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MGI:Als2
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Als2 ( synonyms: Als2cr6, Alsin ) | |
| Protein Name(s) | amyotrophic lateral sclerosis 2 (juvenile) homolog (human), | |
| External Links | ||
| MGI | MGI:1921268 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0001662 |
behavioral fear response |
MGI:MGI:3588008 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3522476 |
P |
From MGI |
||
| GO:0001726 |
ruffle |
MGI:MGI:3759339 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0001881 |
receptor recycling |
MGI:MGI:3690398 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3522476 |
P |
From MGI |
||
| GO:0001934 |
positive regulation of protein phosphorylation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0005085 |
guanyl-nucleotide exchange factor activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0344 |
F |
From MGI |
||
| GO:0005089 |
Rho guanyl-nucleotide exchange factor activity |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0005097 |
Rab GTPase activator activity |
MGI:MGI:2154458 |
ISO: Inferred from Sequence Orthology |
EMBL:AB053305 |
F |
From MGI |
||
| GO:0005515 |
protein binding |
MGI:MGI:3690398 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005543 |
phospholipid binding |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0005622 |
intracellular |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
C |
From MGI |
|||
| GO:0005622 |
intracellular |
MGI:MGI:3611988 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3612978 |
C |
From MGI |
||
| GO:0005622 |
intracellular |
MGI:MGI:3652645 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3653518 |
C |
From MGI |
||
| GO:0005634 |
nucleus |
MGI:MGI:2154458 |
ISO: Inferred from Sequence Orthology |
EMBL:AB053306 |
C |
From MGI |
||
| GO:0005737 |
cytoplasm |
MGI:MGI:3590026 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_001013431 |
C |
From MGI |
||
| GO:0005769 |
early endosome |
MGI:MGI:2154458 |
ISO: Inferred from Sequence Orthology |
EMBL:AB053305 |
C |
From MGI |
||
| GO:0005769 |
early endosome |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005792 |
microsome |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_001013431 |
C |
From MGI |
||
| GO:0005813 |
centrosome |
MGI:MGI:2154458 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005829 |
cytosol |
MGI:MGI:2154458 |
ISO: Inferred from Sequence Orthology |
EMBL:AB053305 |
C |
From MGI |
||
| GO:0005829 |
cytosol |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0006979 |
response to oxidative stress |
MGI:MGI:3588008 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3522476 |
P |
From MGI |
||
| GO:0007032 |
endosome organization |
MGI:MGI:2154458 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0007041 |
lysosomal transport |
MGI:MGI:2154458 |
ISO: Inferred from Sequence Orthology |
EMBL:AB053305 |
P |
From MGI |
||
| GO:0007409 |
axonogenesis |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_001013431 |
P |
From MGI |
||
| GO:0007528 |
neuromuscular junction development |
MGI:MGI:3611988 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3612978 |
P |
From MGI |
||
| GO:0007626 |
locomotory behavior |
MGI:MGI:3588008 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3522476 |
P |
From MGI |
||
| GO:0007626 |
locomotory behavior |
MGI:MGI:3652645 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3653518 |
P |
From MGI |
||
| GO:0008104 |
protein localization |
MGI:MGI:3690398 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3522476 |
P |
From MGI |
||
| GO:0008219 |
cell death |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_001013431 |
P |
From MGI |
||
| GO:0014069 |
postsynaptic density |
MGI:MGI:3690398 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0016020 |
membrane |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_001013431 |
C |
From MGI |
||
| GO:0016050 |
vesicle organization |
MGI:MGI:3590026 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0016197 |
endosome transport |
MGI:MGI:3611988 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3612978 |
P |
From MGI |
||
| GO:0016197 |
endosome transport |
MGI:MGI:3652645 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3653518 |
P |
From MGI |
||
| GO:0016601 |
Rac protein signal transduction |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_001013431 |
P |
From MGI |
||
| GO:0017112 |
Rab guanyl-nucleotide exchange factor activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0017137 |
Rab GTPase binding |
MGI:MGI:2154458 |
ISO: Inferred from Sequence Orthology |
