HUMAN:WWP2

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Species (Taxon ID)	Homo sapiens (Human). (taxon:9606)
Gene Name(s)	WWP2
Protein Name(s)	NEDD4-like E3 ubiquitin-protein ligase WWP2 Atrophin-1-interacting protein 2 AIP2 WW domain-containing protein 2
External Links
UniProt Identifier	WWP2_HUMAN
UniProt Accessions	O00308, A6NEP1, B2R706, Q96CZ2, Q9BWN6,
EMBL	U96114, AK312792, AC026468, CH471092, BC000108, BC013645, BC064531,
RefSeq	NP_008945.2, NP_955455.1, NP_955456.1,
IntAct	O00308,
Ensembl	ENST00000356003, ENST00000359154, ENST00000448661,
Pfam	PF00632, PF00397,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0005634	nucleus		IDA: Inferred from Direct Assay		C	Source: UniProtKB
	GO:0000151	ubiquitin ligase complex		TAS: Traceable Author Statement		C	Source: ProtInc
	GO:0008134	transcription factor binding		IPI: Inferred from Physical Interaction		F	Source: UniProtKB
	GO:0004842	ubiquitin-protein ligase activity		IDA: Inferred from Direct Assay		F	Source: UniProtKB
	GO:0046718	entry of virus into host cell		TAS: Traceable Author Statement		P	Source: UniProtKB
	GO:0010629	negative regulation of gene expression		IMP: Inferred from Mutant Phenotype		P	Source: UniProtKB
	GO:0051224	negative regulation of protein transport		IMP: Inferred from Mutant Phenotype		P	Source: UniProtKB
	GO:0032410	negative regulation of transporter activity		IDA: Inferred from Direct Assay		P	Source: UniProtKB
	GO:0070534	protein K63-linked ubiquitination		ISS: Inferred from Sequence or Structural Similarity		P	Source: UniProtKB
	GO:0000122	negative regulation of transcription from RNA polymerase II promoter	PMID:15047715^[1]	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q9DBH0	P
	GO:0000122	negative regulation of transcription from RNA polymerase II promoter	PMID:19274063^[2]	IMP: Inferred from Mutant Phenotype		P
	GO:0000151	ubiquitin ligase complex	PMID:9647693^[3]	TAS: Traceable Author Statement		C
	GO:0001085	RNA polymerase II transcription factor binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000132224	F
	GO:0001085	RNA polymerase II transcription factor binding	PMID:15047715^[1]	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q9DBH0	F
	GO:0001085	RNA polymerase II transcription factor binding	PMID:19274063^[2]	IPI: Inferred from Physical Interaction	UniProtKB:Q01860	F
	GO:0004842	ubiquitin-protein ligase activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000132224	F
	GO:0004842	ubiquitin-protein ligase activity	PMID:18776082^[4]	IMP: Inferred from Mutant Phenotype		F
	GO:0004842	ubiquitin-protein ligase activity	PMID:19274063^[2]	IDA: Inferred from Direct Assay		F
	GO:0004842	ubiquitin-protein ligase activity	PMID:19651900^[5]	IDA: Inferred from Direct Assay		F
	GO:0004842	ubiquitin-protein ligase activity	PMID:9169421^[6]	TAS: Traceable Author Statement		F
	GO:0005515	protein binding	PMID:17719543^[7]	IPI: Inferred from Physical Interaction	UniProtKB:P0CG47	F
	GO:0005515	protein binding	PMID:18776082^[4]	IPI: Inferred from Physical Interaction	UniProtKB:P49281	F
	GO:0005515	protein binding	PMID:21572392^[8]	IPI: Inferred from Physical Interaction	UniProtKB:Q9H469	F
	GO:0005515	protein binding	PMID:9647693^[3]	IPI: Inferred from Physical Interaction	UniProtKB:P54259	F
	GO:0005622	intracellular	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000569	C
	GO:0005634	nucleus	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0539	C
	GO:0005634	nucleus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000132224	C
	GO:0005634	nucleus	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0191	C
	GO:0005634	nucleus	PMID:19274063^[2]	IDA: Inferred from Direct Assay		C
	GO:0005737	cytoplasm	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000132224	C
	GO:0005737	cytoplasm	PMID:15047715^[1]	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q9DBH0	C
	GO:0006464	protein modification process	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000569	P
	GO:0006464	protein modification process	PMID:9169421^[6]	TAS: Traceable Author Statement		P
	GO:0008134	transcription factor binding	PMID:19651900^[5]	IPI: Inferred from Physical Interaction	UniProtKB:P11161	F
	GO:0010629	negative regulation of gene expression	PMID:18776082^[4]	IMP: Inferred from Mutant Phenotype		P
	GO:0016567	protein ubiquitination	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000132224	P
	GO:0016567	protein ubiquitination	PMID:18776082^[4]	IDA: Inferred from Direct Assay		P
	GO:0016567	protein ubiquitination	PMID:18776082^[4]	IMP: Inferred from Mutant Phenotype		P
	GO:0016567	protein ubiquitination	PMID:9169421^[6]	TAS: Traceable Author Statement		P
	GO:0016874	ligase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0436	F
	GO:0016881	acid-amino acid ligase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000569	F
	GO:0032410	negative regulation of transporter activity	PMID:18776082^[4]	IDA: Inferred from Direct Assay		P
	GO:0042787	protein ubiquitination involved in ubiquitin-dependent protein catabolic process	GO_REF:0000033		PANTHER:PTHR11254_AN0	P
	GO:0043161	proteasomal ubiquitin-dependent protein catabolic process	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000132224	P
	GO:0043161	proteasomal ubiquitin-dependent protein catabolic process	PMID:19274063^[2]	IMP: Inferred from Mutant Phenotype		P
	GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000132224	P
	GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity	PMID:15047715^[1]	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q9DBH0	P
	GO:0044419	interspecies interaction between organisms	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0945	P
	GO:0045892	negative regulation of transcription, DNA-dependent	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000132224	P
	GO:0045892	negative regulation of transcription, DNA-dependent	PMID:15047715^[1]	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q9DBH0	P
	GO:0046718	entry of virus into host cell	PMID:12450395^[9]	TAS: Traceable Author Statement		P
	GO:0051224	negative regulation of protein transport	PMID:18776082^[4]	IMP: Inferred from Mutant Phenotype		P
	GO:0070534	protein K63-linked ubiquitination	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000132224	P
	GO:0070534	protein K63-linked ubiquitination	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q9DBH0	P
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 Xu HM et al. (2004) Wwp2, an E3 ubiquitin ligase that targets transcription factor Oct-4 for ubiquitination. J Biol Chem 279: 23495-503 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 Xu H et al. (2009) WWP2 promotes degradation of transcription factor OCT4 in human embryonic stem cells. Cell Res 19: 561-73 PubMed GONUTS page
↑ ^3.0 ^3.1 Wood JD et al. (1998) Atrophin-1, the DRPLA gene product, interacts with two families of WW domain-containing proteins. Mol Cell Neurosci 11: 149-60 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 Foot NJ et al. (2008) Regulation of the divalent metal ion transporter DMT1 and iron homeostasis by a ubiquitin-dependent mechanism involving Ndfips and WWP2. Blood 112: 4268-75 PubMed GONUTS page
↑ ^5.0 ^5.1 Chen A et al. (2009) The HECT-type E3 ubiquitin ligase AIP2 inhibits activation-induced T-cell death by catalyzing EGR2 ubiquitination. Mol Cell Biol 29: 5348-56 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Pirozzi G et al. (1997) Identification of novel human WW domain-containing proteins by cloning of ligand targets. J Biol Chem 272: 14611-6 PubMed GONUTS page
↑ Wiesner S et al. (2007) Autoinhibition of the HECT-type ubiquitin ligase Smurf2 through its C2 domain. Cell 130: 651-62 PubMed GONUTS page
↑ Cui Y et al. (2011) SCFFBXL¹⁵ regulates BMP signalling by directing the degradation of HECT-type ubiquitin ligase Smurf1. EMBO J 30: 2675-89 PubMed GONUTS page
↑ Galinier R et al. (2002) Adenovirus protein involved in virus internalization recruits ubiquitin-protein ligases. Biochemistry 41: 14299-305 PubMed GONUTS page

