MGI:Adipoq

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Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0001934	positive regulation of protein phosphorylation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q15848	P	From MGI
	GO:0005102	receptor binding	MGI:MGI:3043961 PMID:12802337^[1]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0005102	receptor binding	MGI:MGI:3055867 PMID:14522956^[2]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0005102	receptor binding	MGI:MGI:3055868 PMID:12087086^[3]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0005179	hormone activity	MGI:MGI:2138009 PMID:11479627^[4]	TAS: Traceable Author Statement		F	From MGI
	GO:0005179	hormone activity	MGI:MGI:3055866 PMID:11479628^[5]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0005179	hormone activity	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_653345	F	From MGI
	GO:0005179	hormone activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q15848	F	From MGI
	GO:0005515	protein binding	MGI:MGI:3043961 PMID:12802337^[1]	IPI: Inferred from Physical Interaction	UniProtKB:Q8BQS5 UniProtKB:Q91VH1	F	From MGI
	GO:0005515	protein binding	MGI:MGI:3055457 PMID:15210937^[6]	IPI: Inferred from Physical Interaction	UniProtKB:Q9WTR5	F	From MGI
	GO:0005576	extracellular region	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0964	C	From MGI
	GO:0005581	collagen	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0176	C	From MGI
	GO:0005615	extracellular space	MGI:MGI:2679365 PMID:14578283^[7]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005615	extracellular space	MGI:MGI:3055457 PMID:15210937^[6]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005615	extracellular space	MGI:MGI:3055459 PMID:15231994^[8]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005615	extracellular space	MGI:MGI:3055460 PMID:10444069^[9]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005615	extracellular space	MGI:MGI:3055866 PMID:11479628^[5]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005615	extracellular space	MGI:MGI:3055867 PMID:14522956^[2]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005615	extracellular space	MGI:MGI:3055868 PMID:12087086^[3]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005615	extracellular space	MGI:MGI:3761982 PMID:17693256^[10]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005615	extracellular space	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_653345	C	From MGI
	GO:0005615	extracellular space	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q15848	C	From MGI
	GO:0005615	extracellular space	MGI:MGI:80451 PMID:7592907^[11]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005783	endoplasmic reticulum	MGI:MGI:3055460 PMID:10444069^[9]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0006006	glucose metabolic process	MGI:MGI:2181851 PMID:12068289^[12]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0006006	glucose metabolic process	MGI:MGI:2181851 PMID:12068289^[12]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2387344	P	From MGI
	GO:0006006	glucose metabolic process	MGI:MGI:2182846 PMID:12032136^[13]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2384094	P	From MGI
	GO:0006006	glucose metabolic process	MGI:MGI:3043961 PMID:12802337^[1]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0006006	glucose metabolic process	MGI:MGI:3055866 PMID:11479628^[5]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0006635	fatty acid beta-oxidation	MGI:MGI:2387247 PMID:12151381^[14]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2388007	P	From MGI
	GO:0009749	response to glucose stimulus	MGI:MGI:2181851 PMID:12068289^[12]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0009749	response to glucose stimulus	MGI:MGI:2181851 PMID:12068289^[12]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2387344	P	From MGI
	GO:0009749	response to glucose stimulus	MGI:MGI:2182846 PMID:12032136^[13]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2384094	P	From MGI
	GO:0009967	positive regulation of signal transduction	MGI:MGI:3055867 PMID:14522956^[2]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0009967	positive regulation of signal transduction	MGI:MGI:3055868 PMID:12087086^[3]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0010642	negative regulation of platelet-derived growth factor receptor signaling pathway	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q15848	P	From MGI
