HUMAN:WT1

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Species (Taxon ID)	Homo sapiens (Human). ([1])
Gene Name(s)	WT1
Protein Name(s)	Wilms tumor protein WT33
External Links
EMBL	X51630 M80232 M80217 M80218 M80219 M80220 M80221 M80228 M80229 M80231 X61631 X61632 X61633 X61634 X61635 X61636 X61637 X61638 AK291736 AY245105 AL049692 AL049692 AL049692 AL049692 CH471064 CH471064 BC032861 M30393 S75264 S61515 S61522 S61524 S60755
IPI	IPI00019517 IPI00374173 IPI00550100 IPI00853526 IPI00935507 IPI00935900 IPI00936595
PIR	A38080
RefSeq	NP_000369.3 NP_001185480.1 NP_001185481.1 NP_077742.2 NP_077744.3
UniGene	Hs.591980
PDB	1LU6 1XF7 2G7T 2G7V 2G7W 2G7X 2JP9 2JPA 2PRT 3HPJ 3MYJ
PDBsum	1LU6 1XF7 2G7T 2G7V 2G7W 2G7X 2JP9 2JPA 2PRT 3HPJ 3MYJ
ProteinModelPortal	P19544
SMR	P19544
IntAct	P19544
STRING	P19544
PhosphoSite	P19544
PRIDE	P19544
Ensembl	ENST00000332351
GeneID	7490
KEGG	hsa:7490
UCSC	uc001mtn.1 uc001mto.1 uc001mtp.1 uc001mtq.1
CTD	7490
GeneCards	GC11M032104
H-InvDB	HIX0009531
HGNC	HGNC:12796
HPA	CAB000327
MIM	136680 156240 194070 194080 256370 607102 608978
neXtProt	NX_P19544
Orphanet	251510 220 83469 93217 93213 347 3097 654 93220 893
HOVERGEN	HBG006960
InParanoid	P19544
PhylomeDB	P19544
Pathway_Interaction_DB	telomerasepathway
NextBio	29336
ArrayExpress	P19544
Bgee	P19544
CleanEx	HS_WT1
Genevestigator	P19544
GermOnline	ENSG00000184937
GO	GO:0005737 GO:0016607 GO:0005730 GO:0005654 GO:0070742 GO:0003723 GO:0001077 GO:0043565 GO:0044212 GO:0008270 GO:0035802 GO:0001658 GO:0043010 GO:0060923 GO:0071320 GO:0071371 GO:0060539 GO:0007281 GO:0032836 GO:0072112 GO:0006917 GO:0030539 GO:0008584 GO:0060231 GO:0072207 GO:0072075 GO:0072284 GO:0043066 GO:0030308 GO:2000195 GO:0072302 GO:0000122 GO:0045892 GO:0017148 GO:0060421 GO:2000020 GO:2001076 GO:0045893 GO:0072166 GO:0003156 GO:0008380 GO:0007530 GO:0007356 GO:0001570 GO:0061032
InterPro	IPR017987 IPR000976 IPR007087 IPR015880 IPR013087
Gene3D	G3DSA:3.30.160.60
KO	K09234
Pfam	PF02165 PF00096
PRINTS	PR00049
SMART	SM00355
PROSITE	PS00028 PS50157

