HUMAN:WNT5B

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Species (Taxon ID)	Homo sapiens (Human). (taxon:9606)
Gene Name(s)	WNT5B
Protein Name(s)	Protein Wnt-5b
External Links
UniProt Identifier	WNT5B_HUMAN
UniProt Accessions	Q9H1J7, A8K315, D3DUP9, Q96S49, Q9BV04,
EMBL	AY009399, AB060966, AK290430, CH471116, CH471116, BC001749,
RefSeq	NP_110402.2, NP_116031.1,
IntAct	Q9H1J7,
Ensembl	ENST00000310594, ENST00000397196,
Pfam	PF00110,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0005615	extracellular space		NAS: Non-traceable Author Statement		C	Source: UniProtKB
	GO:0005578	proteinaceous extracellular matrix		IEA: Inferred from Electronic Annotation		C	Source: UniProtKB-SubCell
	GO:0005102	receptor binding		IPI: Inferred from Physical Interaction		F	Source: UniProtKB
	GO:0004871	signal transducer activity		IEA: Inferred from Electronic Annotation		F	Source: InterPro
	GO:0002062	chondrocyte differentiation		IEP: Inferred from Expression Pattern		P	Source: UniProtKB
	GO:0045444	fat cell differentiation		NAS: Non-traceable Author Statement		P	Source: UniProtKB
	GO:0030335	positive regulation of cell migration		IDA: Inferred from Direct Assay		P	Source: UniProtKB
	GO:0007223	Wnt receptor signaling pathway, calcium mod...		IEA: Inferred from Electronic Annotation		P	Source: InterPro
	GO:0001525	angiogenesis	GO_REF:0000033		PANTHER:PTHR12027_AN347	P
	GO:0002062	chondrocyte differentiation	PMID:15135146^[1]	IEP: Inferred from Expression Pattern		P
	GO:0005102	receptor binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR005817	F
	GO:0005102	receptor binding	PMID:19486338^[2]	IPI: Inferred from Physical Interaction	UniProtKB:Q01974	F
	GO:0005110	frizzled-2 binding	GO_REF:0000033		PANTHER:PTHR12027_AN265	F
	GO:0005576	extracellular region	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR005817	C
	GO:0005576	extracellular region	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0964	C
	GO:0005578	proteinaceous extracellular matrix	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0272	C
	GO:0005578	proteinaceous extracellular matrix	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0111	C
	GO:0005615	extracellular space	GO_REF:0000033		PANTHER:PTHR12027_AN0	C
	GO:0005615	extracellular space	PMID:15135146^[1]	NAS: Non-traceable Author Statement		C
	GO:0005886	plasma membrane	GO_REF:0000033		PANTHER:PTHR12027_AN0	C
	GO:0007223	Wnt receptor signaling pathway, calcium modulating pathway	GO_REF:0000033		PANTHER:PTHR12027_AN294	P
	GO:0007275	multicellular organismal development	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR005817	P
	GO:0007275	multicellular organismal development	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0217	P
	GO:0009950	dorsal/ventral axis specification	GO_REF:0000033		PANTHER:PTHR12027_AN265	P
	GO:0009952	anterior/posterior pattern formation	GO_REF:0000033		PANTHER:PTHR12027_AN0	P
	GO:0016055	Wnt receptor signaling pathway	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR005817	P
	GO:0016055	Wnt receptor signaling pathway	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0879	P
	GO:0016055	Wnt receptor signaling pathway	PMID:15135146^[1]	IMP: Inferred from Mutant Phenotype		P
	GO:0016055	Wnt receptor signaling pathway	PMID:15731909^[3]	IDA: Inferred from Direct Assay		P
	GO:0030182	neuron differentiation	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P56706	P
	GO:0030335	positive regulation of cell migration	PMID:19486338^[2]	IDA: Inferred from Direct Assay		P
	GO:0031018	endocrine pancreas development	GO_REF:0000033		PANTHER:PTHR12027_AN347	P
	GO:0042074	cell migration involved in gastrulation	GO_REF:0000033		PANTHER:PTHR12027_AN347	P
	GO:0045444	fat cell differentiation	PMID:19577541^[4]	NAS: Non-traceable Author Statement		P
	GO:0045600	positive regulation of fat cell differentiation	GO_REF:0000033		PANTHER:PTHR12027_AN347	P
	GO:0060027	convergent extension involved in gastrulation	GO_REF:0000033		PANTHER:PTHR12027_AN347	P
	GO:0060028	convergent extension involved in axis elongation	GO_REF:0000033		PANTHER:PTHR12027_AN347	P
	GO:0060541	respiratory system development	GO_REF:0000033		PANTHER:PTHR12027_AN265	P
	GO:0070307	lens fiber cell development	PMID:16258938^[5]	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q3L255	P
	GO:0071300	cellular response to retinoic acid	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P56706	P
	GO:0090090	negative regulation of canonical Wnt receptor signaling pathway	GO_REF:0000033		PANTHER:PTHR12027_AN347	P
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Yates KE (2004) Demineralized bone alters expression of Wnt network components during chondroinduction of post-natal fibroblasts. Osteoarthritis Cartilage 12: 497-505 PubMed GONUTS page
↑ ^2.0 ^2.1 Morioka K et al. (2009) Orphan receptor tyrosine kinase ROR2 as a potential therapeutic target for osteosarcoma. Cancer Sci 100: 1227-33 PubMed GONUTS page
↑ Lin-Marq N et al. (2005) Peutz-Jeghers LKB1 mutants fail to activate GSK-3beta, preventing it from inhibiting Wnt signaling. Mol Genet Genomics 273: 184-96 PubMed GONUTS page
↑ van Tienen FH et al. (2009) Wnt5b stimulates adipogenesis by activating PPARgamma, and inhibiting the beta-catenin dependent Wnt signaling pathway together with Wnt5a. Biochem Biophys Res Commun 387: 207-11 PubMed GONUTS page
↑ Fokina VM & Frolova EI (2006) Expression patterns of Wnt genes during development of an anterior part of the chicken eye. Dev Dyn 235: 496-505 PubMed GONUTS page

[PMID:15135146-0] 1.0 ^1.1 ^1.2 Yates KE (2004) Demineralized bone alters expression of Wnt network components during chondroinduction of post-natal fibroblasts. Osteoarthritis Cartilage 12: 497-505 PubMed GONUTS page

[PMID:19486338-1] 2.0 ^2.1 Morioka K et al. (2009) Orphan receptor tyrosine kinase ROR2 as a potential therapeutic target for osteosarcoma. Cancer Sci 100: 1227-33 PubMed GONUTS page

[PMID:15731909-2] Lin-Marq N et al. (2005) Peutz-Jeghers LKB1 mutants fail to activate GSK-3beta, preventing it from inhibiting Wnt signaling. Mol Genet Genomics 273: 184-96 PubMed GONUTS page

[PMID:19577541-3] van Tienen FH et al. (2009) Wnt5b stimulates adipogenesis by activating PPARgamma, and inhibiting the beta-catenin dependent Wnt signaling pathway together with Wnt5a. Biochem Biophys Res Commun 387: 207-11 PubMed GONUTS page

[PMID:16258938-4] Fokina VM & Frolova EI (2006) Expression patterns of Wnt genes during development of an anterior part of the chicken eye. Dev Dyn 235: 496-505 PubMed GONUTS page

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HUMAN:WNT5B

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