor signaling pathway

MGI:MGI:3655896
PMID:16887818[78]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1856318

P

From MGI

GO:0030178

negative regulation of Wnt receptor signaling pathway

MGI:MGI:3706260
PMID:17363566[81]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857966
MGI:MGI:2385927

P

From MGI

GO:0030178

negative regulation of Wnt receptor signaling pathway

MGI:MGI:3813409
PMID:18644872[70]

IGI: Inferred from Genetic Interaction

MGI:MGI:1333813

P

From MGI

GO:0030334

regulation of cell migration

MGI:MGI:1099354
PMID:9371501[82]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1856318

P

From MGI

GO:0030334

regulation of cell migration

MGI:MGI:3710040
PMID:17377531[53]

IGI: Inferred from Genetic Interaction

MGI:MGI:97250

P

From MGI

GO:0030335

positive regulation of cell migration

MGI:MGI:2154458

ISO: Inferred from Sequence Orthology

UniProtKB:P25054

P

From MGI

GO:0030335

positive regulation of cell migration

MGI:MGI:3720409
PMID:17192415[83]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0030426

growth cone

MGI:MGI:3047466
PMID:15207235[13]

IDA: Inferred from Direct Assay

C

From MGI

GO:0030426

growth cone

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P70478

C

From MGI

GO:0030856

regulation of epithelial cell differentiation

MGI:MGI:3640757
PMID:9771477[84]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1856318

P

From MGI

GO:0030858

positive regulation of epithelial cell differentiation

MGI:MGI:3054506
PMID:15314168[85]

IGI: Inferred from Genetic Interaction

MGI:MGI:88313

P

From MGI

GO:0030877

beta-catenin destruction complex

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P25054

C

From MGI

GO:0031116

positive regulation of microtubule polymerization

MGI:MGI:3656452
PMID:16525027[8]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0031122

cytoplasmic microtubule organization

MGI:MGI:3806438
PMID:18716223[14]

IGI: Inferred from Genetic Interaction

MGI:MGI:98956

P

From MGI

GO:0031175

neuron projection development

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P70478

P

From MGI

GO:0031253

cell projection membrane

MGI:MGI:3689461
PMID:16621792[9]

IDA: Inferred from Direct Assay

C

From MGI

GO:0031274

positive regulation of pseudopodium assembly

MGI:MGI:2154458

ISO: Inferred from Sequence Orthology

UniProtKB:P25054

P

From MGI

GO:0032587

ruffle membrane

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P25054

C

From MGI

GO:0032886

regulation of microtubule-based process

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P25054

P

From MGI

GO:0033077

T cell differentiation in thymus

MGI:MGI:3588595
PMID:16025118[11]

IMP: Inferred from Mutant Phenotype

MGI:MGI:3589207

P

From MGI

GO:0033267

axon part

MGI:MGI:3047466
PMID:15207235[13]

IDA: Inferred from Direct Assay

C

From MGI

GO:0034742

APC-Axin-1-beta-catenin complex

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P25054

C

From MGI

GO:0034747

Axin-APC-beta-catenin-GSK3B complex

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P25054

C

From MGI

GO:0035019

somatic stem cell maintenance

MGI:MGI:50403
PMID:1541640[86]

IGI: Inferred from Genetic Interaction

MGI:MGI:104642

P

From MGI

GO:0035019

somatic stem cell maintenance

MGI:MGI:50403
PMID:1541640[86]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1856318

P

From MGI

GO:0035371

microtubule plus end

MGI:MGI:3806438
PMID:18716223[14]

IDA: Inferred from Direct Assay

C

From MGI

GO:0042483

negative regulation of odontogenesis

MGI:MGI:3688426
PMID:17002498[4]

IMP: Inferred from Mutant Phenotype

MGI:MGI:3688435

P

From MGI

GO:0042981

regulation of apoptotic process

MGI:MGI:3710040
PMID:17377531[53]

IGI: Inferred from Genetic Interaction

MGI:MGI:97250

P

From MGI

GO:0042995

cell projection

MGI:MGI:3656452
PMID:16525027[8]