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0000122	negative regulation of transcription from RNA polymerase II promoter	PMID:7585606^[1]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P22561	F	Seeded From UniProt
	GO:0001570	vasculogenesis	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P22561	P	Seeded From UniProt
	GO:0001657	ureteric bud development	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P22561	P	Seeded From UniProt
	GO:0001658	branching involved in ureteric bud morphogenesis	PMID:10101119^[2]	IGI: Inferred from Genetic Interaction	UniProtKB:P22561	P	Seeded From UniProt
	GO:0001822	kidney development	PMID:11912180^[3]	IGI: Inferred from Genetic Interaction	UniProtKB:P22561	P	Seeded From UniProt
	GO:0003156	regulation of organ formation	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P22561	P	Seeded From UniProt
	GO:0003676	nucleic acid binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR013087	F	Seeded From UniProt
	GO:0003677	DNA binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0238	F	Seeded From UniProt
	GO:0003700	sequence-specific DNA binding transcription factor activity	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P22561	F	Seeded From UniProt
	GO:0003700	sequence-specific DNA binding transcription factor activity	PMID:7862533^[4]	NAS: Non-traceable Author Statement		F	Seeded From UniProt
	GO:0003700	sequence-specific DNA binding transcription factor activity	PMID:8393820^[5]	NAS: Non-traceable Author Statement		F	Seeded From UniProt
	GO:0003723	RNA binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0694	F	Seeded From UniProt
	GO:0005515	protein binding	PMID:14701728^[6]	IPI: Inferred from Physical Interaction	UniProtKB:P80723	F	Seeded From UniProt
	GO:0005515	protein binding	PMID:16934801^[7]	IPI: Inferred from Physical Interaction	UniProtKB:Q9BWF3	F	Seeded From UniProt
	GO:0005515	protein binding	PMID:21390327^[8]	IPI: Inferred from Physical Interaction	UniProtKB:P48059	F	Seeded From UniProt
	GO:0005515	protein binding	PMID:8119964^[9]	IPI: Inferred from Physical Interaction	UniProtKB:P19544	F	Seeded From UniProt
	GO:0005515	protein binding	PMID:9178767^[10]	IPI: Inferred from Physical Interaction	UniProtKB:Q02962	F	Seeded From UniProt
	GO:0005515	protein binding	PMID:9553041^[11]	IPI: Inferred from Physical Interaction	UniProtKB:P08107	F	Seeded From UniProt
	GO:0005622	intracellular	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR007087	C	Seeded From UniProt
	GO:0005622	intracellular	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR015880	C	Seeded From UniProt
	GO:0005634	nucleus	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000976	C	Seeded From UniProt
	GO:0005634	nucleus	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0539	C	Seeded From UniProt
	GO:0005634	nucleus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000046055	C	Seeded From UniProt
	GO:0005634	nucleus	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0191	C	Seeded From UniProt
	GO:0005634	nucleus	PMID:14701728^[6]	IDA: Inferred from Direct Assay		C	Seeded From UniProt
	GO:0005634	nucleus	PMID:15961562^[12]	IDA: Inferred from Direct Assay		C	Seeded From UniProt
	GO:0005634	nucleus	PMID:1662794^[13]	IDA: Inferred from Direct Assay		C	Seeded From UniProt
	GO:0005634	nucleus	PMID:16934801^[7]	IDA: Inferred from Direct Assay		C	Seeded From UniProt
	GO:0005634	nucleus	PMID:7588596^[14]	IDA: Inferred from Direct Assay		C	Seeded From UniProt
	GO:0005634	nucleus	PMID:8306891^[15]	IDA: Inferred from Direct Assay		C	Seeded From UniProt
	GO:0005654	nucleoplasm	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0190	C	Seeded From UniProt
	GO:0005654	nucleoplasm	PMID:15520190^[16]	IDA: Inferred from Direct Assay		C	Seeded From UniProt
	GO:0005730	nucleolus	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0188	C	Seeded From UniProt
	GO:0005737	cytoplasm	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0963	C	Seeded From UniProt
	GO:0005737	cytoplasm	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0086	C	Seeded From UniProt
	GO:0005737	cytoplasm	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P22561	C	Seeded From UniProt
	GO:0006351	transcription, DNA-dependent	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0804	P	Seeded From UniProt
