MGI:Agt

From GONUTS

Jump to: navigation, search

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0001543	ovarian follicle rupture	MGI:MGI:1934990 PMID:11384650^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857122	P	From MGI
	GO:0001568	blood vessel development	MGI:MGI:1196814 PMID:9466969^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2183545	P	From MGI
	GO:0001568	blood vessel development	MGI:MGI:77583 PMID:8675666^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2183545	P	From MGI
	GO:0001658	branching involved in ureteric bud morphogenesis	MGI:MGI:2655949 PMID:12657564^[4]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0001822	kidney development	MGI:MGI:1196814 PMID:9466969^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2183545	P	From MGI
	GO:0001822	kidney development	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01019	P	From MGI
	GO:0001822	kidney development	MGI:MGI:77583 PMID:8675666^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2183545	P	From MGI
	GO:0001991	regulation of systemic arterial blood pressure by circulatory renin-angiotensin	MGI:MGI:1196814 PMID:9466969^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2183545	P	From MGI
	GO:0001991	regulation of systemic arterial blood pressure by circulatory renin-angiotensin	MGI:MGI:1201253 PMID:9507198^[5]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2136636	P	From MGI
	GO:0001991	regulation of systemic arterial blood pressure by circulatory renin-angiotensin	MGI:MGI:1332965 PMID:10076178^[6]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2136636	P	From MGI
	GO:0001991	regulation of systemic arterial blood pressure by circulatory renin-angiotensin	MGI:MGI:2154640 PMID:11606482^[7]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2136636	P	From MGI
	GO:0001991	regulation of systemic arterial blood pressure by circulatory renin-angiotensin	MGI:MGI:2385818 PMID:9852267^[8]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2136636	P	From MGI
	GO:0001991	regulation of systemic arterial blood pressure by circulatory renin-angiotensin	MGI:MGI:3608266 PMID:12574102^[9]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857121	P	From MGI
	GO:0001991	regulation of systemic arterial blood pressure by circulatory renin-angiotensin	MGI:MGI:69788 PMID:7989296^[10]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2136636	P	From MGI
	GO:0001998	angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressure	MGI:MGI:1342129 PMID:10425188^[11]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0001999	renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure	MGI:MGI:2154640 PMID:11606482^[7]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0002018	renin-angiotensin regulation of aldosterone production	MGI:MGI:1332965 PMID:10076178^[6]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2136636	P	From MGI
	GO:0002018	renin-angiotensin regulation of aldosterone production	MGI:MGI:2385818 PMID:9852267^[8]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2136636	P	From MGI
	GO:0002018	renin-angiotensin regulation of aldosterone production	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P01015	P	From MGI
	GO:0002019	regulation of renal output by angiotensin	MGI:MGI:1201253 PMID:9507198^[5]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2136636	P	From MGI
	GO:0002019	regulation of renal output by angiotensin	MGI:MGI:2154640 PMID:11606482^[7]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0002019	regulation of renal output by angiotensin	MGI:MGI:2385818 PMID:9852267^[8]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2136636	P	From MGI
	GO:0002035	brain renin-angiotensin system	MGI:MGI:1327501 PMID:9878677^[12]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0002035	brain renin-angiotensin system	MGI:MGI:3610800 PMID:15499027^[13]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0003051	angiotensin-mediated drinking behavior	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P01015	P	From MGI
	GO:0003331	positive regulation of extracellular matrix constituent secretion	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P01015	P	From MGI
	GO:0004867	serine-type endopeptidase inhibitor activity	MGI:MGI:4459044		PANTHER:PTHR11461	F	From MGI
	GO:0005179	hormone activity	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P01015	F	From MGI
	GO:0005615	extracellular space	MGI:MGI:1342129 PMID:10425188^[11]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005615	extracellular space	MGI:MGI:2154640 PMID:11606482^[7]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005615	extracellular space	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P01015	C	From MGI
	GO:0005615	extracellular space	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01019	C	From MGI
	GO:0005615	extracellular space	MGI:MGI:69788 PMID:7989296^[10]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0006883	cellular sodium ion homeostasis	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P01015	P	From MGI