IDA: Inferred from Direct Assay

C

From MGI

GO:0043025

neuronal cell body

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P70478

C

From MGI

GO:0043065

positive regulation of apoptotic process

MGI:MGI:2154458

ISO: Inferred from Sequence Orthology

UniProtKB:P25054

P

From MGI

GO:0043065

positive regulation of apoptotic process

MGI:MGI:3701148
PMID:17227893[87]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0043066

negative regulation of apoptotic process

MGI:MGI:2156303
PMID:11756652[80]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857966

P

From MGI

GO:0043066

negative regulation of apoptotic process

MGI:MGI:3703680
PMID:16950562[88]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1856318

P

From MGI

GO:0043409

negative regulation of MAPK cascade

MGI:MGI:3618985
PMID:16478791[51]

IGI: Inferred from Genetic Interaction

MGI:MGI:88276

P

From MGI

GO:0043409

negative regulation of MAPK cascade

MGI:MGI:3618985
PMID:16478791[51]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0043588

skin development

MGI:MGI:1196847
PMID:9453487[89]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857951

P

From MGI

GO:0044295

axonal growth cone

MGI:MGI:3806438
PMID:18716223[14]

IDA: Inferred from Direct Assay

C

From MGI

GO:0045295

gamma-catenin binding

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P25054

F

From MGI

GO:0045595

regulation of cell differentiation

MGI:MGI:3710040
PMID:17377531[53]

IGI: Inferred from Genetic Interaction

MGI:MGI:97250

P

From MGI

GO:0045597

positive regulation of cell differentiation

MGI:MGI:3044547
PMID:15198980[45]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857966

P

From MGI

GO:0045597

positive regulation of cell differentiation

MGI:MGI:3715400
PMID:16709231[90]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1856318

P

From MGI

GO:0045667

regulation of osteoblast differentiation

MGI:MGI:3584206
PMID:15802266[91]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857966

P

From MGI

GO:0045670

regulation of osteoclast differentiation

MGI:MGI:3584206
PMID:15802266[91]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857966

P

From MGI

GO:0045732

positive regulation of protein catabolic process

MGI:MGI:2154458

ISO: Inferred from Sequence Orthology

UniProtKB:P25054

P

From MGI

GO:0045732

positive regulation of protein catabolic process

MGI:MGI:3618985
PMID:16478791[51]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0045736

negative regulation of cyclin-dependent protein kinase activity

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P25054

P

From MGI

GO:0045785

positive regulation of cell adhesion

MGI:MGI:3616385
PMID:16368433[92]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1856318

P

From MGI

GO:0046716

muscle cell homeostasis

MGI:MGI:3771668
PMID:18056981[62]

IGI: Inferred from Genetic Interaction

MGI:MGI:96559

P

From MGI

GO:0048538

thymus development

MGI:MGI:3588595
PMID:16025118[11]

IMP: Inferred from Mutant Phenotype

MGI:MGI:3589207

P

From MGI

GO:0048538

thymus development

MGI:MGI:3688426
PMID:17002498[4]

IMP: Inferred from Mutant Phenotype

MGI:MGI:3688435

P

From MGI

GO:0050680

negative regulation of epithelial cell proliferation

MGI:MGI:1329759
PMID:10451698[93]

IGI: Inferred from Genetic Interaction

MGI:MGI:104642

P

From MGI

GO:0050680

negative regulation of epithelial cell proliferation

MGI:MGI:3029148
PMID:14758356[94]

IGI: Inferred from Genetic Interaction

MGI:MGI:101884

P

From MGI

GO:0050680

negative regulation of epithelial cell proliferation

MGI:MGI:85996
PMID:9037065[95]

IGI: Inferred from Genetic Interaction

MGI:MGI:1857932

P

From MGI

GO:0050680

negative regulation of epithelial cell proliferation

MGI:MGI:86316
PMID:9060821[96]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1856318

P

From MGI

GO:0051010

microtubule plus-end binding

MGI:MGI:3806438
PMID:18716223[14]

IDA: Inferred from Direct Assay

F

From MGI

GO:0051010

microtubule plus-end binding

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P25054

F

From MGI

GO:0051171

regulation of nitrogen compound metabolic process

MGI:MGI:3629263
PMID:16740478[12]