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000976	P	Seeded From UniProt
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0805	P	Seeded From UniProt
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P22561	P	Seeded From UniProt
	GO:0006355	regulation of transcription, DNA-dependent	PMID:7862533^[4]	NAS: Non-traceable Author Statement		P	Seeded From UniProt
	GO:0006355	regulation of transcription, DNA-dependent	PMID:8393820^[5]	NAS: Non-traceable Author Statement		P	Seeded From UniProt
	GO:0006357	regulation of transcription from RNA polymerase II promoter	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P22561	P	Seeded From UniProt
	GO:0006917	induction of apoptosis	PMID:7588596^[14]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0007281	germ cell development	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P22561	P	Seeded From UniProt
	GO:0007356	thorax and anterior abdomen determination	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P22561	P	Seeded From UniProt
	GO:0007507	heart development	PMID:10101119^[2]	IGI: Inferred from Genetic Interaction	UniProtKB:P22561	P	Seeded From UniProt
	GO:0007530	sex determination	PMID:9815658^[17]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0008270	zinc ion binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR007087	F	Seeded From UniProt
	GO:0008270	zinc ion binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR015880	F	Seeded From UniProt
	GO:0008270	zinc ion binding	PMID:15518539^[18]	IDA: Inferred from Direct Assay		F	Seeded From UniProt
	GO:0008285	negative regulation of cell proliferation	PMID:9553041^[11]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0008285	negative regulation of cell proliferation	PMID:9765217^[19]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0008380	RNA splicing	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P22561	P	Seeded From UniProt
	GO:0008406	gonad development	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P22561	P	Seeded From UniProt
	GO:0008584	male gonad development	PMID:17848411^[20]	IEP: Inferred from Expression Pattern		P	Seeded From UniProt
	GO:0009888	tissue development	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P22561	P	Seeded From UniProt
	GO:0016607	nuclear speck	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0186	C	Seeded From UniProt
	GO:0016607	nuclear speck	PMID:15520190^[16]	IDA: Inferred from Direct Assay		C	Seeded From UniProt
	GO:0016607	nuclear speck	PMID:16934801^[7]	IDA: Inferred from Direct Assay		C	Seeded From UniProt
	GO:0016607	nuclear speck	PMID:9553041^[11]	IDA: Inferred from Direct Assay		C	Seeded From UniProt
	GO:0017148	negative regulation of translation	PMID:7588596^[14]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0030308	negative regulation of cell growth	PMID:7588596^[14]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0030308	negative regulation of cell growth	PMID:9553041^[11]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0030308	negative regulation of cell growth	PMID:9765217^[19]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0030325	adrenal gland development	PMID:10101119^[2]	IGI: Inferred from Genetic Interaction	UniProtKB:P22561	P	Seeded From UniProt
	GO:0030539	male genitalia development	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P22561	P	Seeded From UniProt
	GO:0030855	epithelial cell differentiation	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P22561	P	Seeded From UniProt
	GO:0032835	glomerulus development	PMID:10101119^[2]	IGI: Inferred from Genetic Interaction	UniProtKB:P22561	P	Seeded From UniProt
	GO:0032836	glomerular basement membrane development	PMID:19205749^[21]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0035802	adrenal cortex formation	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P22561	P	Seeded From UniProt
	GO:0043010	camera-type eye development	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P22561	P	Seeded From UniProt
	GO:0043066	negative regulation of apoptosis	PMID:10101119^[2]	IGI: Inferred from Genetic Interaction	UniProtKB:P22561	P	Seeded From UniProt
	GO:0043565	sequence-specific DNA binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000046055	F	Seeded From UniProt
