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MGI:Adamts1
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Adamts1 ( synonyms: ADAM-TS1, ADAMTS-1, METH-1, METH1 ) | |
| Protein Name(s) | a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 1, | |
| External Links | ||
| MGI | MGI:109249 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0001542 |
ovulation from ovarian follicle |
MGI:MGI:3531576 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3574351 |
P |
From MGI |
||
| GO:0001822 |
kidney development |
MGI:MGI:3531576 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3574351 |
P |
From MGI |
||
| GO:0001822 |
kidney development |
MGI:MGI:3607633 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3609982 |
P |
From MGI |
||
| GO:0004222 |
metalloendopeptidase activity |
MGI:MGI:2154458 |
ISO: Inferred from Sequence Orthology |
EMBL:AF060152 |
F |
From MGI |
||
| GO:0004222 |
metalloendopeptidase activity |
MGI:MGI:3607633 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0004222 |
metalloendopeptidase activity |
MGI:MGI:3607633 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3609982 |
F |
From MGI |
||
| GO:0005515 |
protein binding |
MGI:MGI:3607633 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005576 |
extracellular region |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0964 |
C |
From MGI |
||
| GO:0005578 |
proteinaceous extracellular matrix |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0272 |
C |
From MGI |
||
| GO:0005578 |
proteinaceous extracellular matrix |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
C |
From MGI |
|||
| GO:0005604 |
basement membrane |
MGI:MGI:3607633 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0006508 |
proteolysis |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0645 |
P |
From MGI |
||
| GO:0006508 |
proteolysis |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
P |
From MGI |
|||
| GO:0008201 |
heparin binding |
MGI:MGI:1335998 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0008201 |
heparin binding |
MGI:MGI:85039 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0008233 |
peptidase activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0645 |
F |
From MGI |
||
| GO:0008237 |
metallopeptidase activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0482 |
F |
From MGI |
||
| GO:0008237 |
metallopeptidase activity |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0008270 |
zinc ion binding |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0016525 |
negative regulation of angiogenesis |
MGI:MGI:1342878 |
ISO: Inferred from Sequence Orthology |
EMBL:AF060152 |
P |
From MGI |
||
| GO:0016787 |
hydrolase activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0378 |
F |
From MGI |
||
| GO:0031012 |
extracellular matrix |
MGI:MGI:1335998 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0031012 |
extracellular matrix |
MGI:MGI:2678858 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0031410 |
cytoplasmic vesicle |
MGI:MGI:2678858 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0046872 |
metal ion binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0479 |
F |
From MGI |
||
| GO:0060347 |
heart trabecula formation |
MGI:MGI:3776329 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3609982 |
P |
From MGI |
| |
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Mittaz L et al. (2004) Adamts-1 is essential for the development and function of the urogenital system. Biol Reprod 70: 1096-105 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 Lee NV et al. (2005) Fibulin-1 acts as a cofactor for the matrix metalloprotease ADAMTS-1. J Biol Chem 280: 34796-804 PubMed GONUTS page
- ↑ 3.0 3.1 Kuno K & Matsushima K (1998) ADAMTS-1 protein anchors at the extracellular matrix through the thrombospondin type I motifs and its spacing region. J Biol Chem 273: 13912-7 PubMed GONUTS page
- ↑ Kuno K et al. (1997) Molecular cloning of a gene encoding a new type of metalloproteinase-disintegrin family protein with thrombospondin motifs as an inflammation associated gene. J Biol Chem 272: 556-62 PubMed GONUTS page
- ↑ Vázquez F et al. (1999) METH-1, a human ortholog of ADAMTS-1, and METH-2 are members of a new family of proteins with angio-inhibitory activity. J Biol Chem 274: 23349-57 PubMed GONUTS page
- ↑ 6.0 6.1 Russell DL et al. (2003) Processing and localization of ADAMTS-1 and proteolytic cleavage of versican during cumulus matrix expansion and ovulation. J Biol Chem 278: 42330-9 PubMed GONUTS page
- ↑ Stankunas K et al. (2008) Endocardial Brg1 represses ADAMTS1 to maintain the microenvironment for myocardial morphogenesis. Dev Cell 14: 298-311 PubMed GONUTS page
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