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MGI:Ada
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Ada | |
| Protein Name(s) | adenosine deaminase, | |
| External Links | ||
| MGI | MGI:87916 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0001666 |
response to hypoxia |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_569083 |
P |
From MGI |
||
| GO:0001666 |
response to hypoxia |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0001701 |
in utero embryonic development |
MGI:MGI:1095761 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857117 |
P |
From MGI |
||
| GO:0001701 |
in utero embryonic development |
MGI:MGI:72798 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857117 |
P |
From MGI |
||
| GO:0001821 |
histamine secretion |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_569083 |
P |
From MGI |
||
| GO:0001829 |
trophectodermal cell differentiation |
MGI:MGI:1095761 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857117 |
P |
From MGI |
||
| GO:0001883 |
purine nucleoside binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_569083 |
F |
From MGI |
||
| GO:0001889 |
liver development |
MGI:MGI:72798 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857117 |
P |
From MGI |
||
| GO:0001889 |
liver development |
MGI:MGI:74163 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2155977 |
P |
From MGI |
||
| GO:0001890 |
placenta development |
MGI:MGI:1095761 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857117 |
P |
From MGI |
||
| GO:0002314 |
germinal center B cell differentiation |
MGI:MGI:3619310 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857117 |
P |
From MGI |
||
| GO:0002636 |
positive regulation of germinal center formation |
MGI:MGI:3619310 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857117 |
P |
From MGI |
||
| GO:0002686 |
negative regulation of leukocyte migration |
MGI:MGI:3051181 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:104847 |
P |
From MGI |
||
| GO:0002686 |
negative regulation of leukocyte migration |
MGI:MGI:3051181 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857117 |
P |
From MGI |
||
| GO:0002686 |
negative regulation of leukocyte migration |
MGI:MGI:3525377 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:99401 |
P |
From MGI |
||
| GO:0002686 |
negative regulation of leukocyte migration |
MGI:MGI:3525377 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857117 |
P |
From MGI |
||
| GO:0002906 |
negative regulation of mature B cell apoptotic process |
MGI:MGI:3619310 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857117 |
P |
From MGI |
||
| GO:0004000 |
adenosine deaminase activity |
MGI:MGI:1095761 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0004000 |
adenosine deaminase activity |
MGI:MGI:1095761 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857117 |
F |
From MGI |
||
| GO:0004000 |
adenosine deaminase activity |
MGI:MGI:2151677 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857117 |
F |
From MGI |
||
| GO:0004000 |
adenosine deaminase activity |
MGI:MGI:2154458 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0004000 |
adenosine deaminase activity |
MGI:MGI:2155238 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857117 |
F |
From MGI |
||
| GO:0004000 |
adenosine deaminase activity |
MGI:MGI:3531253 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0004000 |
adenosine deaminase activity |
MGI:MGI:3531253 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857117 |
F |
From MGI |
||
| GO:0004000 |
adenosine deaminase activity |
MGI:MGI:3808984 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0004000 |
adenosine deaminase activity |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_569083 |
F |
From MGI |
||
| GO:0004000 |
adenosine deaminase activity |
MGI:MGI:4835158 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0004000 |
adenosine deaminase activity |
MGI:MGI:48978 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0004000 |
adenosine deaminase activity |
MGI:MGI:49990 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0004000 |
adenosine deaminase activity |
MGI:MGI:59127 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0004000 |
adenosine deaminase activity |
MGI:MGI:60112 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0004000 |
adenosine deaminase activity |
MGI:MGI:72798 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857117 |
F |
From MGI |
||
| GO:0004000 |