	GO:0043565	sequence-specific DNA binding	PMID:1662794^[13]	IDA: Inferred from Direct Assay		F	Seeded From UniProt
	GO:0043565	sequence-specific DNA binding	PMID:7720589^[22]	IDA: Inferred from Direct Assay		F	Seeded From UniProt
	GO:0043565	sequence-specific DNA binding	PMID:8119964^[9]	IDA: Inferred from Direct Assay		F	Seeded From UniProt
	GO:0044212	transcription regulatory region DNA binding	PMID:1332065^[23]	IDA: Inferred from Direct Assay		F	Seeded From UniProt
	GO:0044212	transcription regulatory region DNA binding	PMID:16467207^[24]	IDA: Inferred from Direct Assay		F	Seeded From UniProt
	GO:0044212	transcription regulatory region DNA binding	PMID:7585606^[1]	IDA: Inferred from Direct Assay		F	Seeded From UniProt
	GO:0044212	transcription regulatory region DNA binding	PMID:7588596^[14]	IDA: Inferred from Direct Assay		F	Seeded From UniProt
	GO:0044212	transcription regulatory region DNA binding	PMID:9815658^[17]	IDA: Inferred from Direct Assay		F	Seeded From UniProt
	GO:0045892	negative regulation of transcription, DNA-dependent	PMID:12802290^[25]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0045892	negative regulation of transcription, DNA-dependent	PMID:1332065^[23]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0045892	negative regulation of transcription, DNA-dependent	PMID:14701728^[6]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0045892	negative regulation of transcription, DNA-dependent	PMID:19050011^[26]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0045892	negative regulation of transcription, DNA-dependent	PMID:7585606^[1]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0045892	negative regulation of transcription, DNA-dependent	PMID:7588596^[14]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0045892	negative regulation of transcription, DNA-dependent	PMID:7720589^[22]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0045892	negative regulation of transcription, DNA-dependent	PMID:8119964^[9]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0045892	negative regulation of transcription, DNA-dependent	PMID:9815658^[17]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0045892	negative regulation of transcription, DNA-dependent	PMID:9815658^[17]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0045892	negative regulation of transcription, DNA-dependent	PMID:9815658^[17]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0045892	negative regulation of transcription, DNA-dependent	PMID:9815658^[17]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0045893	positive regulation of transcription, DNA-dependent	PMID:11912180^[3]	IGI: Inferred from Genetic Interaction	UniProtKB:P22561	P	Seeded From UniProt
	GO:0045893	positive regulation of transcription, DNA-dependent	PMID:12802290^[25]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0045893	positive regulation of transcription, DNA-dependent	PMID:14701728^[6]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0045893	positive regulation of transcription, DNA-dependent	PMID:16467207^[24]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0045893	positive regulation of transcription, DNA-dependent	PMID:21390327^[8]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0045893	positive regulation of transcription, DNA-dependent	PMID:7588596^[14]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0045893	positive regulation of transcription, DNA-dependent	PMID:8132626^[27]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0045893	positive regulation of transcription, DNA-dependent	PMID:9178767^[10]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0045893	positive regulation of transcription, DNA-dependent	PMID:9553041^[11]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0045893	positive regulation of transcription, DNA-dependent	PMID:9765217^[19]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0045893	positive regulation of transcription, DNA-dependent	PMID:9815658^[17]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0045893	positive regulation of transcription, DNA-dependent	PMID:9815658^[17]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000046055	P	Seeded From UniProt
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P22561	P	Seeded From UniProt
