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MGI:Aes

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Contents

Species (Taxon ID) Mus musculus (house mouse) (taxon:10090)
Gene Name(s) Aes ( synonyms: AES, Grg, Grg5 )
Protein Name(s) amino-terminal enhancer of split,
External Links
MGI MGI:95806

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000122

negative regulation of transcription from RNA polymerase II promoter

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:Q08117

P

From MGI

GO:0001501

skeletal system development

MGI:MGI:2179356
PMID:11984876[1]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2180116

P

From MGI

GO:0003714

transcription corepressor activity

MGI:MGI:2182264
PMID:12050133[2]

IDA: Inferred from Direct Assay

F

From MGI

GO:0003714

transcription corepressor activity

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:Q08117

F

From MGI

GO:0005515

protein binding

MGI:MGI:2182264
PMID:12050133[2]

IPI: Inferred from Physical Interaction

UniProtKB:Q9QZ28
UniProtKB:Q62233

F

From MGI

GO:0005515

protein binding

MGI:MGI:3603095
PMID:16002402[3]

IPI: Inferred from Physical Interaction

UniProtKB:P25425
UniProtKB:P13297

F

From MGI

GO:0005634

nucleus

MGI:MGI:2182264
PMID:12050133[2]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005634

nucleus

MGI:MGI:3603095
PMID:16002402[3]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005634

nucleus

MGI:MGI:4367296
PMID:19796622[4]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005634

nucleus

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P63003

C

From MGI

GO:0006351

transcription, DNA-dependent

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0804

P

From MGI

GO:0006355

regulation of transcription, DNA-dependent

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0805

P

From MGI

GO:0006357

regulation of transcription from RNA polymerase II promoter

MGI:MGI:3603095
PMID:16002402[3]

IGI: Inferred from Genetic Interaction

MGI:MGI:97168

P

From MGI

GO:0016055

Wnt receptor signaling pathway

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0879

P

From MGI

GO:0031668

cellular response to extracellular stimulus

MGI:MGI:1335904
PMID:10322635[5]

IDA: Inferred from Direct Assay

P

From MGI

GO:0032091

negative regulation of protein binding

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:Q08117

P

From MGI

GO:0040008

regulation of growth

MGI:MGI:2179356
PMID:11984876[1]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2180116

P

From MGI

GO:0045892

negative regulation of transcription, DNA-dependent

MGI:MGI:2182264
PMID:12050133[2]

IDA: Inferred from Direct Assay

P

From MGI

GO:0045892

negative regulation of transcription, DNA-dependent

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:Q08117

P

From MGI

GO:0060761

negative regulation of response to cytokine stimulus

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:Q08117

P

From MGI

GO:0070555

response to interleukin-1

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:Q08117

P

From MGI

GO:0090090

negative regulation of canonical Wnt receptor signaling pathway

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:Q08117

P

From MGI


Notes

References

See Help:References for how to manage references in GONUTS.
  1. 1.0 1.1 Wang WF et al. (2002) Growth defect in Grg5 null mice is associated with reduced Ihh signaling in growth plates. Dev Dyn 224: 79-89 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 Zhu CC et al. (2002) Six3-mediated auto repression and eye development requires its interaction with members of the Groucho-related family of co-repressors. Development 129: 2835-49 PubMed GONUTS page
  3. 3.0 3.1 3.2 Rave-Harel N et al. (2005) The Groucho-related gene family regulates the gonadotropin-releasing hormone gene through interaction with the homeodomain proteins MSX1 and OCT1. J Biol Chem 280: 30975-83 PubMed GONUTS page
  4. Nishiyama A et al. (2009) Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors. Cell Stem Cell 5: 420-33 PubMed GONUTS page
  5. Leimeister C et al. (1999) Screen for genes regulated during early kidney morphogenesis. Dev Genet 24: 273-83 PubMed GONUTS page
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