	GO:0010642	negative regulation of platelet-derived growth factor receptor signaling pathway	MGI:MGI:4943654 PMID:19460854^[15]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0010739	positive regulation of protein kinase A signaling cascade	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q15848	P	From MGI
	GO:0010745	negative regulation of macrophage derived foam cell differentiation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q15848	P	From MGI
	GO:0010804	negative regulation of tumor necrosis factor-mediated signaling pathway	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q15848	P	From MGI
	GO:0010875	positive regulation of cholesterol efflux	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q15848	P	From MGI
	GO:0010906	regulation of glucose metabolic process	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q15848	P	From MGI
	GO:0014912	negative regulation of smooth muscle cell migration	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q15848	P	From MGI
	GO:0019395	fatty acid oxidation	MGI:MGI:3043961 PMID:12802337^[1]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0030336	negative regulation of cell migration	MGI:MGI:4943654 PMID:19460854^[15]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0030853	negative regulation of granulocyte differentiation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q15848	P	From MGI
	GO:0031953	negative regulation of protein autophosphorylation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q15848	P	From MGI
	GO:0032270	positive regulation of cellular protein metabolic process	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q15848	P	From MGI
	GO:0032720	negative regulation of tumor necrosis factor production	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q15848	P	From MGI
	GO:0032757	positive regulation of interleukin-8 production	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q15848	P	From MGI
	GO:0032869	cellular response to insulin stimulus	MGI:MGI:3761982 PMID:17693256^[10]	IGI: Inferred from Genetic Interaction	MGI:MGI:88157	P	From MGI
	GO:0032869	cellular response to insulin stimulus	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_653345	P	From MGI
	GO:0033034	positive regulation of myeloid cell apoptotic process	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q15848	P	From MGI
	GO:0033211	adiponectin-mediated signaling pathway	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_653345	P	From MGI
	GO:0033691	sialic acid binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q15848	F	From MGI
	GO:0034115	negative regulation of heterotypic cell-cell adhesion	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q15848	P	From MGI
	GO:0034383	low-density lipoprotein particle clearance	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q15848	P	From MGI
	GO:0034612	response to tumor necrosis factor	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q15848	P	From MGI
	GO:0035690	cellular response to drug	MGI:MGI:3822392 PMID:19109165^[16]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0042593	glucose homeostasis	MGI:MGI:2181851 PMID:12068289^[12]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0042593	glucose homeostasis	MGI:MGI:2181851 PMID:12068289^[12]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2387344	P	From MGI
	GO:0042593	glucose homeostasis	MGI:MGI:2182846 PMID:12032136^[13]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2384094	P	From MGI
	GO:0042593	glucose homeostasis	MGI:MGI:3055866 PMID:11479628^[5]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0042803	protein homodimerization activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q15848	F	From MGI
	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB cascade	MGI:MGI:3055867 PMID:14522956^[2]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB cascade	MGI:MGI:3055868 PMID:12087086^[3]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB cascade	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q15848	P	From MGI
	GO:0043407	negative regulation of MAP kinase activity	MGI:MGI:4943654 PMID:19460854^[15]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0043499	eukaryotic cell surface binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q15848	F	From MGI
	GO:0045599	negative regulation of fat cell differentiation	MGI:MGI:3813436 PMID:12021245^[17]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0045599	negative regulation of fat cell differentiation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q15848	P	From MGI
	GO:0045650	negative regulation of macrophage differentiation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q15848	P	From MGI