	GO:0046872	metal ion binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0479	F	Seeded From UniProt
	GO:0060231	mesenchymal to epithelial transition	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P22561	P	Seeded From UniProt
	GO:0060421	positive regulation of heart growth	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P22561	P	Seeded From UniProt
	GO:0060539	diaphragm development	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P22561	P	Seeded From UniProt
	GO:0060923	cardiac muscle cell fate commitment	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P22561	P	Seeded From UniProt
	GO:0061032	visceral serous pericardium development	PMID:10101119^[2]	IGI: Inferred from Genetic Interaction	UniProtKB:P22561	P	Seeded From UniProt
	GO:0070742	C2H2 zinc finger domain binding	PMID:8119964^[9]	IPI: Inferred from Physical Interaction	UniProtKB:P19544	F	Seeded From UniProt
	GO:0071320	cellular response to cAMP	PMID:15961562^[12]	IEP: Inferred from Expression Pattern		P	Seeded From UniProt
	GO:0071371	cellular response to gonadotropin stimulus	PMID:15961562^[12]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0072075	metanephric mesenchyme development	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P22561	P	Seeded From UniProt
	GO:0072112	glomerular visceral epithelial cell differentiation	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P22561	P	Seeded From UniProt
	GO:0072166	posterior mesonephric tubule development	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P22561	P	Seeded From UniProt
	GO:0072207	metanephric epithelium development	PMID:7856737^[28]	IEP: Inferred from Expression Pattern		P	Seeded From UniProt
	GO:0072284	metanephric S-shaped body morphogenesis	PMID:10101119^[2]	IGI: Inferred from Genetic Interaction	UniProtKB:P22561	P	Seeded From UniProt
	GO:0072302	negative regulation of metanephric glomerular mesangial cell proliferation	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P22561	P	Seeded From UniProt
	GO:2000020	positive regulation of male gonad development	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P22561	P	Seeded From UniProt
	GO:2000195	negative regulation of female gonad development	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P22561	P	Seeded From UniProt
	GO:2001076	positive regulation of metanephric ureteric bud development	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P22561	P	Seeded From UniProt
	GO:0045893	positive regulation of transcription, DNA-dependent	PMID:9815658^[17]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0045893	positive regulation of transcription, DNA-dependent	PMID:9815658^[17]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0030539	male genitalia development	PMID:8411073^[29]	IMP: Inferred from Mutant Phenotype		P	Figure 2. Sequence analysis of three of the WT1 mutations detected in DDS patients. Normal and mutant sequences are shown.	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Hewitt SM et al. (1995) Regulation of the proto-oncogenes bcl-2 and c-myc by the Wilms' tumor suppressor gene WT1. Cancer Res 55: 5386-9 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 Moore AW et al. (1999) YAC complementation shows a requirement for Wt1 in the development of epicardium, adrenal gland and throughout nephrogenesis. Development 126: 1845-57 PubMed GONUTS page
↑ ^3.0 ^3.1 Guo JK et al. (2002) WT1 is a key regulator of podocyte function: reduced expression levels cause crescentic glomerulonephritis and mesangial sclerosis. Hum Mol Genet 11: 651-9 PubMed GONUTS page
↑ ^4.0 ^4.1 Hamilton TB et al. (1995) High affinity binding sites for the Wilms' tumour suppressor protein WT1. Nucleic Acids Res 23: 277-84 PubMed GONUTS page
↑ ^5.0 ^5.1 Rauscher FJ 3rd (1993) The WT1 Wilms tumor gene product: a developmentally regulated transcription factor in the kidney that functions as a tumor suppressor. FASEB J 7: 896-903 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 Carpenter B et al. (2004) BASP1 is a transcriptional cosuppressor for the Wilms' tumor suppressor protein WT1. Mol Cell Biol 24: 537-49 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Markus MA et al. (2006) WT1 interacts with the splicing protein RBM4 and regulates its ability to modulate alternative splicing in vivo. Exp Cell Res 312: 3379-88 PubMed GONUTS page