	GO:0006917	induction of apoptosis	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P01015	P	From MGI
	GO:0007160	cell-matrix adhesion	MGI:MGI:2385816 PMID:9734405^[14]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2136636	P	From MGI
	GO:0007166	cell surface receptor signaling pathway	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P01015	P	From MGI
	GO:0007186	G-protein coupled receptor signaling pathway	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P01015	P	From MGI
	GO:0007186	G-protein coupled receptor signaling pathway	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01019	P	From MGI
	GO:0007202	activation of phospholipase C activity	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P01015	P	From MGI
	GO:0007250	activation of NF-kappaB-inducing kinase activity	MGI:MGI:3844151 PMID:19404405^[15]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0007588	excretion	MGI:MGI:3618038 PMID:9557921^[16]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2136636	P	From MGI
	GO:0008065	establishment of blood-nerve barrier	MGI:MGI:2385816 PMID:9734405^[14]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2136636	P	From MGI
	GO:0008217	regulation of blood pressure	MGI:MGI:3618038 PMID:9557921^[16]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2136636	P	From MGI
	GO:0008285	negative regulation of cell proliferation	MGI:MGI:1336863 PMID:10318840^[17]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857121	P	From MGI
	GO:0008285	negative regulation of cell proliferation	MGI:MGI:2154640 PMID:11606482^[7]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0008285	negative regulation of cell proliferation	MGI:MGI:77583 PMID:8675666^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2183545	P	From MGI
	GO:0009409	response to cold	MGI:MGI:3608266 PMID:12574102^[9]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857121	P	From MGI
	GO:0009651	response to salt stress	MGI:MGI:3618038 PMID:9557921^[16]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2136636	P	From MGI
	GO:0010468	regulation of gene expression	MGI:MGI:3710915 PMID:16585392^[18]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0010535	positive regulation of activation of JAK2 kinase activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01019	P	From MGI
	GO:0010595	positive regulation of endothelial cell migration	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01019	P	From MGI
	GO:0010613	positive regulation of cardiac muscle hypertrophy	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P01015	P	From MGI
	GO:0010628	positive regulation of gene expression	MGI:MGI:3844151 PMID:19404405^[15]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0010698	acetyltransferase activator activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01019	F	From MGI
	GO:0010873	positive regulation of cholesterol esterification	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01019	P	From MGI
	GO:0010951	negative regulation of endopeptidase activity	MGI:MGI:4459044		PANTHER:PTHR11461	P	From MGI
	GO:0014061	regulation of norepinephrine secretion	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P01015	P	From MGI
	GO:0014068	positive regulation of phosphatidylinositol 3-kinase cascade	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01019	P	From MGI
	GO:0014824	artery smooth muscle contraction	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P01015	P	From MGI
	GO:0014873	response to muscle activity involved in regulation of muscle adaptation	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P01015	P	From MGI
	GO:0030162	regulation of proteolysis	MGI:MGI:4459044		PANTHER:PTHR11461	P	From MGI
	GO:0030198	extracellular matrix organization	MGI:MGI:2385816 PMID:9734405^[14]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2136636	P	From MGI
	GO:0030308	negative regulation of cell growth	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P01015	P	From MGI
	GO:0030432	peristalsis	MGI:MGI:1313232 PMID:9788961^[19]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2183545	P	From MGI
	GO:0031701	angiotensin receptor binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P01015	F	From MGI
	GO:0031702	type 1 angiotensin receptor binding	MGI:MGI:1327501 PMID:9878677^[12]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0031702	type 1 angiotensin receptor binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P01015	F	From MGI
	GO:0031702	type 1 angiotensin receptor binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01019	F	From MGI
	GO:0031703	type 2 angiotensin receptor binding	MGI:MGI:1327501 PMID:9878677^[12]	IPI: Inferred from Physical Interaction	UniProtKB:P35374	F	From MGI
	GO:0031703	type 2 angiotensin receptor binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P01015	F	From MGI
	GO:0031703	type 2 angiotensin receptor binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01019	F	From MGI
	GO:0032270	positive regulation of cellular protein metabolic process	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01019	P	From MGI