IMP: Inferred from Mutant Phenotype

MGI:MGI:3521822

P

From MGI

GO:0051276

chromosome organization

MGI:MGI:3695814
PMID:17200209[97]

IGI: Inferred from Genetic Interaction

MGI:MGI:98834

P

From MGI

GO:0051276

chromosome organization

MGI:MGI:3695814
PMID:17200209[97]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857951

P

From MGI

GO:0051726

regulation of cell cycle

MGI:MGI:84840
PMID:8988060[98]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1856318

P

From MGI

GO:0051781

positive regulation of cell division

MGI:MGI:3703680
PMID:16950562[88]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1856318

P

From MGI

GO:0051988

regulation of attachment of spindle microtubules to kinetochore

MGI:MGI:2154458

ISO: Inferred from Sequence Orthology

UniProtKB:P25054

P

From MGI

GO:0051988

regulation of attachment of spindle microtubules to kinetochore

MGI:MGI:3701148
PMID:17227893[87]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0060041

retina development in camera-type eye

MGI:MGI:3699582
PMID:10982921[99]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857951

P

From MGI

GO:0060070

canonical Wnt receptor signaling pathway

MGI:MGI:2156303
PMID:11756652[80]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857966

P

From MGI

GO:0060070

canonical Wnt receptor signaling pathway

MGI:MGI:3044547
PMID:15198980[45]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857966

P

From MGI

GO:0060070

canonical Wnt receptor signaling pathway

MGI:MGI:3513734
PMID:15563600[47]

IMP: Inferred from Mutant Phenotype

MGI:MGI:3521822

P

From MGI

GO:0060070

canonical Wnt receptor signaling pathway

MGI:MGI:3655896
PMID:16887818[78]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1856318

P

From MGI

GO:0060770

negative regulation of epithelial cell proliferation involved in prostate gland development

MGI:MGI:3706260
PMID:17363566[81]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857966
MGI:MGI:2385927

