MGI:Acvrl1

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Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0000166	nucleotide binding	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0547	F	From MGI
	GO:0001525	angiogenesis	MGI:MGI:1354528 PMID:10716993^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2155980	P	From MGI
	GO:0001525	angiogenesis	MGI:MGI:1926692 PMID:11062473^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2155981	P	From MGI
	GO:0001525	angiogenesis	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P37023	P	From MGI
	GO:0001701	in utero embryonic development	MGI:MGI:3770582 PMID:17911384^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2680088	P	From MGI
	GO:0001937	negative regulation of endothelial cell proliferation	MGI:MGI:4830635 PMID:20406889^[4]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0001938	positive regulation of endothelial cell proliferation	MGI:MGI:4830635 PMID:20406889^[4]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0001946	lymphangiogenesis	MGI:MGI:4436974 PMID:19903896^[5]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0001974	blood vessel remodeling	MGI:MGI:4436974 PMID:19903896^[5]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0004672	protein kinase activity	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR000719	F	From MGI
	GO:0004674	protein serine/threonine kinase activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P37023	F	From MGI
	GO:0004675	transmembrane receptor protein serine/threonine kinase activity	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR000472 InterPro:IPR003605	F	From MGI
	GO:0004702	receptor signaling protein serine/threonine kinase activity	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P80203	F	From MGI
	GO:0004872	receptor activity	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0675	F	From MGI
	GO:0005024	transforming growth factor beta-activated receptor activity	MGI:MGI:2154458	ISO: Inferred from Sequence Orthology	UniProtKB:P37023	F	From MGI
	GO:0005025	transforming growth factor beta receptor activity, type I	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P80203	F	From MGI
	GO:0005515	protein binding	MGI:MGI:2679137 PMID:14580334^[6]	IPI: Inferred from Physical Interaction	UniProtKB:Q64729	F	From MGI
	GO:0005515	protein binding	MGI:MGI:4830635 PMID:20406889^[4]	IPI: Inferred from Physical Interaction	UniProtKB:Q9WV56	F	From MGI
	GO:0005524	ATP binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P37023	F	From MGI
	GO:0005887	integral to plasma membrane	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P37023	C	From MGI
	GO:0006355	regulation of transcription, DNA-dependent	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P37023	P	From MGI
	GO:0006468	protein phosphorylation	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P80203	P	From MGI
	GO:0006468	protein phosphorylation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P37023	P	From MGI
	GO:0007162	negative regulation of cell adhesion	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P37023	P	From MGI
	GO:0007165	signal transduction	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P37023	P	From MGI
	GO:0007179	transforming growth factor beta receptor signaling pathway	MGI:MGI:2679137 PMID:14580334^[6]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0007179	transforming growth factor beta receptor signaling pathway	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P80203	P	From MGI
	GO:0007179	transforming growth factor beta receptor signaling pathway	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P37023	P	From MGI
	GO:0008015	blood circulation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P37023	P	From MGI
	GO:0008217	regulation of blood pressure	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P37023	P	From MGI
	GO:0008285	negative regulation of cell proliferation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P37023	P	From MGI
	GO:0009986	cell surface	MGI:MGI:2154458	ISO: Inferred from Sequence Orthology	UniProtKB:P37023	C	From MGI
	GO:0010596	negative regulation of endothelial cell migration	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P37023	P	From MGI
	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P37023	P	From MGI
	GO:0016020	membrane	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0472	C	From MGI
	GO:0016020	membrane	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR000472 InterPro:IPR003605	C	From MGI
	GO:0016021	integral to membrane	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0812	C	From MGI
	GO:0016301	kinase activity	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0418	F	From MGI
	GO:0016310	phosphorylation	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0418	P	From MGI
	GO:0016361	activin receptor activity, type I	MGI:MGI:2154458	ISO: Inferred from Sequence Orthology	UniProtKB:P37023	F	From MGI
	GO:0016740	transferase activity	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0808	F	From MGI
	GO:0016772	transferase activity, transferring phosphorus-containing groups	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR011009	F	From MGI
	GO:0019901	protein kinase binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P37023	F	From MGI
	GO:0023014	signal transduction by phosphorylation	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P80203	P	From MGI
	GO:0030308	negative regulation of cell growth	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P37023	P	From MGI
	GO:0030336	negative regulation of cell migration	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P37023	P	From MGI
	GO:0030425	dendrite	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P80203	C	From MGI
	GO:0030509	BMP signaling pathway	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P37023	P	From MGI
	GO:0030513	positive regulation of BMP signaling pathway	MGI:MGI:4830635 PMID:20406889^[4]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0030513	positive regulation of BMP signaling pathway	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P37023	P	From MGI
	GO:0035313	wound healing, spreading of epidermal cells	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P37023	P	From MGI
	GO:0042118	endothelial cell activation	MGI:MGI:4830635 PMID:20406889^[4]	TAS: Traceable Author Statement		P	From MGI
	GO:0043025	neuronal cell body	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P80203	C	From MGI
	GO:0043537	negative regulation of blood vessel endothelial cell migration	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P37023	P	From MGI
	GO:0045602	negative regulation of endothelial cell differentiation	MGI:MGI:4830635 PMID:20406889^[4]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0045603	positive regulation of endothelial cell differentiation	MGI:MGI:4830635 PMID:20406889^[4]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0045893	positive regulation of transcription, DNA-dependent	MGI:MGI:4830635 PMID:20406889^[4]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0045893	positive regulation of transcription, DNA-dependent	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P37023	P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P37023	P	From MGI
	GO:0046332	SMAD binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P80203	F	From MGI
	GO:0046332	SMAD binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P37023	F	From MGI
	GO:0046872	metal ion binding	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0479	F	From MGI
	GO:0048185	activin binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P37023	F	From MGI
	GO:0048514	blood vessel morphogenesis	MGI:MGI:3715670 PMID:17530030^[7]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2680088	P	From MGI
	GO:0048514	blood vessel morphogenesis	MGI:MGI:3770582 PMID:17911384^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2680088	P	From MGI
	GO:0050431	transforming growth factor beta binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P37023	F	From MGI
	GO:0051291	protein heterooligomerization	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P80203	P	From MGI
	GO:0051895	negative regulation of focal adhesion assembly	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P37023	P	From MGI
	GO:0060836	lymphatic endothelial cell differentiation	MGI:MGI:4436974 PMID:19903896^[5]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0060836	lymphatic endothelial cell differentiation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P37023	P	From MGI
	GO:0060840	artery development	MGI:MGI:4436974 PMID:19903896^[5]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0060841	venous blood vessel development	MGI:MGI:4436974 PMID:19903896^[5]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0061154	endothelial tube morphogenesis	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P37023	P	From MGI
	GO:0061298	retina vasculature development in camera-type eye	MGI:MGI:4436974 PMID:19903896^[5]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0071560	cellular response to transforming growth factor beta stimulus	MGI:MGI:3848261 PMID:19494318^[8]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0071560	cellular response to transforming growth factor beta stimulus	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P37023	P	From MGI
	GO:0071773	cellular response to BMP stimulus	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P37023	P	From MGI
	GO:2000279	negative regulation of DNA biosynthetic process	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P37023	P	From MGI
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Oh SP et al. (2000) Activin receptor-like kinase 1 modulates transforming growth factor-beta 1 signaling in the regulation of angiogenesis. Proc Natl Acad Sci U S A 97: 2626-31 PubMed GONUTS page
↑ Urness LD et al. (2000) Arteriovenous malformations in mice lacking activin receptor-like kinase-1. Nat Genet 26: 328-31 PubMed GONUTS page
↑ ^3.0 ^3.1 Park SO et al. (2008) ALK5- and TGFBR2-independent role of ALK1 in the pathogenesis of hereditary hemorrhagic telangiectasia type 2. Blood 111: 633-42 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 Suzuki Y et al. (2010) BMP-9 induces proliferation of multiple types of endothelial cells in vitro and in vivo. J Cell Sci 123: 1684-92 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 Niessen K et al. (2010) ALK1 signaling regulates early postnatal lymphatic vessel development. Blood 115: 1654-61 PubMed GONUTS page
↑ ^6.0 ^6.1 Goumans MJ et al. (2003) Activin receptor-like kinase (ALK)1 is an antagonistic mediator of lateral TGFbeta/ALK5 signaling. Mol Cell 12: 817-28 PubMed GONUTS page
↑ Hong KH et al. (2007) Activin receptor-like kinase 1 is essential for placental vascular development in mice. Lab Invest 87: 670-9 PubMed GONUTS page
↑ Blaney Davidson EN et al. (2009) Increase in ALK1/ALK5 ratio as a cause for elevated MMP-13 expression in osteoarthritis in humans and mice. J Immunol 182: 7937-45 PubMed GONUTS page