↑ ^8.0 ^8.1 Wang D et al. (2011) PINCH1 is transcriptional regulator in podocytes that interacts with WT1 and represses podocalyxin expression. PLoS One 6: e17048 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 Rupprecht HD et al. (1994) The Wilms' tumor suppressor gene WT1 is negatively autoregulated. J Biol Chem 269: 6198-206 PubMed GONUTS page
↑ ^10.0 ^10.1 McConnell MJ et al. (1997) Differential regulation of the human Wilms tumour suppressor gene (WT1) promoter by two isoforms of PAX2. Oncogene 14: 2689-700 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 ^11.4 Maheswaran S et al. (1998) Inhibition of cellular proliferation by the Wilms tumor suppressor WT1 requires association with the inducible chaperone Hsp70. Genes Dev 12: 1108-20 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 Ferretti E et al. (2005) Expression, regulation, and function of paired-box gene 8 in the human placenta and placental cancer cell lines. Endocrinology 146: 4009-15 PubMed GONUTS page
↑ ^13.0 ^13.1 Morris JF et al. (1991) Characterization of the zinc finger protein encoded by the WT1 Wilms' tumor locus. Oncogene 6: 2339-48 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 ^14.3 ^14.4 ^14.5 ^14.6 Englert C et al. (1995) WT1 suppresses synthesis of the epidermal growth factor receptor and induces apoptosis. EMBO J 14: 4662-75 PubMed GONUTS page
↑ Mundlos S et al. (1993) Nuclear localization of the protein encoded by the Wilms' tumor gene WT1 in embryonic and adult tissues. Development 119: 1329-41 PubMed GONUTS page
↑ ^16.0 ^16.1 Smolen GA et al. (2004) SUMO-1 modification of the Wilms' tumor suppressor WT1. Cancer Res 64: 7846-51 PubMed GONUTS page
↑ ^17.0 ^17.1 ^17.2 ^17.3 ^17.4 ^17.5 ^17.6 ^17.7 ^17.8 ^17.9 Shimamura R et al. (1997) The Wilms' tumor gene WT1 can regulate genes involved in sex determination and differentiation: SRY, Müllerian-inhibiting substance, and the androgen receptor. Clin Cancer Res 3: 2571-80 PubMed GONUTS page
↑ Lachenmann MJ et al. (2004) Why zinc fingers prefer zinc: ligand-field symmetry and the hidden thermodynamics of metal ion selectivity. Biochemistry 43: 13910-25 PubMed GONUTS page
↑ ^19.0 ^19.1 ^19.2 Guan LS et al. (1998) Induction of Rb-associated protein (RbAp46) by Wilms' tumor suppressor WT1 mediates growth inhibition. J Biol Chem 273: 27047-50 PubMed GONUTS page
↑ O'Shaughnessy PJ et al. (2007) Developmental changes in human fetal testicular cell numbers and messenger ribonucleic acid levels during the second trimester. J Clin Endocrinol Metab 92: 4792-801 PubMed GONUTS page
↑ Bockenhauer D et al. (2009) Membranoproliferative glomerulonephritis associated with a mutation in Wilms' tumour suppressor gene 1. Pediatr Nephrol 24: 1399-401 PubMed GONUTS page
↑ ^22.0 ^22.1 Ryan G et al. (1995) Repression of Pax-2 by WT1 during normal kidney development. Development 121: 867-75 PubMed GONUTS page
↑ ^23.0 ^23.1 Gashler AL et al. (1992) Human platelet-derived growth factor A chain is transcriptionally repressed by the Wilms tumor suppressor WT1. Proc Natl Acad Sci U S A 89: 10984-8 PubMed GONUTS page
↑ ^24.0 ^24.1 Dame C et al. (2006) Wilms tumor suppressor, Wt1, is a transcriptional activator of the erythropoietin gene. Blood 107: 4282-90 PubMed GONUTS page
↑ ^25.0 ^25.1 Udtha M et al. (2003) Upregulation of c-MYC in WT1-mutant tumors: assessment of WT1 putative transcriptional targets using cDNA microarray expression profiling of genetically defined Wilms' tumors. Oncogene 22: 3821-6 PubMed GONUTS page
↑ Green LM et al. (2009) Dynamic interaction between WT1 and BASP1 in transcriptional regulation during differentiation. Nucleic Acids Res 37: 431-40 PubMed GONUTS page
↑ Fraizer GC et al. (1994) Transcriptional regulation of the human Wilms' tumor gene (WT1). Cell type-specific enhancer and promiscuous promoter. J Biol Chem 269: 8892-900 PubMed GONUTS page
↑ Eccles MR et al. (1995) Comparative in situ hybridization analysis of PAX2, PAX8, and WT1 gene transcription in human fetal kidney and Wilms' tumors. Am J Pathol 146: 40-5 PubMed GONUTS page
↑ Clarkson PA et al. (1993) Mutational screening of the Wilms's tumour gene, WT1, in males with genital abnormalities. J Med Genet 30: 767-72 PubMed GONUTS page