adenosine deaminase activity |
MGI:MGI:76875 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0004000 |
adenosine deaminase activity |
MGI:MGI:83255 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0005615 |
extracellular space |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_569083 |
C |
From MGI |
||
| GO:0005737 |
cytoplasm |
MGI:MGI:2386497 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_569083 |
C |
From MGI |
||
| GO:0005737 |
cytoplasm |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:63524 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005764 |
lysosome |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005829 |
cytosol |
MGI:MGI:4459044 |
PANTHER:PTHR11409 |
C |
From MGI |
|||
| GO:0005886 |
plasma membrane |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0006154 |
adenosine catabolic process |
MGI:MGI:1095761 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0006154 |
adenosine catabolic process |
MGI:MGI:1095761 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857117 |
P |
From MGI |
||
| GO:0006154 |
adenosine catabolic process |
MGI:MGI:1861066 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857117 |
P |
From MGI |
||
| GO:0006154 |
adenosine catabolic process |
MGI:MGI:2151677 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857117 |
P |
From MGI |
||
| GO:0006154 |
adenosine catabolic process |
MGI:MGI:2154458 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0006154 |
adenosine catabolic process |
MGI:MGI:2155238 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857117 |
P |
From MGI |
||
| GO:0006154 |
adenosine catabolic process |
MGI:MGI:3525377 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857117 |
P |
From MGI |
||
| GO:0006154 |
adenosine catabolic process |
MGI:MGI:3531253 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0006154 |
adenosine catabolic process |
MGI:MGI:3531253 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857117 |
P |
From MGI |
||
| GO:0006154 |
adenosine catabolic process |
MGI:MGI:3619310 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857117 |
P |
From MGI |
||
| GO:0006154 |
adenosine catabolic process |
MGI:MGI:3640719 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857117 |
P |
From MGI |
||
| GO:0006154 |
adenosine catabolic process |
MGI:MGI:3664521 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857117 |
P |
From MGI |
||
| GO:0006154 |
adenosine catabolic process |
MGI:MGI:3794903 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857117 |
P |
From MGI |
||
| GO:0006154 |
adenosine catabolic process |
MGI:MGI:3808984 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0006154 |
adenosine catabolic process |
MGI:MGI:4835158 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0006154 |
adenosine catabolic process |
MGI:MGI:49990 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0006154 |
adenosine catabolic process |
MGI:MGI:59127 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0006154 |
adenosine catabolic process |
MGI:MGI:72798 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857117 |
P |
From MGI |
||
| GO:0006154 |
adenosine catabolic process |
MGI:MGI:74163 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2155977 |
P |
From MGI |
||
| GO:0006154 |
adenosine catabolic process |
MGI:MGI:74163 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2155977 |
P |
From MGI |
||
| GO:0006154 |
adenosine catabolic process |
MGI:MGI:76875 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0006154 |
adenosine catabolic process |
MGI:MGI:83255 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0006157 |
deoxyadenosine catabolic process |
MGI:MGI:1095761 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857117 |
P |
From MGI |
||
| GO:0006157 |
deoxyadenosine catabolic process |
MGI:MGI:2155238 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857117 |
P |
From MGI |
||
| GO:0006157 |
deoxyadenosine catabolic process |
MGI:MGI:3619310 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857117 |
P |
From MGI |
||
| GO:0006157 |
deoxyadenosine catabolic process |
MGI:MGI:3640719 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857117 |
P |
From MGI |
||
| GO:0006157 |
deoxyadenosine catabolic process |
MGI:MGI:72798 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857117 |
P |
From MGI |
||
| GO:0006157 |
deoxyadenosine catabolic process |
MGI:MGI:74163 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2155977 |
P |
From MGI |