[PMID:15047715-0] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 Xu HM et al. (2004) Wwp2, an E3 ubiquitin ligase that targets transcription factor Oct-4 for ubiquitination. J Biol Chem 279: 23495-503 PubMed GONUTS page

[PMID:19274063-1] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 Xu H et al. (2009) WWP2 promotes degradation of transcription factor OCT4 in human embryonic stem cells. Cell Res 19: 561-73 PubMed GONUTS page

[PMID:9647693-2] 3.0 ^3.1 Wood JD et al. (1998) Atrophin-1, the DRPLA gene product, interacts with two families of WW domain-containing proteins. Mol Cell Neurosci 11: 149-60 PubMed GONUTS page

[PMID:18776082-3] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 Foot NJ et al. (2008) Regulation of the divalent metal ion transporter DMT1 and iron homeostasis by a ubiquitin-dependent mechanism involving Ndfips and WWP2. Blood 112: 4268-75 PubMed GONUTS page

[PMID:19651900-4] 5.0 ^5.1 Chen A et al. (2009) The HECT-type E3 ubiquitin ligase AIP2 inhibits activation-induced T-cell death by catalyzing EGR2 ubiquitination. Mol Cell Biol 29: 5348-56 PubMed GONUTS page

[PMID:9169421-5] 6.0 ^6.1 ^6.2 Pirozzi G et al. (1997) Identification of novel human WW domain-containing proteins by cloning of ligand targets. J Biol Chem 272: 14611-6 PubMed GONUTS page

[PMID:17719543-6] Wiesner S et al. (2007) Autoinhibition of the HECT-type ubiquitin ligase Smurf2 through its C2 domain. Cell 130: 651-62 PubMed GONUTS page

[PMID:21572392-7] Cui Y et al. (2011) SCFFBXL¹⁵ regulates BMP signalling by directing the degradation of HECT-type ubiquitin ligase Smurf1. EMBO J 30: 2675-89 PubMed GONUTS page

[PMID:12450395-8] Galinier R et al. (2002) Adenovirus protein involved in virus internalization recruits ubiquitin-protein ligases. Biochemistry 41: 14299-305 PubMed GONUTS page

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HUMAN:WWP2

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