[PMID:7585606-0] 1.0 ^1.1 ^1.2 Hewitt SM et al. (1995) Regulation of the proto-oncogenes bcl-2 and c-myc by the Wilms' tumor suppressor gene WT1. Cancer Res 55: 5386-9 PubMed GONUTS page

[PMID:10101119-1] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 Moore AW et al. (1999) YAC complementation shows a requirement for Wt1 in the development of epicardium, adrenal gland and throughout nephrogenesis. Development 126: 1845-57 PubMed GONUTS page

[PMID:11912180-2] 3.0 ^3.1 Guo JK et al. (2002) WT1 is a key regulator of podocyte function: reduced expression levels cause crescentic glomerulonephritis and mesangial sclerosis. Hum Mol Genet 11: 651-9 PubMed GONUTS page

[PMID:7862533-3] 4.0 ^4.1 Hamilton TB et al. (1995) High affinity binding sites for the Wilms' tumour suppressor protein WT1. Nucleic Acids Res 23: 277-84 PubMed GONUTS page

[PMID:8393820-4] 5.0 ^5.1 Rauscher FJ 3rd (1993) The WT1 Wilms tumor gene product: a developmentally regulated transcription factor in the kidney that functions as a tumor suppressor. FASEB J 7: 896-903 PubMed GONUTS page

[PMID:14701728-5] 6.0 ^6.1 ^6.2 ^6.3 Carpenter B et al. (2004) BASP1 is a transcriptional cosuppressor for the Wilms' tumor suppressor protein WT1. Mol Cell Biol 24: 537-49 PubMed GONUTS page

[PMID:16934801-6] 7.0 ^7.1 ^7.2 Markus MA et al. (2006) WT1 interacts with the splicing protein RBM4 and regulates its ability to modulate alternative splicing in vivo. Exp Cell Res 312: 3379-88 PubMed GONUTS page

[PMID:21390327-7] 8.0 ^8.1 Wang D et al. (2011) PINCH1 is transcriptional regulator in podocytes that interacts with WT1 and represses podocalyxin expression. PLoS One 6: e17048 PubMed GONUTS page

[PMID:8119964-8] 9.0 ^9.1 ^9.2 ^9.3 Rupprecht HD et al. (1994) The Wilms' tumor suppressor gene WT1 is negatively autoregulated. J Biol Chem 269: 6198-206 PubMed GONUTS page

[PMID:9178767-9] 10.0 ^10.1 McConnell MJ et al. (1997) Differential regulation of the human Wilms tumour suppressor gene (WT1) promoter by two isoforms of PAX2. Oncogene 14: 2689-700 PubMed GONUTS page

[PMID:9553041-10] 11.0 ^11.1 ^11.2 ^11.3 ^11.4 Maheswaran S et al. (1998) Inhibition of cellular proliferation by the Wilms tumor suppressor WT1 requires association with the inducible chaperone Hsp70. Genes Dev 12: 1108-20 PubMed GONUTS page

[PMID:15961562-11] 12.0 ^12.1 ^12.2 Ferretti E et al. (2005) Expression, regulation, and function of paired-box gene 8 in the human placenta and placental cancer cell lines. Endocrinology 146: 4009-15 PubMed GONUTS page

[PMID:1662794-12] 13.0 ^13.1 Morris JF et al. (1991) Characterization of the zinc finger protein encoded by the WT1 Wilms' tumor locus. Oncogene 6: 2339-48 PubMed GONUTS page

[PMID:7588596-13] 14.0 ^14.1 ^14.2 ^14.3 ^14.4 ^14.5 ^14.6 Englert C et al. (1995) WT1 suppresses synthesis of the epidermal growth factor receptor and induces apoptosis. EMBO J 14: 4662-75 PubMed GONUTS page