	GO:0032930	positive regulation of superoxide anion generation	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P01015	P	From MGI
	GO:0034104	negative regulation of tissue remodeling	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P01015	P	From MGI
	GO:0035411	catenin import into nucleus	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P01015	P	From MGI
	GO:0035813	regulation of renal sodium excretion	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P01015	P	From MGI
	GO:0035815	positive regulation of renal sodium excretion	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P01015	P	From MGI
	GO:0040018	positive regulation of multicellular organism growth	MGI:MGI:2656460 PMID:12660889^[20]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2136636	P	From MGI
	GO:0042310	vasoconstriction	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P01015	P	From MGI
	GO:0042311	vasodilation	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P01015	P	From MGI
	GO:0042445	hormone metabolic process	MGI:MGI:2656460 PMID:12660889^[20]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2136636	P	From MGI
	GO:0042756	drinking behavior	MGI:MGI:2385818 PMID:9852267^[8]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2136636	P	From MGI
	GO:0042981	regulation of apoptotic process	MGI:MGI:3844151 PMID:19404405^[15]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0043065	positive regulation of apoptotic process	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01019	P	From MGI
	GO:0043085	positive regulation of catalytic activity	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P01015	P	From MGI
	GO:0043410	positive regulation of MAPK cascade	MGI:MGI:892747 PMID:9196031^[21]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2136636	P	From MGI
	GO:0043524	negative regulation of neuron apoptotic process	MGI:MGI:2385817 PMID:9310306^[22]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2136636	P	From MGI
	GO:0044444	cytoplasmic part	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P01015	C	From MGI
	GO:0045723	positive regulation of fatty acid biosynthetic process	MGI:MGI:2154640 PMID:11606482^[7]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0045742	positive regulation of epidermal growth factor receptor signaling pathway	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01019	P	From MGI
	GO:0045777	positive regulation of blood pressure	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P01015	P	From MGI
	GO:0045893	positive regulation of transcription, DNA-dependent	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01019	P	From MGI
	GO:0046622	positive regulation of organ growth	MGI:MGI:2656460 PMID:12660889^[20]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2136636	P	From MGI
	GO:0046622	positive regulation of organ growth	MGI:MGI:3614905 PMID:16374517^[23]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0048143	astrocyte activation	MGI:MGI:2385816 PMID:9734405^[14]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2136636	P	From MGI
	GO:0048144	fibroblast proliferation	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P01015	P	From MGI
	GO:0048146	positive regulation of fibroblast proliferation	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P01015	P	From MGI
	GO:0048169	regulation of long-term neuronal synaptic plasticity	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P01015	P	From MGI
	GO:0048659	smooth muscle cell proliferation	MGI:MGI:1313232 PMID:9788961^[19]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0048659	smooth muscle cell proliferation	MGI:MGI:1313232 PMID:9788961^[19]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2183545	P	From MGI
	GO:0048659	smooth muscle cell proliferation	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P01015	P	From MGI
	GO:0050663	cytokine secretion	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P01015	P	From MGI
	GO:0050727	regulation of inflammatory response	MGI:MGI:3844151 PMID:19404405^[15]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0050727	regulation of inflammatory response	MGI:MGI:3844151 PMID:19404405^[15]	IGI: Inferred from Genetic Interaction	MGI:MGI:98259	P	From MGI
	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01019	P	From MGI
	GO:0051145	smooth muscle cell differentiation	MGI:MGI:1313232 PMID:9788961^[19]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0051145	smooth muscle cell differentiation	MGI:MGI:1313232 PMID:9788961^[19]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2183545	P	From MGI
	GO:0051387	negative regulation of nerve growth factor receptor signaling pathway	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01019	P	From MGI
	GO:0051403	stress-activated MAPK cascade	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P01015	P	From MGI
	GO:0051929	positive regulation of calcium ion transport via voltage-gated calcium channel activity	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P01015	P	From MGI
	GO:0061049	cell growth involved in cardiac muscle cell development	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P01015	P	From MGI
