MGI:Ahr

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Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0000122	negative regulation of transcription from RNA polymerase II promoter	MGI:MGI:3774739 PMID:18223155^[1]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0000902	cell morphogenesis	MGI:MGI:1889403 PMID:10973493^[2]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0000902	cell morphogenesis	MGI:MGI:3794480 PMID:16443691^[3]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0001541	ovarian follicle development	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P41738	P	From MGI
	GO:0001568	blood vessel development	MGI:MGI:1889403 PMID:10973493^[2]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0001569	patterning of blood vessels	MGI:MGI:1889403 PMID:10973493^[2]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0001782	B cell homeostasis	MGI:MGI:5284795 PMID:15681594^[4]	TAS: Traceable Author Statement		P	From MGI
	GO:0001782	B cell homeostasis	MGI:MGI:72762 PMID:7732381^[5]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0001889	liver development	MGI:MGI:1889403 PMID:10973493^[2]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0001889	liver development	MGI:MGI:3794480 PMID:16443691^[3]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0001889	liver development	MGI:MGI:72762 PMID:7732381^[5]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0001889	liver development	MGI:MGI:81320 PMID:8692887^[6]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0001922	B-1 B cell homeostasis	MGI:MGI:5284795 PMID:15681594^[4]	TAS: Traceable Author Statement		P	From MGI
	GO:0001974	blood vessel remodeling	MGI:MGI:1889403 PMID:10973493^[2]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0002260	lymphocyte homeostasis	MGI:MGI:5284795 PMID:15681594^[4]	TAS: Traceable Author Statement		P	From MGI
	GO:0002260	lymphocyte homeostasis	MGI:MGI:72762 PMID:7732381^[5]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0002376	immune system process	MGI:MGI:72762 PMID:7732381^[5]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0003085	negative regulation of systemic arterial blood pressure	MGI:MGI:3760685 PMID:14644620^[7]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0003214	cardiac left ventricle morphogenesis	MGI:MGI:3760685 PMID:14644620^[7]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0003243	circumferential growth involved in left ventricle morphogenesis	MGI:MGI:3760685 PMID:14644620^[7]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0003677	DNA binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P35869	F	From MGI
	GO:0003677	DNA binding	MGI:MGI:48693 PMID:1313028^[8]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0003700	sequence-specific DNA binding transcription factor activity	MGI:MGI:1926513 PMID:11025203^[9]	TAS: Traceable Author Statement		F	From MGI
	GO:0003700	sequence-specific DNA binding transcription factor activity	MGI:MGI:2176655 PMID:11782478^[10]	ISO: Inferred from Sequence Orthology	UniProtKB:P35869	F	From MGI
	GO:0003700	sequence-specific DNA binding transcription factor activity	MGI:MGI:48693 PMID:1313028^[8]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0003700	sequence-specific DNA binding transcription factor activity	MGI:MGI:62922 PMID:8215422^[11]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity	MGI:MGI:3774739 PMID:18223155^[1]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0004871	signal transducer activity	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR000014	F	From MGI
	GO:0004872	receptor activity	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0675	F	From MGI
	GO:0004874	aryl hydrocarbon receptor activity	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P41738	F	From MGI
	GO:0004879	ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P41738	F	From MGI
	GO:0004879	ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P35869	F	From MGI
	GO:0004879	ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity	MGI:MGI:49014 PMID:1314586^[12]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0005515	protein binding	MGI:MGI:4418646 PMID:8940073^[13]	IPI: Inferred from Physical Interaction	UniProtKB:P79832	F	From MGI
	GO:0005515	protein binding	MGI:MGI:79449 PMID:8657146^[14]	IPI: Inferred from Physical Interaction	UniProtKB:Q61324	F	From MGI
	GO:0005634	nucleus	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P41738	C	From MGI
	GO:0005634	nucleus	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P35869	C	From MGI
