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MGI:Alas2
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Alas2 ( synonyms: 5-aminolevulinate synthase, ALAS, Alas-2, ALAS-E, ALASE, erythroid-specific ALAS ) | |
| Protein Name(s) | aminolevulinic acid synthase 2, erythroid, | |
| External Links | ||
| MGI | MGI:87990 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0001666 |
response to hypoxia |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0003824 |
catalytic activity |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0003870 |
5-aminolevulinate synthase activity |
MGI:MGI:2154458 |
ISO: Inferred from Sequence Orthology |
EMBL:AF068624 |
F |
From MGI |
||
| GO:0003870 |
5-aminolevulinate synthase activity |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0003870 |
5-aminolevulinate synthase activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0003870 |
5-aminolevulinate synthase activity |
MGI:MGI:75768 |
IMP: Inferred from Mutant Phenotype |
F |
From MGI |
|||
| GO:0005739 |
mitochondrion |
MGI:MGI:2154458 |
ISO: Inferred from Sequence Orthology |
EMBL:AF068624 |
C |
From MGI |
||
| GO:0005739 |
mitochondrion |
MGI:MGI:2682130 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005739 |
mitochondrion |
MGI:MGI:3852644 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005739 |
mitochondrion |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005739 |
mitochondrion |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005743 |
mitochondrial inner membrane |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005759 |
mitochondrial matrix |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
C |
From MGI |
|||
| GO:0006778 |
porphyrin-containing compound metabolic process |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
P |
From MGI |
|||
| GO:0006783 |
heme biosynthetic process |
MGI:MGI:3694153 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0006879 |
cellular iron ion homeostasis |
MGI:MGI:1347738 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2180151 |
P |
From MGI |
||
| GO:0009058 |
biosynthetic process |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
P |
From MGI |
|||
| GO:0016594 |
glycine binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0016740 |
transferase activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0808 |
F |
From MGI |
||
| GO:0016740 |
transferase activity |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0016746 |
transferase activity, transferring acyl groups |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0012 |
F |
From MGI |
||
| GO:0030170 |
pyridoxal phosphate binding |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
InterPro:IPR010961 |
F |
From MGI |
||
| GO:0030218 |
erythrocyte differentiation |
MGI:MGI:3694153 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0033014 |
tetrapyrrole biosynthetic process |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
P |
From MGI |
|||
| GO:0042541 |
hemoglobin biosynthetic process |
MGI:MGI:3694153 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0050662 |
coenzyme binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Meguro K et al. (1995) The role of the erythroid-specific delta-aminolevulinate synthase gene expression in erythroid heme synthesis. Blood 86: 940-8 PubMed GONUTS page
- ↑ Mootha VK et al. (2003) Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Cell 115: 629-40 PubMed GONUTS page
- ↑ Pagliarini DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell 134: 112-23 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 Harigae H et al. (1998) Deficient heme and globin synthesis in embryonic stem cells lacking the erythroid-specific delta-aminolevulinate synthase gene. Blood 91: 798-805 PubMed GONUTS page
- ↑ Nakajima O et al. (1999) Heme deficiency in erythroid lineage causes differentiation arrest and cytoplasmic iron overload. EMBO J 18: 6282-9 PubMed GONUTS page