P

From MGI

GO:0090090

negative regulation of canonical Wnt receptor signaling pathway

MGI:MGI:2154458

ISO: Inferred from Sequence Orthology

UniProtKB:P25054

P

From MGI

colocalizes_with

GO:0043005

neuron projection

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P70478

C

From MGI

colocalizes_with

GO:0045202

synapse

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P70478

C

From MGI


edit table

Notes

References

See Help:References for how to manage references in GONUTS.
  1. ↑ Abal M et al. (2007) APC inactivation associates with abnormal mitosis completion and concomitant BUB1B/MAD2L1 up-regulation. Gastroenterology 132: 2448-58 PubMed GONUTS page
  2. ↑ Caldwell CM et al. (2007) APC mutations lead to cytokinetic failures in vitro and tetraploid genotypes in Min mice. J Cell Biol 178: 1109-20 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 Qian CN et al. (2005) Cystic renal neoplasia following conditional inactivation of apc in mouse renal tubular epithelium. J Biol Chem 280: 3938-45 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 Kuraguchi M et al. (2006) Adenomatous polyposis coli (APC) is required for normal development of skin and thymus. PLoS Genet 2: e146 PubMed GONUTS page
  5. ↑ Ha NC et al. (2004) Mechanism of phosphorylation-dependent binding of APC to beta-catenin and its role in beta-catenin degradation. Mol Cell 15: 511-21 PubMed GONUTS page
  6. ↑ 6.0 6.1 6.2 Smits R et al. (1999) Apc1638T: a mouse model delineating critical domains of the adenomatous polyposis coli protein involved in tumorigenesis and development. Genes Dev 13: 1309-21 PubMed GONUTS page
  7. ↑ Senda T et al. (1996) The tumor suppressor protein APC colocalizes with beta-catenin in the colon epithelial cells. Biochem Biophys Res Commun 223: 329-34 PubMed GONUTS page
  8. ↑ 8.0 8.1 8.2 8.3 Kita K et al. (2006) Adenomatous polyposis coli on microtubule plus ends in cell extensions can promote microtubule net growth with or without EB1. Mol Biol Cell 17: 2331-45 PubMed GONUTS page
  9. ↑ 9.0 9.1 Sharma M et al. (2006) Membrane localization of adenomatous polyposis coli protein at cellular protrusions: targeting sequences and regulation by beta-catenin. J Biol Chem 281: 17140-9 PubMed GONUTS page
  10. ↑ 10.0 10.1 Rao CV et al. (2005) Colonic tumorigenesis in BubR1+/-ApcMin/+ compound mutant mice is linked to premature separation of sister chromatids and enhanced genomic instability. Proc Natl Acad Sci U S A 102: 4365-70 PubMed GONUTS page
  11. ↑ 11.0 11.1 11.2 Gounari F et al. (2005) Loss of adenomatous polyposis coli gene function disrupts thymic development. Nat Immunol 6: 800-9 PubMed GONUTS page
  12. ↑ 12.0 12.1 12.2 Benhamouche S et al. (2006) Apc tumor suppressor gene is the "zonation-keeper" of mouse liver. Dev Cell 10: 759-70 PubMed GONUTS page
  13. ↑ 13.0 13.1 13.2 Zhou FQ et al. (2004) NGF-induced axon growth is mediated by localized inactivation of GSK-3beta and functions of the microtubule plus end binding protein APC. Neuron 42: 897-912 PubMed GONUTS page
  14. ↑ 14.0 14.1 14.2 14.3 14.4 14.5 Purro SA et al. (2008) Wnt regulates axon behavior through changes in microtubule growth directionality: a new role for adenomatous polyposis coli. J Neurosci 28: 8644-54 PubMed GONUTS page
  15. ↑ Kanamori M et al. (2003) The PDZ protein tax-interacting protein-1 inhibits beta-catenin transcriptional activity and growth of colorectal cancer cells. J Biol Chem 278: 38758-64 PubMed GONUTS page
  16. ↑ Cormier RT et al. (1997) Secretory phospholipase Pla2g2a confers resistance to intestinal tumorigenesis. Nat Genet 17: 88-91 PubMed GONUTS page
  17. ↑ Takaku K et al. (1998) Intestinal tumorigenesis in compound mutant mice of both Dpc4 (Smad4) and Apc genes. Cell 92: 645-56 PubMed GONUTS page