	GO:0005634	nucleus	MGI:MGI:49014 PMID:1314586^[12]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005634	nucleus	MGI:MGI:5284778 PMID:17569696^[15]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005634	nucleus	MGI:MGI:5294298 PMID:17329248^[16]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005667	transcription factor complex	MGI:MGI:1926513 PMID:11025203^[9]	TAS: Traceable Author Statement		C	From MGI
	GO:0005737	cytoplasm	MGI:MGI:2445254 PMID:12215427^[17]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005737	cytoplasm	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P35869	C	From MGI
	GO:0005829	cytosol	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P41738	C	From MGI
	GO:0005829	cytosol	MGI:MGI:5284778 PMID:17569696^[15]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005829	cytosol	MGI:MGI:5294298 PMID:17329248^[16]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0006351	transcription, DNA-dependent	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0804	P	From MGI
	GO:0006355	regulation of transcription, DNA-dependent	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P41738	P	From MGI
	GO:0006355	regulation of transcription, DNA-dependent	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P35869	P	From MGI
	GO:0006355	regulation of transcription, DNA-dependent	MGI:MGI:49014 PMID:1314586^[12]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0006357	regulation of transcription from RNA polymerase II promoter	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P35869	P	From MGI
	GO:0006366	transcription from RNA polymerase II promoter	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P41738	P	From MGI
	GO:0006366	transcription from RNA polymerase II promoter	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P35869	P	From MGI
	GO:0006366	transcription from RNA polymerase II promoter	MGI:MGI:49014 PMID:1314586^[12]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0006805	xenobiotic metabolic process	MGI:MGI:54299 PMID:405846^[18]	TAS: Traceable Author Statement		P	From MGI
	GO:0006915	apoptotic process	MGI:MGI:3691912 PMID:12213388^[19]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0006950	response to stress	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P41738	P	From MGI
	GO:0006950	response to stress	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P35869	P	From MGI
	GO:0006950	response to stress	MGI:MGI:49014 PMID:1314586^[12]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0007049	cell cycle	MGI:MGI:3691912 PMID:12213388^[19]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0007165	signal transduction	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR001610 InterPro:IPR000014	P	From MGI
	GO:0008015	blood circulation	MGI:MGI:1889403 PMID:10973493^[2]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0008134	transcription factor binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P35869	F	From MGI
	GO:0008217	regulation of blood pressure	MGI:MGI:3794480 PMID:16443691^[3]	TAS: Traceable Author Statement		P	From MGI
	GO:0009410	response to xenobiotic stimulus	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P41738	P	From MGI
	GO:0009410	response to xenobiotic stimulus	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P35869	P	From MGI
	GO:0009410	response to xenobiotic stimulus	MGI:MGI:70018 PMID:7961644^[20]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0009636	response to toxin	MGI:MGI:5294298 PMID:17329248^[16]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0010468	regulation of gene expression	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P35869	P	From MGI
	GO:0014070	response to organic cyclic compound	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P41738	P	From MGI
	GO:0030183	B cell differentiation	MGI:MGI:5284795 PMID:15681594^[4]	TAS: Traceable Author Statement		P	From MGI
	GO:0030522	intracellular receptor mediated signaling pathway	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P41738	P	From MGI
	GO:0030522	intracellular receptor mediated signaling pathway	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P35869	P	From MGI
	GO:0030522	intracellular receptor mediated signaling pathway	MGI:MGI:49014 PMID:1314586^[12]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0030850	prostate gland development	MGI:MGI:3760679 PMID:12151645^[21]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857427	P	From MGI
	GO:0030888	regulation of B cell proliferation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P35869	P	From MGI
	GO:0034751	aryl hydrocarbon receptor complex	MGI:MGI:5284778 PMID:17569696^[15]	TAS: Traceable Author Statement		C	From MGI
