GONUTS is under stress! The website is currently experiencing long-wait times and frequent time-outs due to the record number of students, groups, and annotations related to CACAO this semester. We are currently working on increasing performance -- please accept our apologies for the technical difficulties.
You can help reduce stress on the server by:
- not reloading pages frequently - this just adds
- opening links in new windows (so you can read the old page)
MGI:Agtpbp1
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Agtpbp1 ( synonyms: Nna1 ) | |
| Protein Name(s) | ATP/GTP binding protein 1, | |
| External Links | ||
| MGI | MGI:2159437 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0001754 |
eye photoreceptor cell differentiation |
MGI:MGI:3614720 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0004180 |
carboxypeptidase activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0121 |
F |
From MGI |
||
| GO:0004181 |
metallocarboxypeptidase activity |
MGI:MGI:4849873 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:4849873 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:2159471 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:2159471 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005739 |
mitochondrion |
MGI:MGI:4821195 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005829 |
cytosol |
MGI:MGI:4887331 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0006508 |
proteolysis |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0645 |
P |
From MGI |
||
| GO:0006508 |
proteolysis |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
P |
From MGI |
|||
| GO:0007005 |
mitochondrion organization |
MGI:MGI:4821195 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0007628 |
adult walking behavior |
MGI:MGI:3694543 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857523 |
P |
From MGI |
||
| GO:0008219 |
cell death |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0523 |
P |
From MGI |
||
| GO:0008233 |
peptidase activity |
MGI:MGI:4821195 |
TAS: Traceable Author Statement |
F |
From MGI |
|||
| GO:0008237 |
metallopeptidase activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0482 |
F |
From MGI |
||
| GO:0008270 |
zinc ion binding |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0015631 |
tubulin binding |
MGI:MGI:4849873 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0016787 |
hydrolase activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0378 |
F |
From MGI |
||
| GO:0021680 |
cerebellar Purkinje cell layer development |
MGI:MGI:4849309 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0021702 |
cerebellar Purkinje cell differentiation |
MGI:MGI:1347769 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856535 |
P |
From MGI |
||
| GO:0021702 |
cerebellar Purkinje cell differentiation |
MGI:MGI:2159417 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0021702 |
cerebellar Purkinje cell differentiation |
MGI:MGI:3614720 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0021702 |
cerebellar Purkinje cell differentiation |
MGI:MGI:4849873 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0021772 |
olfactory bulb development |
MGI:MGI:2159417 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0035609 |
C-terminal protein deglutamylation |
MGI:MGI:4849873 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0035610 |
protein side chain deglutamylation |
MGI:MGI:4849873 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0042133 |
neurotransmitter metabolic process |
MGI:MGI:62875 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856535 |
P |
From MGI |
||
| GO:0046872 |
metal ion binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0479 |
F |
From MGI |
||
| GO:0050905 |
neuromuscular process |
MGI:MGI:1347769 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:109482 |
P |
From MGI |
||
| GO:0050905 |
neuromuscular process |
MGI:MGI:2159417 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0060041 |
retina development in camera-type eye |
MGI:MGI:4849309 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Chakrabarti L et al. (2006) The Purkinje cell degeneration 5J mutation is a single amino acid insertion that destabilizes Nna1 protein. Mamm Genome 17: 103-10 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 Rogowski K et al. (2010) A family of protein-deglutamylating enzymes associated with neurodegeneration. Cell 143: 564-78 PubMed GONUTS page
- ↑ 3.0 3.1 Harris A et al. (2000) Regenerating motor neurons express Nna1, a novel ATP/GTP-binding protein related to zinc carboxypeptidases. Mol Cell Neurosci 16: 578-96 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 Chakrabarti L et al. (2010) Mitochondrial dysfunction in NnaD mutant flies and Purkinje cell degeneration mice reveals a role for Nna proteins in neuronal bioenergetics. Neuron 66: 835-47 PubMed GONUTS page
- ↑ Kalinina E et al. (2007) A novel subfamily of mouse cytosolic carboxypeptidases. FASEB J 21: 836-50 PubMed GONUTS page
- ↑ Wang T et al. (2006) The carboxypeptidase-like substrate-binding site in Nna1 is essential for the rescue of the Purkinje cell degeneration (pcd) phenotype. Mol Cell Neurosci 33: 200-13 PubMed GONUTS page
- ↑ 7.0 7.1 Won J et al. (2011) Mouse model resources for vision research. J Ophthalmol 2011: 391384 PubMed GONUTS page
- ↑ 8.0 8.1 Campbell DB et al. (1999) Tottering mouse motor dysfunction is abolished on the Purkinje cell degeneration (pcd) mutant background. Exp Neurol 160: 268-78 PubMed GONUTS page
- ↑ 9.0 9.1 9.2 Fernandez-Gonzalez A et al. (2002) Purkinje cell degeneration (pcd) phenotypes caused by mutations in the axotomy-induced gene, Nna1. Science 295: 1904-6 PubMed GONUTS page
- ↑ Matsui K et al. (1993) Levels of somatostatin and cholecystokinin in the brain of ataxic mutant mice. Life Sci 53: 333-40 PubMed GONUTS page