	GO:0061098	positive regulation of protein tyrosine kinase activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01019	P	From MGI
	GO:0070371	ERK1 and ERK2 cascade	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P01015	P	From MGI
	GO:0090190	positive regulation of branching involved in ureteric bud morphogenesis	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01019	P	From MGI
NOT	GO:0001658	branching involved in ureteric bud morphogenesis	MGI:MGI:77583 PMID:8675666^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2183545	P	From MGI
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ Hefler LA & Gregg AR (2001) Influence of the angiotensinogen gene on the ovulatory capacity of mice. Fertil Steril 75: 1206-11 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Tsuchida S et al. (1998) Murine double nullizygotes of the angiotensin type 1A and 1B receptor genes duplicate severe abnormal phenotypes of angiotensinogen nullizygotes. J Clin Invest 101: 755-60 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Niimura F et al. (1995) Gene targeting in mice reveals a requirement for angiotensin in the development and maintenance of kidney morphology and growth factor regulation. J Clin Invest 96: 2947-54 PubMed GONUTS page
↑ Iosipiv IV & Schroeder M (2003) A role for angiotensin II AT1 receptors in ureteric bud cell branching. Am J Physiol Renal Physiol 285: F199-207 PubMed GONUTS page
↑ ^5.0 ^5.1 Kihara M et al. (1998) Genetic deficiency of angiotensinogen produces an impaired urine concentrating ability in mice. Kidney Int 53: 548-55 PubMed GONUTS page
↑ ^6.0 ^6.1 Tamura K et al. (1999) Tissue-specific changes of type 1 angiotensin II receptor and angiotensin-converting enzyme mRNA in angiotensinogen gene-knockout mice. J Endocrinol 160: 401-8 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 Massiéra F et al. (2001) Adipose angiotensinogen is involved in adipose tissue growth and blood pressure regulation. FASEB J 15: 2727-9 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 Taniguchi K et al. (1998) Pathologic characterization of hypotensive C57BL/6J-agt: angiotensinogen-deficient C57BL/6J mice. Int J Mol Med 1: 583-7 PubMed GONUTS page
↑ ^9.0 ^9.1 Sun Z et al. (2003) Angiotensinogen gene knockout delays and attenuates cold-induced hypertension. Hypertension 41: 322-7 PubMed GONUTS page
↑ ^10.0 ^10.1 Tanimoto K et al. (1994) Angiotensinogen-deficient mice with hypotension. J Biol Chem 269: 31334-7 PubMed GONUTS page
↑ ^11.0 ^11.1 Akishita M et al. (1999) Increased vasoconstrictor response of the mouse lacking angiotensin II type 2 receptor. Biochem Biophys Res Commun 261: 345-9 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 Daubert DL et al. (1999) Changes in angiotensin II receptors in dopamine-rich regions of the mouse brain with age and ethanol consumption. Brain Res 816: 8-16 PubMed GONUTS page
↑ Kazama K et al. (2004) Angiotensin II impairs neurovascular coupling in neocortex through NADPH oxidase-derived radicals. Circ Res 95: 1019-26 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 ^14.3 Kakinuma Y et al. (1998) Impaired blood-brain barrier function in angiotensinogen-deficient mice. Nat Med 4: 1078-80 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 ^15.3 ^15.4 Esteban V et al. (2009) Angiotensin-(1-7) and the g protein-coupled receptor MAS are key players in renal inflammation. PLoS One 4: e5406 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 Umemura S et al. (1998) Endocrinological abnormalities in angiotensinogen-gene knockout mice: studies of hormonal responses to dietary salt loading. J Hypertens 16: 285-9 PubMed GONUTS page
↑ Kim HS et al. (1999) Homeostasis in mice with genetically decreased angiotensinogen is primarily by an increased number of renin-producing cells. J Biol Chem 274: 14210-7 PubMed GONUTS page
↑ Itoh S et al. (2006) Role of p90 ribosomal S6 kinase-mediated prorenin-converting enzyme in ischemic and diabetic myocardium. Circulation 113: 1787-98 PubMed GONUTS page
↑ ^19.0 ^19.1 ^19.2 ^19.3 ^19.4 Miyazaki Y et al. (1998) Angiotensin induces the urinary peristaltic machinery during the perinatal period. J Clin Invest 102: 1489-97 PubMed GONUTS page
↑ ^20.0 ^20.1 ^20.2 Kim S et al. (2002) Effects of high-fat diet, angiotensinogen (agt) gene inactivation, and targeted expression to adipose tissue on lipid metabolism and renal gene expression. Horm Metab Res 34: 721-5 PubMed GONUTS page
↑ Nyui N et al. (1997) Stretch-induced MAP kinase activation in cardiomyocytes of angiotensinogen-deficient mice. Biochem Biophys Res Commun 235: 36-41 PubMed GONUTS page
↑ Kakinuma Y et al. (1997) Anti-apoptotic action of angiotensin fragments to neuronal cells from angiotensinogen knock-out mice. Neurosci Lett 232: 167-70 PubMed GONUTS page
↑ Peng X et al. (2006) Inactivation of focal adhesion kinase in cardiomyocytes promotes eccentric cardiac hypertrophy and fibrosis in mice. J Clin Invest 116: 217-27 PubMed GONUTS page