	GO:0034752	cytosolic aryl hydrocarbon receptor complex	MGI:MGI:5284778 PMID:17569696^[15]	TAS: Traceable Author Statement		C	From MGI
	GO:0034753	nuclear aryl hydrocarbon receptor complex	MGI:MGI:5284778 PMID:17569696^[15]	TAS: Traceable Author Statement		C	From MGI
	GO:0035162	embryonic hemopoiesis	MGI:MGI:3794480 PMID:16443691^[3]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0035166	post-embryonic hemopoiesis	MGI:MGI:81320 PMID:8692887^[6]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0040010	positive regulation of growth rate	MGI:MGI:72762 PMID:7732381^[5]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0040010	positive regulation of growth rate	MGI:MGI:81320 PMID:8692887^[6]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0043010	camera-type eye development	MGI:MGI:1889403 PMID:10973493^[2]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0043029	T cell homeostasis	MGI:MGI:72762 PMID:7732381^[5]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0043565	sequence-specific DNA binding	MGI:MGI:49394 PMID:1605850^[22]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0044212	transcription regulatory region DNA binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P35869	F	From MGI
	GO:0045793	positive regulation of cell size	MGI:MGI:1889403 PMID:10973493^[2]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0045893	positive regulation of transcription, DNA-dependent	MGI:MGI:48693 PMID:1313028^[8]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0045899	positive regulation of RNA polymerase II transcriptional preinitiation complex assembly	MGI:MGI:62922 PMID:8215422^[11]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0045906	negative regulation of vasoconstriction	MGI:MGI:3760685 PMID:14644620^[7]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0046982	protein heterodimerization activity	MGI:MGI:3843443 PMID:11230806^[23]	IPI: Inferred from Physical Interaction	UniProtKB:P79832	F	From MGI
	GO:0048514	blood vessel morphogenesis	MGI:MGI:1889403 PMID:10973493^[2]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0048536	spleen development	MGI:MGI:72762 PMID:7732381^[5]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0048536	spleen development	MGI:MGI:81320 PMID:8692887^[6]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0048608	reproductive structure development	MGI:MGI:3760679 PMID:12151645^[21]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857427	P	From MGI
	GO:0048732	gland development	MGI:MGI:3760679 PMID:12151645^[21]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857427	P	From MGI
	GO:0048745	smooth muscle tissue development	MGI:MGI:3794480 PMID:16443691^[3]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0050880	regulation of blood vessel size	MGI:MGI:3794480 PMID:16443691^[3]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0051879	Hsp90 protein binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P35869	F	From MGI
	GO:0051879	Hsp90 protein binding	MGI:MGI:5284778 PMID:17569696^[15]	TAS: Traceable Author Statement		F	From MGI
	GO:0060420	regulation of heart growth	MGI:MGI:3760685 PMID:14644620^[7]	TAS: Traceable Author Statement		P	From MGI
	GO:0060420	regulation of heart growth	MGI:MGI:3794480 PMID:16443691^[3]	TAS: Traceable Author Statement		P	From MGI
	GO:0060547	negative regulation of necrotic cell death	MGI:MGI:3794480 PMID:16443691^[3]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0060841	venous blood vessel development	MGI:MGI:3794480 PMID:16443691^[3]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0060993	kidney morphogenesis	MGI:MGI:3760685 PMID:14644620^[7]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0061009	common bile duct development	MGI:MGI:3794480 PMID:16443691^[3]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0071320	cellular response to cAMP	MGI:MGI:5294298 PMID:17329248^[16]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0072102	glomerulus morphogenesis	MGI:MGI:3760685 PMID:14644620^[7]	IMP: Inferred from Mutant Phenotype		P	From MGI
