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MGI:Acvr1
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Acvr1 ( synonyms: ActR-I, ActRIA, Acvr, Acvrlk2, Alk-2, ALK2, Alk8, SKR1, Tsk7L ) | |
| Protein Name(s) | activin A receptor, type 1, | |
| External Links | ||
| MGI | MGI:87911 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000082 |
G1/S transition of mitotic cell cycle |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0000166 |
nucleotide binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0547 |
F |
From MGI |
||
| GO:0001569 |
patterning of blood vessels |
MGI:MGI:3703113 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2651395 |
P |
From MGI |
||
| GO:0001655 |
urogenital system development |
MGI:MGI:2154458 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0001701 |
in utero embryonic development |
MGI:MGI:2686855 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0001701 |
in utero embryonic development |
MGI:MGI:3043889 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2651395 |
P |
From MGI |
||
| GO:0001701 |
in utero embryonic development |
MGI:MGI:3695845 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3696672 |
P |
From MGI |
||
| GO:0001702 |
gastrulation with mouth forming second |
MGI:MGI:3695845 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3696672 |
P |
From MGI |
||
| GO:0001707 |
mesoderm formation |
MGI:MGI:1345529 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1931734 |
P |
From MGI |
||
| GO:0001707 |
mesoderm formation |
MGI:MGI:3695845 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3696672 |
P |
From MGI |
||
| GO:0001755 |
neural crest cell migration |
MGI:MGI:3045641 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2651395 |
P |
From MGI |
||
| GO:0003143 |
embryonic heart tube morphogenesis |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0003183 |
mitral valve morphogenesis |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0003197 |
endocardial cushion development |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0003289 |
atrial septum primum morphogenesis |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0004672 |
protein kinase activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0004674 |
protein serine/threonine kinase activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0004675 |
transmembrane receptor protein serine/threonine kinase activity |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0004702 |
receptor signaling protein serine/threonine kinase activity |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0004872 |
receptor activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0675 |
F |
From MGI |
||
| GO:0005024 |
transforming growth factor beta-activated receptor activity |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0005025 |
transforming growth factor beta receptor activity, type I |
MGI:MGI:73273 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0005524 |
ATP binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005887 |
integral to plasma membrane |
MGI:MGI:1935017 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005887 |
integral to plasma membrane |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0006468 |
protein phosphorylation |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0006468 |
protein phosphorylation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0007178 |
transmembrane receptor protein serine/threonine kinase signaling pathway |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
P |
From MGI |
|||
| GO:0007179 |
transforming growth factor beta receptor signaling pathway |
MGI:MGI:1935017 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0007179 |
transforming growth factor beta receptor signaling pathway |
MGI:MGI:2181509 |
TAS: Traceable Author Statement |
P |
From MGI |
|||
| GO:0007179 |
transforming growth factor beta receptor signaling pathway |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0007179 |
transforming growth factor beta receptor signaling pathway |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0007281 |
germ cell development |
MGI:MGI:3050161 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857711 |
P |
From MGI |
||
| GO:0007368 |
determination of left/right symmetry |
MGI:MGI:3522525 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1931734 |
P |
From MGI |
||
| GO:0007369 |
gastrulation |
MGI:MGI:1335818 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857711 |
P |
From MGI |
||
| GO:0007498 |
mesoderm development |
MGI:MGI:3695845 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3696672 |
P |
From MGI |
||
| GO:0007507 |
heart development |
MGI:MGI:3045641 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2651395 |
P |
From MGI |
||
| GO:0007507 |
heart development |
MGI:MGI:3610266 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2651395 |
P |
From MGI |
||
| GO:0007507 |
heart development |
MGI:MGI:3703113 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2651395 |
P |
From MGI |
||
| GO:0009790 |
embryo development |
MGI:MGI:2686855 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0009790 |
embryo development |
MGI:MGI:3043889 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2651395 |
P |
From MGI |
||
| GO:0009968 |
negative regulation of signal transduction |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0010862 |
positive regulation of pathway-restricted SMAD protein phosphorylation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0016020 |
membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0472 |
C |
From MGI |
||
| GO:0016020 |
membrane |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
C |
From MGI |
|||
| GO:0016021 |
integral to membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0812 |
C |
From MGI |
||
| GO:0016301 |
kinase activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0418 |
F |
From MGI |
||
| GO:0016310 |
phosphorylation |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0418 |
P |
From MGI |
||
| GO:0016361 |
activin receptor activity, type I |
MGI:MGI:1935017 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0016361 |
activin receptor activity, type I |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0016740 |
