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I96A0:PB2
Contents |
| Species (Taxon ID) | Gs/Gd). (taxon:93838) | |
| Gene Name(s) | PB2 | |
| Protein Name(s) |
| |
| External Links | ||
| UniProt Identifier | PB2_I96A0 | |
| UniProt Accessions | Q9Q0V1, | |
| EMBL | AF144300, | |
| RefSeq | YP_308664.1, | |
| Pfam | PF00604, | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0042025 |
host cell nucleus |
IEA: Inferred from Electronic Annotation |
SP_SL:SL-0414 |
C |
||||
| GO:0019012 |
virion |
IEA: Inferred from Electronic Annotation |
C |
|||||
| GO:0042025 |
host cell nucleus |
IEA: Inferred from Electronic Annotation |
C |
|||||
| GO:0003723 |
RNA binding |
IEA: Inferred from Electronic Annotation |
F |
|||||
| GO:0033650 |
host cell mitochondrion |
IEA: Inferred from Electronic Annotation |
C |
|||||
| GO:0003968 |
RNA-directed RNA polymerase activity |
IEA: Inferred from Electronic Annotation |
F |
|||||
| GO:0006370 |
mRNA capping |
IEA: Inferred from Electronic Annotation |
P |
|||||
| GO:0006397 |
mRNA processing |
IEA: Inferred from Electronic Annotation |
P |
|||||
| GO:0019012 |
virion |
IEA: Inferred from Electronic Annotation |
SP_SL:SL-0274 |
C |
||||
| GO:0003968 |
RNA-directed RNA polymerase activity |
IGI: Inferred from Genetic Interaction |
F |
The polymorphic amino acid sites in the protein sequences of the Egyptian human and avian strains in comparison to the equine isolate were examined, as was the distribution of the alternative residues among strains classified as virulent or nonvirulent (Table 2), such residues having functional significance for virulence in H5N1. H5N1 influenza virus isolated from equines and humans in Egypt contained most of the amino acids specific to the avian virus, where the PB2 contained two avian virus-like amino acids (alanine, A 661 and lysine, K 702). These two amino acids are located in the domain of the PB2 gene, which is believed to be responsible for interaction with other polymerase components [30]. One genetic indicator of adaptation and efficient replication in humans is the E627K substitution in the PB2 protein [34, 37]. |
Missing: with/from | |||
| GO:0033650 |
host cell mitochondrion |
IEA: Inferred from Electronic Annotation |
SP_SL:SL-0407 |
C |
||||
| GO:0003723 |
RNA binding |
IEA: Inferred from Electronic Annotation |
F |
|||||
| GO:0003968 |
RNA-directed RNA polymerase activity |
IEA: Inferred from Electronic Annotation |
F |
|||||
| GO:0006351 |
transcription, DNA-dependent |
IEA: Inferred from Electronic Annotation |
P |
|||||
| GO:0006370 |
mRNA capping |
IEA: Inferred from Electronic Annotation |
P |
|||||
| GO:0006397 |
mRNA processing |
IEA: Inferred from Electronic Annotation |
P |
|||||
| GO:0019012 |
virion |
IEA: Inferred from Electronic Annotation |
C |
|||||
| GO:0019012 |
virion |
IEA: Inferred from Electronic Annotation |
SP_SL:SL-0274 |
C |
||||
| GO:0033650 |
host cell mitochondrion |
IEA: Inferred from Electronic Annotation |
C |
|||||
| GO:0033650 |
host cell mitochondrion |
IEA: Inferred from Electronic Annotation |
SP_SL:SL-0407 |
C |
||||
| GO:0042025 |
host cell nucleus |
IEA: Inferred from Electronic Annotation |
C |
|||||
| GO:0042025 |
host cell nucleus |
IEA: Inferred from Electronic Annotation |
SP_SL:SL-0414 |
C |
| |||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Abdel-Moneim AS et al. (2011) Molecular evolution of the six internal genes of H5N1 equine influenza A virus. Arch Virol 156: 1257-62 PubMed GONUTS page
