MGI:Agtr2

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Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0001991	regulation of systemic arterial blood pressure by circulatory renin-angiotensin	MGI:MGI:76991 PMID:7477267^[1]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0002018	renin-angiotensin regulation of aldosterone production	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P35351	P	From MGI
	GO:0002033	vasodilation by angiotensin involved in regulation of systemic arterial blood pressure	MGI:MGI:1342129 PMID:10425188^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857123	P	From MGI
	GO:0002035	brain renin-angiotensin system	MGI:MGI:1327501 PMID:9878677^[3]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0004871	signal transducer activity	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0807	F	From MGI
	GO:0004872	receptor activity	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0675	F	From MGI
	GO:0004930	G-protein coupled receptor activity	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0297	F	From MGI
	GO:0004945	angiotensin type II receptor activity	MGI:MGI:1327501 PMID:9878677^[3]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0004945	angiotensin type II receptor activity	MGI:MGI:1327501 PMID:9878677^[3]	IPI: Inferred from Physical Interaction	UniProtKB:P11859	F	From MGI
	GO:0004945	angiotensin type II receptor activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P50052	F	From MGI
	GO:0005622	intracellular	MGI:MGI:4399018 PMID:17000928^[4]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005886	plasma membrane	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P35351	C	From MGI
	GO:0006883	cellular sodium ion homeostasis	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P35351	P	From MGI
	GO:0006954	inflammatory response	MGI:MGI:3844151 PMID:19404405^[5]	IGI: Inferred from Genetic Interaction	MGI:MGI:87965 MGI:MGI:87964	P	From MGI
	GO:0007165	signal transduction	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0807	P	From MGI
	GO:0007166	cell surface receptor signaling pathway	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P50052	P	From MGI
	GO:0007186	G-protein coupled receptor signaling pathway	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0297	P	From MGI
	GO:0007186	G-protein coupled receptor signaling pathway	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P50052	P	From MGI
	GO:0007199	G-protein signaling, coupled to cGMP nucleotide second messenger	MGI:MGI:4399018 PMID:17000928^[4]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0007243	intracellular protein kinase cascade	MGI:MGI:4399018 PMID:17000928^[4]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0007610	behavior	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P50052	P	From MGI
	GO:0007610	behavior	MGI:MGI:76991 PMID:7477267^[1]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0008134	transcription factor binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P35351	F	From MGI
	GO:0010459	negative regulation of heart rate	MGI:MGI:3626025 PMID:9449684^[6]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0016020	membrane	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0472	C	From MGI
	GO:0016021	integral to membrane	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0812	C	From MGI
	GO:0016021	integral to membrane	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR000276 InterPro:IPR000147 InterPro:IPR000248	C	From MGI
	GO:0017046	peptide hormone binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P35351	F	From MGI
	GO:0032516	positive regulation of phosphoprotein phosphatase activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P50052	P	From MGI
	GO:0035566	regulation of metanephros size	MGI:MGI:3808848 PMID:18607644^[7]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0035815	positive regulation of renal sodium excretion	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P35351	P	From MGI
	GO:0042990	regulation of transcription factor import into nucleus	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P35351	P	From MGI
	GO:0043065	positive regulation of apoptotic process	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P50052	P	From MGI
	GO:0045893	positive regulation of transcription, DNA-dependent	MGI:MGI:3808848 PMID:18607644^[7]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0045893	positive regulation of transcription, DNA-dependent	MGI:MGI:5009172 PMID:15153556^[8]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0045909	positive regulation of vasodilation	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P35351	P	From MGI
	GO:0045909	positive regulation of vasodilation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P50052	P	From MGI
	GO:0048471	perinuclear region of cytoplasm	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P35351	C	From MGI
	GO:0051000	positive regulation of nitric-oxide synthase activity	MGI:MGI:4399018 PMID:17000928^[4]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0051387	negative regulation of nerve growth factor receptor signaling pathway	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P50052	P	From MGI
	GO:0071549	cellular response to dexamethasone stimulus	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P35351	P	From MGI
	GO:0072300	positive regulation of metanephric glomerulus development	MGI:MGI:3808848 PMID:18607644^[7]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0090190	positive regulation of branching involved in ureteric bud morphogenesis	MGI:MGI:3808848 PMID:18607644^[7]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0090190	positive regulation of branching involved in ureteric bud morphogenesis	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P35351	P	From MGI
NOT	GO:0043524	negative regulation of neuron apoptotic process	MGI:MGI:2385817 PMID:9310306^[9]	IMP: Inferred from Mutant Phenotype		P	From MGI
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Ichiki T et al. (1995) Effects on blood pressure and exploratory behaviour of mice lacking angiotensin II type-2 receptor. Nature 377: 748-50 PubMed GONUTS page
↑ Akishita M et al. (1999) Increased vasoconstrictor response of the mouse lacking angiotensin II type 2 receptor. Biochem Biophys Res Commun 261: 345-9 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Daubert DL et al. (1999) Changes in angiotensin II receptors in dopamine-rich regions of the mouse brain with age and ethanol consumption. Brain Res 816: 8-16 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 Yayama K et al. (2006) Angiotensin II stimulates endothelial NO synthase phosphorylation in thoracic aorta of mice with abdominal aortic banding via type 2 receptor. Hypertension 48: 958-64 PubMed GONUTS page
↑ Esteban V et al. (2009) Angiotensin-(1-7) and the g protein-coupled receptor MAS are key players in renal inflammation. PLoS One 4: e5406 PubMed GONUTS page
↑ Masaki H et al. (1998) Cardiac-specific overexpression of angiotensin II AT2 receptor causes attenuated response to AT1 receptor-mediated pressor and chronotropic effects. J Clin Invest 101: 527-35 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 Chen YW et al. (2008) Deficiency of intrarenal angiotensin II type 2 receptor impairs paired homeo box-2 and N-myc expression during nephrogenesis. Pediatr Nephrol 23: 1769-77 PubMed GONUTS page
↑ Zhang SL et al. (2004) Angiotensin II increases Pax-2 expression in fetal kidney cells via the AT2 receptor. J Am Soc Nephrol 15: 1452-65 PubMed GONUTS page
↑ Kakinuma Y et al. (1997) Anti-apoptotic action of angiotensin fragments to neuronal cells from angiotensinogen knock-out mice. Neurosci Lett 232: 167-70 PubMed GONUTS page

