MGI:Abca1

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Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0000166	nucleotide binding	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0547	F	From MGI
	GO:0000166	nucleotide binding	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR003593	F	From MGI
	GO:0002790	peptide secretion	MGI:MGI:3056863 PMID:15269218^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1935192	P	From MGI
	GO:0005515	protein binding	MGI:MGI:3611144 PMID:16204232^[2]	IPI: Inferred from Physical Interaction	UniProtKB:Q00623	F	From MGI
	GO:0005515	protein binding	MGI:MGI:84362 PMID:8751592^[3]	IPI: Inferred from Physical Interaction	UniProtKB:O35704	F	From MGI
	GO:0005524	ATP binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:O95477	F	From MGI
	GO:0005548	phospholipid transporter activity	MGI:MGI:3513719 PMID:15520449^[4]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0005548	phospholipid transporter activity	MGI:MGI:3513719 PMID:15520449^[4]	IMP: Inferred from Mutant Phenotype		F	From MGI
	GO:0005548	phospholipid transporter activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:O95477	F	From MGI
	GO:0005622	intracellular	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:O95477	C	From MGI
	GO:0005624	membrane fraction	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:O95477	C	From MGI
	GO:0005794	Golgi apparatus	MGI:MGI:1860694 PMID:10878804^[5]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005886	plasma membrane	MGI:MGI:2675932 PMID:12869555^[6]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005886	plasma membrane	MGI:MGI:3513719 PMID:15520449^[4]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005887	integral to plasma membrane	MGI:MGI:1860694 PMID:10878804^[5]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005887	integral to plasma membrane	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:O95477	C	From MGI
	GO:0006200	ATP catabolic process	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR003439 InterPro:IPR017871	P	From MGI
	GO:0006200	ATP catabolic process	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_835196	P	From MGI
	GO:0006497	protein lipidation	MGI:MGI:3611144 PMID:16204232^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3577725	P	From MGI
	GO:0006810	transport	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0813	P	From MGI
	GO:0006820	anion transport	MGI:MGI:3765261 PMID:9006906^[7]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0006911	phagocytosis, engulfment	MGI:MGI:1860694 PMID:10878804^[5]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1935192	P	From MGI
	GO:0007040	lysosome organization	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:O95477	P	From MGI
	GO:0007186	G-protein coupled receptor signaling pathway	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:O95477	P	From MGI
	GO:0008152	metabolic process	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR003593	P	From MGI
	GO:0008203	cholesterol metabolic process	MGI:MGI:2153573 PMID:11559713^[8]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0008203	cholesterol metabolic process	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:O95477	P	From MGI
	GO:0008509	anion transmembrane transporter activity	MGI:MGI:3765261 PMID:9006906^[7]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0009986	cell surface	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_835196	C	From MGI
	GO:0010875	positive regulation of cholesterol efflux	MGI:MGI:3047008 PMID:15210959^[9]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0015914	phospholipid transport	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_835196	P	From MGI
	GO:0016020	membrane	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0472	C	From MGI
	GO:0016021	integral to membrane	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0812	C	From MGI
	GO:0016197	endosome transport	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:O95477	P	From MGI
	GO:0016887	ATPase activity	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR003439 InterPro:IPR017871	F	From MGI
	GO:0017111	nucleoside-triphosphatase activity	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR003593	F	From MGI
	GO:0017127	cholesterol transporter activity	MGI:MGI:3513719 PMID:15520449^[4]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0017127	cholesterol transporter activity	MGI:MGI:3513719 PMID:15520449^[4]	IMP: Inferred from Mutant Phenotype		F	From MGI
	GO:0017127	cholesterol transporter activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:O95477	F	From MGI
	GO:0019905	syntaxin binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:O95477	F	From MGI
	GO:0030139	endocytic vesicle	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:O95477	C	From MGI
	GO:0030301	cholesterol transport	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_835196	P	From MGI
	GO:0030819	positive regulation of cAMP biosynthetic process	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:O95477	P	From MGI
	GO:0031267	small GTPase binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:O95477	F	From MGI
	GO:0032367	intracellular cholesterol transport	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:O95477	P	From MGI
	GO:0032488	Cdc42 protein signal transduction	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:O95477	P	From MGI
	GO:0033344	cholesterol efflux	MGI:MGI:2675932 PMID:12869555^[6]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0033344	cholesterol efflux	MGI:MGI:3056863 PMID:15269218^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1935192	P	From MGI
	GO:0033344	cholesterol efflux	MGI:MGI:3513719 PMID:15520449^[4]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0033344	cholesterol efflux	MGI:MGI:3513719 PMID:15520449^[4]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0033344	cholesterol efflux	MGI:MGI:3706212 PMID:17148552^[10]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3613250	P	From MGI
	GO:0033344	cholesterol efflux	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:O95477	P	From MGI