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Roman AC et al. (2008) Genome-wide B1 retrotransposon binds the transcription factors dioxin receptor and Slug and regulates gene expression in vivo. Proc Natl Acad Sci U S A 105: 1632-7 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 ^2.8 Lahvis GP et al. (2000) Portosystemic shunting and persistent fetal vascular structures in aryl hydrocarbon receptor-deficient mice. Proc Natl Acad Sci U S A 97: 10442-7 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 ^3.7 ^3.8 ^3.9 Harstad EB et al. (2006) Liver deformation in Ahr-null mice: evidence for aberrant hepatic perfusion in early development. Mol Pharmacol 69: 1534-41 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 Allan LL & Sherr DH (2005) Constitutive activation and environmental chemical induction of the aryl hydrocarbon receptor/transcription factor in activated human B lymphocytes. Mol Pharmacol 67: 1740-50 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 Fernandez-Salguero P et al. (1995) Immune system impairment and hepatic fibrosis in mice lacking the dioxin-binding Ah receptor. Science 268: 722-6 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 Schmidt JV et al. (1996) Characterization of a murine Ahr null allele: involvement of the Ah receptor in hepatic growth and development. Proc Natl Acad Sci U S A 93: 6731-6 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 Lund AK et al. (2003) Cardiac hypertrophy in aryl hydrocarbon receptor null mice is correlated with elevated angiotensin II, endothelin-1, and mean arterial blood pressure. Toxicol Appl Pharmacol 193: 177-87 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Okino ST et al. (1992) Phorbol esters inhibit the dioxin receptor-mediated transcriptional activation of the mouse Cyp1a-1 and Cyp1a-2 genes by 2,3,7,8-tetrachlorodibenzo-p-dioxin. J Biol Chem 267: 6991-8 PubMed GONUTS page
↑ ^9.0 ^9.1 Sadek CM et al. (2000) Isolation and characterization of AINT: a novel ARNT interacting protein expressed during murine embryonic development. Mech Dev 97: 13-26 PubMed GONUTS page
↑ Woods SL & Whitelaw ML (2002) Differential activities of murine single minded 1 (SIM1) and SIM2 on a hypoxic response element. Cross-talk between basic helix-loop-helix/per-Arnt-Sim homology transcription factors. J Biol Chem 277: 10236-43 PubMed GONUTS page
↑ ^11.0 ^11.1 Pendurthi UR et al. (1993) Accumulation of the nuclear dioxin (Ah) receptor and transcriptional activation of the mouse Cyp1a-1 and Cyp1a-2 genes. Arch Biochem Biophys 306: 65-9 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 ^12.4 ^12.5 Ema M et al. (1992) cDNA cloning and structure of mouse putative Ah receptor. Biochem Biophys Res Commun 184: 246-53 PubMed GONUTS page
↑ Pollenz RS et al. (1996) Isolation and expression of cDNAs from rainbow trout (Oncorhynchus mykiss) that encode two novel basic helix-loop-Helix/PER-ARNT-SIM (bHLH/PAS) proteins with distinct functions in the presence of the aryl hydrocarbon receptor. Evidence for alternative mRNA splicing and dominant negative activity in the bHLH/PAS family. J Biol Chem 271: 30886-96 PubMed GONUTS page
↑ Hirose K et al. (1996) cDNA cloning and tissue-specific expression of a novel basic helix-loop-helix/PAS factor (Arnt2) with close sequence similarity to the aryl hydrocarbon receptor nuclear translocator (Arnt). Mol Cell Biol 16: 1706-13 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 ^15.3 ^15.4 ^15.5 Okey AB (2007) An aryl hydrocarbon receptor odyssey to the shores of toxicology: the Deichmann Lecture, International Congress of Toxicology-XI. Toxicol Sci 98: 5-38 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 ^16.3 de Oliveira SK et al. (2007) Phosphodiesterase 2A forms a complex with the co-chaperone XAP2 and regulates nuclear translocation of the aryl hydrocarbon receptor. J Biol Chem 282: 13656-63 PubMed GONUTS page
↑ Antenos M et al. (2002) Interaction with Nedd8, a ubiquitin-like protein, enhances the transcriptional activity of the aryl hydrocarbon receptor. J Biol Chem 277: 44028-34 PubMed GONUTS page
↑ Thorgeirsson SS & Nebert DW (1977) The Ah locus and the metabolism of chemical carcinogens and other foreign compounds. Adv Cancer Res 25: 149-93 PubMed GONUTS page
↑ ^19.0 ^19.1 Puga A et al. (2002) Role of the aryl hydrocarbon receptor in cell cycle regulation. Chem Biol Interact 141: 117-30 PubMed GONUTS page
↑ Ema M et al. (1994) Dioxin binding activities of polymorphic forms of mouse and human arylhydrocarbon receptors. J Biol Chem 269: 27337-43 PubMed GONUTS page
↑ ^21.0 ^21.1 ^21.2 Lin TM et al. (2002) Effects of aryl hydrocarbon receptor null mutation and in utero and lactational 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure on prostate and seminal vesicle development in C57BL/6 mice. Toxicol Sci 68: 479-87 PubMed GONUTS page
↑ Puga A et al. (1992) Dioxin induces expression of c-fos and c-jun proto-oncogenes and a large increase in transcription factor AP-1. DNA Cell Biol 11: 269-81 PubMed GONUTS page
↑ Necela B & Pollenz RS (1999) Functional analysis of activation and repression domains of the rainbow trout aryl hydrocarbon receptor nuclear translocator (rtARNT) protein isoforms. Biochem Pharmacol 57: 1177-90 PubMed GONUTS page