[PMID:11384650-0] Hefler LA & Gregg AR (2001) Influence of the angiotensinogen gene on the ovulatory capacity of mice. Fertil Steril 75: 1206-11 PubMed GONUTS page

[PMID:9466969-1] 2.0 ^2.1 ^2.2 Tsuchida S et al. (1998) Murine double nullizygotes of the angiotensin type 1A and 1B receptor genes duplicate severe abnormal phenotypes of angiotensinogen nullizygotes. J Clin Invest 101: 755-60 PubMed GONUTS page

[PMID:8675666-2] 3.0 ^3.1 ^3.2 ^3.3 Niimura F et al. (1995) Gene targeting in mice reveals a requirement for angiotensin in the development and maintenance of kidney morphology and growth factor regulation. J Clin Invest 96: 2947-54 PubMed GONUTS page

[PMID:12657564-3] Iosipiv IV & Schroeder M (2003) A role for angiotensin II AT1 receptors in ureteric bud cell branching. Am J Physiol Renal Physiol 285: F199-207 PubMed GONUTS page

[PMID:9507198-4] 5.0 ^5.1 Kihara M et al. (1998) Genetic deficiency of angiotensinogen produces an impaired urine concentrating ability in mice. Kidney Int 53: 548-55 PubMed GONUTS page

[PMID:10076178-5] 6.0 ^6.1 Tamura K et al. (1999) Tissue-specific changes of type 1 angiotensin II receptor and angiotensin-converting enzyme mRNA in angiotensinogen gene-knockout mice. J Endocrinol 160: 401-8 PubMed GONUTS page

[PMID:11606482-6] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 Massiéra F et al. (2001) Adipose angiotensinogen is involved in adipose tissue growth and blood pressure regulation. FASEB J 15: 2727-9 PubMed GONUTS page

[PMID:9852267-7] 8.0 ^8.1 ^8.2 ^8.3 Taniguchi K et al. (1998) Pathologic characterization of hypotensive C57BL/6J-agt: angiotensinogen-deficient C57BL/6J mice. Int J Mol Med 1: 583-7 PubMed GONUTS page

[PMID:12574102-8] 9.0 ^9.1 Sun Z et al. (2003) Angiotensinogen gene knockout delays and attenuates cold-induced hypertension. Hypertension 41: 322-7 PubMed GONUTS page

[PMID:7989296-9] 10.0 ^10.1 Tanimoto K et al. (1994) Angiotensinogen-deficient mice with hypotension. J Biol Chem 269: 31334-7 PubMed GONUTS page

