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MGI:Acadl

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Species (Taxon ID) Mus musculus (house mouse) (taxon:10090)
Gene Name(s) Acadl ( synonyms: C79855, LCAD )
Protein Name(s) acyl-Coenzyme A dehydrogenase, long-chain,
External Links
MGI MGI:87866

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000062

fatty-acyl-CoA binding

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P15650

F

From MGI

GO:0001659

temperature homeostasis

MGI:MGI:3526480
PMID:15639194[1]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0003995

acyl-CoA dehydrogenase activity

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR006089
InterPro:IPR006092
InterPro:IPR006091

F

From MGI

GO:0004466

long-chain-acyl-CoA dehydrogenase activity

MGI:MGI:1321427
PMID:9861014[2]

IMP: Inferred from Mutant Phenotype

F

From MGI

GO:0004466

long-chain-acyl-CoA dehydrogenase activity

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P15650

F

From MGI

GO:0005737

cytoplasm

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P28330

C

From MGI

GO:0005739

mitochondrion

MGI:MGI:2682130
PMID:14651853[3]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005739

mitochondrion

MGI:MGI:3852644
PMID:18614015[4]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005739

mitochondrion

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P15650

C

From MGI

GO:0005739

mitochondrion

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P28330

C

From MGI

GO:0005759

mitochondrial matrix

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P15650

C

From MGI

GO:0006629

lipid metabolic process

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0443

P

From MGI

GO:0006631

fatty acid metabolic process

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0276

P

From MGI

GO:0008152

metabolic process

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR013786
InterPro:IPR009100

P

From MGI

GO:0016401

palmitoyl-CoA oxidase activity

MGI:MGI:1321427
PMID:9861014[2]

IMP: Inferred from Mutant Phenotype

F

From MGI

GO:0016491

oxidoreductase activity

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0560

F

From MGI

GO:0016627

oxidoreductase activity, acting on the CH-CH group of donors

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR006090
InterPro:IPR009075
InterPro:IPR013786
InterPro:IPR009100

F

From MGI

GO:0019254

carnitine metabolic process, CoA-linked

MGI:MGI:1321427
PMID:9861014[2]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0031966

mitochondrial membrane

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P15650

C

From MGI

GO:0033539

fatty acid beta-oxidation using acyl-CoA dehydrogenase

MGI:MGI:3526480
PMID:15639194[1]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0033539

fatty acid beta-oxidation using acyl-CoA dehydrogenase

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P15650

P

From MGI

GO:0042413

carnitine catabolic process

MGI:MGI:1321427
PMID:9861014[2]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0042758

long-chain fatty acid catabolic process

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P15650

P

From MGI

GO:0044242

cellular lipid catabolic process

MGI:MGI:1321427
PMID:9861014[2]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0045717

negative regulation of fatty acid biosynthetic process

MGI:MGI:3526480
PMID:15639194[1]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0046322

negative regulation of fatty acid oxidation

MGI:MGI:3526480
PMID:15639194[1]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0050660

flavin adenine dinucleotide binding

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P15650

F

From MGI

GO:0051289

protein homotetramerization

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P15650

P

From MGI

GO:0055114

oxidation-reduction process

MGI:MGI:1321427
PMID:9861014[2]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0055114

oxidation-reduction process

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0560

P

From MGI

GO:0055114

oxidation-reduction process

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR006089
InterPro:IPR006092
InterPro:IPR006091

P

From MGI

GO:0090181

regulation of cholesterol metabolic process

MGI:MGI:3526480
PMID:15639194[1]

IMP: Inferred from Mutant Phenotype

P

From MGI


Notes

References

See Help:References for how to manage references in GONUTS.
  1. 1.0 1.1 1.2 1.3 1.4 Goetzman, ES et al. (2005) Differential induction of genes in liver and brown adipose tissue regulated by peroxisome proliferator-activated receptor-alpha during fasting and cold exposure in acyl-CoA dehydrogenase-deficient mice. Mol. Genet. Metab. 84 39-47 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 2.4 2.5 Kurtz, DM et al. (1998) Targeted disruption of mouse long-chain acyl-CoA dehydrogenase gene reveals crucial roles for fatty acid oxidation. Proc. Natl. Acad. Sci. U.S.A. 95 15592-7 PubMed GONUTS page
  3. Mootha, VK et al. (2003) Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Cell 115 629-40 PubMed GONUTS page
  4. Pagliarini, DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell 134 112-23 PubMed GONUTS page
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