  18. ↑ Baker SM et al. (1998) Enhanced intestinal adenomatous polyp formation in Pms2-/-;Min mice. Cancer Res 58: 1087-9 PubMed GONUTS page
  19. ↑ Yang K et al. (1998) Dietary modulation of carcinoma development in a mouse model for human familial adenomatous polyposis. Cancer Res 58: 5713-7 PubMed GONUTS page
  20. ↑ Mahmoud NN et al. (1999) Genotype-phenotype correlation in murine Apc mutation: differences in enterocyte migration and response to sulindac. Cancer Res 59: 353-9 PubMed GONUTS page
  21. ↑ Williamson SL et al. (1999) Intestinal tumorigenesis in the Apc1638N mouse treated with aspirin and resistant starch for up to 5 months. Carcinogenesis 20: 805-10 PubMed GONUTS page
  22. ↑ Pierre F et al. (1999) T cell status influences colon tumor occurrence in min mice fed short chain fructo-oligosaccharides as a diet supplement. Carcinogenesis 20: 1953-6 PubMed GONUTS page
  23. ↑ Takaku K et al. (1999) Gastric and duodenal polyps in Smad4 (Dpc4) knockout mice. Cancer Res 59: 6113-7 PubMed GONUTS page
  24. ↑ Novelli MR et al. (1999) Tumor burden and clonality in multiple intestinal neoplasia mouse/normal mouse aggregation chimeras. Proc Natl Acad Sci U S A 96: 12553-8 PubMed GONUTS page
  25. ↑ Halberg RB et al. (2000) Tumorigenesis in the multiple intestinal neoplasia mouse: redundancy of negative regulators and specificity of modifiers. Proc Natl Acad Sci U S A 97: 3461-6 PubMed GONUTS page
  26. ↑ Taketo MM & Takaku K (2000) Gastro-intestinal tumorigenesis in Smad4 mutant mice. Cytokine Growth Factor Rev 11: 147-57 PubMed GONUTS page
  27. ↑ Sasai H et al. (2000) Suppression of polypogenesis in a new mouse strain with a truncated Apc(Delta474) by a novel COX-2 inhibitor, JTE-522. Carcinogenesis 21: 953-8 PubMed GONUTS page
  28. ↑ Cormier RT & Dove WF (2000) Dnmt1N/+ reduces the net growth rate and multiplicity of intestinal adenomas in C57BL/6-multiple intestinal neoplasia (Min)/+ mice independently of p53 but demonstrates strong synergy with the modifier of Min 1(AKR) resistance allele. Cancer Res 60: 3965-70 PubMed GONUTS page
  29. ↑ Chulada PC et al. (2000) Genetic disruption of Ptgs-1, as well as Ptgs-2, reduces intestinal tumorigenesis in Min mice. Cancer Res 60: 4705-8 PubMed GONUTS page
  30. ↑ Takaku K et al. (2000) Suppression of intestinal polyposis in Apc(delta 716) knockout mice by an additional mutation in the cytosolic phospholipase A(2) gene. J Biol Chem 275: 34013-6 PubMed GONUTS page
  31. ↑ Taketo MM & Takaku K (2000) Gastrointestinal tumorigenesis in Smad4 (Dpc4) mutant mice. Hum Cell 13: 85-95 PubMed GONUTS page
  32. ↑ Hong KH et al. (2001) Deletion of cytosolic phospholipase A(2) suppresses Apc(Min)-induced tumorigenesis. Proc Natl Acad Sci U S A 98: 3935-9 PubMed GONUTS page
  33. ↑ Oshima M et al. (2001) Chemoprevention of intestinal polyposis in the Apcdelta716 mouse by rofecoxib, a specific cyclooxygenase-2 inhibitor. Cancer Res 61: 1733-40 PubMed GONUTS page
  34. ↑ Moser AR et al. (2001) Genetic background affects susceptibility to mammary hyperplasias and carcinomas in Apc(min)/+ mice. Cancer Res 61: 3480-5 PubMed GONUTS page
  35. ↑ Rudolph KL et al. (2001) Telomere dysfunction and evolution of intestinal carcinoma in mice and humans. Nat Genet 28: 155-9 PubMed GONUTS page
  36. ↑ Yu CF et al. (2001) Differential dietary effects on colonic and small bowel neoplasia in C57BL/6J Apc Min/+ mice. Dig Dis Sci 46: 1367-80 PubMed GONUTS page
  37. ↑ Sonoshita M et al. (2001) Acceleration of intestinal polyposis through prostaglandin receptor EP2 in Apc(Delta 716) knockout mice. Nat Med 7: 1048-51 PubMed GONUTS page
