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MGI:Adm

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Contents

Species (Taxon ID) Mus musculus (house mouse) (taxon:10090)
Gene Name(s) Adm ( synonyms: AM )
Protein Name(s) adrenomedullin,
External Links
MGI MGI:108058

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0001570

vasculogenesis

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P35318

P

From MGI

GO:0001843

neural tube closure

MGI:MGI:3689296
PMID:16981008[1]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2176598

P

From MGI

GO:0002026

regulation of the force of heart contraction

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P43145

P

From MGI

GO:0002031

G-protein coupled receptor internalization

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P35318

P

From MGI

GO:0005179

hormone activity

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0372

F

From MGI

GO:0005179

hormone activity

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR001710
InterPro:IPR021116

F

From MGI

GO:0005576

extracellular region

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0964

C

From MGI

GO:0005576

extracellular region

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR001710
InterPro:IPR021116

C

From MGI

GO:0005615

extracellular space

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P43145

C

From MGI

GO:0005615

extracellular space

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P35318

C

From MGI

GO:0005737

cytoplasm

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P35318

C

From MGI

GO:0006171

cAMP biosynthetic process

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P35318

P

From MGI

GO:0006950

response to stress

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P43145

P

From MGI

GO:0007204

elevation of cytosolic calcium ion concentration

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P43145

P

From MGI

GO:0007507

heart development

MGI:MGI:3619781
PMID:16537897[2]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2176598

P

From MGI

GO:0007507

heart development

MGI:MGI:3689296
PMID:16981008[1]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2176598

P

From MGI

GO:0007507

heart development

MGI:MGI:3772552
PMID:18097473[3]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0008209

androgen metabolic process

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P43145

P

From MGI

GO:0008284

positive regulation of cell proliferation

MGI:MGI:3619781
PMID:16537897[2]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2176598

P

From MGI

GO:0008285

negative regulation of cell proliferation

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P43145

P

From MGI

GO:0009611

response to wounding

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P43145

P

From MGI

GO:0010460

positive regulation of heart rate

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P43145

P

From MGI

GO:0030819

positive regulation of cAMP biosynthetic process

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P35318

P

From MGI

GO:0031102

neuron projection regeneration

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P43145

P

From MGI

GO:0031623

receptor internalization

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P35318

P

From MGI

GO:0031700

adrenomedullin receptor binding

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P43145

F

From MGI

GO:0032496

response to lipopolysaccharide

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P43145

P

From MGI

GO:0043116

negative regulation of vascular permeability

MGI:MGI:3772552
PMID:18097473[3]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0045766

positive regulation of angiogenesis

MGI:MGI:3772552
PMID:18097473[3]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0045768

positive regulation of anti-apoptosis

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P43145

P

From MGI

GO:0045906

negative regulation of vasoconstriction

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P35318

P

From MGI

GO:0045909

positive regulation of vasodilation

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P43145

P

From MGI

GO:0046879

hormone secretion

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P43145

P

From MGI

GO:0048589

developmental growth

MGI:MGI:3689296
PMID:16981008[1]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2176598

P

From MGI

GO:0055074

calcium ion homeostasis

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P43145

P

From MGI

GO:0060670

branching involved in embryonic placenta morphogenesis

MGI:MGI:3689296
PMID:16981008[1]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2176598

P

From MGI

GO:0060712

spongiotrophoblast layer development

MGI:MGI:3689296
PMID:16981008[1]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2176598

P

From MGI

GO:0097084

vascular smooth muscle cell development

MGI:MGI:3772552
PMID:18097473[3]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:2001214

positive regulation of vasculogenesis

MGI:MGI:3772552
PMID:18097473[3]

IMP: Inferred from Mutant Phenotype

P

From MGI


Notes

References

See Help:References for how to manage references in GONUTS.
  1. 1.0 1.1 1.2 1.3 1.4 Li M et al. (2006) Reduced maternal expression of adrenomedullin disrupts fertility, placentation, and fetal growth in mice. J Clin Invest 116: 2653-62 PubMed GONUTS page
  2. 2.0 2.1 Dackor RT et al. (2006) Hydrops fetalis, cardiovascular defects, and embryonic lethality in mice lacking the calcitonin receptor-like receptor gene. Mol Cell Biol 26: 2511-8 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 3.4 Ichikawa-Shindo Y et al. (2008) The GPCR modulator protein RAMP2 is essential for angiogenesis and vascular integrity. J Clin Invest 118: 29-39 PubMed GONUTS page
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