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MGI:Alox5
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Alox5 ( synonyms: 5-LOX, 5LO, 5LX ) | |
| Protein Name(s) | arachidonate 5-lipoxygenase, | |
| External Links | ||
| MGI | MGI:87999 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0002526 |
acute inflammatory response |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0002540 |
leukotriene production involved in inflammatory response |
MGI:MGI:86611 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1933120 |
P |
From MGI |
||
| GO:0004051 |
arachidonate 5-lipoxygenase activity |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0004051 |
arachidonate 5-lipoxygenase activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005506 |
iron ion binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005625 |
soluble fraction |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:2388233 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005635 |
nuclear envelope |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005635 |
nuclear envelope |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005641 |
nuclear envelope lumen |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:2388233 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005829 |
cytosol |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0006691 |
leukotriene metabolic process |
MGI:MGI:2176389 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857125 |
P |
From MGI |
||
| GO:0006954 |
inflammatory response |
MGI:MGI:2176389 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857125 |
P |
From MGI |
||
| GO:0016020 |
membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0472 |
C |
From MGI |
||
| GO:0016165 |
lipoxygenase activity |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0016363 |
nuclear matrix |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0016491 |
oxidoreductase activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0560 |
F |
From MGI |
||
| GO:0016702 |
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0223 |
F |
From MGI |
||
| GO:0016702 |
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
InterPro:IPR000907 |
F |
From MGI |
||
| GO:0019233 |
sensory perception of pain |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0019369 |
arachidonic acid metabolic process |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0019370 |
leukotriene biosynthetic process |
MGI:MGI:3821938 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0019370 |
leukotriene biosynthetic process |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0019370 |
leukotriene biosynthetic process |
MGI:MGI:86602 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1933120 |
P |
From MGI |
||
| GO:0019372 |
lipoxygenase pathway |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0030425 |
dendrite |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0031965 |
nuclear membrane |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0042383 |
sarcolemma |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0045907 |
positive regulation of vasoconstriction |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0046872 |
metal ion binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0479 |
F |
From MGI |
||
| GO:0046872 |
metal ion binding |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
InterPro:IPR000907 |
F |
From MGI |
| |
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Byrum RS et al. (1997) Role of the 5-lipoxygenase-activating protein (FLAP) in murine acute inflammatory responses. J Exp Med 185: 1065-75 PubMed GONUTS page
- ↑ 2.0 2.1 Jones SM et al. (2002) Structural and functional criteria reveal a new nuclear import sequence on the 5-lipoxygenase protein. J Biol Chem 277: 38550-6 PubMed GONUTS page
- ↑ 3.0 3.1 Segal BH et al. (2002) Thioglycollate peritonitis in mice lacking C5, 5-lipoxygenase, or p47(phox): complement, leukotrienes, and reactive oxidants in acute inflammation. J Leukoc Biol 71: 410-6 PubMed GONUTS page
- ↑ Mandal AK et al. (2008) The nuclear membrane organization of leukotriene synthesis. Proc Natl Acad Sci U S A 105: 20434-9 PubMed GONUTS page
- ↑ Edmiston JS & Lebman DA (1997) A transforming growth factor-beta regulable RNA-binding protein interacts specifically with germline Ig alpha transcripts. Int Immunol 9: 427-33 PubMed GONUTS page