  38. ↑ Sohn KJ et al. (2001) Molecular genetics of ulcerative colitis-associated colon cancer in the interleukin 2- and beta(2)-microglobulin-deficient mouse. Cancer Res 61: 6912-7 PubMed GONUTS page
  39. ↑ Scott DJ et al. (2001) Lack of inducible nitric oxide synthase promotes intestinal tumorigenesis in the Apc(Min/+) mouse. Gastroenterology 121: 889-99 PubMed GONUTS page
  40. ↑ Ahn B & Ohshima H (2001) Suppression of intestinal polyposis in Apc(Min/+) mice by inhibiting nitric oxide production. Cancer Res 61: 8357-60 PubMed GONUTS page
  41. ↑ Seno H et al. (2002) Cyclooxygenase 2- and prostaglandin E(2) receptor EP(2)-dependent angiogenesis in Apc(Delta716) mouse intestinal polyps. Cancer Res 62: 506-11 PubMed GONUTS page
  42. ↑ Stanton JL & Green DP (2001) Meta-analysis of gene expression in mouse preimplantation embryo development. Mol Hum Reprod 7: 545-52 PubMed GONUTS page
  43. ↑ Dinchuk JE et al. (2002) Absence of post-translational aspartyl beta-hydroxylation of epidermal growth factor domains in mice leads to developmental defects and an increased incidence of intestinal neoplasia. J Biol Chem 277: 12970-7 PubMed GONUTS page
  44. ↑ Girnun GD et al. (2002) APC-dependent suppression of colon carcinogenesis by PPARgamma. Proc Natl Acad Sci U S A 99: 13771-6 PubMed GONUTS page
  45. ↑ 45.0 45.1 45.2 45.3 45.4 Sansom OJ et al. (2004) Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration. Genes Dev 18: 1385-90 PubMed GONUTS page
  46. ↑ Wang D et al. (2004) Prostaglandin E(2) promotes colorectal adenoma growth via transactivation of the nuclear peroxisome proliferator-activated receptor delta. Cancer Cell 6: 285-95 PubMed GONUTS page
  47. ↑ 47.0 47.1 47.2 Colnot S et al. (2004) Liver-targeted disruption of Apc in mice activates beta-catenin signaling and leads to hepatocellular carcinomas. Proc Natl Acad Sci U S A 101: 17216-21 PubMed GONUTS page
  48. ↑ Schoonjans K et al. (2005) Liver receptor homolog 1 contributes to intestinal tumor formation through effects on cell cycle and inflammation. Proc Natl Acad Sci U S A 102: 2058-62 PubMed GONUTS page
  49. ↑ Tucker JM et al. (2005) Potent modulation of intestinal tumorigenesis in Apcmin/+ mice by the polyamine catabolic enzyme spermidine/spermine N1-acetyltransferase. Cancer Res 65: 5390-8 PubMed GONUTS page
  50. ↑ Nateri AS et al. (2005) Interaction of phosphorylated c-Jun with TCF4 regulates intestinal cancer development. Nature 437: 281-5 PubMed GONUTS page
  51. ↑ 51.0 51.1 51.2 51.3 Park KS et al. (2006) APC inhibits ERK pathway activation and cellular proliferation induced by RAS. J Cell Sci 119: 819-27 PubMed GONUTS page
  52. ↑ Ellender M et al. (2006) In utero and neonatal sensitivity of ApcMin/+ mice to radiation-induced intestinal neoplasia. Int J Radiat Biol 82: 141-51 PubMed GONUTS page
  53. ↑ 53.0 53.1 53.2 53.3 Sansom OJ et al. (2007) Myc deletion rescues Apc deficiency in the small intestine. Nature 446: 676-9 PubMed GONUTS page
  54. ↑ Berger FG et al. (2007) Polyamine metabolism and tumorigenesis in the Apc(Min/+) mouse. Biochem Soc Trans 35: 336-9 PubMed GONUTS page
  55. ↑ Rakoff-Nahoum S & Medzhitov R (2007) Regulation of spontaneous intestinal tumorigenesis through the adaptor protein MyD88. Science 317: 124-7 PubMed GONUTS page
  56. ↑ Ghaleb AM et al. (2007) Haploinsufficiency of Krüppel-like factor 4 promotes adenomatous polyposis coli dependent intestinal tumorigenesis. Cancer Res 67: 7147-54 PubMed GONUTS page
  57. ↑ 57.0 57.1 Strom A et al. (2007) Unique mechanisms of growth regulation and tumor suppression upon Apc inactivation in the pancreas. Development 134: 2719-25 PubMed GONUTS page
  58. ↑ Blanc V et al. (2007) Deletion of the AU-rich RNA binding protein Apobec-1 reduces intestinal tumor burden in Apc(min) mice. Cancer Res 67: 8565-73 PubMed GONUTS page