[PMID:10716993-0] Oh SP et al. (2000) Activin receptor-like kinase 1 modulates transforming growth factor-beta 1 signaling in the regulation of angiogenesis. Proc Natl Acad Sci U S A 97: 2626-31 PubMed GONUTS page

[PMID:11062473-1] Urness LD et al. (2000) Arteriovenous malformations in mice lacking activin receptor-like kinase-1. Nat Genet 26: 328-31 PubMed GONUTS page

[PMID:17911384-2] 3.0 ^3.1 Park SO et al. (2008) ALK5- and TGFBR2-independent role of ALK1 in the pathogenesis of hereditary hemorrhagic telangiectasia type 2. Blood 111: 633-42 PubMed GONUTS page

[PMID:20406889-3] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 Suzuki Y et al. (2010) BMP-9 induces proliferation of multiple types of endothelial cells in vitro and in vivo. J Cell Sci 123: 1684-92 PubMed GONUTS page

[PMID:19903896-4] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 Niessen K et al. (2010) ALK1 signaling regulates early postnatal lymphatic vessel development. Blood 115: 1654-61 PubMed GONUTS page

[PMID:14580334-5] 6.0 ^6.1 Goumans MJ et al. (2003) Activin receptor-like kinase (ALK)1 is an antagonistic mediator of lateral TGFbeta/ALK5 signaling. Mol Cell 12: 817-28 PubMed GONUTS page

[PMID:17530030-6] Hong KH et al. (2007) Activin receptor-like kinase 1 is essential for placental vascular development in mice. Lab Invest 87: 670-9 PubMed GONUTS page

[PMID:19494318-7] Blaney Davidson EN et al. (2009) Increase in ALK1/ALK5 ratio as a cause for elevated MMP-13 expression in osteoarthritis in humans and mice. J Immunol 182: 7937-45 PubMed GONUTS page

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Species (Taxon ID)	Mus musculus (house mouse) (taxon:10090)
Gene Name(s)	Acvrl1 ( synonyms: activin receptor-like kinase-1, Acvrlk1, Alk-1, Alk1 )
Protein Name(s)	activin A receptor, type II-like 1,
External Links
MGI	MGI:1338946

MGI:Acvrl1

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