EMBL:AB053305 |
F |
From MGI |
||
| GO:0017137 |
Rab GTPase binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0019717 |
synaptosome |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_001013431 |
C |
From MGI |
||
| GO:0030027 |
lamellipodium |
MGI:MGI:3759339 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0030424 |
axon |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_001013431 |
C |
From MGI |
||
| GO:0030425 |
dendrite |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_001013431 |
C |
From MGI |
||
| GO:0030425 |
dendrite |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0030426 |
growth cone |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_001013431 |
C |
From MGI |
||
| GO:0030675 |
Rac GTPase activator activity |
MGI:MGI:2154458 |
ISO: Inferred from Sequence Orthology |
EMBL:AB053305 |
F |
From MGI |
||
| GO:0030676 |
Rac guanyl-nucleotide exchange factor activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0032313 |
regulation of Rab GTPase activity |
MGI:MGI:3590026 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0032851 |
positive regulation of Rab GTPase activity |
MGI:MGI:2154458 |
ISO: Inferred from Sequence Orthology |
EMBL:AB053305 |
P |
From MGI |
||
| GO:0032855 |
positive regulation of Rac GTPase activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0035023 |
regulation of Rho protein signal transduction |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
P |
From MGI |
|||
| GO:0035249 |
synaptic transmission, glutamatergic |
MGI:MGI:3690398 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3522476 |
P |
From MGI |
||
| GO:0042598 |
vesicular fraction |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0042802 |
identical protein binding |
MGI:MGI:2154458 |
ISO: Inferred from Sequence Orthology |
EMBL:AB053305 |
F |
From MGI |
||
| GO:0042803 |
protein homodimerization activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0043025 |
neuronal cell body |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_001013431 |
C |
From MGI |
||
| GO:0043197 |
dendritic spine |
MGI:MGI:3690398 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0043234 |
protein complex |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0043539 |
protein serine/threonine kinase activator activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0045860 |
positive regulation of protein kinase activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0048365 |
Rac GTPase binding |
MGI:MGI:2154458 |
ISO: Inferred from Sequence Orthology |
EMBL:AB053305 |
F |
From MGI |
||
| GO:0048812 |
neuron projection morphogenesis |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0050790 |
regulation of catalytic activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0344 |
P |
From MGI |
||
| GO:0050790 |
regulation of catalytic activity |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
P |
From MGI |
|||
| GO:0051260 |
protein homooligomerization |
MGI:MGI:2154458 |
ISO: Inferred from Sequence Orthology |
EMBL:AB053305 |
P |
From MGI |
||
| GO:0071902 |
positive regulation of protein serine/threonine kinase activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
|
colocalizes_with |
GO:0005813 |
centrosome |
MGI:MGI:3590026 |
IDA: Inferred from Direct Assay |
C |
From MGI |
| |
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Cai H et al. (2005) Loss of ALS2 function is insufficient to trigger motor neuron degeneration in knock-out mice but predisposes neurons to oxidative stress. J Neurosci 25: 7567-74 PubMed GONUTS page
- ↑ 2.0 2.1 Topp JD et al. (2004) Alsin is a Rab5 and Rac1 guanine nucleotide exchange factor. J Biol Chem 279: 24612-23 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 3.4 3.5 Lai C et al. (2006) Amyotrophic lateral sclerosis 2-deficiency leads to neuronal degeneration in amyotrophic lateral sclerosis through altered AMPA receptor trafficking. J Neurosci 26: 11798-806 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 Hadano S et al. (2006) Mice deficient in the Rab5 guanine nucleotide exchange factor ALS2/alsin exhibit age-dependent neurological deficits and altered endosome trafficking. Hum Mol Genet 15: 233-50 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 Devon RS et al. (2006) Als2-deficient mice exhibit disturbances in endosome trafficking associated with motor behavioral abnormalities. Proc Natl Acad Sci U S A 103: 9595-600 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 6.3 Millecamps S et al. (2005) Alsin is partially associated with centrosome in human cells. Biochim Biophys Acta 1745: 84-100 PubMed GONUTS page