[PMID:10425188-10] 11.0 ^11.1 Akishita M et al. (1999) Increased vasoconstrictor response of the mouse lacking angiotensin II type 2 receptor. Biochem Biophys Res Commun 261: 345-9 PubMed GONUTS page

[PMID:9878677-11] 12.0 ^12.1 ^12.2 Daubert DL et al. (1999) Changes in angiotensin II receptors in dopamine-rich regions of the mouse brain with age and ethanol consumption. Brain Res 816: 8-16 PubMed GONUTS page

[PMID:15499027-12] Kazama K et al. (2004) Angiotensin II impairs neurovascular coupling in neocortex through NADPH oxidase-derived radicals. Circ Res 95: 1019-26 PubMed GONUTS page

[PMID:9734405-13] 14.0 ^14.1 ^14.2 ^14.3 Kakinuma Y et al. (1998) Impaired blood-brain barrier function in angiotensinogen-deficient mice. Nat Med 4: 1078-80 PubMed GONUTS page

[PMID:19404405-14] 15.0 ^15.1 ^15.2 ^15.3 ^15.4 Esteban V et al. (2009) Angiotensin-(1-7) and the g protein-coupled receptor MAS are key players in renal inflammation. PLoS One 4: e5406 PubMed GONUTS page

[PMID:9557921-15] 16.0 ^16.1 ^16.2 Umemura S et al. (1998) Endocrinological abnormalities in angiotensinogen-gene knockout mice: studies of hormonal responses to dietary salt loading. J Hypertens 16: 285-9 PubMed GONUTS page

[PMID:10318840-16] Kim HS et al. (1999) Homeostasis in mice with genetically decreased angiotensinogen is primarily by an increased number of renin-producing cells. J Biol Chem 274: 14210-7 PubMed GONUTS page

[PMID:16585392-17] Itoh S et al. (2006) Role of p90 ribosomal S6 kinase-mediated prorenin-converting enzyme in ischemic and diabetic myocardium. Circulation 113: 1787-98 PubMed GONUTS page

[PMID:9788961-18] 19.0 ^19.1 ^19.2 ^19.3 ^19.4 Miyazaki Y et al. (1998) Angiotensin induces the urinary peristaltic machinery during the perinatal period. J Clin Invest 102: 1489-97 PubMed GONUTS page

[PMID:12660889-19] 20.0 ^20.1 ^20.2 Kim S et al. (2002) Effects of high-fat diet, angiotensinogen (agt) gene inactivation, and targeted expression to adipose tissue on lipid metabolism and renal gene expression. Horm Metab Res 34: 721-5 PubMed GONUTS page

[PMID:9196031-20] Nyui N et al. (1997) Stretch-induced MAP kinase activation in cardiomyocytes of angiotensinogen-deficient mice. Biochem Biophys Res Commun 235: 36-41 PubMed GONUTS page

[PMID:9310306-21] Kakinuma Y et al. (1997) Anti-apoptotic action of angiotensin fragments to neuronal cells from angiotensinogen knock-out mice. Neurosci Lett 232: 167-70 PubMed GONUTS page

[PMID:16374517-22] Peng X et al. (2006) Inactivation of focal adhesion kinase in cardiomyocytes promotes eccentric cardiac hypertrophy and fibrosis in mice. J Clin Invest 116: 217-27 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

[12]

[13]

[14]

[15]

[16]

[17]

[18]

[19]

[20]

[21]

[22]

[23]

Species (Taxon ID)	Mus musculus (house mouse) (taxon:10090)
Gene Name(s)	Agt ( synonyms: angiotensin precursor, Aogen, Serpina8 )
Protein Name(s)	angiotensinogen (serpin peptidase inhibitor, clade A, member 8),
External Links
MGI	MGI:87963

MGI:Agt

Contents

Annotations

Notes

References

a

b

c

d

e

f

g

h

i

k

n

o

p

p cont.

r

s

t

v

Personal tools

Namespaces

Variants

Views

Actions

Search

Navigation

Cacao

Journal Clubs

page contributors

Toolbox