[PMID:18223155-0] 1.0 ^1.1 Roman AC et al. (2008) Genome-wide B1 retrotransposon binds the transcription factors dioxin receptor and Slug and regulates gene expression in vivo. Proc Natl Acad Sci U S A 105: 1632-7 PubMed GONUTS page

[PMID:10973493-1] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 ^2.8 Lahvis GP et al. (2000) Portosystemic shunting and persistent fetal vascular structures in aryl hydrocarbon receptor-deficient mice. Proc Natl Acad Sci U S A 97: 10442-7 PubMed GONUTS page

[PMID:16443691-2] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 ^3.7 ^3.8 ^3.9 Harstad EB et al. (2006) Liver deformation in Ahr-null mice: evidence for aberrant hepatic perfusion in early development. Mol Pharmacol 69: 1534-41 PubMed GONUTS page

[PMID:15681594-3] 4.0 ^4.1 ^4.2 ^4.3 Allan LL & Sherr DH (2005) Constitutive activation and environmental chemical induction of the aryl hydrocarbon receptor/transcription factor in activated human B lymphocytes. Mol Pharmacol 67: 1740-50 PubMed GONUTS page

[PMID:7732381-4] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 Fernandez-Salguero P et al. (1995) Immune system impairment and hepatic fibrosis in mice lacking the dioxin-binding Ah receptor. Science 268: 722-6 PubMed GONUTS page

[PMID:8692887-5] 6.0 ^6.1 ^6.2 ^6.3 Schmidt JV et al. (1996) Characterization of a murine Ahr null allele: involvement of the Ah receptor in hepatic growth and development. Proc Natl Acad Sci U S A 93: 6731-6 PubMed GONUTS page

[PMID:14644620-6] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 Lund AK et al. (2003) Cardiac hypertrophy in aryl hydrocarbon receptor null mice is correlated with elevated angiotensin II, endothelin-1, and mean arterial blood pressure. Toxicol Appl Pharmacol 193: 177-87 PubMed GONUTS page

[PMID:1313028-7] 8.0 ^8.1 ^8.2 Okino ST et al. (1992) Phorbol esters inhibit the dioxin receptor-mediated transcriptional activation of the mouse Cyp1a-1 and Cyp1a-2 genes by 2,3,7,8-tetrachlorodibenzo-p-dioxin. J Biol Chem 267: 6991-8 PubMed GONUTS page

[PMID:11025203-8] 9.0 ^9.1 Sadek CM et al. (2000) Isolation and characterization of AINT: a novel ARNT interacting protein expressed during murine embryonic development. Mech Dev 97: 13-26 PubMed GONUTS page

