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MGI:Aif1
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Aif1 ( synonyms: D17H6S50E, G1, Iba1 ) | |
| Protein Name(s) | allograft inflammatory factor 1, | |
| External Links | ||
| MGI | MGI:1343098 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0001726 |
ruffle |
MGI:MGI:3042556 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0001774 |
microglial cell activation |
MGI:MGI:5315342 |
NAS: Non-traceable Author Statement |
P |
From MGI |
|||
| GO:0001891 |
phagocytic cup |
MGI:MGI:3042556 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0001891 |
phagocytic cup |
MGI:MGI:5315376 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0001934 |
positive regulation of protein phosphorylation |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0003779 |
actin binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0009 |
F |
From MGI |
||
| GO:0005509 |
calcium ion binding |
MGI:MGI:5315342 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3042556 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005622 |
intracellular |
MGI:MGI:5315376 |
IMP: Inferred from Mutant Phenotype |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:5315376 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:3042556 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:5315376 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005829 |
cytosol |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005829 |
cytosol |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005856 |
cytoskeleton |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0206 |
C |
From MGI |
||
| GO:0005884 |
actin filament |
MGI:MGI:3042556 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005886 |
plasma membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-1003 |
C |
From MGI |
||
| GO:0006911 |
phagocytosis, engulfment |
MGI:MGI:5315376 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0010629 |
negative regulation of gene expression |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0014739 |
positive regulation of muscle hyperplasia |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0016020 |
membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0472 |
C |
From MGI |
||
| GO:0016601 |
Rac protein signal transduction |
MGI:MGI:5315376 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0030027 |
lamellipodium |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0030027 |
lamellipodium |
MGI:MGI:5315376 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0030041 |
actin filament polymerization |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0030335 |
positive regulation of cell migration |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0032587 |
ruffle membrane |
MGI:MGI:5315376 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0042102 |
positive regulation of T cell proliferation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0042995 |
cell projection |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0043066 |
negative regulation of apoptotic process |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0043204 |
perikaryon |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0045429 |
positive regulation of nitric oxide biosynthetic process |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0048661 |
positive regulation of smooth muscle cell proliferation |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0048661 |
positive regulation of smooth muscle cell proliferation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0051015 |
actin filament binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0051017 |
actin filament bundle assembly |
MGI:MGI:3042556 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0051017 |
actin filament bundle assembly |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0071673 |
positive regulation of smooth muscle cell chemotaxis |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0090026 |
positive regulation of monocyte chemotaxis |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0097178 |
ruffle assembly |
MGI:MGI:5315342 |
NAS: Non-traceable Author Statement |
P |
From MGI |
|||
| GO:0097178 |
ruffle assembly |
MGI:MGI:5315376 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:1900087 |
positive regulation of G1/S transition of mitotic cell cycle |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:2000406 |
positive regulation of T cell migration |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Ohsawa K et al. (2004) Microglia/macrophage-specific protein Iba1 binds to fimbrin and enhances its actin-bundling activity. J Neurochem 88: 844-56 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Yamada M et al. (2006) X-ray structures of the microglia/macrophage-specific protein Iba1 from human and mouse demonstrate novel molecular conformation change induced by calcium binding. J Mol Biol 364: 449-57 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 3.4 3.5 3.6 3.7 3.8 Ohsawa K et al. (2000) Involvement of Iba1 in membrane ruffling and phagocytosis of macrophages/microglia. J Cell Sci 113 ( Pt 17): 3073-84 PubMed GONUTS page