||
| GO:0006157 |
deoxyadenosine catabolic process |
MGI:MGI:76875 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0007155 |
cell adhesion |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0130 |
P |
From MGI |
||
| GO:0008270 |
zinc ion binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0008270 |
zinc ion binding |
MGI:MGI:4835158 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0009117 |
nucleotide metabolic process |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0546 |
P |
From MGI |
||
| GO:0009168 |
purine ribonucleoside monophosphate biosynthetic process |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
P |
From MGI |
|||
| GO:0009897 |
external side of plasma membrane |
MGI:MGI:4459044 |
PANTHER:PTHR11409 |
C |
From MGI |
|||
| GO:0009897 |
external side of plasma membrane |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0009986 |
cell surface |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0010460 |
positive regulation of heart rate |
MGI:MGI:3653129 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857117 |
P |
From MGI |
||
| GO:0016020 |
membrane |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0016787 |
hydrolase activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0378 |
F |
From MGI |
||
| GO:0019239 |
deaminase activity |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0030054 |
cell junction |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0965 |
C |
From MGI |
||
| GO:0030324 |
lung development |
MGI:MGI:74163 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2155977 |
P |
From MGI |
||
| GO:0030890 |
positive regulation of B cell proliferation |
MGI:MGI:3619310 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857117 |
P |
From MGI |
||
| GO:0031410 |
cytoplasmic vesicle |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0968 |
C |
From MGI |
||
| GO:0032261 |
purine nucleotide salvage |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0032839 |
dendrite cytoplasm |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_569083 |
C |
From MGI |
||
| GO:0033089 |
positive regulation of T cell differentiation in thymus |
MGI:MGI:3620422 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0033089 |
positive regulation of T cell differentiation in thymus |
MGI:MGI:3640996 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857117 |
P |
From MGI |
||
| GO:0033089 |
positive regulation of T cell differentiation in thymus |
MGI:MGI:3690682 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0033089 |
positive regulation of T cell differentiation in thymus |
MGI:MGI:3690682 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857117 |
P |
From MGI |
||
| GO:0033089 |
positive regulation of T cell differentiation in thymus |
MGI:MGI:3774231 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0033089 |
positive regulation of T cell differentiation in thymus |
MGI:MGI:3774231 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857117 |
P |
From MGI |
||
| GO:0033632 |
regulation of cell-cell adhesion mediated by integrin |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0042110 |
T cell activation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0042323 |
negative regulation of circadian sleep/wake cycle, non-REM sleep |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_569083 |
P |
From MGI |
||
| GO:0043025 |
neuronal cell body |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_569083 |
C |
From MGI |
||
| GO:0043066 |
negative regulation of apoptotic process |
MGI:MGI:65017 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0043066 |
negative regulation of apoptotic process |
MGI:MGI:74163 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2155977 |
P |
From MGI |
||
| GO:0043103 |
hypoxanthine salvage |
MGI:MGI:4459044 |
PANTHER:PTHR11409 |
P |
From MGI |
|||
| GO:0043278 |
response to morphine |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_569083 |
P |
From MGI |
||
| GO:0045580 |
regulation of T cell differentiation |
MGI:MGI:74163 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2155977 |
P |
From MGI |
||
| GO:0045582 |
positive regulation of T cell differentiation |
MGI:MGI:2155238 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857117 |
P |
From MGI |
||
| GO:0045582 |
positive regulation of T cell differentiation |
MGI:MGI:72798 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857117 |
P |
From MGI |
||
| GO:0045987 |
positive regulation of smooth muscle contraction |