	GO:0045715	negative regulation of low-density lipoprotein particle receptor biosynthetic process	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q15848	P	From MGI
	GO:0045721	negative regulation of gluconeogenesis	MGI:MGI:3055866 PMID:11479628^[5]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0045776	negative regulation of blood pressure	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q15848	P	From MGI
	GO:0045777	positive regulation of blood pressure	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_653345	P	From MGI
	GO:0045860	positive regulation of protein kinase activity	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_653345	P	From MGI
	GO:0045892	negative regulation of transcription, DNA-dependent	MGI:MGI:3795840 PMID:18431508^[18]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0045892	negative regulation of transcription, DNA-dependent	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q15848	P	From MGI
	GO:0045923	positive regulation of fatty acid metabolic process	MGI:MGI:2181851 PMID:12068289^[12]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2387344	P	From MGI
	GO:0046326	positive regulation of glucose import	MGI:MGI:2181851 PMID:12068289^[12]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0046888	negative regulation of hormone secretion	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_653345	P	From MGI
	GO:0048662	negative regulation of smooth muscle cell proliferation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q15848	P	From MGI
	GO:0050728	negative regulation of inflammatory response	MGI:MGI:3822392 PMID:19109165^[16]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_653345	P	From MGI
	GO:0050765	negative regulation of phagocytosis	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q15848	P	From MGI
	GO:0050805	negative regulation of synaptic transmission	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q15848	P	From MGI
	GO:0050873	brown fat cell differentiation	MGI:MGI:3801349 PMID:18492766^[19]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0051260	protein homooligomerization	MGI:MGI:3055457 PMID:15210937^[6]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0051260	protein homooligomerization	MGI:MGI:3055867 PMID:14522956^[2]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0051260	protein homooligomerization	MGI:MGI:3055868 PMID:12087086^[3]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0051260	protein homooligomerization	MGI:MGI:80451 PMID:7592907^[11]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0051899	membrane depolarization	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_653345	P	From MGI
	GO:0060081	membrane hyperpolarization	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_653345	P	From MGI
	GO:0070208	protein heterotrimerization	MGI:MGI:3829513 PMID:18783346^[20]	IPI: Inferred from Physical Interaction	UniProtKB:Q9D8U4	P	From MGI
	GO:0070373	negative regulation of ERK1 and ERK2 cascade	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q15848	P	From MGI
	GO:0070994	detection of oxidative stress	MGI:MGI:3795840 PMID:18431508^[18]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0071320	cellular response to cAMP	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_653345	P	From MGI
	GO:0071639	positive regulation of monocyte chemotactic protein-1 production	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q15848	P	From MGI
	GO:0071872	cellular response to epinephrine stimulus	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_653345	P	From MGI
	GO:0072659	protein localization in plasma membrane	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q15848	P	From MGI
	GO:0090317	negative regulation of intracellular protein transport	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q15848	P	From MGI
	GO:2000279	negative regulation of DNA biosynthetic process	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q15848	P	From MGI
	GO:2000461	negative regulation of eukaryotic cell surface binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q15848	P	From MGI
	GO:2000467	positive regulation of glycogen (starch) synthase activity	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_653345	P	From MGI
	GO:2000478	positive regulation of metanephric glomerular visceral epithelial cell development	MGI:MGI:3795840 PMID:18431508^[18]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:2000481	positive regulation of cAMP-dependent protein kinase activity	MGI:MGI:3795840 PMID:18431508^[18]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:2000481	positive regulation of cAMP-dependent protein kinase activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q15848	P	From MGI