  59. ↑ Li P et al. (2007) Guanylyl cyclase C suppresses intestinal tumorigenesis by restricting proliferation and maintaining genomic integrity. Gastroenterology 133: 599-607 PubMed GONUTS page
  60. ↑ Ploplis VA et al. (2007) A urokinase-type plasminogen activator deficiency diminishes the frequency of intestinal adenomas in ApcMin/+ mice. J Pathol 213: 266-74 PubMed GONUTS page
  61. ↑ Shibata H et al. (2007) Alpha-catenin is essential in intestinal adenoma formation. Proc Natl Acad Sci U S A 104: 18199-204 PubMed GONUTS page
  62. ↑ 62.0 62.1 Baltgalvis KA et al. (2008) Interleukin-6 and cachexia in ApcMin/+ mice. Am J Physiol Regul Integr Comp Physiol 294: R393-401 PubMed GONUTS page
  63. ↑ Leitges M (2007) Functional PKC in vivo analysis using deficient mouse models. Biochem Soc Trans 35: 1018-20 PubMed GONUTS page
  64. ↑ Mutoh M et al. (2008) Plasminogen activator inhibitor-1 (Pai-1) blockers suppress intestinal polyp formation in Min mice. Carcinogenesis 29: 824-9 PubMed GONUTS page
  65. ↑ Elander N et al. (2008) Genetic deletion of mPGES-1 accelerates intestinal tumorigenesis in APC(Min/+) mice. Biochem Biophys Res Commun 372: 249-53 PubMed GONUTS page
  66. ↑ Giroux V et al. (2008) Estrogen receptor beta deficiency enhances small intestinal tumorigenesis in ApcMin/+ mice. Int J Cancer 123: 303-11 PubMed GONUTS page
  67. ↑ Yoshimizu T et al. (2008) The H19 locus acts in vivo as a tumor suppressor. Proc Natl Acad Sci U S A 105: 12417-22 PubMed GONUTS page
  68. ↑ 68.0 68.1 Dahlhoff M et al. (2008) Betacellulin stimulates growth of the mouse intestinal epithelium and increases adenoma multiplicity in Apc+/Min mice. FEBS Lett 582: 2911-5 PubMed GONUTS page
  69. ↑ Sansom OJ et al. (2007) Deficiency of SPARC suppresses intestinal tumorigenesis in APCMin/+ mice. Gut 56: 1410-4 PubMed GONUTS page
  70. ↑ 70.0 70.1 Phesse TJ et al. (2008) Deficiency of Mbd2 attenuates Wnt signaling. Mol Cell Biol 28: 6094-103 PubMed GONUTS page
  71. ↑ Levy DB et al. (1994) Inactivation of both APC alleles in human and mouse tumors. Cancer Res 54: 5953-8 PubMed GONUTS page
  72. ↑ 72.0 72.1 Oshima M et al. (1996) Suppression of intestinal polyposis in Apc delta716 knockout mice by inhibition of cyclooxygenase 2 (COX-2). Cell 87: 803-9 PubMed GONUTS page
  73. ↑ Gould KA et al. (1996) Genetic evaluation of candidate genes for the Mom1 modifier of intestinal neoplasia in mice. Genetics 144: 1777-85 PubMed GONUTS page
  74. ↑ Gould KA et al. (1996) Mom1 is a semi-dominant modifier of intestinal adenoma size and multiplicity in Min/+ mice. Genetics 144: 1769-76 PubMed GONUTS page
  75. ↑ Oshima H et al. (1997) Morphological and molecular processes of polyp formation in Apc(delta716) knockout mice. Cancer Res 57: 1644-9 PubMed GONUTS page
  76. ↑ Gould KA & Dove WF (1997) Localized gene action controlling intestinal neoplasia in mice. Proc Natl Acad Sci U S A 94: 5848-53 PubMed GONUTS page
  77. ↑ 77.0 77.1 77.2 77.3 Ishikawa TO et al. (2003) Requirement for tumor suppressor Apc in the morphogenesis of anterior and ventral mouse embryo. Dev Biol 253: 230-46 PubMed GONUTS page
  78. ↑ 78.0 78.1 78.2 Chazaud C & Rossant J (2006) Disruption of early proximodistal patterning and AVE formation in Apc mutants. Development 133: 3379-87 PubMed GONUTS page
  79. ↑ Qian Z et al. (2008) A critical role for Apc in hematopoietic stem and progenitor cell survival. J Exp Med 205: 2163-75 PubMed GONUTS page
  80. ↑ 80.0 80.1 80.2 Hasegawa S et al. (2002) Apoptosis in neural crest cells by functional loss of APC tumor suppressor gene. Proc Natl Acad Sci U S A 99: 297-302 PubMed GONUTS page