MGI:MGI:3794903 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857117 |
P |
From MGI |
||
| GO:0046061 |
dATP catabolic process |
MGI:MGI:2155238 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857117 |
P |
From MGI |
||
| GO:0046061 |
dATP catabolic process |
MGI:MGI:3619310 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857117 |
P |
From MGI |
||
| GO:0046061 |
dATP catabolic process |
MGI:MGI:72798 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857117 |
P |
From MGI |
||
| GO:0046061 |
dATP catabolic process |
MGI:MGI:74163 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2155977 |
P |
From MGI |
||
| GO:0046061 |
dATP catabolic process |
MGI:MGI:76875 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0046085 |
adenosine metabolic process |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_569083 |
P |
From MGI |
||
| GO:0046101 |
hypoxanthine biosynthetic process |
MGI:MGI:3640719 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857117 |
P |
From MGI |
||
| GO:0046103 |
inosine biosynthetic process |
MGI:MGI:1095761 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0046103 |
inosine biosynthetic process |
MGI:MGI:1095761 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857117 |
P |
From MGI |
||
| GO:0046103 |
inosine biosynthetic process |
MGI:MGI:2154458 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0046103 |
inosine biosynthetic process |
MGI:MGI:3531253 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0046103 |
inosine biosynthetic process |
MGI:MGI:3531253 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857117 |
P |
From MGI |
||
| GO:0046103 |
inosine biosynthetic process |
MGI:MGI:3640719 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857117 |
P |
From MGI |
||
| GO:0046103 |
inosine biosynthetic process |
MGI:MGI:3808984 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0046103 |
inosine biosynthetic process |
MGI:MGI:4835158 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0046103 |
inosine biosynthetic process |
MGI:MGI:49990 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0046103 |
inosine biosynthetic process |
MGI:MGI:72798 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857117 |
P |
From MGI |
||
| GO:0046103 |
inosine biosynthetic process |
MGI:MGI:76875 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0046103 |
inosine biosynthetic process |
MGI:MGI:83255 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0046111 |
xanthine biosynthetic process |
MGI:MGI:3640719 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857117 |
P |
From MGI |
||
| GO:0046638 |
positive regulation of alpha-beta T cell differentiation |
MGI:MGI:3620422 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0046638 |
positive regulation of alpha-beta T cell differentiation |
MGI:MGI:3690682 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0046638 |
positive regulation of alpha-beta T cell differentiation |
MGI:MGI:3690682 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857117 |
P |
From MGI |
||
| GO:0046638 |
positive regulation of alpha-beta T cell differentiation |
MGI:MGI:3774231 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0046638 |
positive regulation of alpha-beta T cell differentiation |
MGI:MGI:3774231 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857117 |
P |
From MGI |
||
| GO:0046872 |
metal ion binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0479 |
F |
From MGI |
||
| GO:0048286 |
lung alveolus development |
MGI:MGI:1861066 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857117 |
P |
From MGI |
||
| GO:0048541 |
Peyer's patch development |
MGI:MGI:3640719 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857117 |
P |
From MGI |
||
| GO:0048566 |
embryonic digestive tract development |
MGI:MGI:74163 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2155977 |
P |
From MGI |
||
| GO:0050728 |
negative regulation of inflammatory response |
MGI:MGI:1861066 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857117 |
P |
From MGI |
||
| GO:0050728 |
negative regulation of inflammatory response |
MGI:MGI:2151677 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857117 |
P |
From MGI |
||
| GO:0050728 |
negative regulation of inflammatory response |
MGI:MGI:3051181 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:104847 |
P |
From MGI |
||
| GO:0050728 |
negative regulation of inflammatory response |
