MGI:Adora2b

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Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0001609	G-protein coupled adenosine receptor activity	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P29276	F	From MGI
	GO:0001973	adenosine receptor signaling pathway	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P29276	P	From MGI
	GO:0002882	positive regulation of chronic inflammatory response to non-antigenic stimulus	MGI:MGI:3664521 PMID:16841096^[1]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0004871	signal transducer activity	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0807	F	From MGI
	GO:0004872	receptor activity	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0675	F	From MGI
	GO:0004930	G-protein coupled receptor activity	MGI:MGI:3664521 PMID:16841096^[1]	IMP: Inferred from Mutant Phenotype		F	From MGI
	GO:0005622	intracellular	MGI:MGI:3664521 PMID:16841096^[1]	IMP: Inferred from Mutant Phenotype		C	From MGI
	GO:0005622	intracellular	MGI:MGI:3794903 PMID:18340377^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3773754	C	From MGI
	GO:0005886	plasma membrane	MGI:MGI:2664591 PMID:12817016^[3]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005886	plasma membrane	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P29276	C	From MGI
	GO:0007165	signal transduction	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0807	P	From MGI
	GO:0007186	G-protein coupled receptor signaling pathway	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0297	P	From MGI
	GO:0007186	G-protein coupled receptor signaling pathway	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR000276 InterPro:IPR001435	P	From MGI
	GO:0007189	activation of adenylate cyclase activity by G-protein signaling pathway	MGI:MGI:3664521 PMID:16841096^[1]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0007189	activation of adenylate cyclase activity by G-protein signaling pathway	MGI:MGI:3794903 PMID:18340377^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3773754	P	From MGI
	GO:0008284	positive regulation of cell proliferation	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P29276	P	From MGI
	GO:0008285	negative regulation of cell proliferation	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P29276	P	From MGI
	GO:0009986	cell surface	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P29276	C	From MGI
	GO:0010575	positive regulation vascular endothelial growth factor production	MGI:MGI:3806198 PMID:18559975^[4]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3773754	P	From MGI
	GO:0010701	positive regulation of norepinephrine secretion	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P29276	P	From MGI
	GO:0010893	positive regulation of steroid biosynthetic process	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P29276	P	From MGI
	GO:0016020	membrane	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0472	C	From MGI
	GO:0016021	integral to membrane	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0812	C	From MGI
	GO:0016021	integral to membrane	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR000276 InterPro:IPR001435 InterPro:IPR001634	C	From MGI
	GO:0030819	positive regulation of cAMP biosynthetic process	MGI:MGI:3664521 PMID:16841096^[1]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0030819	positive regulation of cAMP biosynthetic process	MGI:MGI:3794903 PMID:18340377^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3773754	P	From MGI
	GO:0030819	positive regulation of cAMP biosynthetic process	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P29276	P	From MGI
	GO:0030828	positive regulation of cGMP biosynthetic process	MGI:MGI:3794903 PMID:18340377^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3773754	P	From MGI
	GO:0031284	positive regulation of guanylate cyclase activity	MGI:MGI:3794903 PMID:18340377^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3773754	P	From MGI
	GO:0031668	cellular response to extracellular stimulus	MGI:MGI:65736 PMID:8157966^[5]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0032722	positive regulation of chemokine production	MGI:MGI:3806198 PMID:18559975^[4]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3773754	P	From MGI
	GO:0032755	positive regulation of interleukin-6 production	MGI:MGI:3806198 PMID:18559975^[4]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3773754	P	From MGI
	GO:0032966	negative regulation of collagen biosynthetic process	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P29276	P	From MGI
	GO:0033605	positive regulation of catecholamine secretion	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P29276	P	From MGI
	GO:0043306	positive regulation of mast cell degranulation	MGI:MGI:3776334 PMID:11454903^[6]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0045765	regulation of angiogenesis	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P29276	P	From MGI
	GO:0045909	positive regulation of vasodilation	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P29276	P	From MGI
	GO:0060087	relaxation of vascular smooth muscle	MGI:MGI:3794903 PMID:18340377^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3773754	P	From MGI
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 Sun CX et al. (2006) Role of A2B adenosine receptor signaling in adenosine-dependent pulmonary inflammation and injury. J Clin Invest 116: 2173-2182 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Mi T et al. (2008) Excess adenosine in murine penile erectile tissues contributes to priapism via A2B adenosine receptor signaling. J Clin Invest 118: 1491-501 PubMed GONUTS page
↑ Zhong H et al. (2003) Activation of murine lung mast cells by the adenosine A3 receptor. J Immunol 171: 338-45 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Novitskiy SV et al. (2008) Adenosine receptors in regulation of dendritic cell differentiation and function. Blood 112: 1822-31 PubMed GONUTS page
↑ Marquardt DL et al. (1994) Cloning of two adenosine receptor subtypes from mouse bone marrow-derived mast cells. J Immunol 152: 4508-15 PubMed GONUTS page
↑ Zhong H et al. (2001) Adenosine-mediated mast cell degranulation in adenosine deaminase-deficient mice. J Pharmacol Exp Ther 298: 433-40 PubMed GONUTS page

[PMID:16841096-0] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 Sun CX et al. (2006) Role of A2B adenosine receptor signaling in adenosine-dependent pulmonary inflammation and injury. J Clin Invest 116: 2173-2182 PubMed GONUTS page

[PMID:18340377-1] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Mi T et al. (2008) Excess adenosine in murine penile erectile tissues contributes to priapism via A2B adenosine receptor signaling. J Clin Invest 118: 1491-501 PubMed GONUTS page

[PMID:12817016-2] Zhong H et al. (2003) Activation of murine lung mast cells by the adenosine A3 receptor. J Immunol 171: 338-45 PubMed GONUTS page

[PMID:18559975-3] 4.0 ^4.1 ^4.2 Novitskiy SV et al. (2008) Adenosine receptors in regulation of dendritic cell differentiation and function. Blood 112: 1822-31 PubMed GONUTS page

[PMID:8157966-4] Marquardt DL et al. (1994) Cloning of two adenosine receptor subtypes from mouse bone marrow-derived mast cells. J Immunol 152: 4508-15 PubMed GONUTS page

[PMID:11454903-5] Zhong H et al. (2001) Adenosine-mediated mast cell degranulation in adenosine deaminase-deficient mice. J Pharmacol Exp Ther 298: 433-40 PubMed GONUTS page

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Species (Taxon ID)	Mus musculus (house mouse) (taxon:10090)
Gene Name(s)	Adora2b ( synonyms: A2b, A2b, Rs, A2BAR, A2BR, AA2BR )
Protein Name(s)	adenosine A2b receptor,
External Links
MGI	MGI:99403

MGI:Adora2b

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