[PMID:7477267-0] 1.0 ^1.1 Ichiki T et al. (1995) Effects on blood pressure and exploratory behaviour of mice lacking angiotensin II type-2 receptor. Nature 377: 748-50 PubMed GONUTS page

[PMID:10425188-1] Akishita M et al. (1999) Increased vasoconstrictor response of the mouse lacking angiotensin II type 2 receptor. Biochem Biophys Res Commun 261: 345-9 PubMed GONUTS page

[PMID:9878677-2] 3.0 ^3.1 ^3.2 Daubert DL et al. (1999) Changes in angiotensin II receptors in dopamine-rich regions of the mouse brain with age and ethanol consumption. Brain Res 816: 8-16 PubMed GONUTS page

[PMID:17000928-3] 4.0 ^4.1 ^4.2 ^4.3 Yayama K et al. (2006) Angiotensin II stimulates endothelial NO synthase phosphorylation in thoracic aorta of mice with abdominal aortic banding via type 2 receptor. Hypertension 48: 958-64 PubMed GONUTS page

[PMID:19404405-4] Esteban V et al. (2009) Angiotensin-(1-7) and the g protein-coupled receptor MAS are key players in renal inflammation. PLoS One 4: e5406 PubMed GONUTS page

[PMID:9449684-5] Masaki H et al. (1998) Cardiac-specific overexpression of angiotensin II AT2 receptor causes attenuated response to AT1 receptor-mediated pressor and chronotropic effects. J Clin Invest 101: 527-35 PubMed GONUTS page

[PMID:18607644-6] 7.0 ^7.1 ^7.2 ^7.3 Chen YW et al. (2008) Deficiency of intrarenal angiotensin II type 2 receptor impairs paired homeo box-2 and N-myc expression during nephrogenesis. Pediatr Nephrol 23: 1769-77 PubMed GONUTS page

[PMID:15153556-7] Zhang SL et al. (2004) Angiotensin II increases Pax-2 expression in fetal kidney cells via the AT2 receptor. J Am Soc Nephrol 15: 1452-65 PubMed GONUTS page

[PMID:9310306-8] Kakinuma Y et al. (1997) Anti-apoptotic action of angiotensin fragments to neuronal cells from angiotensinogen knock-out mice. Neurosci Lett 232: 167-70 PubMed GONUTS page

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Species (Taxon ID)	Mus musculus (house mouse) (taxon:10090)
Gene Name(s)	Agtr2 ( synonyms: AT2 receptor )
Protein Name(s)	angiotensin II receptor, type 2,
External Links
MGI	MGI:87966

MGI:Agtr2

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