[PMID:11782478-9] Woods SL & Whitelaw ML (2002) Differential activities of murine single minded 1 (SIM1) and SIM2 on a hypoxic response element. Cross-talk between basic helix-loop-helix/per-Arnt-Sim homology transcription factors. J Biol Chem 277: 10236-43 PubMed GONUTS page

[PMID:8215422-10] 11.0 ^11.1 Pendurthi UR et al. (1993) Accumulation of the nuclear dioxin (Ah) receptor and transcriptional activation of the mouse Cyp1a-1 and Cyp1a-2 genes. Arch Biochem Biophys 306: 65-9 PubMed GONUTS page

[PMID:1314586-11] 12.0 ^12.1 ^12.2 ^12.3 ^12.4 ^12.5 Ema M et al. (1992) cDNA cloning and structure of mouse putative Ah receptor. Biochem Biophys Res Commun 184: 246-53 PubMed GONUTS page

[PMID:8940073-12] Pollenz RS et al. (1996) Isolation and expression of cDNAs from rainbow trout (Oncorhynchus mykiss) that encode two novel basic helix-loop-Helix/PER-ARNT-SIM (bHLH/PAS) proteins with distinct functions in the presence of the aryl hydrocarbon receptor. Evidence for alternative mRNA splicing and dominant negative activity in the bHLH/PAS family. J Biol Chem 271: 30886-96 PubMed GONUTS page

[PMID:8657146-13] Hirose K et al. (1996) cDNA cloning and tissue-specific expression of a novel basic helix-loop-helix/PAS factor (Arnt2) with close sequence similarity to the aryl hydrocarbon receptor nuclear translocator (Arnt). Mol Cell Biol 16: 1706-13 PubMed GONUTS page

[PMID:17569696-14] 15.0 ^15.1 ^15.2 ^15.3 ^15.4 ^15.5 Okey AB (2007) An aryl hydrocarbon receptor odyssey to the shores of toxicology: the Deichmann Lecture, International Congress of Toxicology-XI. Toxicol Sci 98: 5-38 PubMed GONUTS page

[PMID:17329248-15] 16.0 ^16.1 ^16.2 ^16.3 de Oliveira SK et al. (2007) Phosphodiesterase 2A forms a complex with the co-chaperone XAP2 and regulates nuclear translocation of the aryl hydrocarbon receptor. J Biol Chem 282: 13656-63 PubMed GONUTS page

[PMID:12215427-16] Antenos M et al. (2002) Interaction with Nedd8, a ubiquitin-like protein, enhances the transcriptional activity of the aryl hydrocarbon receptor. J Biol Chem 277: 44028-34 PubMed GONUTS page

[PMID:405846-17] Thorgeirsson SS & Nebert DW (1977) The Ah locus and the metabolism of chemical carcinogens and other foreign compounds. Adv Cancer Res 25: 149-93 PubMed GONUTS page

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[PMID:12151645-20] 21.0 ^21.1 ^21.2 Lin TM et al. (2002) Effects of aryl hydrocarbon receptor null mutation and in utero and lactational 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure on prostate and seminal vesicle development in C57BL/6 mice. Toxicol Sci 68: 479-87 PubMed GONUTS page

[PMID:1605850-21] Puga A et al. (1992) Dioxin induces expression of c-fos and c-jun proto-oncogenes and a large increase in transcription factor AP-1. DNA Cell Biol 11: 269-81 PubMed GONUTS page

[PMID:11230806-22] Necela B & Pollenz RS (1999) Functional analysis of activation and repression domains of the rainbow trout aryl hydrocarbon receptor nuclear translocator (rtARNT) protein isoforms. Biochem Pharmacol 57: 1177-90 PubMed GONUTS page

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Species (Taxon ID)	Mus musculus (house mouse) (taxon:10090)
Gene Name(s)	Ahr ( synonyms: Ah, Ahh, Ahre, bHLHe76, dioxin receptor, In )
Protein Name(s)	aryl-hydrocarbon receptor,
External Links
MGI	MGI:105043

MGI:Ahr

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