GONUTS is under stress! The website is currently experiencing long-wait times and frequent time-outs due to the record number of students, groups, and annotations related to CACAO this semester. We are currently working on increasing performance -- please accept our apologies for the technical difficulties.
You can help reduce stress on the server by:
- not reloading pages frequently - this just adds
- opening links in new windows (so you can read the old page)
MGI:Alx4
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Alx4 ( synonyms: Aristaless-like 4 ) | |
| Protein Name(s) | aristaless-like homeobox 4, | |
| External Links | ||
| MGI | MGI:108359 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0001942 |
hair follicle development |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0003677 |
DNA binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0238 |
F |
From MGI |
||
| GO:0003677 |
DNA binding |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0003700 |
sequence-specific DNA binding transcription factor activity |
MGI:MGI:1290111 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0003700 |
sequence-specific DNA binding transcription factor activity |
MGI:MGI:1314705 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0003700 |
sequence-specific DNA binding transcription factor activity |
MGI:MGI:2156285 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:1290111 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:2156285 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:1098911 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:1290111 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005667 |
transcription factor complex |
MGI:MGI:1314705 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005667 |
transcription factor complex |
MGI:MGI:2156285 |
IPI: Inferred from Physical Interaction |
C |
From MGI |
|||
| GO:0006351 |
transcription, DNA-dependent |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0804 |
P |
From MGI |
||
| GO:0006355 |
regulation of transcription, DNA-dependent |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0805 |
P |
From MGI |
||
| GO:0006355 |
regulation of transcription, DNA-dependent |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
P |
From MGI |
|||
| GO:0006357 |
regulation of transcription from RNA polymerase II promoter |
MGI:MGI:2156285 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0007275 |
multicellular organismal development |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0217 |
P |
From MGI |
||
| GO:0007389 |
pattern specification process |
MGI:MGI:2151109 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1277097 |
P |
From MGI |
||
| GO:0007517 |
muscle organ development |
MGI:MGI:1098911 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857484 |
P |
From MGI |
||
| GO:0009791 |
post-embryonic development |
MGI:MGI:1095762 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857484 |
P |
From MGI |
||
| GO:0009952 |
anterior/posterior pattern specification |
MGI:MGI:1098911 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857484 |
P |
From MGI |
||
| GO:0009952 |
anterior/posterior pattern specification |
MGI:MGI:1314705 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:104621 |
P |
From MGI |
||
| GO:0009952 |
anterior/posterior pattern specification |
MGI:MGI:1314705 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857484 |
P |
From MGI |
||
| GO:0035108 |
limb morphogenesis |
MGI:MGI:1098911 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857484 |
P |
From MGI |
||
| GO:0035108 |
limb morphogenesis |
MGI:MGI:1314705 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:104621 |
P |
From MGI |
||
| GO:0035108 |
limb morphogenesis |
MGI:MGI:1314705 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857484 |
P |
From MGI |
||
| GO:0035115 |
embryonic forelimb morphogenesis |
MGI:MGI:2151109 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1277097 |
P |
From MGI |
||
| GO:0035116 |
embryonic hindlimb morphogenesis |
MGI:MGI:2151109 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1277097 |
P |
From MGI |
||
| GO:0042733 |
embryonic digit morphogenesis |
MGI:MGI:1095762 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857484 |
P |
From MGI |
||
| GO:0042733 |
embryonic digit morphogenesis |
MGI:MGI:1095777 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:88180 |
P |
From MGI |
||
| GO:0042981 |
regulation of apoptotic process |
MGI:MGI:2151109 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1277097 |
P |
From MGI |
||
| GO:0043565 |
sequence-specific DNA binding |
MGI:MGI:1290111 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:1290111 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:1314705 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:1314705 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:104621 |
P |
From MGI |
||
| GO:0046982 |
protein heterodimerization activity |
MGI:MGI:1314705 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0048565 |
digestive tract development |
MGI:MGI:1095762 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857484 |
P |
From MGI |
||
| GO:0048704 |
embryonic skeletal system morphogenesis |
MGI:MGI:1314705 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:104621 |
P |
From MGI |
||
| GO:0048704 |
embryonic skeletal system morphogenesis |
MGI:MGI:2151109 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1277097 |
P |
From MGI |
||
| GO:0048704 |
embryonic skeletal system morphogenesis |
MGI:MGI:3604843 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:104621 |
P |
From MGI |
||
| GO:0048704 |
embryonic skeletal system morphogenesis |
MGI:MGI:3604843 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856069 |
P |
From MGI |
||
| GO:0048705 |
skeletal system morphogenesis |
MGI:MGI:1098911 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857484 |
P |
From MGI |
||
| GO:0060021 |
palate development |
MGI:MGI:1314705 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:104621 |
P |
From MGI |
||
| GO:0071837 |
HMG box domain binding |
MGI:MGI:5284787 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 Hudson R et al. (1998) Alx-4, a transcriptional activator whose expression is restricted to sites of epithelial-mesenchymal interactions. Dev Dyn 213: 159-69 PubMed GONUTS page
- ↑ 2.00 2.01 2.02 2.03 2.04 2.05 2.06 2.07 2.08 2.09 2.10 Qu S et al. (1999) Physical and genetic interactions between Alx4 and Cart1. Development 126: 359-69 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 Boras K & Hamel PA (2002) Alx4 binding to LEF-1 regulates N-CAM promoter activity. J Biol Chem 277: 1120-7 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 4.4 Qu S et al. (1997) Polydactyly and ectopic ZPA formation in Alx-4 mutant mice. Development 124: 3999-4008 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 5.4 Beverdam A et al. (2001) Severe nasal clefting and abnormal embryonic apoptosis in Alx3/Alx4 double mutant mice. Development 128: 3975-86 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 Dunn NR et al. (1997) Haploinsufficient phenotypes in Bmp4 heterozygous null mice and modification by mutations in Gli3 and Alx4. Dev Biol 188: 235-47 PubMed GONUTS page
- ↑ Dunwoodie SL et al. (1997) Mouse Dll3: a novel divergent Delta gene which may complement the function of other Delta homologues during early pattern formation in the mouse embryo. Development 124: 3065-76 PubMed GONUTS page
- ↑ 8.0 8.1 Kuijper S et al. (2005) Genetics of shoulder girdle formation: roles of Tbx15 and aristaless-like genes. Development 132: 1601-10 PubMed GONUTS page
- ↑ Wissmüller S et al. (2006) The high-mobility-group domain of Sox proteins interacts with DNA-binding domains of many transcription factors. Nucleic Acids Res 34: 1735-44 PubMed GONUTS page