	GO:2000534	positive regulation of renal albumin absorption	MGI:MGI:3795840 PMID:18431508^[18]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:2000534	positive regulation of renal albumin absorption	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q15848	P	From MGI
	GO:2000584	negative regulation of platelet-derived growth factor receptor-alpha signaling pathway	MGI:MGI:4943654 PMID:19460854^[15]	IDA: Inferred from Direct Assay		P	From MGI
	GO:2000590	negative regulation of metanephric mesenchymal cell migration	MGI:MGI:4943654 PMID:19460854^[15]	IDA: Inferred from Direct Assay		P	From MGI
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Yamauchi T et al. (2003) Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature 423: 762-9 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 Tsao TS et al. (2003) Role of disulfide bonds in Acrp30/adiponectin structure and signaling specificity. Different oligomers activate different signal transduction pathways. J Biol Chem 278: 50810-7 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 Tsao TS et al. (2002) Oligomerization state-dependent activation of NF-kappa B signaling pathway by adipocyte complement-related protein of 30 kDa (Acrp30). J Biol Chem 277: 29359-62 PubMed GONUTS page
↑ Yamauchi T et al. (2001) The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat Med 7: 941-6 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 Berg AH et al. (2001) The adipocyte-secreted protein Acrp30 enhances hepatic insulin action. Nat Med 7: 947-53 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Hug C et al. (2004) T-cadherin is a receptor for hexameric and high-molecular-weight forms of Acrp30/adiponectin. Proc Natl Acad Sci U S A 101: 10308-13 PubMed GONUTS page
↑ Minami A et al. (2003) Increased insulin sensitivity and hypoinsulinemia in APS knockout mice. Diabetes 52: 2657-65 PubMed GONUTS page
↑ Wong GW et al. (2004) A family of Acrp30/adiponectin structural and functional paralogs. Proc Natl Acad Sci U S A 101: 10302-7 PubMed GONUTS page
↑ ^9.0 ^9.1 Bogan JS & Lodish HF (1999) Two compartments for insulin-stimulated exocytosis in 3T3-L1 adipocytes defined by endogenous ACRP30 and GLUT4. J Cell Biol 146: 609-20 PubMed GONUTS page
↑ ^10.0 ^10.1 Lee NK et al. (2007) Endocrine regulation of energy metabolism by the skeleton. Cell 130: 456-69 PubMed GONUTS page
↑ ^11.0 ^11.1 Scherer PE et al. (1995) A novel serum protein similar to C1q, produced exclusively in adipocytes. J Biol Chem 270: 26746-9 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 ^12.4 ^12.5 ^12.6 ^12.7 Maeda N et al. (2002) Diet-induced insulin resistance in mice lacking adiponectin/ACRP30. Nat Med 8: 731-7 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 Kubota N et al. (2002) Disruption of adiponectin causes insulin resistance and neointimal formation. J Biol Chem 277: 25863-6 PubMed GONUTS page
↑ Ma K et al. (2002) Increased beta -oxidation but no insulin resistance or glucose intolerance in mice lacking adiponectin. J Biol Chem 277: 34658-61 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 ^15.3 ^15.4 Ishizawa K et al. (2009) Inhibitory effects of adiponectin on platelet-derived growth factor-induced mesangial cell migration. J Endocrinol 202: 309-16 PubMed GONUTS page
↑ ^16.0 ^16.1 Aprahamian T et al. (2009) The peroxisome proliferator-activated receptor gamma agonist rosiglitazone ameliorates murine lupus by induction of adiponectin. J Immunol 182: 340-6 PubMed GONUTS page
↑ Yokota T et al. (2002) Paracrine regulation of fat cell formation in bone marrow cultures via adiponectin and prostaglandins. J Clin Invest 109: 1303-10 PubMed GONUTS page
↑ ^18.0 ^18.1 ^18.2 ^18.3 ^18.4 Sharma K et al. (2008) Adiponectin regulates albuminuria and podocyte function in mice. J Clin Invest 118: 1645-56 PubMed GONUTS page
↑ Wu Y & Smas CM (2008) Wdnm1-like, a new adipokine with a role in MMP-2 activation. Am J Physiol Endocrinol Metab 295: E205-15 PubMed GONUTS page
↑ Wong GW et al. (2008) Molecular, biochemical and functional characterizations of C1q/TNF family members: adipose-tissue-selective expression patterns, regulation by PPAR-gamma agonist, cysteine-mediated oligomerizations, combinatorial associations and metabolic functions. Biochem J 416: 161-77 PubMed GONUTS page