MGI:MGI:3051181 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857117 |
P |
From MGI |
||
| GO:0050728 |
negative regulation of inflammatory response |
MGI:MGI:3525377 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:99401 |
P |
From MGI |
||
| GO:0050728 |
negative regulation of inflammatory response |
MGI:MGI:3525377 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857117 |
P |
From MGI |
||
| GO:0050728 |
negative regulation of inflammatory response |
MGI:MGI:3765393 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:99402 |
P |
From MGI |
||
| GO:0050728 |
negative regulation of inflammatory response |
MGI:MGI:3765393 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857117 |
P |
From MGI |
||
| GO:0050850 |
positive regulation of calcium-mediated signaling |
MGI:MGI:3640996 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0050862 |
positive regulation of T cell receptor signaling pathway |
MGI:MGI:3640996 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857117 |
P |
From MGI |
||
| GO:0050870 |
positive regulation of T cell activation |
MGI:MGI:1860411 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857117 |
P |
From MGI |
||
| GO:0050870 |
positive regulation of T cell activation |
MGI:MGI:3640996 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857117 |
P |
From MGI |
||
| GO:0060169 |
negative regulation of adenosine receptor signaling pathway |
MGI:MGI:4459044 |
PANTHER:PTHR11409 |
P |
From MGI |
|||
| GO:0060169 |
negative regulation of adenosine receptor signaling pathway |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0060407 |
negative regulation of penile erection |
MGI:MGI:3794903 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857117 |
P |
From MGI |
||
| GO:0070244 |
negative regulation of thymocyte apoptotic process |
MGI:MGI:3690682 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0070244 |
negative regulation of thymocyte apoptotic process |
MGI:MGI:3774231 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0070256 |
negative regulation of mucus secretion |
MGI:MGI:3051181 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:104847 |
P |
From MGI |
||
| GO:0070256 |
negative regulation of mucus secretion |
MGI:MGI:3051181 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857117 |
P |
From MGI |
||
| GO:0070256 |
negative regulation of mucus secretion |
MGI:MGI:3525377 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:99401 |
P |
From MGI |
||
| GO:0070256 |
negative regulation of mucus secretion |
MGI:MGI:3525377 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857117 |
P |
From MGI |
| |
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 Blackburn MR et al. (1997) Genetically engineered mice demonstrate that adenosine deaminase is essential for early postimplantation development. Development 124: 3089-97 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 Wakamiya M et al. (1995) Disruption of the adenosine deaminase gene causes hepatocellular impairment and perinatal lethality in mice. Proc Natl Acad Sci U S A 92: 3673-7 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 3.4 3.5 3.6 3.7 3.8 Migchielsen AA et al. (1995) Adenosine-deaminase-deficient mice die perinatally and exhibit liver-cell degeneration, atelectasis and small intestinal cell death. Nat Genet 10: 279-87 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 4.4 4.5 4.6 Aldrich MB et al. (2003) Impaired germinal center maturation in adenosine deaminase deficiency. J Immunol 171: 5562-70 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 5.4 5.5 Young HW et al. (2004) A3 adenosine receptor signaling contributes to airway inflammation and mucus production in adenosine deaminase-deficient mice. J Immunol 173: 1380-9 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 6.3 6.4 6.5 6.6 Sun CX et al. (2005) A protective role for the A1 adenosine receptor in adenosine-dependent pulmonary injury. J Clin Invest 115: 35-43 PubMed GONUTS page
- ↑ 7.0 7.1 7.2 Chunn JL et al. (2001) Adenosine-dependent airway inflammation and hyperresponsiveness in partially adenosine deaminase-deficient mice. J Immunol 167: 4676-85 PubMed GONUTS page
- ↑ 8.0 8.1 8.2 8.3 8.4 Blackburn MR et al. (1998) Adenosine deaminase-deficient mice generated using a two-stage genetic engineering strategy exhibit a combined immunodeficiency. J Biol Chem 273: 5093-100 PubMed GONUTS page
- ↑ 9.0 9.1 9.2 9.3 9.4 9.5 Blackburn MR et al. (1996) Metabolic and immunologic consequences of limited adenosine deaminase expression in mice. J Biol Chem 271: 15203-10 PubMed GONUTS page