	GO:0033700	phospholipid efflux	MGI:MGI:3513719 PMID:15520449^[4]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0033700	phospholipid efflux	MGI:MGI:3513719 PMID:15520449^[4]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0033700	phospholipid efflux	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:O95477	P	From MGI
	GO:0034185	apolipoprotein binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:O95477	F	From MGI
	GO:0034186	apolipoprotein A-I binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:O95477	F	From MGI
	GO:0034188	apolipoprotein A-I receptor activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:O95477	F	From MGI
	GO:0034220	ion transmembrane transport	MGI:MGI:3765261 PMID:9006906^[7]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0034380	high-density lipoprotein particle assembly	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:O95477	P	From MGI
	GO:0038027	apolipoprotein A-I-mediated signaling pathway	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:O95477	P	From MGI
	GO:0042157	lipoprotein metabolic process	MGI:MGI:3056863 PMID:15269218^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1935192	P	From MGI
	GO:0042158	lipoprotein biosynthetic process	MGI:MGI:2668299 PMID:12859204^[11]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1935192	P	From MGI
	GO:0042158	lipoprotein biosynthetic process	MGI:MGI:3522380 PMID:15520446^[12]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1935192	P	From MGI
	GO:0042158	lipoprotein biosynthetic process	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_835196	P	From MGI
	GO:0042626	ATPase activity, coupled to transmembrane movement of substances	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_835196	F	From MGI
	GO:0042632	cholesterol homeostasis	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:O95477	P	From MGI
	GO:0043231	intracellular membrane-bounded organelle	MGI:MGI:1860694 PMID:10878804^[5]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0043691	reverse cholesterol transport	MGI:MGI:3720273 PMID:17657311^[13]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0043691	reverse cholesterol transport	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:O95477	P	From MGI
	GO:0045121	membrane raft	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:O95477	C	From MGI
	GO:0045332	phospholipid translocation	MGI:MGI:1860694 PMID:10878804^[5]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1935192	P	From MGI
	GO:0045335	phagocytic vesicle	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:O95477	C	From MGI
	GO:0050702	interleukin-1 beta secretion	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:O95477	P	From MGI
	GO:0055085	transmembrane transport	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_835196	P	From MGI
	GO:0055091	phospholipid homeostasis	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:O95477	P	From MGI
	GO:0060155	platelet dense granule organization	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:O95477	P	From MGI
	GO:0071222	cellular response to lipopolysaccharide	MGI:MGI:4411947 PMID:19752193^[14]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0071300	cellular response to retinoic acid	MGI:MGI:4411947 PMID:19752193^[14]	IDA: Inferred from Direct Assay		P	From MGI
NOT	GO:0055099	response to high density lipoprotein particle stimulus	MGI:MGI:3047008 PMID:15210959^[9]	IMP: Inferred from Mutant Phenotype		P	From MGI
colocalizes_with	GO:0034364	high-density lipoprotein particle	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_835196	C	From MGI
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Hirsch-Reinshagen V et al. (2004) Deficiency of ABCA1 impairs apolipoprotein E metabolism in brain. J Biol Chem 279: 41197-207 PubMed GONUTS page
↑ ^2.0 ^2.1 Maric J et al. (2005) Intracellular lipidation of newly synthesized apolipoprotein A-I in primary murine hepatocytes. J Biol Chem 280: 39942-9 PubMed GONUTS page
↑ Coveney E et al. (1996) Active immunotherapy with transiently transfected cytokine-secreting tumor cells inhibits breast cancer metastases in tumor-bearing animals. Surgery 120: 265-72; discussion 272-3 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 ^4.8 Linsel-Nitschke P et al. (2005) Potential role of ABCA7 in cellular lipid efflux to apoA-I. J Lipid Res 46: 86-92 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 Hamon Y et al. (2000) ABC1 promotes engulfment of apoptotic cells and transbilayer redistribution of phosphatidylserine. Nat Cell Biol 2: 399-406 PubMed GONUTS page
↑ ^6.0 ^6.1 Martinez LO et al. (2003) Phosphorylation of a pest sequence in ABCA1 promotes calpain degradation and is reversed by ApoA-I. J Biol Chem 278: 37368-74 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Becq F et al. (1997) ABC1, an ATP binding cassette transporter required for phagocytosis of apoptotic cells, generates a regulated anion flux after expression in Xenopus laevis oocytes. J Biol Chem 272: 2695-9 PubMed GONUTS page
↑ Chen W et al. (2001) Preferential ATP-binding cassette transporter A1-mediated cholesterol efflux from late endosomes/lysosomes. J Biol Chem 276: 43564-9 PubMed GONUTS page
↑ ^9.0 ^9.1 Wang N et al. (2004) ATP-binding cassette transporters G1 and G4 mediate cellular cholesterol efflux to high-density lipoproteins. Proc Natl Acad Sci U S A 101: 9774-9 PubMed GONUTS page
↑ Wang MD et al. (2007) Different cellular traffic of LDL-cholesterol and acetylated LDL-cholesterol leads to distinct reverse cholesterol transport pathways. J Lipid Res 48: 633-45 PubMed GONUTS page
↑ Francone OL et al. (2003) Abnormal phospholipid composition impairs HDL biogenesis and maturation in mice lacking Abca1. Biochemistry 42: 8569-78 PubMed GONUTS page
↑ Tsujita M et al. (2005) On the hepatic mechanism of HDL assembly by the ABCA1/apoA-I pathway. J Lipid Res 46: 154-62 PubMed GONUTS page
↑ Wang X et al. (2007) Macrophage ABCA1 and ABCG1, but not SR-BI, promote macrophage reverse cholesterol transport in vivo. J Clin Invest 117: 2216-24 PubMed GONUTS page
↑ ^14.0 ^14.1 Maitra U et al. (2009) An innate immunity signaling process suppresses macrophage ABCA1 expression through IRAK-1-mediated downregulation of retinoic acid receptor alpha and NFATc2. Mol Cell Biol 29: 5989-97 PubMed GONUTS page

