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HUMAN:ZN423

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Contents

Species (Taxon ID) Homo sapiens (Human). (taxon:9606)
Gene Name(s) ZNF423 ( synonyms: KIAA0760, OAZ )
Protein Name(s)
  • Zinc finger protein 423
  • Olf1/EBF-associated zinc finger protein
  • hOAZ
  • Smad- and Olf-interacting zinc finger protein
External Links
UniProt Identifier ZN423_HUMAN
UniProt Accessions Q2M1K9, O94860, Q76N04, Q9NZ13,
EMBL BC112315, BC112317, AF221712, AB018303,
RefSeq NP_055884.2,
IntAct Q2M1K9,
Ensembl ENST00000262383,
Pfam PF00096,



Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0005634

nucleus

IDA: Inferred from Direct Assay

C

Source: UniProtKB

GO:0016563

transcription activator activity

IDA: Inferred from Direct Assay

F

Source: UniProtKB

GO:0016564

transcription repressor activity

IDA: Inferred from Direct Assay

F

Source: UniProtKB

GO:0016481

negative regulation of transcription

IDA: Inferred from Direct Assay

P

Source: UniProtKB

GO:0045941

positive regulation of transcription

IDA: Inferred from Direct Assay

P

Source: UniProtKB

GO:0003676

nucleic acid binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR013087

F

GO:0003677

DNA binding

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0238

F

GO:0005515

protein binding

PMID:19345331[1]

IPI: Inferred from Physical Interaction

UniProtKB:P10276

F

GO:0005622

intracellular

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR007087

C

GO:0005622

intracellular

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR015880

C

GO:0005634

nucleus

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0539

C

GO:0005634

nucleus

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-0191

C

GO:0005634

nucleus

PMID:10660046[2]

IDA: Inferred from Direct Assay

C

GO:0006351

transcription, DNA-dependent

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0804

P

GO:0006355

regulation of transcription, DNA-dependent

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0805

P

GO:0007219

Notch signaling pathway

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:Q80TS5

P

GO:0007275

multicellular organismal development

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0217

P

GO:0007399

nervous system development

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0524

P

GO:0008270

zinc ion binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR007087

F

GO:0008270

zinc ion binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR015880

F

GO:0030154

cell differentiation

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0221

P

GO:0030513

positive regulation of BMP signaling pathway

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:Q80TS5

P

GO:0042803

protein homodimerization activity

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000020028

F

GO:0043565

sequence-specific DNA binding

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000020028

F

GO:0045892

negative regulation of transcription, DNA-dependent

PMID:10660046[2]

IDA: Inferred from Direct Assay

P

GO:0045893

positive regulation of transcription, DNA-dependent

PMID:10660046[2]

IDA: Inferred from Direct Assay

P

GO:0046872

metal ion binding

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0479

F

GO:0046982

protein heterodimerization activity

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000020028

F


Notes

References

See Help:References for how to manage references in GONUTS.

  1. Huang S et al. (2009) ZNF423 is critically required for retinoic acid-induced differentiation and is a marker of neuroblastoma outcome. Cancer Cell 15: 328-40 PubMed GONUTS page
  2. 2.0 2.1 2.2 Hata A et al. (2000) OAZ uses distinct DNA- and protein-binding zinc fingers in separate BMP-Smad and Olf signaling pathways. Cell 100: 229-40 PubMed GONUTS page
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