transferase activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0808 |
F |
From MGI |
||
| GO:0016772 |
transferase activity, transferring phosphorus-containing groups |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0018107 |
peptidyl-threonine phosphorylation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0019838 |
growth factor binding |
MGI:MGI:73273 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0023014 |
signal transduction by phosphorylation |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0030278 |
regulation of ossification |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0030501 |
positive regulation of bone mineralization |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0030509 |
BMP signaling pathway |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0032924 |
activin receptor signaling pathway |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0032926 |
negative regulation of activin receptor signaling pathway |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0042803 |
protein homodimerization activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0043066 |
negative regulation of apoptotic process |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045177 |
apical part of cell |
MGI:MGI:1354816 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0045177 |
apical part of cell |
MGI:MGI:1932593 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0045669 |
positive regulation of osteoblast differentiation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045893 |
positive regulation of transcription, DNA-dependent |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0046332 |
SMAD binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0046332 |
SMAD binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0046872 |
metal ion binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0479 |
F |
From MGI |
||
| GO:0048179 |
activin receptor complex |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0048179 |
activin receptor complex |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0048185 |
activin binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0048185 |
activin binding |
MGI:MGI:59666 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0048185 |
activin binding |
MGI:MGI:75241 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0050431 |
transforming growth factor beta binding |
MGI:MGI:2181509 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0050431 |
transforming growth factor beta binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0051145 |
smooth muscle cell differentiation |
MGI:MGI:3703113 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2651395 |
P |
From MGI |
||
| GO:0060037 |
pharyngeal system development |
MGI:MGI:3703113 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2651395 |
P |
From MGI |
||
| GO:0060389 |
pathway-restricted SMAD protein phosphorylation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0060923 |
cardiac muscle cell fate commitment |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:2000017 |
positive regulation of determination of dorsal identity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 Wang J et al. (2006) Defective ALK5 signaling in the neural crest leads to increased postmigratory neural crest cell apoptosis and severe outflow tract defects. BMC Dev Biol 6: 51 PubMed GONUTS page
- ↑ 2.0 2.1 Dudas M et al. (2004) Tgf-beta3-induced palatal fusion is mediated by Alk-5/Smad pathway. Dev Biol 266: 96-108 PubMed GONUTS page
- ↑ 3.0 3.1 Dudas M et al. (2004) Craniofacial defects in mice lacking BMP type I receptor Alk2 in neural crest cells. Mech Dev 121: 173-82 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 Komatsu Y et al. (2007) BMP type I receptor ALK2 is essential for proper patterning at late gastrulation during mouse embryogenesis. Dev Dyn 236: 512-7 PubMed GONUTS page
- ↑ Mishina Y et al. (1999) Multiple roles for activin-like kinase-2 signaling during mouse embryogenesis. Dev Biol 213: 314-26 PubMed GONUTS page
- ↑ 6.0 6.1 Kaartinen V et al. (2004) Cardiac outflow tract defects in mice lacking ALK2 in neural crest cells. Development 131: 3481-90 PubMed GONUTS page
- ↑ 7.0 7.1 Ebner R et al. (1993) Cloning of a type I TGF-beta receptor and its effect on TGF-beta binding to the type II receptor. Science 260: 1344-8 PubMed GONUTS page
- ↑ 8.0 8.1 8.2 Visser JA et al. (2001) The serine/threonine transmembrane receptor ALK2 mediates Müllerian inhibiting substance signaling. Mol Endocrinol 15: 936-45 PubMed GONUTS page
- ↑ 9.0 9.1 de Caestecker MP et al. (2002) The novel type I serine-threonine kinase receptor Alk8 binds TGF-beta in the presence of TGF-betaRII. Biochem Biophys Res Commun 293: 1556-65 PubMed GONUTS page
- ↑ de Sousa Lopes SM et al. (2004) BMP signaling mediated by ALK2 in the visceral endoderm is necessary for the generation of primordial germ cells in the mouse embryo. Genes Dev 18: 1838-49 PubMed GONUTS page
- ↑ Kishigami S et al. (2004) BMP signaling through ACVRI is required for left-right patterning in the early mouse embryo. Dev Biol 276: 185-93 PubMed GONUTS page
- ↑ Gu Z et al. (1999) The type I serine/threonine kinase receptor ActRIA (ALK2) is required for gastrulation of the mouse embryo. Development 126: 2551-61 PubMed GONUTS page
- ↑ Wang J et al. (2005) Atrioventricular cushion transformation is mediated by ALK2 in the developing mouse heart. Dev Biol 286: 299-310 PubMed GONUTS page
- ↑ Yoshikawa SI et al. (2000) The ActR-I activin receptor protein is expressed in notochord, lens placode and pituitary primordium cells in the mouse embryo. Mech Dev 91: 439-44 PubMed GONUTS page
- ↑ Izon DJ et al. (2001) Notch1 regulates maturation of CD4+ and CD8+ thymocytes by modulating TCR signal strength. Immunity 14: 253-64 PubMed GONUTS page
- ↑ Mathews LS & Vale WW (1991) Expression cloning of an activin receptor, a predicted transmembrane serine kinase. Cell 65: 973-82 PubMed GONUTS page
- ↑ Verschueren K et al. (1995) Expression of type I and type IB receptors for activin in midgestation mouse embryos suggests distinct functions in organogenesis. Mech Dev 52: 109-23 PubMed GONUTS page