[PMID:15269218-0] 1.0 ^1.1 ^1.2 Hirsch-Reinshagen V et al. (2004) Deficiency of ABCA1 impairs apolipoprotein E metabolism in brain. J Biol Chem 279: 41197-207 PubMed GONUTS page

[PMID:16204232-1] 2.0 ^2.1 Maric J et al. (2005) Intracellular lipidation of newly synthesized apolipoprotein A-I in primary murine hepatocytes. J Biol Chem 280: 39942-9 PubMed GONUTS page

[PMID:8751592-2] Coveney E et al. (1996) Active immunotherapy with transiently transfected cytokine-secreting tumor cells inhibits breast cancer metastases in tumor-bearing animals. Surgery 120: 265-72; discussion 272-3 PubMed GONUTS page

[PMID:15520449-3] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 ^4.8 Linsel-Nitschke P et al. (2005) Potential role of ABCA7 in cellular lipid efflux to apoA-I. J Lipid Res 46: 86-92 PubMed GONUTS page

[PMID:10878804-4] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 Hamon Y et al. (2000) ABC1 promotes engulfment of apoptotic cells and transbilayer redistribution of phosphatidylserine. Nat Cell Biol 2: 399-406 PubMed GONUTS page

[PMID:12869555-5] 6.0 ^6.1 Martinez LO et al. (2003) Phosphorylation of a pest sequence in ABCA1 promotes calpain degradation and is reversed by ApoA-I. J Biol Chem 278: 37368-74 PubMed GONUTS page

[PMID:9006906-6] 7.0 ^7.1 ^7.2 Becq F et al. (1997) ABC1, an ATP binding cassette transporter required for phagocytosis of apoptotic cells, generates a regulated anion flux after expression in Xenopus laevis oocytes. J Biol Chem 272: 2695-9 PubMed GONUTS page

[PMID:11559713-7] Chen W et al. (2001) Preferential ATP-binding cassette transporter A1-mediated cholesterol efflux from late endosomes/lysosomes. J Biol Chem 276: 43564-9 PubMed GONUTS page

[PMID:15210959-8] 9.0 ^9.1 Wang N et al. (2004) ATP-binding cassette transporters G1 and G4 mediate cellular cholesterol efflux to high-density lipoproteins. Proc Natl Acad Sci U S A 101: 9774-9 PubMed GONUTS page

[PMID:17148552-9] Wang MD et al. (2007) Different cellular traffic of LDL-cholesterol and acetylated LDL-cholesterol leads to distinct reverse cholesterol transport pathways. J Lipid Res 48: 633-45 PubMed GONUTS page

[PMID:12859204-10] Francone OL et al. (2003) Abnormal phospholipid composition impairs HDL biogenesis and maturation in mice lacking Abca1. Biochemistry 42: 8569-78 PubMed GONUTS page

[PMID:15520446-11] Tsujita M et al. (2005) On the hepatic mechanism of HDL assembly by the ABCA1/apoA-I pathway. J Lipid Res 46: 154-62 PubMed GONUTS page

[PMID:17657311-12] Wang X et al. (2007) Macrophage ABCA1 and ABCG1, but not SR-BI, promote macrophage reverse cholesterol transport in vivo. J Clin Invest 117: 2216-24 PubMed GONUTS page

[PMID:19752193-13] 14.0 ^14.1 Maitra U et al. (2009) An innate immunity signaling process suppresses macrophage ABCA1 expression through IRAK-1-mediated downregulation of retinoic acid receptor alpha and NFATc2. Mol Cell Biol 29: 5989-97 PubMed GONUTS page

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Species (Taxon ID)	Mus musculus (house mouse) (taxon:10090)
Gene Name(s)	Abca1 ( synonyms: ABC1 )
Protein Name(s)	ATP-binding cassette, sub-family A (ABC1), member 1,
External Links
MGI	MGI:99607

MGI:Abca1

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