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MGI:Angptl3
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Angptl3 ( synonyms: hypl ) | |
| Protein Name(s) | angiopoietin-like 3, | |
| External Links | ||
| MGI | MGI:1353627 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0004857 |
enzyme inhibitor activity |
MGI:MGI:2386514 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0004859 |
phospholipase inhibitor activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005102 |
receptor binding |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0005178 |
integrin binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005576 |
extracellular region |
MGI:MGI:1353079 |
ISS: Inferred from Sequence or Structural Similarity |
C |
From MGI |
|||
| GO:0005615 |
extracellular space |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0006071 |
glycerol metabolic process |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0006631 |
fatty acid metabolic process |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0006641 |
triglyceride metabolic process |
MGI:MGI:2386514 |
NAS: Non-traceable Author Statement |
P |
From MGI |
|||
| GO:0006644 |
phospholipid metabolic process |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0007160 |
cell-matrix adhesion |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0007165 |
signal transduction |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0008083 |
growth factor activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0008203 |
cholesterol metabolic process |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0009395 |
phospholipid catabolic process |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0010519 |
negative regulation of phospholipase activity |
MGI:MGI:3773779 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0010519 |
negative regulation of phospholipase activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0019915 |
lipid storage |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0030335 |
positive regulation of cell migration |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0042632 |
cholesterol homeostasis |
MGI:MGI:3773779 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0042632 |
cholesterol homeostasis |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0043498 |
cell surface binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0045766 |
positive regulation of angiogenesis |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045834 |
positive regulation of lipid metabolic process |
MGI:MGI:2176373 |
NAS: Non-traceable Author Statement |
P |
From MGI |
|||
| GO:0048844 |
artery morphogenesis |
MGI:MGI:2664626 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0050996 |
positive regulation of lipid catabolic process |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0051005 |
negative regulation of lipoprotein lipase activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0055088 |
lipid homeostasis |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0055090 |
acylglycerol homeostasis |
MGI:MGI:3773779 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0055090 |
acylglycerol homeostasis |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0055091 |
phospholipid homeostasis |
MGI:MGI:3773779 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0055091 |
phospholipid homeostasis |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0070328 |
triglyceride homeostasis |
MGI:MGI:4412214 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Shimizugawa T et al. (2002) ANGPTL3 decreases very low density lipoprotein triglyceride clearance by inhibition of lipoprotein lipase. J Biol Chem 277: 33742-8 PubMed GONUTS page
- ↑ Conklin D et al. (1999) Identification of a mammalian angiopoietin-related protein expressed specifically in liver. Genomics 62: 477-82 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 Shimamura M et al. (2007) Angiopoietin-like protein3 regulates plasma HDL cholesterol through suppression of endothelial lipase. Arterioscler Thromb Vasc Biol 27: 366-72 PubMed GONUTS page
- ↑ Koishi R et al. (2002) Angptl3 regulates lipid metabolism in mice. Nat Genet 30: 151-7 PubMed GONUTS page
- ↑ Ando Y et al. (2003) A decreased expression of angiopoietin-like 3 is protective against atherosclerosis in apoE-deficient mice. J Lipid Res 44: 1216-23 PubMed GONUTS page
- ↑ Sonnenburg WK et al. (2009) GPIHBP1 stabilizes lipoprotein lipase and prevents its inhibition by angiopoietin-like 3 and angiopoietin-like 4. J Lipid Res 50: 2421-9 PubMed GONUTS page