  81. ↑ 81.0 81.1 Bruxvoort KJ et al. (2007) Inactivation of Apc in the mouse prostate causes prostate carcinoma. Cancer Res 67: 2490-6 PubMed GONUTS page
  82. ↑ Mahmoud NN et al. (1997) Apc gene mutation is associated with a dominant-negative effect upon intestinal cell migration. Cancer Res 57: 5045-50 PubMed GONUTS page
  83. ↑ Kroboth K et al. (2007) Lack of adenomatous polyposis coli protein correlates with a decrease in cell migration and overall changes in microtubule stability. Mol Biol Cell 18: 910-8 PubMed GONUTS page
  84. ↑ Wasan HS et al. (1998) APC in the regulation of intestinal crypt fission. J Pathol 185: 246-55 PubMed GONUTS page
  85. ↑ Hulit J et al. (2004) Cyclin D1 genetic heterozygosity regulates colonic epithelial cell differentiation and tumor number in ApcMin mice. Mol Cell Biol 24: 7598-611 PubMed GONUTS page
  86. ↑ 86.0 86.1 Moser AR et al. (1992) The Min (multiple intestinal neoplasia) mutation: its effect on gut epithelial cell differentiation and interaction with a modifier system. J Cell Biol 116: 1517-26 PubMed GONUTS page
  87. ↑ 87.0 87.1 Dikovskaya D et al. (2007) Loss of APC induces polyploidy as a result of a combination of defects in mitosis and apoptosis. J Cell Biol 176: 183-95 PubMed GONUTS page
  88. ↑ 88.0 88.1 Hu Y et al. (2007) Defective acute apoptotic response to genotoxic carcinogen in small intestine of APC(Min/+) mice is restored by sulindac. Cancer Lett 248: 234-44 PubMed GONUTS page
  89. ↑ Smits R et al. (1998) Apc1638N: a mouse model for familial adenomatous polyposis-associated desmoid tumors and cutaneous cysts. Gastroenterology 114: 275-83 PubMed GONUTS page
  90. ↑ You S et al. (2006) Developmental abnormalities in multiple proliferative tissues of Apc(Min/+) mice. Int J Exp Pathol 87: 227-36 PubMed GONUTS page
  91. ↑ 91.0 91.1 Holmen SL et al. (2005) Essential role of beta-catenin in postnatal bone acquisition. J Biol Chem 280: 21162-8 PubMed GONUTS page
  92. ↑ Carothers AM et al. (2006) Deficient E-cadherin adhesion in C57BL/6J-Min/+ mice is associated with increased tyrosine kinase activity and RhoA-dependent actomyosin contractility. Exp Cell Res 312: 387-400 PubMed GONUTS page
  93. ↑ van der Houven van Oordt CW et al. (1999) The genetic background modifies the spontaneous and X-ray-induced tumor spectrum in the Apc1638N mouse model. Genes Chromosomes Cancer 24: 191-8 PubMed GONUTS page
  94. ↑ Gupta RA et al. (2004) Activation of nuclear hormone receptor peroxisome proliferator-activated receptor-delta accelerates intestinal adenoma growth. Nat Med 10: 245-7 PubMed GONUTS page
  95. ↑ Wilson CL et al. (1997) Intestinal tumorigenesis is suppressed in mice lacking the metalloproteinase matrilysin. Proc Natl Acad Sci U S A 94: 1402-7 PubMed GONUTS page
  96. ↑ Bjerknes M et al. (1997) APC mutation and the crypt cycle in murine and human intestine. Am J Pathol 150: 833-9 PubMed GONUTS page
  97. ↑ 97.0 97.1 Alberici P et al. (2007) Aneuploidy arises at early stages of Apc-driven intestinal tumorigenesis and pinpoints conserved chromosomal loci of allelic imbalance between mouse and human. Am J Pathol 170: 377-87 PubMed GONUTS page
  98. ↑ Zhang T et al. (1997) Concurrent overexpression of cyclin D1 and cyclin-dependent kinase 4 (Cdk4) in intestinal adenomas from multiple intestinal neoplasia (Min) mice and human familial adenomatous polyposis patients. Cancer Res 57: 169-75 PubMed GONUTS page
  99. ↑ Marcus DM et al. (2000) Ultrastructural and ERG findings in mice with adenomatous polyposis coli gene disruption. Mol Vis 6: 169-77 PubMed GONUTS page
Retrieved from "http://gowiki.tamu.edu/wiki/index.php/MGI:Apc"
Personal tools
Namespaces
Variants
Actions
Navigation
Cacao
Journal Clubs
page contributors
Toolbox