[PMID:8306891-14] Mundlos S et al. (1993) Nuclear localization of the protein encoded by the Wilms' tumor gene WT1 in embryonic and adult tissues. Development 119: 1329-41 PubMed GONUTS page

[PMID:15520190-15] 16.0 ^16.1 Smolen GA et al. (2004) SUMO-1 modification of the Wilms' tumor suppressor WT1. Cancer Res 64: 7846-51 PubMed GONUTS page

[PMID:9815658-16] 17.0 ^17.1 ^17.2 ^17.3 ^17.4 ^17.5 ^17.6 ^17.7 ^17.8 ^17.9 Shimamura R et al. (1997) The Wilms' tumor gene WT1 can regulate genes involved in sex determination and differentiation: SRY, Müllerian-inhibiting substance, and the androgen receptor. Clin Cancer Res 3: 2571-80 PubMed GONUTS page

[PMID:15518539-17] Lachenmann MJ et al. (2004) Why zinc fingers prefer zinc: ligand-field symmetry and the hidden thermodynamics of metal ion selectivity. Biochemistry 43: 13910-25 PubMed GONUTS page

[PMID:9765217-18] 19.0 ^19.1 ^19.2 Guan LS et al. (1998) Induction of Rb-associated protein (RbAp46) by Wilms' tumor suppressor WT1 mediates growth inhibition. J Biol Chem 273: 27047-50 PubMed GONUTS page

[PMID:17848411-19] O'Shaughnessy PJ et al. (2007) Developmental changes in human fetal testicular cell numbers and messenger ribonucleic acid levels during the second trimester. J Clin Endocrinol Metab 92: 4792-801 PubMed GONUTS page

[PMID:19205749-20] Bockenhauer D et al. (2009) Membranoproliferative glomerulonephritis associated with a mutation in Wilms' tumour suppressor gene 1. Pediatr Nephrol 24: 1399-401 PubMed GONUTS page

[PMID:7720589-21] 22.0 ^22.1 Ryan G et al. (1995) Repression of Pax-2 by WT1 during normal kidney development. Development 121: 867-75 PubMed GONUTS page

[PMID:1332065-22] 23.0 ^23.1 Gashler AL et al. (1992) Human platelet-derived growth factor A chain is transcriptionally repressed by the Wilms tumor suppressor WT1. Proc Natl Acad Sci U S A 89: 10984-8 PubMed GONUTS page

[PMID:16467207-23] 24.0 ^24.1 Dame C et al. (2006) Wilms tumor suppressor, Wt1, is a transcriptional activator of the erythropoietin gene. Blood 107: 4282-90 PubMed GONUTS page

[PMID:12802290-24] 25.0 ^25.1 Udtha M et al. (2003) Upregulation of c-MYC in WT1-mutant tumors: assessment of WT1 putative transcriptional targets using cDNA microarray expression profiling of genetically defined Wilms' tumors. Oncogene 22: 3821-6 PubMed GONUTS page

[PMID:19050011-25] Green LM et al. (2009) Dynamic interaction between WT1 and BASP1 in transcriptional regulation during differentiation. Nucleic Acids Res 37: 431-40 PubMed GONUTS page

[PMID:8132626-26] Fraizer GC et al. (1994) Transcriptional regulation of the human Wilms' tumor gene (WT1). Cell type-specific enhancer and promiscuous promoter. J Biol Chem 269: 8892-900 PubMed GONUTS page

[PMID:7856737-27] Eccles MR et al. (1995) Comparative in situ hybridization analysis of PAX2, PAX8, and WT1 gene transcription in human fetal kidney and Wilms' tumors. Am J Pathol 146: 40-5 PubMed GONUTS page

[PMID:8411073-28] Clarkson PA et al. (1993) Mutational screening of the Wilms's tumour gene, WT1, in males with genital abnormalities. J Med Genet 30: 767-72 PubMed GONUTS page

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