- ↑ 10.0 10.1 10.2 Knudsen TB et al. (1991) Ontogeny of adenosine deaminase in the mouse decidua and placenta: immunolocalization and embryo transfer studies. Biol Reprod 44: 171-84 PubMed GONUTS page
- ↑ 11.0 11.1 11.2 11.3 Sideraki V et al. (1996) Probing the functional role of two conserved active site aspartates in mouse adenosine deaminase. Biochemistry 35: 7862-72 PubMed GONUTS page
- ↑ Yasue M et al. (1991) Chromosomal assignments of 23 biochemical loci of the rat by using rat x mouse somatic cell hybrids. Cytogenet Cell Genet 57: 142-8 PubMed GONUTS page
- ↑ 13.0 13.1 13.2 Winston JH et al. (1992) 5' flanking sequences of the murine adenosine deaminase gene direct expression of a reporter gene to specific prenatal and postnatal tissues in transgenic mice. J Biol Chem 267: 13472-9 PubMed GONUTS page
- ↑ 14.0 14.1 al-Ubaidi MR et al. (1990) Structural and functional analysis of the murine adenosine deaminase gene. Genomics 7: 476-85 PubMed GONUTS page
- ↑ Jinnah HA et al. (1993) Brain purines in a genetic mouse model of Lesch-Nyhan disease. J Neurochem 60: 2036-45 PubMed GONUTS page
- ↑ 16.0 16.1 16.2 16.3 16.4 Blackburn MR et al. (1995) Tissue-specific rescue suggests that placental adenosine deaminase is important for fetal development in mice. J Biol Chem 270: 23891-4 PubMed GONUTS page
- ↑ 17.0 17.1 17.2 Migchielsen AA et al. (1996) Full genetic rescue of adenosine deaminase-deficient mice through introduction of the human gene. Hum Mol Genet 5: 1523-32 PubMed GONUTS page
- ↑ Werling U & Schorle H (2002) Transcription factor gene AP-2 gamma essential for early murine development. Mol Cell Biol 22: 3149-56 PubMed GONUTS page
- ↑ Bodine DM et al. (1993) Long-term in vivo expression of a murine adenosine deaminase gene in rhesus monkey hematopoietic cells of multiple lineages after retroviral mediated gene transfer into CD34+ bone marrow cells. Blood 82: 1975-80 PubMed GONUTS page
- ↑ 20.0 20.1 20.2 Blackburn MR et al. (2000) Metabolic consequences of adenosine deaminase deficiency in mice are associated with defects in alveogenesis, pulmonary inflammation, and airway obstruction. J Exp Med 192: 159-70 PubMed GONUTS page
- ↑ 21.0 21.1 21.2 21.3 21.4 21.5 Xu PA & Kellems RE (2000) Function of murine adenosine deaminase in the gastrointestinal tract. Biochem Biophys Res Commun 269: 749-57 PubMed GONUTS page
- ↑ Sun CX et al. (2006) Role of A2B adenosine receptor signaling in adenosine-dependent pulmonary inflammation and injury. J Clin Invest 116: 2173-2182 PubMed GONUTS page
- ↑ 23.0 23.1 23.2 Mi T et al. (2008) Excess adenosine in murine penile erectile tissues contributes to priapism via A2B adenosine receptor signaling. J Clin Invest 118: 1491-501 PubMed GONUTS page
- ↑ Willems L et al. (2006) Effects of adenosine deaminase and A1 receptor deficiency in normoxic and ischaemic mouse hearts. Cardiovasc Res 71: 79-87 PubMed GONUTS page
- ↑ 25.0 25.1 Van De Wiele CJ et al. (2002) Adenosine kinase inhibition promotes survival of fetal adenosine deaminase-deficient thymocytes by blocking dATP accumulation. J Clin Invest 110: 395-402 PubMed GONUTS page
- ↑ 26.0 26.1 26.2 26.3 Apasov SG et al. (2001) Adenosine deaminase deficiency increases thymic apoptosis and causes defective T cell receptor signaling. J Clin Invest 108: 131-41 PubMed GONUTS page
- ↑ 27.0 27.1 27.2 27.3 27.4 Thompson LF et al. (2000) Metabolites from apoptotic thymocytes inhibit thymopoiesis in adenosine deaminase-deficient fetal thymic organ cultures. J Clin Invest 106: 1149-57 PubMed GONUTS page
- ↑ 28.0 28.1 28.2 28.3 28.4 Van De Wiele CJ et al. (2006) Further differentiation of murine double-positive thymocytes is inhibited in adenosine deaminase-deficient murine fetal thymic organ culture. J Immunol 176: 5925-33 PubMed GONUTS page
- ↑ Gao X et al. (1994) Activation of apoptosis in early mouse embryos by 2'-deoxyadenosine exposure. Teratology 49: 1-12 PubMed GONUTS page
- ↑ 30.0 30.1 Mohsenin A et al. (2007) Genetic removal of the A2A adenosine receptor enhances pulmonary inflammation, mucin production, and angiogenesis in adenosine deaminase-deficient mice. Am J Physiol Lung Cell Mol Physiol 293: L753-61 PubMed GONUTS page
- ↑ Apasov S et al. (2000) A(2A) receptor dependent and A(2A) receptor independent effects of extracellular adenosine on murine thymocytes in conditions of adenosine deaminase deficiency. Blood 95: 3859-67 PubMed GONUTS page
