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MGI:Apbb1
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Apbb1 ( synonyms: Fe65, Rir ) | |
| Protein Name(s) | amyloid beta (A4) precursor protein-binding, family B, member 1, | |
| External Links | ||
| MGI | MGI:107765 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0001540 |
beta-amyloid binding |
MGI:MGI:3698695 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0001540 |
beta-amyloid binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0001540 |
beta-amyloid binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0001764 |
neuron migration |
MGI:MGI:3614238 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:108405 |
P |
From MGI |
||
| GO:0003682 |
chromatin binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:1101412 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3612205 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3688062 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:4835135 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:83225 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:3687936 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:3698695 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:3698695 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005886 |
plasma membrane |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0006302 |
double-strand break repair |
MGI:MGI:3698695 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0006302 |
double-strand break repair |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0006351 |
transcription, DNA-dependent |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0804 |
P |
From MGI |
||
| GO:0006355 |
regulation of transcription, DNA-dependent |
MGI:MGI:3687936 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0006915 |
apoptotic process |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0053 |
P |
From MGI |
||
| GO:0006974 |
response to DNA damage stimulus |
MGI:MGI:3698695 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0006974 |
response to DNA damage stimulus |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0007050 |
cell cycle arrest |
MGI:MGI:3687936 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0007411 |
axon guidance |
MGI:MGI:3614238 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:108405 |
P |
From MGI |
||
| GO:0008134 |
transcription factor binding |
MGI:MGI:3687936 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0008542 |
visual learning |
MGI:MGI:3522016 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3514266 |
P |
From MGI |
||
| GO:0016020 |
membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0472 |
C |
From MGI |
||
| GO:0016568 |
chromatin modification |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0156 |
P |
From MGI |
||
| GO:0030027 |
lamellipodium |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0030048 |
actin filament-based movement |
MGI:MGI:3687936 |
NAS: Non-traceable Author Statement |
P |
From MGI |
|||
| GO:0030198 |
extracellular matrix organization |
MGI:MGI:3614238 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:108405 |
P |
From MGI |
||
| GO:0030308 |
negative regulation of cell growth |
MGI:MGI:3687936 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0030426 |
growth cone |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0030426 |
growth cone |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0032403 |
protein complex binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0035035 |
histone acetyltransferase binding |
MGI:MGI:3687936 |
NAS: Non-traceable Author Statement |
F |
From MGI |
|||
| GO:0042393 |
histone binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0042734 |
presynaptic membrane |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0042995 |
cell projection |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0966 |
C |
From MGI |
||
| GO:0043065 |
positive regulation of apoptotic process |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0043197 |
dendritic spine |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0043234 |
protein complex |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0043967 |
histone H4 acetylation |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045202 |
synapse |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0045211 |
postsynaptic membrane |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0045665 |
negative regulation of neuron differentiation |
MGI:MGI:3835738 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3514266 |
P |
From MGI |
||
| GO:0045739 |
positive regulation of DNA repair |
MGI:MGI:3698695 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0045739 |
positive regulation of DNA repair |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045749 |
negative regulation of S phase of mitotic cell cycle |
MGI:MGI:3687936 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045893 |
positive regulation of transcription, DNA-dependent |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045893 |
positive regulation of transcription, DNA-dependent |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:3589585 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:88059 |
P |
From MGI |
||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0048471 |
perinuclear region of cytoplasm |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0050714 |
positive regulation of protein secretion |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0050760 |
negative regulation of thymidylate synthase biosynthetic process |
MGI:MGI:3687936 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0050821 |
protein stabilization |
MGI:MGI:3688060 |
NAS: Non-traceable Author Statement |
P |
From MGI |
|||
| GO:0070064 |
proline-rich region binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Minopoli G et al. (2007) Essential roles for Fe65, Alzheimer amyloid precursor-binding protein, in the cellular response to DNA damage. J Biol Chem 282: 831-5 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Guénette S et al. (2006) Essential roles for the FE65 amyloid precursor protein-interacting proteins in brain development. EMBO J 25: 420-31 PubMed GONUTS page
- ↑ Ermekova KS et al. (1997) The WW domain of neural protein FE65 interacts with proline-rich motifs in Mena, the mammalian homolog of Drosophila enabled. J Biol Chem 272: 32869-77 PubMed GONUTS page
- ↑ Muresan Z & Muresan V (2005) Coordinated transport of phosphorylated amyloid-beta precursor protein and c-Jun NH2-terminal kinase-interacting protein-1. J Cell Biol 171: 615-25 PubMed GONUTS page
- ↑ Matsuda S et al. (2001) c-Jun N-terminal kinase (JNK)-interacting protein-1b/islet-brain-1 scaffolds Alzheimer's amyloid precursor protein with JNK. J Neurosci 21: 6597-607 PubMed GONUTS page
- ↑ Kajiwara Y et al. (2009) FE65 binds Teashirt, inhibiting expression of the primate-specific caspase-4. PLoS One 4: e5071 PubMed GONUTS page
- ↑ Bressler SL et al. (1996) cDNA cloning and chromosome mapping of the human Fe65 gene: interaction of the conserved cytoplasmic domains of the human beta-amyloid precursor protein and its homologues with the mouse Fe65 protein. Hum Mol Genet 5: 1589-98 PubMed GONUTS page
- ↑ 8.0 8.1 8.2 8.3 8.4 8.5 8.6 8.7 8.8 Bruni P et al. (2002) Fe65, a ligand of the Alzheimer's beta-amyloid precursor protein, blocks cell cycle progression by down-regulating thymidylate synthase expression. J Biol Chem 277: 35481-8 PubMed GONUTS page
- ↑ Wang B et al. (2004) Isoform-specific knockout of FE65 leads to impaired learning and memory. J Neurosci Res 75: 12-24 PubMed GONUTS page
- ↑ Ma QH et al. (2008) A TAG1-APP signalling pathway through Fe65 negatively modulates neurogenesis. Nat Cell Biol 10: 283-94 PubMed GONUTS page
- ↑ Pardossi-Piquard R et al. (2005) Presenilin-dependent transcriptional control of the Abeta-degrading enzyme neprilysin by intracellular domains of betaAPP and APLP. Neuron 46: 541-54 PubMed GONUTS page
- ↑ Kimberly WT et al. (2001) The intracellular domain of the beta-amyloid precursor protein is stabilized by Fe65 and translocates to the nucleus in a notch-like manner. J Biol Chem 276: 40288-92 PubMed GONUTS page
