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MGI:Ache
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Ache | |
| Protein Name(s) | acetylcholinesterase, | |
| External Links | ||
| MGI | MGI:87876 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0001919 |
regulation of receptor recycling |
MGI:MGI:3609472 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2179948 |
P |
From MGI |
||
| GO:0003990 |
acetylcholinesterase activity |
MGI:MGI:3654414 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0003990 |
acetylcholinesterase activity |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0003990 |
acetylcholinesterase activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0003990 |
acetylcholinesterase activity |
MGI:MGI:65815 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0004091 |
carboxylesterase activity |
MGI:MGI:4459044 |
PANTHER:PTHR11559 |
F |
From MGI |
|||
| GO:0004104 |
cholinesterase activity |
MGI:MGI:4459044 |
PANTHER:PTHR11559 |
F |
From MGI |
|||
| GO:0004104 |
cholinesterase activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005518 |
collagen binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005576 |
extracellular region |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005605 |
basal lamina |
MGI:MGI:71472 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005615 |
extracellular space |
MGI:MGI:3654414 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005615 |
extracellular space |
MGI:MGI:78969 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005635 |
nuclear envelope |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005788 |
endoplasmic reticulum lumen |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005788 |
endoplasmic reticulum lumen |
MGI:MGI:4459044 |
PANTHER:PTHR11559 |
C |
From MGI |
|||
| GO:0005791 |
rough endoplasmic reticulum |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005794 |
Golgi apparatus |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005794 |
Golgi apparatus |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005886 |
plasma membrane |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005886 |
plasma membrane |
MGI:MGI:78969 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0006581 |
acetylcholine catabolic process |
MGI:MGI:3654414 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0006581 |
acetylcholine catabolic process |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0006581 |
acetylcholine catabolic process |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0006581 |
acetylcholine catabolic process |
MGI:MGI:65815 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0007155 |
cell adhesion |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0007271 |
synaptic transmission, cholinergic |
MGI:MGI:4459044 |
PANTHER:PTHR11559 |
P |
From MGI |
|||
| GO:0007416 |
synapse assembly |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0007416 |
synapse assembly |
MGI:MGI:4459044 |
PANTHER:PTHR11559 |
P |
From MGI |
|||
| GO:0008291 |
acetylcholine metabolic process |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0009986 |
cell surface |
MGI:MGI:3654414 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0009986 |
cell surface |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0016020 |
membrane |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0016787 |
hydrolase activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0017171 |
serine hydrolase activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0019695 |
choline metabolic process |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0019695 |
choline metabolic process |
MGI:MGI:4459044 |
PANTHER:PTHR11559 |
P |
From MGI |
|||
| GO:0030054 |
cell junction |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0965 |
C |
From MGI |
||
| GO:0030424 |
axon |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0030424 |
axon |
MGI:MGI:4459044 |
PANTHER:PTHR11559 |
C |
From MGI |
|||
| GO:0030425 |
dendrite |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0030425 |
dendrite |
MGI:MGI:4459044 |
PANTHER:PTHR11559 |
C |
From MGI |
|||
| GO:0031225 |
anchored to membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0336 |
C |
From MGI |
||
| GO:0031594 |
neuromuscular junction |
MGI:MGI:71472 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0031623 |
receptor internalization |
MGI:MGI:3609472 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2179948 |
P |
From MGI |
||
| GO:0033265 |
choline binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0042135 |
neurotransmitter catabolic process |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0531 |
P |
From MGI |
||
| GO:0042166 |
acetylcholine binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0042166 |
acetylcholine binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0042734 |
presynaptic membrane |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0042734 |
presynaptic membrane |
MGI:MGI:4459044 |
PANTHER:PTHR11559 |
C |
From MGI |
|||
| GO:0042803 |
protein homodimerization activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0043005 |
neuron projection |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0043025 |
neuronal cell body |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0043236 |
laminin binding |
MGI:MGI:3056824 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0043236 |
laminin binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0043621 |
protein self-association |
MGI:MGI:78969 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0045202 |
synapse |
MGI:MGI:2179537 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0045202 |
synapse |
MGI:MGI:2449890 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0045202 |
synapse |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0045202 |
synapse |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0045211 |
postsynaptic membrane |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0045211 |
postsynaptic membrane |
MGI:MGI:4459044 |
PANTHER:PTHR11559 |
C |
From MGI |
|||
| GO:0045212 |
neurotransmitter receptor biosynthetic process |
MGI:MGI:3609472 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2179948 |
P |
From MGI |
||
| GO:0048471 |
perinuclear region of cytoplasm |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0048471 |
perinuclear region of cytoplasm |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0048814 |
regulation of dendrite morphogenesis |
MGI:MGI:4459044 |
PANTHER:PTHR11559 |
P |
From MGI |
|||
| GO:0050770 |
regulation of axonogenesis |
MGI:MGI:4459044 |
PANTHER:PTHR11559 |
P |
From MGI |
|||
| GO:0050772 |
positive regulation of axonogenesis |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0050775 |
positive regulation of dendrite morphogenesis |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0051262 |
protein tetramerization |
MGI:MGI:78969 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0060041 |
retina development in camera-type eye |
MGI:MGI:3603700 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2179948 |
P |
From MGI |
||
| GO:0070997 |
neuron death |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Volpicelli-Daley LA et al. (2003) Altered striatal function and muscarinic cholinergic receptors in acetylcholinesterase knockout mice. Mol Pharmacol 64: 1309-16 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 De Jaco A et al. (2006) A mutation linked with autism reveals a common mechanism of endoplasmic reticulum retention for the alpha,beta-hydrolase fold protein family. J Biol Chem 281: 9667-76 PubMed GONUTS page
- ↑ 3.0 3.1 Randall WR (1994) Cellular expression of a cloned, hydrophilic, murine acetylcholinesterase. Evidence of palmitoylated membrane-bound forms. J Biol Chem 269: 12367-74 PubMed GONUTS page
- ↑ 4.0 4.1 Noakes PG et al. (1995) Aberrant differentiation of neuromuscular junctions in mice lacking s-laminin/laminin beta 2. Nature 374: 258-62 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 Coleman BA & Taylor P (1996) Regulation of acetylcholinesterase expression during neuronal differentiation. J Biol Chem 271: 4410-6 PubMed GONUTS page
- ↑ Paraoanu LE & Layer PG (2004) Mouse acetylcholinesterase interacts in yeast with the extracellular matrix component laminin-1beta. FEBS Lett 576: 161-4 PubMed GONUTS page
- ↑ Adams ME et al. (2000) Absence of alpha-syntrophin leads to structurally aberrant neuromuscular synapses deficient in utrophin. J Cell Biol 150: 1385-98 PubMed GONUTS page
- ↑ Brandon EP et al. (2003) Aberrant patterning of neuromuscular synapses in choline acetyltransferase-deficient mice. J Neurosci 23: 539-49 PubMed GONUTS page
- ↑ Bytyqi AH et al. (2004) Impaired formation of the inner retina in an AChE knockout mouse results in degeneration of all photoreceptors. Eur J Neurosci 20: 2953-62 PubMed GONUTS page