[PMID:12802337-0] 1.0 ^1.1 ^1.2 ^1.3 Yamauchi T et al. (2003) Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature 423: 762-9 PubMed GONUTS page

[PMID:14522956-1] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 Tsao TS et al. (2003) Role of disulfide bonds in Acrp30/adiponectin structure and signaling specificity. Different oligomers activate different signal transduction pathways. J Biol Chem 278: 50810-7 PubMed GONUTS page

[PMID:12087086-2] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 Tsao TS et al. (2002) Oligomerization state-dependent activation of NF-kappa B signaling pathway by adipocyte complement-related protein of 30 kDa (Acrp30). J Biol Chem 277: 29359-62 PubMed GONUTS page

[PMID:11479627-3] Yamauchi T et al. (2001) The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat Med 7: 941-6 PubMed GONUTS page

[PMID:11479628-4] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 Berg AH et al. (2001) The adipocyte-secreted protein Acrp30 enhances hepatic insulin action. Nat Med 7: 947-53 PubMed GONUTS page

[PMID:15210937-5] 6.0 ^6.1 ^6.2 Hug C et al. (2004) T-cadherin is a receptor for hexameric and high-molecular-weight forms of Acrp30/adiponectin. Proc Natl Acad Sci U S A 101: 10308-13 PubMed GONUTS page

[PMID:14578283-6] Minami A et al. (2003) Increased insulin sensitivity and hypoinsulinemia in APS knockout mice. Diabetes 52: 2657-65 PubMed GONUTS page

[PMID:15231994-7] Wong GW et al. (2004) A family of Acrp30/adiponectin structural and functional paralogs. Proc Natl Acad Sci U S A 101: 10302-7 PubMed GONUTS page

[PMID:10444069-8] 9.0 ^9.1 Bogan JS & Lodish HF (1999) Two compartments for insulin-stimulated exocytosis in 3T3-L1 adipocytes defined by endogenous ACRP30 and GLUT4. J Cell Biol 146: 609-20 PubMed GONUTS page

[PMID:17693256-9] 10.0 ^10.1 Lee NK et al. (2007) Endocrine regulation of energy metabolism by the skeleton. Cell 130: 456-69 PubMed GONUTS page

[PMID:7592907-10] 11.0 ^11.1 Scherer PE et al. (1995) A novel serum protein similar to C1q, produced exclusively in adipocytes. J Biol Chem 270: 26746-9 PubMed GONUTS page

[PMID:12068289-11] 12.0 ^12.1 ^12.2 ^12.3 ^12.4 ^12.5 ^12.6 ^12.7 Maeda N et al. (2002) Diet-induced insulin resistance in mice lacking adiponectin/ACRP30. Nat Med 8: 731-7 PubMed GONUTS page

[PMID:12032136-12] 13.0 ^13.1 ^13.2 Kubota N et al. (2002) Disruption of adiponectin causes insulin resistance and neointimal formation. J Biol Chem 277: 25863-6 PubMed GONUTS page

[PMID:12151381-13] Ma K et al. (2002) Increased beta -oxidation but no insulin resistance or glucose intolerance in mice lacking adiponectin. J Biol Chem 277: 34658-61 PubMed GONUTS page

[PMID:19460854-14] 15.0 ^15.1 ^15.2 ^15.3 ^15.4 Ishizawa K et al. (2009) Inhibitory effects of adiponectin on platelet-derived growth factor-induced mesangial cell migration. J Endocrinol 202: 309-16 PubMed GONUTS page

[PMID:19109165-15] 16.0 ^16.1 Aprahamian T et al. (2009) The peroxisome proliferator-activated receptor gamma agonist rosiglitazone ameliorates murine lupus by induction of adiponectin. J Immunol 182: 340-6 PubMed GONUTS page

[PMID:12021245-16] Yokota T et al. (2002) Paracrine regulation of fat cell formation in bone marrow cultures via adiponectin and prostaglandins. J Clin Invest 109: 1303-10 PubMed GONUTS page

[PMID:18431508-17] 18.0 ^18.1 ^18.2 ^18.3 ^18.4 Sharma K et al. (2008) Adiponectin regulates albuminuria and podocyte function in mice. J Clin Invest 118: 1645-56 PubMed GONUTS page

[PMID:18492766-18] Wu Y & Smas CM (2008) Wdnm1-like, a new adipokine with a role in MMP-2 activation. Am J Physiol Endocrinol Metab 295: E205-15 PubMed GONUTS page

[PMID:18783346-19] Wong GW et al. (2008) Molecular, biochemical and functional characterizations of C1q/TNF family members: adipose-tissue-selective expression patterns, regulation by PPAR-gamma agonist, cysteine-mediated oligomerizations, combinatorial associations and metabolic functions. Biochem J 416: 161-77 PubMed GONUTS page

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Species (Taxon ID)	Mus musculus (house mouse) (taxon:10090)
Gene Name(s)	Adipoq ( synonyms: Acdc, Acrp30, adipo, adiponectin, apM1, APN, GBP28 )
Protein Name(s)	adiponectin, C1Q and collagen domain containing,
External Links
MGI	MGI:106675

MGI:Adipoq

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